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2009

Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display.

Richman, S. A., Kranz, D. M. & Stone, J. D., 2009, In : Methods in molecular biology (Clifton, N.J.). 504, p. 323-350 28 p.

Research output: Contribution to journalArticle

Cutting edge: Inhibitory effects of CD4 and CD8 on T cell activation induced by high-affinity noncognate ligands

Chervin, A. S., Stone, J. D., Bowerman, N. A. & Kranz, D. M., Dec 15 2009, In : Journal of Immunology. 183, 12, p. 7639-7643 5 p.

Research output: Contribution to journalArticle

Different strategies adopted by Kb and Ld to generate T cell specificity directed against their respective bound peptides

Bowerman, N. A., Colf, L. A., Garcia, K. C. & Kranz, D. M., Nov 20 2009, In : Journal of Biological Chemistry. 284, 47, p. 32551-32561 11 p.

Research output: Contribution to journalArticle

Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity

Bowerman, N. A., Crofts, T. S., Chlewicki, L., Do, P., Baker, B. M., Christopher Garcia, K. & Kranz, D. M., Sep 2009, In : Molecular Immunology. 46, 15, p. 3000-3008 9 p.

Research output: Contribution to journalArticle

Imaging membrane intercalating near infrared dyes to track multiple cell populations

Roy, E. J., Sivaguru, M., Fried, G., Gray, B. D. & Kranz, D. M., Aug 31 2009, In : Journal of Immunological Methods. 348, 1-2, p. 18-29 12 p.

Research output: Contribution to journalArticle

Recurrence of intracranial tumors following adoptive T cell therapy can be prevented by direct and indirect killing aided by high levels of tumor antigen cross-presented on stromal cells

Thomas, D. L., Kim, M., Bowerman, N. A., Narayanan, S., Kranz, D. M., Schreiber, H. & Roy, E. J., Aug 1 2009, In : Journal of Immunology. 183, 3, p. 1828-1837 10 p.

Research output: Contribution to journalArticle

Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity

John, C. C., Niermann, M., Sharon, B., Peterson, M. L., Kranz, D. M. & Schlievert, P. M., Dec 2009, In : Clinical Infectious Diseases. 49, 12, p. 1893-1896 4 p.

Research output: Contribution to journalArticle

Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain VαVβ fragments

Richman, S. A., Aggen, D. H., Dossett, M. L., Donermeyer, D. L., Allen, P. M., Greenberg, P. D. & Kranz, D. M., Feb 1 2009, In : Molecular Immunology. 46, 5, p. 902-916 15 p.

Research output: Contribution to journalArticle

The impact of TCR-binding properties and antigen presentation format on T cell responsiveness

Chervin, A. S., Stone, J. D., Holler, P. D., Bai, A., Chen, J., Eisen, H. N. & Kranz, D. M., Jul 15 2009, In : Journal of Immunology. 183, 2, p. 1166-1178 13 p.

Research output: Contribution to journalArticle

2008

Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors

Jones, L. L., Colf, L. A., Bankovich, A. J., Stone, J. D., Gao, Y. G., Choi, M. C., Huang, R. H., Garcia, K. C. & Kranz, D. M., Nov 25 2008, In : Biochemistry. 47, 47, p. 12398-12408 11 p.

Research output: Contribution to journalArticle

Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation

Jones, L. L., Colf, L. A., Stone, J. D., Garcia, K. C. & Kranz, D. M., Nov 1 2008, In : Journal of Immunology. 181, 9, p. 6255-6264 10 p.

Research output: Contribution to journalArticle

Engineering higher affinity T cell receptors using a T cell display system

Chervin, A. S., Aggen, D. H., Raseman, J. M. & Kranz, D. M., Dec 31 2008, In : Journal of Immunological Methods. 339, 2, p. 175-184 10 p.

Research output: Contribution to journalArticle

Equilibrium between host and cancer caused by effector T cells killing tumor stroma

Zhang, B., Zhang, Y., Bowerman, N. A., Schietinger, A., Fu, Y. X., Kranz, D. M., Rowley, D. A. & Schreiber, H., Mar 1 2008, In : Cancer Research. 68, 5, p. 1563-1571 9 p.

Research output: Contribution to journalArticle

Experimental manipulations of afferent immune responses influence efferent immune responses to brain tumors

Thomas, D. L., Kranz, D. M. & Roy, E. J., Sep 1 2008, In : Cancer Immunology, Immunotherapy. 57, 9, p. 1323-1333 11 p.

Research output: Contribution to journalArticle

Neutralization of multiple Staphylococcal superantigens by a single-chain protein consisting of affinity-matured, variable domain repeats

Yang, X., Buonpane, R. A., Moza, B., Rahman, A. K. M. N. U., Wang, N., Schlievert, P. M., McCormick, J. K., Sundberg, E. J. & Kranz, D. M., Aug 1 2008, In : Journal of Infectious Diseases. 198, 3, p. 344-348 5 p.

Research output: Contribution to journalArticle

2007

Cellular uptake followed by class I MHC presentation of some exogenous peptides contributes to T cell stimulatory capacity

Brophy, S. E., Jones, L. L., Holler, P. D. & Kranz, D. M., Mar 1 2007, In : Molecular Immunology. 44, 9, p. 2184-2194 11 p.

Research output: Contribution to journalArticle

Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC

Wang, L., Zhao, Y., Li, Z., Guo, Y., Jones, L. L., Kranz, D. M., Mourad, W. & Li, H., Feb 2007, In : Nature Structural and Molecular Biology. 14, 2, p. 169-171 3 p.

Research output: Contribution to journalArticle

Disulfide bond engineering to trap peptides in the MHC class I binding groove

Truscott, S. M., Lybarger, L., Martinko, J. M., Mitaksov, V. E., Kranz, D. M., Connolly, J. M., Fremont, D. H. & Hansen, T. H., May 15 2007, In : Journal of Immunology. 178, 10, p. 6280-6289 10 p.

Research output: Contribution to journalArticle

Enhancing antitumor immunity: Combining IL-12 with TGFβ1 antagonism

Fan, T. M., Kranz, D. M. & Roy, E. J., Jul 2007, In : Journal of Immunotherapy. 30, 5, p. 479-489 11 p.

Research output: Contribution to journalArticle

How a Single T Cell Receptor Recognizes Both Self and Foreign MHC

Colf, L. A., Bankovich, A. J., Hanick, N. A., Bowerman, N. A., Jones, L. L., Kranz, DM. M. & Garcia, K. C., Apr 6 2007, In : Cell. 129, 1, p. 135-146 12 p.

Research output: Contribution to journalArticle

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

Zhang, B., Bowerman, N. A., Salama, J. K., Schmidt, H., Spiotto, M. T., Schietinger, A., Yu, P., Fu, Y. X., Weichselbaum, R. R., Rowley, D. A., Kranz, D. M. & Schreiber, H., Jan 22 2007, In : Journal of Experimental Medicine. 204, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists

Buonpane, R. A., Churchill, H. R. O., Moza, B., Sundberg, E. J., Peterson, M. L., Schlievert, P. M. & Kranz, D. M., Jun 1 2007, In : Nature Medicine. 13, 6, p. 725-729 5 p.

Research output: Contribution to journalArticle

Solution mapping of T cell receptor docking footprints on peptide-MHC

Varani, L., Bankovich, A. J., Liu, C. W., Colf, L. A., Jones, L. L., Kranz, D. M., Puglisi, J. D. & Garcia, K. C., Aug 7 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 32, p. 13080-13085 6 p.

Research output: Contribution to journalArticle

Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1

Moza, B., Varma, A. K., Buonpane, R. A., Zhu, P., Herfst, C. A., Nicholson, M. J., Wilbuer, A. K., Seth, N. P., Wucherpfennig, K. W., McCormick, J. K., Kranz, D. M. & Sundberg, E. J., Feb 21 2007, In : EMBO Journal. 26, 4, p. 1187-1197 11 p.

Research output: Contribution to journalArticle

2006

Development of a novel strategy for engineering high-affinity proteins by yeast display

Richman, S. A., Healan, S. J., Weber, K. S., Donermeyer, D. L., Dossett, M. L., Greenberg, P. D., Allen, P. M. & Kranz, D. M., Jun 1 2006, In : Protein Engineering, Design and Selection. 19, 6, p. 255-264 10 p.

Research output: Contribution to journalArticle

Engineering and characterization of a stabilized α1/α2 module of the class I major histocompatibility complex product Ld

Jones, L. L., Brophy, S. E., Bankovich, A. J., Colf, L. A., Hanick, N. A., Garcia, K. C. & Kranz, D. M., Sep 1 2006, In : Journal of Biological Chemistry. 281, 35, p. 25734-25744 11 p.

Research output: Contribution to journalArticle

Long-range cooperative binding effects in a T cell receptor variable domain

Moza, B., Buonpane, R. A., Zhu, P., Herfst, C. A., Nur-Ur Rahman, A. K. M., McCormick, J. K., Kranz, D. M. & Sundberg, E. J., Jun 27 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 26, p. 9867-9872 6 p.

Research output: Contribution to journalArticle

The study of high-affinity TCRs reveals duality in T cell recognition of antigen: Specificity and degeneracy

Ponermeyer, D. L., Weber, K. S., Kranz, D. M. & Allen, P. M., Nov 15 2006, In : Journal of Immunology. 177, 10, p. 6911-6919 9 p.

Research output: Contribution to journalArticle

Open Access
2005

Characterization of T cell receptors engineered for high affinity against toxic shock syndrome toxin-1

Buonpane, R. A., Moza, B., Sundberg, E. J. & Kranz, D. M., Oct 21 2005, In : Journal of Molecular Biology. 353, 2, p. 308-321 14 p.

Research output: Contribution to journalArticle

Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function

Weber, K. S., Donermeyer, D. L., Allen, P. M. & Kranz, D. M., Dec 27 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 52, p. 19033-19038 6 p.

Research output: Contribution to journalArticle

High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3

Chlewicki, L. K., Holler, P. D., Monti, B. C., Clutter, M. R. & Kranz, D. M., Feb 11 2005, In : Journal of Molecular Biology. 346, 1, p. 223-239 17 p.

Research output: Contribution to journalArticle

Neuronal localization of indoleamine 2,3-dioxygenase in mice

Roy, E. J., Takikawa, O., Kranz, D. M., Brown, A. R. & Thomas, D. L., Oct 21 2005, In : Neuroscience Letters. 387, 2, p. 95-99 5 p.

Research output: Contribution to journalArticle

Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction

Cho, S., Swaminathan, C. P., Yang, J., Kerzic, M. C., Guan, R., Kieke, M. C., Kranz, D. M., Mariuzza, R. A. & Sundberg, E. J., Dec 2005, In : Structure. 13, 12, p. 1775-1787 13 p.

Research output: Contribution to journalArticle

2004

A conjugate of a tumor-targeting ligand and a T cell costimulatory antibody to treat brain tumors

Gawlick, U., Kranz, D. M., Schepkin, V. D. & Roy, E. J., Sep 1 2004, In : Bioconjugate Chemistry. 15, 5, p. 1137-1145 9 p.

Research output: Contribution to journalArticle

Expression profiling using a hexamer-based universal microarray

Roth, M. E., Feng, L., McConnell, K. J., Schaffer, P. J., Guerra, C. E., Affourtit, J. P., Piper, K. R., Guccione, L., Hariharan, J., Ford, M. J., Powell, S. W., Krishnaswamy, H., Lane, J., Guccione, L., Intrieri, G., Merkel, J. S., Perbost, C., Valerio, A., Zolla, B., Graham, C. D. & 18 others, Hnath, J., Michaelson, C., Wang, R., Ying, B., Halling, C., Parman, C. E., Raha, D., Orr, B., Jedrzkiewicz, B., Liao, J., Tevelev, A., Mattessich, M. J., Kranz, D. M., Lacey, M., Kaufman, J. C., Kim, J., Latimer, D. R. & Lizardi, P. M., Apr 2004, In : Nature Biotechnology. 22, 4, p. 418-426 9 p.

Research output: Contribution to journalArticle

Folate-mediated targeting of T cells to tumors

Roy, E. J., Gawlick, U., Orr, B. A. & Kranz, D. M., Apr 29 2004, In : Advanced Drug Delivery Reviews. 56, 8, p. 1219-1231 13 p.

Research output: Contribution to journalArticle

Targeting virus entry and membrane fusion through specific peptide/MHC complexes using a high-affinity T-cell receptor

Peng, K. W., Holler, P. D., Orr, B. A., Kranz, D. M. & Russell, S. J., Aug 1 2004, In : Gene therapy. 11, 15, p. 1234-1239 6 p.

Research output: Contribution to journalArticle

T cell receptors: Affinities, cross-reactivities, and a conformer model

Holler, P. D. & Kranz, D. M., Feb 2004, In : Molecular Immunology. 40, 14-15, p. 1027-1031 5 p.

Research output: Contribution to journalArticle

2003

Allogeneic and syngeneic class I MHC complexes drive the association of CD8 and TCR on 2C T cells

Lee, P. U. Y. & Kranz, D. M., Jan 1 2003, In : Molecular Immunology. 39, 12, p. 687-695 9 p.

Research output: Contribution to journalArticle

Analysis of superantigen binding to soluble T-cell receptors.

Churchill, H. R. O. & Kranz, D. M., 2003, In : Methods in molecular biology (Clifton, N.J.). 214, p. 101-111 11 p.

Research output: Contribution to journalArticle

A yeast display system for engineering functional peptide-MHC complexes

Brophy, S. E., Holler, P. D. & Kranz, D. M., Jan 15 2003, In : Journal of Immunological Methods. 272, 1-2, p. 235-246 12 p.

Research output: Contribution to journalArticle

Directed evolution of a single-chain class II MHC product by yeast display

Starwalt, S. E., Mastellela, E. L., Bluestone, J. A. & Kranz, D. M., Feb 1 2003, In : Protein Engineering. 16, 2, p. 147-156 10 p.

Research output: Contribution to journalArticle

Directed evolution of T-cell receptors for binding superantigens.

Churchill, H. R. O. & Kranz, D. M., 2003, In : Methods in molecular biology (Clifton, N.J.). 214, p. 87-99 13 p.

Research output: Contribution to journalArticle

Dissecting Cooperative and Additive Binding Energetics in the Affinity Maturation Pathway of a Protein-Protein Interface

Yang, J., Swaminathan, C. P., Huang, Y., Guan, R., Cho, S., Kieke, M. C., Kranz, D. M., Mariuzza, R. A. & Sundberg, E. J., Dec 12 2003, In : Journal of Biological Chemistry. 278, 50, p. 50412-50421 10 p.

Research output: Contribution to journalArticle

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

Holler, P. D. & Kranz, D. M., Feb 1 2003, In : Immunity. 18, 2, p. 255-264 10 p.

Research output: Contribution to journalArticle

Rapid method for measuring scFv thermal stability by yeast surface display

Orr, B. A., Carr, L. M., Wittrup, K. D., Roy, E. J. & Kranz, D. M., Mar 1 2003, In : Biotechnology Progress. 19, 2, p. 631-638 8 p.

Research output: Contribution to journalArticle

The cationic region from HIV tat enhances the cell-surface expression of epitope/MHC class I complexes

Leifert, J. A., Holler, P. D., Harkins, S., Kranz, D. M. & Whitton, J. L., Dec 1 2003, In : Gene therapy. 10, 25, p. 2067-2073 7 p.

Research output: Contribution to journalArticle

Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb

Dam, J., Guan, R., Natarajan, K., Dimasi, N., Chlewicki, L. K., Kranz, D. M., Schuck, P., Margulies, D. H. & Mariuzza, R. A., Dec 1 2003, In : Nature Immunology. 4, 12, p. 1213-1222 10 p.

Research output: Contribution to journalArticle