David M Kranz

1975 …2019
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Research Output 1975 2019

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1994

Efficient tumor cell lysis mediated by a bispecific single chain antibody expressed in Escherichia coli

Gruber, M., Schodin, B. A., Wilson, E. R. & Kranz, D. M., Jun 1 1994, In : Journal of Immunology. 152, 11, p. 5368-5374 7 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
Single-Chain Antibodies
Fluorescein
Escherichia coli
Neoplasms

Generation of Cytotoxic T-Lymphocytes to a Self-Peptide/Class I Complex: A Model for Peptide-mediated Tumor Rejection

Tjoa, B. A. & Kranz, D. M., Jan 1994, In : Cancer Research. 54, 1, p. 204-208 5 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Peptides
Neoplasms
Neoplasm Antigens
Autoantigens

Sequence restrictions in T cell receptor β-chains that have specificity for a self-peptide/Ld complex

Tjoa, B. A. & Kranz, D. M., Jul 1994, In : Molecular Immunology. 31, 10, p. 705-711 7 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Peptides
Cytotoxic T-Lymphocytes
Glutamic Acid
Oxidoreductases
1995

Characterization of a single-chain antibody to the β-chain of the T cell receptor

Cho, B. K., Schodin, B. A. & Kranz, D. M., Jan 1 1995, In : Journal of Biological Chemistry. 270, 43, p. 25819-25826 8 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
T-Cell Antigen Receptor
Antibodies
Immunoglobulin Fab Fragments
Peptides
T-Cell Antigen Receptor
Folic Acid
Antibodies
Neoplasms
Bispecific Antibodies

Properties of Bispecific Single Chain Antibodies Expressed in Escherichia coli

Kranz, D. M., Gruber, M. & Wilson, E. R., Oct 1995, In : Journal of Hematotherapy and Stem Cell Research. 4, 5, p. 403-408 6 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
Single-Chain Antibodies
Fluorescein
Escherichia coli
Antigens
1996

A Residue in the Center of Peptide QL9 Affects Binding to Both Ld and the T Cell Receptor

Schlueter, C. J., Manning, T. C., Schodin, B. A. & Kranz, D. M., Nov 15 1996, In : Journal of Immunology. 157, 10, p. 4478-4485 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Peptides
QL9 peptide
Clone Cells
T-Lymphocytes

A strategy for the synthesis and screening of thiol-modified peptide variants recognized by T cells

Manning, T. C., Schodin, B. A. & Kranz, D. M., Jun 10 1996, In : Journal of Immunological Methods. 192, 1-2, p. 125-132 8 p.

Research output: Contribution to journalArticle

Sulfhydryl Compounds
T-Lymphocytes
Peptides
Cysteine
Contact Dermatitis

Binding properties and solubility of single-chain T cell receptors expressed in E. coli

Schodin, B. A., Schlueter, C. J. & Kranz, D. M., Jun 1996, In : Molecular Immunology. 33, 9, p. 819-829 11 p.

Research output: Contribution to journalArticle

Thioredoxins
T-Cell Antigen Receptor
Solubility
Escherichia coli
Proteins

Comparison of affinity purification techniques for single chain antibody NC 6.8

Jackson, M. G., Brodnicki, T. C., Kranz, D. M. & Linthicum, D. S., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

Single-Chain Antibodies
purification methods
Purification
Fusion reactions
Immunoglobulin G

Construction and characterization of a single chain antibody that binds a superpotent sweetener ligand

Pledger, D. W., Graham, B. L., Brodnicki, T. C., Kranz, D. M. & Linthicum, D. S., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

Sweetening Agents
Single-Chain Antibodies
His-His-His-His-His-His
Dialysis
Complementary DNA

Correlation between the number of T cell receptors required for T cell activation and TCR-ligand affinity

Schodin, B. A., Tsomides, T. J. & Kranz, D. M., Aug 1996, In : Immunity. 5, 2, p. 137-146 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Ligands
T-Lymphocytes
Superantigens
Peptides

Determination of the role of aromatic residues in the binding pocket of an antibody that binds a sweetener lioand

Harris, J. S., Brodnicki, T. C., Kranz, D. M. & Linthicum, D. S., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

Sweetening Agents
sweeteners
aromatic compounds
Quenching
His-His-His-His-His-His

Identification of peptide and T cell receptor residues involved in the interaction of CTL 2C and QL9/Ld

Schlueter, C., Manning, T., Brodnicki, T. & Kranz, D. M., Dec 1 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

Peptide T
T-Cell Antigen Receptor
Alanine
alanine
T-lymphocytes

Reactivity and epitope mapping of single-chain T cell receptors with monoclonal antibodies

Brodnicki, T. C., Holman, P. O. & Kranz, D. M., Feb 1996, In : Molecular Immunology. 33, 3, p. 253-263 11 p.

Research output: Contribution to journalArticle

Epitope Mapping
T-Cell Antigen Receptor
Monoclonal Antibodies
Antibodies
Epitopes

Specificity and binding properties of a single-chain T cell receptor

Schlueter, C. J., Schodin, B. A., Tetin, S. Y. & Kranz, D. M., Mar 15 1996, In : Journal of Molecular Biology. 256, 5, p. 859-869 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Complementarity Determining Regions
Peptides
T-Cell Antigen Receptor Specificity
1997

Antigen Recognition and Allogeneic Tumor Rejection in CD8+ TCR Transgenic/RAG-/- Mice

Manning, T. C., Rund, L. A., Gruber, M. M., Fallarino, F., Gajewski, T. F. & Kranz, D. M., Nov 15 1997, In : Journal of Immunology. 159, 10, p. 4665-4675 11 p.

Research output: Contribution to journalArticle

Transgenic Mice
Antigens
T-Lymphocytes
Neoplasms
B7 Antigens

Folate receptors as potential therapeutic targets in choroid plexus tumors of SV40 transgenic mice

Patrick, T. A., Kranz, D. M., Van Dyke, T. A. & Roy, E. J., Feb 25 1997, In : Journal of Neuro-Oncology. 32, 2, p. 111-123 13 p.

Research output: Contribution to journalArticle

Choroid Plexus Neoplasms
Folic Acid
Transgenic Mice
Choroid Plexus
Ependymoma

Isolation of anti-T cell receptor scFv mutants by yeast surface display

Kieke, M. C., Cho, B. K., Boder, E. T., Kranz, D. M. & Wittrup, K. D., Dec 1 1997, In : Protein Engineering. 10, 11, p. 1303-1310 8 p.

Research output: Contribution to journalArticle

T-cells
T-Cell Antigen Receptor
Yeast
Epitopes
Yeasts

Single-chain Fv/folate conjugates mediate efficient lysis of folate-receptor-positive tumor cells

Cho, B. K., Roy, E. J., Patrick, T. A. & Kranz, D. M., May 1 1997, In : Bioconjugate Chemistry. 8, 3, p. 338-346 9 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Folic Acid
Tumors
T-cells
Cells
1998

Alanine scanning mutagenesis of an αβ T cell receptor: Mapping the energy of antigen recognition

Manning, T. C., Schlueter, C. J., Brodnicki, T. C., Parke, E. A., Speir, J. A., Garcia, K. C., Teyton, L., Wilson, I. A. & Kranz, D. M., Apr 1998, In : Immunity. 8, 4, p. 413-425 13 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Mutagenesis
Alanine
Antigens
T-Lymphocytes

A yeast surface display system for the discovery of ligands that trigger cell activation

Cho, B. K., Kieke, M. C., Boder, E. T., Wittrup, K. D. & Kranz, D. M., Nov 1 1998, In : Journal of Immunological Methods. 220, 1-2, p. 179-188 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Yeasts
Ligands
Antigen-Presenting Cells
T-Lymphocytes

Construction of a single-chain antibody derived from 5H7, a monoclonal antibody specific for a death signaling domain of human class I major histocompatibility complex

Kulkarni, S., Holman, P., Kranz, D., Zhou, N., Van Seventer, J. & Woodle, E. S., Jul 15 1998, In : Transplantation Proceedings. 30, 4, 1 p.

Research output: Contribution to journalArticle

Immunoglobulin Variable Region
Immunoglobulin Light Chains
Single-Chain Antibodies
Gene Transfer Techniques
Immunoglobulin Heavy Chains

Intracerebral bispecific ligand-antibody conjugate increases survival of animals bearing endogenously arising brain tumors

Patrick, T. A., Kranz, D. M., Zachary, J. F. & Roy, E. J., Nov 2 1998, In : International Journal of Cancer. 78, 4, p. 470-479 10 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
Brain Neoplasms
Ligands
Choroid Plexus Neoplasms
T-Lymphocytes

Targeting T cells against brain tumors with a bispecific ligand-antibody conjugate

Roy, E. J., Cho, B. K., Rund, L. A., Patrick, T. A. & Kranz, D. M., Jun 10 1998, In : International Journal of Cancer. 76, 5, p. 761-766 6 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
Folic Acid
Brain Neoplasms
Ligands
T-Lymphocytes

Targeting tumor cells with bispecific antibodies and T cells

Kranz, D. M., Manning, T. C., Rund, L. A., Cho, B. K., Gruber, M. M. & Roy, E. J., Apr 30 1998, In : Journal of Controlled Release. 53, 1-3, p. 77-84 8 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
T-Lymphocytes
Folic Acid
T-Cell Antigen Receptor
Neoplasms
1999

Bispecific agents target endogenous murine T cells against human tumor xenografts

Rund, L. A., Cho, B. K., Manning, T. C., Holler, P. D., Roy, E. J. & Kranz, D. M., Sep 7 1999, In : International Journal of Cancer. 83, 1, p. 141-149 9 p.

Research output: Contribution to journalArticle

Heterografts
T-Lymphocytes
T-Cell Antigen Receptor
Neoplasms
Bispecific Antibodies

Construction and characterization of two anti-sweetener single chain antibodies using radioligand binding, fluorescence and circular dichroism spectroscopy

Pledger, D. W., Brodnicki, T. C., Graham, B. L., Tetin, S., Kranz, D. M. & Linthicum, D. S., Jan 1 1999, In : Journal of Molecular Recognition. 12, 4, p. 258-266 9 p.

Research output: Contribution to journalArticle

Sweetening Agents
Single-Chain Antibodies
Circular Dichroism
Spectrum Analysis
His-His-His-His-His-His
Complementarity Determining Regions
T-Cell Antigen Receptor
Major Histocompatibility Complex
Mutation
Peptides

Role of the T cell receptor α chain in stabilizing TCR-superantigen- MHC class II complexes

Andersen, P. S., Lavoie, P. M., Sékaly, R. P., Churchill, H., Kranz, D. M., Schlievert, P. M., Karjalainen, K. & Mariuzza, R. A., Apr 1999, In : Immunity. 10, 4, p. 473-483 11 p.

Research output: Contribution to journalArticle

Superantigens
T-Cell Antigen Receptor
T-Lymphocytes
Antigen-Presenting Cells
Half-Life

Selection of functional T cell receptor mutants from a yeast surface- display library

Kieke, M. C., Shusta, E. V., Boder, E. T., Teyton, L., Wittrup, K. D. & Kranz, D. M., May 11 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 10, p. 5651-5656 6 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Libraries
Yeasts
Antibodies
T-Cell Antigen Receptor Specificity

Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency

Shusta, E. V., Kieke, M. C., Parke, E., Kranz, D. M. & Wittrup, K. D., Oct 8 1999, In : Journal of Molecular Biology. 292, 5, p. 949-956 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Hot Temperature
Yeasts
Peptides
Mutant Proteins
2000

Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152)

Griffin, M. D., Hong, D. K., Holman, P. O., Lee, K. M., Whitters, M. J., O'Herrin, S. M., Fallarino, F., Collins, M., Segal, D. M., Gajewski, T. F., Kranz, D. M. & Bluestone, J. A., May 1 2000, In : Journal of Immunology. 164, 9, p. 4433-4442 10 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
T-Lymphocytes
Ligation
Ligands
Immune Tolerance

Directed evolution of a stable scaffold for T-cell receptor engineering

Shusta, E. V., Holler, P. D., Kieke, M. C., Kranz, D. M. & Wittrup, K. D., Jul 1 2000, In : Nature Biotechnology. 18, 7, p. 754-759 6 p.

Research output: Contribution to journalArticle

Cell Engineering
T-cells
T-Cell Antigen Receptor
Scaffolds
Major Histocompatibility Complex

IL-12 treatment of endogenously arising murine brain tumors

Roy, E. J., Gawlick, U., Orr, B. A., Rund, L. A., Webb, A. G. & Kranz, D. M., Dec 15 2000, In : Journal of Immunology. 165, 12, p. 7293-7299 7 p.

Research output: Contribution to journalArticle

Interleukin-12
Brain Neoplasms
T-Lymphocytes
Neoplasms
Therapeutics

In vitro evolution of a T cell receptor with high affinity for peptide/MHC

Holler, P. D., Holman, P. O., Shusta, E. V., O'Herrin, S., Wittrup, K. D. & Kranz, D. M., May 9 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 10, p. 5387-5392 6 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Peptides
In Vitro Techniques
Antigen-Presenting Cells
Libraries

Mapping the energy of superantigen Staphylococcus enterotoxin C3 recognition of an α/β T cell receptor using alanine scanning mutagenesis

Churchill, H. R. O., Andersen, P. S., Parke, E. A., Mariuzza, R. A. & Kranz, D. M., Mar 6 2000, In : Journal of Experimental Medicine. 191, 5, p. 835-846 12 p.

Research output: Contribution to journalArticle

Superantigens
Enterotoxins
T-Cell Antigen Receptor
Complementarity Determining Regions
Staphylococcus

Programmed cell death signaling via cell-surface expression of a single- chain antibody transgene

Kulkarni, S., Holman, P. O., Kopelan, A., Van Seventer, G. A., Van Seventer, J. M., Kranz, D. M. & Woodle, E. S., Mar 27 2000, In : Transplantation. 69, 6, p. 1209-1217 9 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Transgenes
Cell Death
Membranes
Blood Cells

Role of 2C T cell receptor residues in the binding of self- and allo- major histocompatibility complexes

Lee, P. U. Y., Churchill, H. R. O., Daniels, M., Jameson, S. C. & Kranz, D. M., Apr 17 2000, In : Journal of Experimental Medicine. 191, 8, p. 1355-1364 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Ligands
Alanine
Complementarity Determining Regions
2001

CD8-T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation

Holler, P. D., Lim, A. R., Cho, B. K., Rund, L. A. & Kranz, D. M., Oct 15 2001, In : Journal of Experimental Medicine. 194, 8, p. 1043-1052 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Peptides
Cytotoxic T-Lymphocytes
Antigen-Presenting Cells

Development and applications of surface-linked single chain antibodies against T-cell antigens

Griffin, M. D., Holman, P. O., Tang, Q., Ashourian, N., Korthäuer, U., Kranz, D. M. & Bluestone, J. A., Feb 1 2001, In : Journal of Immunological Methods. 248, 1-2, p. 77-90 14 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Viral Tumor Antigens
T-Lymphocytes
Product Packaging
Mutagenesis

Differences in antigen recognition and cytolytic activity of CD8+ and CD8- T cells that express the same antigen-specific receptor

Cho, B. K., Lian, K. C., Lee, P., Brunmark, A., McKinley, C., Chen, J., Kranz, D. M. & Eisen, H. N., Feb 13 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 4, p. 1723-1727 5 p.

Research output: Contribution to journalArticle

Antigen Receptors
T-Lymphocytes
Antigens
T-Cell Antigen Receptor
Peptides

High affinity T cell receptors from yeast display libraries block T cell activation by superantigens

Kieke, M. C., Sundberg, E., Shusta, E. V., Mariuzza, R. A., Wittrup, K. D. & Kranz, D. M., Apr 13 2001, In : Journal of Molecular Biology. 307, 5, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

Superantigens
Enterotoxins
T-Cell Antigen Receptor
Yeasts
T-Lymphocytes
2003

Allogeneic and syngeneic class I MHC complexes drive the association of CD8 and TCR on 2C T cells

Lee, P. U. Y. & Kranz, D. M., Jan 1 2003, In : Molecular Immunology. 39, 12, p. 687-695 9 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Fluorescence Resonance Energy Transfer
Ligands
Clone Cells

Analysis of superantigen binding to soluble T-cell receptors.

Churchill, H. R. O. & Kranz, D. M., 2003, In : Methods in molecular biology (Clifton, N.J.). 214, p. 101-111 11 p.

Research output: Contribution to journalArticle

Superantigens
T-Cell Antigen Receptor
Protein Binding
Solubility
Monoclonal Antibodies

A yeast display system for engineering functional peptide-MHC complexes

Brophy, S. E., Holler, P. D. & Kranz, D. M., Jan 15 2003, In : Journal of Immunological Methods. 272, 1-2, p. 235-246 12 p.

Research output: Contribution to journalArticle

Yeasts
Peptides
T-Lymphocytes
T-Cell Antigen Receptor
Cellular Immunity

Directed evolution of a single-chain class II MHC product by yeast display

Starwalt, S. E., Mastellela, E. L., Bluestone, J. A. & Kranz, D. M., Feb 1 2003, In : Protein Engineering. 16, 2, p. 147-156 10 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Yeast
T-cells
Yeasts
Display devices

Directed evolution of T-cell receptors for binding superantigens.

Churchill, H. R. O. & Kranz, D. M., 2003, In : Methods in molecular biology (Clifton, N.J.). 214, p. 87-99 13 p.

Research output: Contribution to journalArticle

Directed Molecular Evolution
Superantigens
T-Cell Antigen Receptor
Saccharomyces cerevisiae
Flow Cytometry

Dissecting Cooperative and Additive Binding Energetics in the Affinity Maturation Pathway of a Protein-Protein Interface

Yang, J., Swaminathan, C. P., Huang, Y., Guan, R., Cho, S., Kieke, M. C., Kranz, D. M., Mariuzza, R. A. & Sundberg, E. J., Dec 12 2003, In : Journal of Biological Chemistry. 278, 50, p. 50412-50421 10 p.

Research output: Contribution to journalArticle

Proteins
Mutation
Complementarity Determining Regions
Superantigens
Mutagenesis

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

Holler, P. D. & Kranz, D. M., Feb 1 2003, In : Immunity. 18, 2, p. 255-264 10 p.

Research output: Contribution to journalArticle

T-Lymphocytes
TCF Transcription Factors
Peptides
In Vitro Techniques