David M Kranz

1975 …2019
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Research Output 1975 2019

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2009

Recurrence of intracranial tumors following adoptive T cell therapy can be prevented by direct and indirect killing aided by high levels of tumor antigen cross-presented on stromal cells

Thomas, D. L., Kim, M., Bowerman, N. A., Narayanan, S., Kranz, D. M., Schreiber, H. & Roy, E. J., Aug 1 2009, In : Journal of Immunology. 183, 3, p. 1828-1837 10 p.

Research output: Contribution to journalArticle

Neoplasm Antigens
Stromal Cells
Cell- and Tissue-Based Therapy
T-Lymphocytes
Recurrence

Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity

John, C. C., Niermann, M., Sharon, B., Peterson, M. L., Kranz, D. M. & Schlievert, P. M., Dec 1 2009, In : Clinical Infectious Diseases. 49, 12, p. 1893-1896 4 p.

Research output: Contribution to journalArticle

Exfoliative Dermatitis
Septic Shock
Hypersensitivity
Superantigens
Enterotoxins

Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain VαVβ fragments

Richman, S. A., Aggen, D. H., Dossett, M. L., Donermeyer, D. L., Allen, P. M., Greenberg, P. D. & Kranz, D. M., Feb 1 2009, In : Molecular Immunology. 46, 5, p. 902-916 15 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Yeasts
Single-Chain Antibodies
Mutation
Sequence Homology

The impact of TCR-binding properties and antigen presentation format on T cell responsiveness

Chervin, A. S., Stone, J. D., Holler, P. D., Bai, A., Chen, J., Eisen, H. N. & Kranz, D. M., Jul 15 2009, In : Journal of Immunology. 183, 2, p. 1166-1178 13 p.

Research output: Contribution to journalArticle

Antigen Presentation
T-Lymphocytes
Peptides
Gallopamil
Surface Plasmon Resonance
2008
Transforming Growth Factors
Regulatory T-Lymphocytes
T-Lymphocytes
Lymphocytes
Cytokines

Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors

Jones, L. L., Colf, L. A., Bankovich, A. J., Stone, J. D., Gao, Y. G., Choi, M. C., Huang, R. H., Garcia, K. C. & Kranz, D. M., Nov 25 2008, In : Biochemistry. 47, 47, p. 12398-12408 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Thermodynamics
Peptides
Complementarity Determining Regions
Mutagenesis

Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation

Jones, L. L., Colf, L. A., Stone, J. D., Garcia, K. C. & Kranz, D. M., Nov 1 2008, In : Journal of Immunology. 181, 9, p. 6255-6264 10 p.

Research output: Contribution to journalArticle

Ligands
Antigens
Isoantigens
T-Lymphocytes
Peptides

Engineering higher affinity T cell receptors using a T cell display system

Chervin, A. S., Aggen, D. H., Raseman, J. M. & Kranz, D. M., Dec 31 2008, In : Journal of Immunological Methods. 339, 2, p. 175-184 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Hybridomas
CD3 Antigens
Protein Engineering

Equilibrium between host and cancer caused by effector T cells killing tumor stroma

Zhang, B., Zhang, Y., Bowerman, N. A., Schietinger, A., Fu, Y. X., Kranz, D. M., Rowley, D. A. & Schreiber, H., Mar 1 2008, In : Cancer Research. 68, 5, p. 1563-1571 9 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Neoplasms
Stromal Cells
Neoplasm Antigens
Myeloid Cells

Experimental manipulations of afferent immune responses influence efferent immune responses to brain tumors

Thomas, D. L., Kranz, D. M. & Roy, E. J., Sep 1 2008, In : Cancer Immunology, Immunotherapy. 57, 9, p. 1323-1333 11 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Lymph Nodes
Neoplasms
Brain
Radioactivity

Neutralization of multiple Staphylococcal superantigens by a single-chain protein consisting of affinity-matured, variable domain repeats

Yang, X., Buonpane, R. A., Moza, B., Rahman, A. K. M. N. U., Wang, N., Schlievert, P. M., McCormick, J. K., Sundberg, E. J. & Kranz, D. M., Aug 1 2008, In : Journal of Infectious Diseases. 198, 3, p. 344-348 5 p.

Research output: Contribution to journalArticle

Superantigens
Proteins
Septic Shock
T-Cell Antigen Receptor
Staphylococcus aureus
2007

Cellular uptake followed by class I MHC presentation of some exogenous peptides contributes to T cell stimulatory capacity

Brophy, S. E., Jones, L. L., Holler, P. D. & Kranz, D. M., Mar 1 2007, In : Molecular Immunology. 44, 9, p. 2184-2194 11 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Peptides
T-Cell Antigen Receptor
Brefeldin A
Antigen Presentation

Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC

Wang, L., Zhao, Y., Li, Z., Guo, Y., Jones, L. L., Kranz, D. M., Mourad, W. & Li, H., Feb 2007, In : Nature Structural and Molecular Biology. 14, 2, p. 169-171 3 p.

Research output: Contribution to journalArticle

HLA-DR1 Antigen
Superantigens
Cell Communication
T-Lymphocytes
Peptides

Disulfide bond engineering to trap peptides in the MHC class I binding groove

Truscott, S. M., Lybarger, L., Martinko, J. M., Mitaksov, V. E., Kranz, D. M., Connolly, J. M., Fremont, D. H. & Hansen, T. H., May 15 2007, In : Journal of Immunology. 178, 10, p. 6280-6289 10 p.

Research output: Contribution to journalArticle

Disulfides
Peptides
T-Lymphocytes
Endoplasmic Reticulum
Vaccination

Enhancing antitumor immunity: Combining IL-12 with TGFβ1 antagonism

Fan, T. M., Kranz, D. M. & Roy, E. J., Jul 1 2007, In : Journal of Immunotherapy. 30, 5, p. 479-489 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Interleukin-12
Immunity
T-Lymphocytes
Interferons

How a Single T Cell Receptor Recognizes Both Self and Foreign MHC

Colf, L. A., Bankovich, A. J., Hanick, N. A., Bowerman, N. A., Jones, L. L., Kranz, DM. M. & Garcia, K. C., Apr 6 2007, In : Cell. 129, 1, p. 135-146 12 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Ligands
Molecular Mimicry
Antigens

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

Zhang, B., Bowerman, N. A., Salama, J. K., Schmidt, H., Spiotto, M. T., Schietinger, A., Yu, P., Fu, Y. X., Weichselbaum, R. R., Rowley, D. A., Kranz, D. M. & Schreiber, H., Jan 22 2007, In : Journal of Experimental Medicine. 204, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Stromal Cells
Antigens
Neoplasms
Cytotoxic T-Lymphocytes

Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists

Buonpane, R. A., Churchill, H. R. O., Moza, B., Sundberg, E. J., Peterson, M. L., Schlievert, P. M. & Kranz, D. M., Jun 1 2007, In : Nature Medicine. 13, 6, p. 725-729 5 p.

Research output: Contribution to journalArticle

Superantigens
T-cells
Exotoxins
Bacterial Proteins
Poisons

Solution mapping of T cell receptor docking footprints on peptide-MHC

Varani, L., Bankovich, A. J., Liu, C. W., Colf, L. A., Jones, L. L., Kranz, D. M., Puglisi, J. D. & Garcia, K. C., Aug 7 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 32, p. 13080-13085 6 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Peptides
T-Cell Receptor Genes
Molecular Dynamics Simulation
Cellular Immunity

Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1

Moza, B., Varma, A. K., Buonpane, R. A., Zhu, P., Herfst, C. A., Nicholson, M. J., Wilbuer, A. K., Seth, N. P., Wucherpfennig, K. W., McCormick, J. K., Kranz, D. M. & Sundberg, E. J., Feb 21 2007, In : EMBO Journal. 26, 4, p. 1187-1197 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor Specificity
Superantigens
T-cells
T-Cell Antigen Receptor
Chemical activation
2006

Development of a novel strategy for engineering high-affinity proteins by yeast display

Richman, S. A., Healan, S. J., Weber, K. S., Donermeyer, D. L., Dossett, M. L., Greenberg, P. D., Allen, P. M. & Kranz, D. M., Jun 1 2006, In : Protein Engineering, Design and Selection. 19, 6, p. 255-264 10 p.

Research output: Contribution to journalArticle

Fungal Proteins
T-cells
Yeast
T-Cell Antigen Receptor
Yeasts

Engineering and characterization of a stabilized α1/α2 module of the class I major histocompatibility complex product L d

Jones, L. L., Brophy, S. E., Bankovich, A. J., Colf, L. A., Hanick, N. A., Garcia, K. C. & Kranz, D. M., Sep 1 2006, In : Journal of Biological Chemistry. 281, 35, p. 25734-25744 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Yeasts
Yeast
Proteins
Granzymes
Cytotoxic T-Lymphocytes
Natural Killer Cells
Estrogens
Peptide Hydrolases

Long-range cooperative binding effects in a T cell receptor variable domain

Moza, B., Buonpane, R. A., Zhu, P., Herfst, C. A., Nur-Ur Rahman, A. K. M., McCormick, J. K., Kranz, D. M. & Sundberg, E. J., Jun 27 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 26, p. 9867-9872 6 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Proteins
Superantigens
Surface Plasmon Resonance
Mutagenesis

The study of high-affinity TCRs reveals duality in T cell recognition of antigen: Specificity and degeneracy

Ponermeyer, D. L., Weber, K. S., Kranz, D. M. & Allen, P. M., Nov 15 2006, In : Journal of Immunology. 177, 10, p. 6911-6919 9 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Antigens
Peptides
Ligands
Moths
2005

Characterization of T cell receptors engineered for high affinity against toxic shock syndrome toxin-1

Buonpane, R. A., Moza, B., Sundberg, E. J. & Kranz, D. M., Oct 21 2005, In : Journal of Molecular Biology. 353, 2, p. 308-321 14 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Superantigens
Mutation
Staphylococcal enterotoxin F
Enterotoxins

Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function

Weber, K. S., Donermeyer, D. L., Allen, P. M. & Kranz, D. M., Dec 27 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 52, p. 19033-19038 6 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Peptides
Hemoglobins
Clonal Deletion

High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3

Chlewicki, L. K., Holler, P. D., Monti, B. C., Clutter, M. R. & Kranz, D. M., Feb 11 2005, In : Journal of Molecular Biology. 346, 1, p. 223-239 17 p.

Research output: Contribution to journalArticle

Peptide T
T-Cell Antigen Receptor
Mutation
Major Histocompatibility Complex
Peptides

Neuronal localization of indoleamine 2,3-dioxygenase in mice

Roy, E. J., Takikawa, O., Kranz, D. M., Brown, A. R. & Thomas, D. L., Oct 21 2005, In : Neuroscience Letters. 387, 2, p. 95-99 5 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Kynurenine
Neurons
Tryptophan
Interferons

Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction

Cho, S., Swaminathan, C. P., Yang, J., Kerzic, M. C., Guan, R., Kieke, M. C., Kranz, D. M., Mariuzza, R. A. & Sundberg, E. J., Dec 1 2005, In : Structure. 13, 12, p. 1775-1787 13 p.

Research output: Contribution to journalArticle

Proteins
Molecular Structure
Protein Binding
X-Rays
2004

A conjugate of a tumor-targeting ligand and a T cell costimulatory antibody to treat brain tumors

Gawlick, U., Kranz, D. M., Schepkin, V. D. & Roy, E. J., Sep 1 2004, In : Bioconjugate Chemistry. 15, 5, p. 1137-1145 9 p.

Research output: Contribution to journalArticle

T-cells
Antibodies
Brain Neoplasms
Interleukin-12
Tumors

Expression profiling using a hexamer-based universal microarray

Roth, M. E., Feng, L., McConnell, K. J., Schaffer, P. J., Guerra, C. E., Affourtit, J. P., Piper, K. R., Guccione, L., Hariharan, J., Ford, M. J., Powell, S. W., Krishnaswamy, H., Lane, J., Guccione, L., Intrieri, G., Merkel, J. S., Perbost, C., Valerio, A., Zolla, B., Graham, C. D. & 18 others, Hnath, J., Michaelson, C., Wang, R., Ying, B., Halling, C., Parman, C. E., Raha, D., Orr, B., Jedrzkiewicz, B., Liao, J., Tevelev, A., Mattessich, M. J., Kranz, D. M., Lacey, M., Kaufman, J. C., Kim, J., Latimer, D. R. & Lizardi, P. M., Apr 1 2004, In : Nature Biotechnology. 22, 4, p. 418-426 9 p.

Research output: Contribution to journalArticle

Microarrays
Transcriptome
Yeast
DNA
Technology

Folate-mediated targeting of T cells to tumors

Roy, E. J., Gawlick, U., Orr, B. A. & Kranz, D. M., Apr 29 2004, In : Advanced Drug Delivery Reviews. 56, 8, p. 1219-1231 13 p.

Research output: Contribution to journalArticle

Folic Acid
T-Lymphocytes
Neoplasms
Bispecific Antibodies
Vaccines

Targeting virus entry and membrane fusion through specific peptide/MHC complexes using a high-affinity T-cell receptor

Peng, K. W., Holler, P. D., Orr, B. A., Kranz, D. M. & Russell, S. J., Aug 1 2004, In : Gene therapy. 11, 15, p. 1234-1239 6 p.

Research output: Contribution to journalArticle

Virus Internalization
T-Cell Antigen Receptor
Major Histocompatibility Complex
Peptides
Cell Fusion

T cell receptors: Affinities, cross-reactivities, and a conformer model

Holler, P. D. & Kranz, D. M., Feb 2004, In : Molecular Immunology. 40, 14-15, p. 1027-1031 5 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Ligands
T-Lymphocytes
Amino Acid Sequence
Clone Cells
2003

Allogeneic and syngeneic class I MHC complexes drive the association of CD8 and TCR on 2C T cells

Lee, P. U. Y. & Kranz, D. M., Jan 1 2003, In : Molecular Immunology. 39, 12, p. 687-695 9 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Fluorescence Resonance Energy Transfer
Ligands
Clone Cells

Analysis of superantigen binding to soluble T-cell receptors.

Churchill, H. R. O. & Kranz, D. M., 2003, In : Methods in molecular biology (Clifton, N.J.). 214, p. 101-111 11 p.

Research output: Contribution to journalArticle

Superantigens
T-Cell Antigen Receptor
Protein Binding
Solubility
Monoclonal Antibodies

A yeast display system for engineering functional peptide-MHC complexes

Brophy, S. E., Holler, P. D. & Kranz, D. M., Jan 15 2003, In : Journal of Immunological Methods. 272, 1-2, p. 235-246 12 p.

Research output: Contribution to journalArticle

Yeasts
Peptides
T-Lymphocytes
T-Cell Antigen Receptor
Cellular Immunity

Directed evolution of a single-chain class II MHC product by yeast display

Starwalt, S. E., Mastellela, E. L., Bluestone, J. A. & Kranz, D. M., Feb 1 2003, In : Protein Engineering. 16, 2, p. 147-156 10 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Yeast
T-cells
Yeasts
Display devices

Directed evolution of T-cell receptors for binding superantigens.

Churchill, H. R. O. & Kranz, D. M., 2003, In : Methods in molecular biology (Clifton, N.J.). 214, p. 87-99 13 p.

Research output: Contribution to journalArticle

Directed Molecular Evolution
Superantigens
T-Cell Antigen Receptor
Saccharomyces cerevisiae
Flow Cytometry

Dissecting Cooperative and Additive Binding Energetics in the Affinity Maturation Pathway of a Protein-Protein Interface

Yang, J., Swaminathan, C. P., Huang, Y., Guan, R., Cho, S., Kieke, M. C., Kranz, D. M., Mariuzza, R. A. & Sundberg, E. J., Dec 12 2003, In : Journal of Biological Chemistry. 278, 50, p. 50412-50421 10 p.

Research output: Contribution to journalArticle

Proteins
Mutation
Complementarity Determining Regions
Superantigens
Mutagenesis

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

Holler, P. D. & Kranz, D. M., Feb 1 2003, In : Immunity. 18, 2, p. 255-264 10 p.

Research output: Contribution to journalArticle

T-Lymphocytes
TCF Transcription Factors
Peptides
In Vitro Techniques

Rapid method for measuring scFv thermal stability by yeast surface display

Orr, B. A., Carr, L. M., Wittrup, K. D., Roy, E. J. & Kranz, D. M., Mar 1 2003, In : Biotechnology Progress. 19, 2, p. 631-638 8 p.

Research output: Contribution to journalArticle

Hot Temperature
Yeasts
Single-Chain Antibodies
Immobilized Proteins
Protein Denaturation

The cationic region from HIV tat enhances the cell-surface expression of epitope/MHC class I complexes

Leifert, J. A., Holler, P. D., Harkins, S., Kranz, D. M. & Whitton, J. L., Dec 1 2003, In : Gene therapy. 10, 25, p. 2067-2073 7 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Epitopes
HIV
Immunization
Human Immunodeficiency Virus tat Gene Products

Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb

Dam, J., Guan, R., Natarajan, K., Dimasi, N., Chlewicki, L. K., Kranz, D. M., Schuck, P., Margulies, D. H. & Mariuzza, R. A., Dec 1 2003, In : Nature Immunology. 4, 12, p. 1213-1222 10 p.

Research output: Contribution to journalArticle

Natural Killer Cell Receptors
Major Histocompatibility Complex
Peptides
Peptide Receptors
Dimerization
2001

CD8-T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation

Holler, P. D., Lim, A. R., Cho, B. K., Rund, L. A. & Kranz, D. M., Oct 15 2001, In : Journal of Experimental Medicine. 194, 8, p. 1043-1052 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Peptides
Cytotoxic T-Lymphocytes
Antigen-Presenting Cells

Development and applications of surface-linked single chain antibodies against T-cell antigens

Griffin, M. D., Holman, P. O., Tang, Q., Ashourian, N., Korthäuer, U., Kranz, D. M. & Bluestone, J. A., Feb 1 2001, In : Journal of Immunological Methods. 248, 1-2, p. 77-90 14 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Viral Tumor Antigens
T-Lymphocytes
Product Packaging
Mutagenesis

Differences in antigen recognition and cytolytic activity of CD8+ and CD8- T cells that express the same antigen-specific receptor

Cho, B. K., Lian, K. C., Lee, P., Brunmark, A., McKinley, C., Chen, J., Kranz, D. M. & Eisen, H. N., Feb 13 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 4, p. 1723-1727 5 p.

Research output: Contribution to journalArticle

Antigen Receptors
T-Lymphocytes
Antigens
T-Cell Antigen Receptor
Peptides

High affinity T cell receptors from yeast display libraries block T cell activation by superantigens

Kieke, M. C., Sundberg, E., Shusta, E. V., Mariuzza, R. A., Wittrup, K. D. & Kranz, D. M., Apr 13 2001, In : Journal of Molecular Biology. 307, 5, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

Superantigens
Enterotoxins
T-Cell Antigen Receptor
Yeasts
T-Lymphocytes
2000

Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152)

Griffin, M. D., Hong, D. K., Holman, P. O., Lee, K. M., Whitters, M. J., O'Herrin, S. M., Fallarino, F., Collins, M., Segal, D. M., Gajewski, T. F., Kranz, D. M. & Bluestone, J. A., May 1 2000, In : Journal of Immunology. 164, 9, p. 4433-4442 10 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
T-Lymphocytes
Ligation
Ligands
Immune Tolerance