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2019

Breaking tolerance with engineered class I antigen-presenting molecules

Parks, C. A., Henning, K. R., Pavelko, K. D., Hansen, M. J., Van Keulen, V. P., Reed, B. K., Stone, J. D., Schrum, A. G., Gil, D., Kranz, D. M., Bordner, A. J., Barry, M. A. & Pease, L. R., Feb 19 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3136-3145 10 p.

Research output: Contribution to journalArticle

High-throughput stability screening of neoantigen/HLA complexes improves immunogenicity predictions

Blaha, D. T., Anderson, S. D., Yoakum, D. M., Hager, M. V., Zha, Y., Gajewski, T. F. & Kranz, D. M., Jan 2019, In : Cancer Immunology Research. 7, 1, p. 50-61 12 p.

Research output: Contribution to journalArticle

Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell

He, Y., Schreiber, K., Wolf, S. P., Wen, F., Steentoft, C., Zerweck, J., Steiner, M., Sharma, P., Michael Shepard, H., Posey, A., June, C. H., Mandel, U., Clausen, H., Leisegang, M., Meredith, S. C., Kranz, D. M. & Schreiber, H., Oct 17 2019, In : JCI Insight. 4, 21, e130416.

Research output: Contribution to journalArticle

Open Access

T-cell receptors engineered de novo for peptide specificity can mediate optimal t-cell activity without self cross-reactivity

Sharma, P., Harris, D. T., Stone, J. D. & Kranz, D. M., Jan 1 2019, In : Cancer Immunology Research. 7, 12, p. 2025-2035 11 p.

Research output: Contribution to journalArticle

T cell receptors for gene transfer in adoptive T cell therapy

Sharma, P. & Kranz, D. M., Jan 1 2019, In : Critical Reviews in Immunology. 39, 2, p. 105-122 18 p.

Research output: Contribution to journalArticle

2018

Comparison of t cell activities mediated by human TCRs and CARs that use the same recognition domains

Harris, D. T., Hager, M. V., Smith, S. N., Cai, Q., Stone, J. D., Kruger, P., Lever, M., Dushek, O., Schmitt, T. M., Greenberg, P. D. & Kranz, D. M., Feb 1 2018, In : Journal of Immunology. 200, 3, p. 1088-1100 13 p.

Research output: Contribution to journalArticle

Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity

Sharma, P. & Kranz, D. M., Feb 2 2018, In : Journal of Biological Chemistry. 293, 5, p. 1820-1834 15 p.

Research output: Contribution to journalArticle

2017

Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor t cells in vitro

Schmitt, T. M., Aggen, D. H., Ishida-Tsubota, K., Ochsenreither, S., Kranz, D. M. & Greenberg, P. D., Jan 1 2017, In : Nature Biotechnology. 35, 12, p. 1188-1195 8 p.

Research output: Contribution to journalArticle

2016

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry

Harris, DT., Singh, NK. K., Cai, Q., Smith, SN. N., Vander Kooi, CW. W., Procko, E., Kranz, DM. M. & Baker, BM. M., Jul 6 2016, In : Structure. 24, 7, p. 1142-1154 13 p.

Research output: Contribution to journalArticle

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

Posey, A. D., Schwab, R. D., Boesteanu, A. C., Steentoft, C., Mandel, U., Engels, B., Stone, J. D., Madsen, T. D., Schreiber, K., Haines, K. M., Cogdill, A. P., Chen, T. J., Song, D., Scholler, J., Kranz, D. M., Feldman, M. D., Young, R., Keith, B., Schreiber, H., Clausen, H. & 2 others, Johnson, L. A. & June, C. H., Jun 21 2016, In : Immunity. 44, 6, p. 1444-1454 11 p.

Research output: Contribution to journalArticle

Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity

Adams, J. J., Narayanan, S., Birnbaum, M. E., Sidhu, S. S., Blevins, S. J., Gee, M. H., Sibener, L. V., Baker, B. M., Kranz, D. M. & Garcia, K. C., Jan 1 2016, In : Nature Immunology. 17, 1, p. 87-94 8 p.

Research output: Contribution to journalArticle

2015

A multiplex assay for detection of staphylococcal and streptococcal exotoxins

Sharma, P., Wang, N., Chervin, A. S., Quinn, C. L., Stone, J. D. & Kranz, D. M., Aug 25 2015, In : PloS one. 10, 8, e0135986.

Research output: Contribution to journalArticle

Herman N. Eisen: Mentor to many

Kranz, D. M. & Sykulev, Y., Feb 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 6, p. 1650-1651 2 p.

Research output: Contribution to journalArticle

Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses

Mattis, D. M., Chervin, A. S., Ranoa, D. R., Kelley, S. L., Tapping, R. I. & Kranz, D. M., May 8 2015, In : Molecular Immunology. 68, 2, p. 203-212 10 p.

Research output: Contribution to journalArticle

T cell receptor engineering and analysis using the yeast display platform

Smith, S. N., Harris, D. T. & Kranz, D. M., Jan 1 2015, In : Methods in Molecular Biology. 1319, p. 95-141 47 p.

Research output: Contribution to journalArticle

2014

A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control

Stone, J. D., Harris, D. T., Soto, C. M., Chervin, A. S., Aggen, D. H., Roy, E. J. & Kranz, D. M., Jan 1 2014, In : Cancer Immunology, Immunotherapy. 63, 11, p. 1163-1176 14 p.

Research output: Contribution to journalArticle

Changing the peptide specificity of a human T-cell receptor by directed evolution

Smith, S. N., Wang, Y., Baylon, J. L., Singh, N. K., Baker, B. M., Tajkhorshid, E. & Kranz, D. M., 2014, In : Nature communications. 5, 5223.

Research output: Contribution to journalArticle

Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity

Tosic, V., Thomas, D. L., Kranz, D. M., Liu, J., McFadden, G., Shisler, J. L., MacNeill, A. L. & Roy, E. J., Oct 16 2014, In : PloS one. 9, 10, e109801.

Research output: Contribution to journalArticle

TCR scanning of peptide/MHC through complementary matching of receptor and ligand molecular flexibility

Hawse, W. F., De, S., Greenwood, A. I., Nicholson, L. K., Zajicek, J., Kovrigin, E. L., Kranz, D. M., Garcia, K. C. & Baker, B. M., Mar 15 2014, In : Journal of Immunology. 192, 6, p. 2885-2891 7 p.

Research output: Contribution to journalArticle

2013

Characterization of the Staphylococcal enterotoxin A: Vβ receptor interaction using human receptor fragments engineered for high affinity

Sharma, P., Postel, S., Sundberg, E. J. & Kranz, D. M., Dec 1 2013, In : Protein Engineering, Design and Selection. 26, 12, p. 781-789 9 p.

Research output: Contribution to journalArticle

Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses

Chervin, A. S., Stone, J. D., Soto, C. M., Engels, B., Schreiber, H., Roy, E. J. & Kranz, D. M., Jun 1 2013, In : Gene therapy. 20, 6, p. 634-644 11 p.

Research output: Contribution to journalArticle

Engineering a soluble high-affinity receptor domain that neutralizes staphylococcal enterotoxin C in rabbit models of disease

Mattis, D. M., Spaulding, A. R., Chuang-Smith, O. N., Sundberg, E. J., Schlievert, P. M. & Kranz, D. M., Feb 1 2013, In : Protein Engineering, Design and Selection. 26, 2, p. 133-142 10 p.

Research output: Contribution to journalArticle

Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection

Schmitt, T. M., Aggen, D. H., Stromnes, I. M., Dossett, M. L., Richman, S. A., Kranz, D. M. & Greenberg, P. D., Jul 18 2013, In : Blood. 122, 3, p. 348-356 9 p.

Research output: Contribution to journalArticle

MHC-class I-restricted CD4 T cells: A nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR

Soto, C. M., Stone, J. D., Chervin, A. S., Engels, B., Schreiber, H., Roy, E. J. & Kranz, D. M., Feb 1 2013, In : Cancer Immunology, Immunotherapy. 62, 2, p. 359-369 11 p.

Research output: Contribution to journalArticle

Novel platform for the detection of staphylococcus aureus enterotoxin B in foods

Tallent, S. M., DeGrasse, J. A., Wang, N., Mattis, D. M. & Kranz, D. M., Mar 1 2013, In : Applied and environmental microbiology. 79, 5, p. 1422-1427 6 p.

Research output: Contribution to journalArticle

Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes

Smith, S. N., Sommermeyer, D., Piepenbrink, K. H., Blevins, S. J., Bernhard, H., Uckert, W., Baker, B. M. & Kranz, D. M., Nov 15 2013, In : Journal of Molecular Biology. 425, 22, p. 4496-4507 12 p.

Research output: Contribution to journalArticle

Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity

Engels, B., Engelhard, V. H., Sidney, J., Sette, A., Binder, D. C., Liu, R. B., Kranz, D. M., Meredith, S. C., Rowley, D. A. & Schreiber, H., Apr 15 2013, In : Cancer Cell. 23, 4, p. 516-526 11 p.

Research output: Contribution to journalArticle

Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells

Lynch, J. N., Donermeyer, D. L., Weber, K. S., Kranz, D. M. & Allen, P. M., Mar 1 2013, In : Molecular Immunology. 53, 3, p. 283-294 12 p.

Research output: Contribution to journalArticle

2012

A sensitivity scale for targeting t cells with chimeric antigen receptors (CARs) and bispecific t-cell engagers (BiTEs)

Stone, J. D., Aggen, D. H., Schietinger, A., Schreiber, H. & Kranz, D. M., Dec 1 2012, In : OncoImmunology. 1, 6, p. 863-873 11 p.

Research output: Contribution to journalArticle

Binding of TCR Multimers and a TCR-Like Antibody with Distinct Fine-Specificities Is Dependent on the Surface Density of HLA Complexes

Low, J. L., Naidoo, A., Yeo, G., Gehring, A. J., Ho, Z. Z., Yau, Y. H., Shochat, S. G., Kranz, D. M., Bertoletti, A. & Grotenbreg, G. M., Dec 10 2012, In : PloS one. 7, 12, e51397.

Research output: Contribution to journalArticle

Design and characterization of a protein superagonist of IL-15 fused with IL-15Rα and a high-affinity T cell receptor

Stone, J. D., Chervin, A. S., Schreiber, H. & Kranz, D. M., Nov 1 2012, In : Biotechnology Progress. 28, 6, p. 1588-1597 10 p.

Research output: Contribution to journalArticle

Endogenous viral antigen processing generates pepvtide-specific MHC class I cell-surface clusters

Lu, X., Gibbs, J. S., Hickman, H. D., David, A., Dolan, B. P., Jin, Y., Kranz, D. M., Bennink, J. R., Yewdell, J. W. & Varma, R., Sep 18 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 38, p. 15407-15412 6 p.

Research output: Contribution to journalArticle

Long-term persistence of CD4+ but rapid disappearance of CD8+ T cells expressing an MHC class I-restricted TCR of nanomolar affinity

Engels, B., Chervin, A. S., Sant, A. J., Kranz, D. M. & Schreiber, H., Mar 2012, In : Molecular Therapy. 20, 3, p. 652-660 9 p.

Research output: Contribution to journalArticle

Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains

Aggen, D. H., Chervin, A. S., Schmitt, T. M., Engels, B., Stone, J. D., Richman, S. A., Piepenbrink, K. H., Baker, B. M., Greenberg, P. D., Schreiber, H. & Kranz, D. M., Apr 1 2012, In : Gene therapy. 19, 4, p. 365-374 10 p.

Research output: Contribution to journalArticle

Staphylococcus aureus isolates encode variant staphylococcal enterotoxin B proteins that are diverse in superantigenicity and lethality

Kohler, P. L., Greenwood, S. D., Nookala, S., Kotb, M., Kranz, D. M. & Schlievert, P. M., Jul 16 2012, In : PloS one. 7, 7, e41157.

Research output: Contribution to journalArticle

2011

Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells

Fuertes, M. B., Kacha, A. K., Kline, J., Woo, S. R., Kranz, D. M., Murphy, K. M. & Gajewski, T. F., Sep 26 2011, In : Journal of Experimental Medicine. 208, 10, p. 2005-2016 12 p.

Research output: Contribution to journalArticle

Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors

Aggen, D. H., Chervin, A. S., Insaidoo, F. K., Piepenbrink, K. H., Baker, B. M. & Kranz, D. M., Apr 1 2011, In : Protein Engineering, Design and Selection. 24, 4, p. 361-372 12 p.

Research output: Contribution to journalArticle

Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRs

Stone, J. D., Artyomov, M. N., Chervin, A. S., Chakraborty, A. K., Eisen, H. N. & Kranz, D. M., Dec 15 2011, In : Journal of Immunology. 187, 12, p. 6281-6290 10 p.

Research output: Contribution to journalArticle

Molecular basis of a million-fold affinity maturation process in a protein-protein interaction

Bonsor, D. A., Postel, S., Pierce, B. G., Wang, N., Zhu, P., Buonpane, R. A., Weng, Z., Kranz, D. M. & Sundberg, E. J., Aug 12 2011, In : Journal of Molecular Biology. 411, 2, p. 321-328 8 p.

Research output: Contribution to journalArticle

Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors

Thomas, D. L., Doty, R., Tosic, V., Liu, J., Kranz, D. M., McFadden, G., MacNeill, A. L. & Roy, E. J., Oct 1 2011, In : Cancer Immunology, Immunotherapy. 60, 10, p. 1461-1472 12 p.

Research output: Contribution to journalArticle

Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8

Stone, J. D., Aggen, D. H., Chervin, A. S., Narayanan, S., Schmitt, T. M., Greenberg, P. D. & Kranz, D. M., May 1 2011, In : Journal of Immunology. 186, 9, p. 5193-5200 8 p.

Research output: Contribution to journalArticle

T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex

Adams, J. J., Narayanan, S., Liu, B., Birnbaum, M. E., Kruse, A. C., Bowerman, N. A., Chen, W., Levin, A. M., Connolly, J. M., Zhu, C., Kranz, D. M. & Garcia, K. C., Nov 23 2011, In : Immunity. 35, 5, p. 681-693 13 p.

Research output: Contribution to journalArticle

2010

A single, engineered protein therapeutic agent neutralizes exotoxins from both Staphylococcus aureus and Streptococcus pyogenes

Wang, N., Mattis, D. M., Sundberg, E. J., Schlievert, P. M. & Kranz, D. M., Nov 1 2010, In : Clinical and Vaccine Immunology. 17, 11, p. 1781-1789 9 p.

Research output: Contribution to journalArticle

Assessing energetic contributions to binding from a disordered region in a protein-protein interaction

Cho, S., Swaminathan, C. P., Bonsor, D. A., Kerzic, M. C., Guan, R., Yang, J., Kieke, M. C., Andersen, P. S., Kranz, D. M., Mariuzza, R. A. & Sundberg, E. J., Nov 2 2010, In : Biochemistry. 49, 43, p. 9256-9268 13 p.

Research output: Contribution to journalArticle

High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics

Persaud, S. P., Donermeyer, D. L., Weber, K. S., Kranz, D. M. & Allen, P. M., May 1 2010, In : Molecular Immunology. 47, 9, p. 1793-1801 9 p.

Research output: Contribution to journalArticle

Staphylococcal superantigens cause lethal pulmonary disease in rabbits

Strandberg, K. L., Rotschafer, J. H., Vetter, S. M., Buonpane, R. A., Kranz, D. M. & Schlievert, P. M., Dec 1 2010, In : Journal of Infectious Diseases. 202, 11, p. 1690-1697 8 p.

Research output: Contribution to journalArticle

2009

Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display.

Richman, S. A., Kranz, D. M. & Stone, J. D., 2009, In : Methods in molecular biology (Clifton, N.J.). 504, p. 323-350 28 p.

Research output: Contribution to journalArticle

Cutting edge: Inhibitory effects of CD4 and CD8 on T cell activation induced by high-affinity noncognate ligands

Chervin, A. S., Stone, J. D., Bowerman, N. A. & Kranz, D. M., Dec 15 2009, In : Journal of Immunology. 183, 12, p. 7639-7643 5 p.

Research output: Contribution to journalArticle

Different strategies adopted by Kb and Ld to generate T cell specificity directed against their respective bound peptides

Bowerman, N. A., Colf, L. A., Garcia, K. C. & Kranz, D. M., Nov 20 2009, In : Journal of Biological Chemistry. 284, 47, p. 32551-32561 11 p.

Research output: Contribution to journalArticle