David M Kranz

1975 …2019
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Research Output 1975 2019

2003

Directed evolution of a single-chain class II MHC product by yeast display

Starwalt, S. E., Mastellela, E. L., Bluestone, J. A. & Kranz, D. M., Feb 1 2003, In : Protein Engineering. 16, 2, p. 147-156 10 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Yeast
T-cells
Yeasts
Display devices

Directed evolution of T-cell receptors for binding superantigens.

Churchill, H. R. O. & Kranz, D. M., Jan 1 2003, In : Methods in molecular biology (Clifton, N.J.). 214, p. 87-99 13 p.

Research output: Contribution to journalArticle

Directed Molecular Evolution
Superantigens
T-Cell Antigen Receptor
Saccharomyces cerevisiae
Flow Cytometry

Dissecting Cooperative and Additive Binding Energetics in the Affinity Maturation Pathway of a Protein-Protein Interface

Yang, J., Swaminathan, C. P., Huang, Y., Guan, R., Cho, S., Kieke, M. C., Kranz, D. M., Mariuzza, R. A. & Sundberg, E. J., Dec 12 2003, In : Journal of Biological Chemistry. 278, 50, p. 50412-50421 10 p.

Research output: Contribution to journalArticle

Proteins
Mutation
Complementarity Determining Regions
Superantigens
Mutagenesis

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

Holler, P. D. & Kranz, D. M., Feb 1 2003, In : Immunity. 18, 2, p. 255-264 10 p.

Research output: Contribution to journalArticle

T-Lymphocytes
TCF Transcription Factors
Peptides
In Vitro Techniques

Rapid method for measuring scFv thermal stability by yeast surface display

Orr, B. A., Carr, L. M., Wittrup, K. D., Roy, E. J. & Kranz, D. M., Mar 1 2003, In : Biotechnology Progress. 19, 2, p. 631-638 8 p.

Research output: Contribution to journalArticle

Hot Temperature
Yeasts
Single-Chain Antibodies
Immobilized Proteins
Protein Denaturation

TCRs with high affinity for foreign pMHC show self-reactivity

Holler, P. D., Chlewicki, L. K. & Kranz, D. M., Jan 1 2003, In : Nature Immunology. 4, 1, p. 55-62 8 p.

Research output: Contribution to journalReview article

T-Cell Antigen Receptor
Major Histocompatibility Complex
Peptides
T-Lymphocytes
Complementarity Determining Regions

The cationic region from HIV tat enhances the cell-surface expression of epitope/MHC class I complexes

Leifert, J. A., Holler, P. D., Harkins, S., Kranz, D. M. & Whitton, J. L., Dec 1 2003, In : Gene therapy. 10, 25, p. 2067-2073 7 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Epitopes
HIV
Immunization
Human Immunodeficiency Virus tat Gene Products

Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb

Dam, J., Guan, R., Natarajan, K., Dimasi, N., Chlewicki, L. K., Kranz, D. M., Schuck, P., Margulies, D. H. & Mariuzza, R. A., Dec 1 2003, In : Nature Immunology. 4, 12, p. 1213-1222 10 p.

Research output: Contribution to journalArticle

Natural Killer Cell Receptors
Major Histocompatibility Complex
Peptides
Peptide Receptors
Dimerization
2001

CD8-T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation

Holler, P. D., Lim, A. R., Cho, B. K., Rund, L. A. & Kranz, D. M., Oct 15 2001, In : Journal of Experimental Medicine. 194, 8, p. 1043-1052 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Peptides
Cytotoxic T-Lymphocytes
Antigen-Presenting Cells

Development and applications of surface-linked single chain antibodies against T-cell antigens

Griffin, M. D., Holman, P. O., Tang, Q., Ashourian, N., Korthäuer, U., Kranz, D. M. & Bluestone, J. A., Feb 1 2001, In : Journal of Immunological Methods. 248, 1-2, p. 77-90 14 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Viral Tumor Antigens
T-Lymphocytes
Product Packaging
Mutagenesis

Differences in antigen recognition and cytolytic activity of CD8+ and CD8- T cells that express the same antigen-specific receptor

Cho, B. K., Lian, K. C., Lee, P., Brunmark, A., McKinley, C., Chen, J., Kranz, D. M. & Eisen, H. N., Feb 13 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 4, p. 1723-1727 5 p.

Research output: Contribution to journalArticle

Antigen Receptors
T-Lymphocytes
Antigens
T-Cell Antigen Receptor
Peptides

High affinity T cell receptors from yeast display libraries block T cell activation by superantigens

Kieke, M. C., Sundberg, E., Shusta, E. V., Mariuzza, R. A., Wittrup, K. D. & Kranz, D. M., Apr 13 2001, In : Journal of Molecular Biology. 307, 5, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

Superantigens
Enterotoxins
T-Cell Antigen Receptor
Yeasts
T-Lymphocytes
2000

Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152)

Griffin, M. D., Hong, D. K., Holman, P. O., Lee, K. M., Whitters, M. J., O'Herrin, S. M., Fallarino, F., Collins, M., Segal, D. M., Gajewski, T. F., Kranz, D. M. & Bluestone, J. A., May 1 2000, In : Journal of Immunology. 164, 9, p. 4433-4442 10 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
T-Lymphocytes
Ligation
Ligands
Immune Tolerance

Directed evolution of a stable scaffold for T-cell receptor engineering

Shusta, E. V., Holler, P. D., Kieke, M. C., Kranz, D. M. & Wittrup, K. D., Jul 1 2000, In : Nature Biotechnology. 18, 7, p. 754-759 6 p.

Research output: Contribution to journalArticle

Cell Engineering
T-cells
T-Cell Antigen Receptor
Scaffolds
Major Histocompatibility Complex
Interleukin-12
Brain Neoplasms
T-Lymphocytes
Neoplasms
Therapeutics
Interleukin-12
Brain Neoplasms
T-Lymphocytes
Neoplasms
Therapeutics

IL-12 treatment of endogenously arising murine brain tumors

Roy, E. J., Gawlick, U., Orr, B. A., Rund, L. A., Webb, A. G. & Kranz, D. M., Dec 15 2000, In : Journal of Immunology. 165, 12, p. 7293-7299 7 p.

Research output: Contribution to journalArticle

Interleukin-12
Brain Neoplasms
T-Lymphocytes
Neoplasms
Therapeutics

Incompatible differences: View of an allogeneic pMHC-TCR complex

Kranz, D. M., Jan 1 2000, In : Nature Immunology. 1, 4, p. 277-278 2 p.

Research output: Contribution to journalShort survey

Peptide T
T-Cell Antigen Receptor
T-Lymphocytes

In vitro evolution of a T cell receptor with high affinity for peptide/MHC

Holler, P. D., Holman, P. O., Shusta, E. V., O'Herrin, S., Wittrup, K. D. & Kranz, D. M., May 9 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 10, p. 5387-5392 6 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Peptides
In Vitro Techniques
Antigen-Presenting Cells
Libraries

Mapping the energy of superantigen Staphylococcus enterotoxin C3 recognition of an α/β T cell receptor using alanine scanning mutagenesis

Churchill, H. R. O., Andersen, P. S., Parke, E. A., Mariuzza, R. A. & Kranz, D. M., Mar 6 2000, In : Journal of Experimental Medicine. 191, 5, p. 835-846 12 p.

Research output: Contribution to journalArticle

Superantigens
Enterotoxins
T-Cell Antigen Receptor
Complementarity Determining Regions
Staphylococcus

Programmed cell death signaling via cell-surface expression of a single- chain antibody transgene

Kulkarni, S., Holman, P. O., Kopelan, A., Van Seventer, G. A., Van Seventer, J. M., Kranz, D. M. & Woodle, E. S., Mar 27 2000, In : Transplantation. 69, 6, p. 1209-1217 9 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Transgenes
Cell Death
Membranes
Blood Cells

Role of 2C T cell receptor residues in the binding of self- and allo- major histocompatibility complexes

Lee, P. U. Y., Churchill, H. R. O., Daniels, M., Jameson, S. C. & Kranz, D. M., Apr 17 2000, In : Journal of Experimental Medicine. 191, 8, p. 1355-1364 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Ligands
Alanine
Complementarity Determining Regions
1999

Binding energetics of T-cell receptors: Correlation with immunological consequences

Manning, T. C. & Kranz, D. M., Sep 1 1999, In : Immunology Today. 20, 9, p. 417-422 6 p.

Research output: Contribution to journalReview article

T-Cell Antigen Receptor

Bispecific agents target endogenous murine T cells against human tumor xenografts

Rund, L. A., Cho, B. K., Manning, T. C., Holler, P. D., Roy, E. J. & Kranz, D. M., Sep 7 1999, In : International Journal of Cancer. 83, 1, p. 141-149 9 p.

Research output: Contribution to journalArticle

Heterografts
T-Lymphocytes
T-Cell Antigen Receptor
Neoplasms
Bispecific Antibodies

Construction and characterization of two anti-sweetener single chain antibodies using radioligand binding, fluorescence and circular dichroism spectroscopy

Pledger, D. W., Brodnicki, T. C., Graham, B. L., Tetin, S., Kranz, D. M. & Linthicum, D. S., Jan 1 1999, In : Journal of Molecular Recognition. 12, 4, p. 258-266 9 p.

Research output: Contribution to journalArticle

Sweetening Agents
Single-Chain Antibodies
Circular Dichroism
Spectrum Analysis
His-His-His-His-His-His
Complementarity Determining Regions
T-Cell Antigen Receptor
Major Histocompatibility Complex
Mutation
Peptides

Role of the T cell receptor α chain in stabilizing TCR-superantigen- MHC class II complexes

Andersen, P. S., Lavoie, P. M., Sékaly, R. P., Churchill, H., Kranz, D. M., Schlievert, P. M., Karjalainen, K. & Mariuzza, R. A., Jan 1 1999, In : Immunity. 10, 4, p. 473-483 11 p.

Research output: Contribution to journalArticle

Superantigens
T-Cell Antigen Receptor
T-Lymphocytes
Antigen-Presenting Cells
Half-Life

Selection of functional T cell receptor mutants from a yeast surface- display library

Kieke, M. C., Shusta, E. V., Boder, E. T., Teyton, L., Wittrup, K. D. & Kranz, D. M., May 11 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 10, p. 5651-5656 6 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Libraries
Yeasts
Antibodies
T-Cell Antigen Receptor Specificity

Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency

Shusta, E. V., Kieke, M. C., Parke, E., Kranz, D. M. & Wittrup, K. D., Oct 8 1999, In : Journal of Molecular Biology. 292, 5, p. 949-956 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Hot Temperature
Yeasts
Peptides
Mutant Proteins
1998

Alanine scanning mutagenesis of an αβ T cell receptor: Mapping the energy of antigen recognition

Manning, T. C., Schlueter, C. J., Brodnicki, T. C., Parke, E. A., Speir, J. A., Garcia, K. C., Teyton, L., Wilson, I. A. & Kranz, D. M., Jan 1 1998, In : Immunity. 8, 4, p. 413-425 13 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Mutagenesis
Alanine
Antigens
T-Lymphocytes

A yeast surface display system for the discovery of ligands that trigger cell activation

Cho, B. K., Kieke, M. C., Boder, E. T., Wittrup, K. D. & Kranz, D. M., Nov 1 1998, In : Journal of Immunological Methods. 220, 1-2, p. 179-188 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Yeasts
Ligands
Antigen-Presenting Cells
T-Lymphocytes

Construction of a single-chain antibody derived from 5H7, a monoclonal antibody specific for a death signaling domain of human class I major histocompatibility complex

Kulkarni, S., Holman, P., Kranz, D. M., Zhou, N., Van Seventer, J. & Woodle, E. S., Jul 15 1998, In : Transplantation Proceedings. 30, 4, 1 p.

Research output: Contribution to journalArticle

Immunoglobulin Variable Region
Immunoglobulin Light Chains
Single-Chain Antibodies
Gene Transfer Techniques
Immunoglobulin Heavy Chains

Intracerebral bispecific ligand-antibody conjugate increases survival of animals bearing endogenously arising brain tumors

Patrick, T. A., Kranz, D. M., Zachary, J. F. & Roy, E. J., Nov 2 1998, In : International Journal of Cancer. 78, 4, p. 470-479 10 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
Brain Neoplasms
Ligands
Choroid Plexus Neoplasms
T-Lymphocytes

Targeting T cells against brain tumors with a bispecific ligand-antibody conjugate

Roy, E. J., Cho, B. K., Rund, L. A., Patrick, T. A. & Kranz, D. M., Jun 10 1998, In : International Journal of Cancer. 76, 5, p. 761-766 6 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
Folic Acid
Brain Neoplasms
Ligands
T-Lymphocytes

Targeting tumor cells with bispecific antibodies and T cells

Kranz, D. M., Manning, T. C., Rund, L. A., Cho, B. K., Gruber, M. M. & Roy, E. J., Apr 30 1998, In : Journal of Controlled Release. 53, 1-3, p. 77-84 8 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
T-Lymphocytes
Folic Acid
T-Cell Antigen Receptor
Neoplasms
1997

Antigen Recognition and Allogeneic Tumor Rejection in CD8+ TCR Transgenic/RAG-/- Mice

Manning, T. C., Rund, L. A., Gruber, M. M., Fallarino, F., Gajewski, T. F. & Kranz, D. M., Nov 15 1997, In : Journal of Immunology. 159, 10, p. 4665-4675 11 p.

Research output: Contribution to journalArticle

Transgenic Mice
Antigens
T-Lymphocytes
Neoplasms
B7 Antigens

Folate receptors as potential therapeutic targets in choroid plexus tumors of SV40 transgenic mice

Patrick, T. A., Kranz, D. M., Van Dyke, T. A. & Roy, E. J., Feb 25 1997, In : Journal of Neuro-Oncology. 32, 2, p. 111-123 13 p.

Research output: Contribution to journalArticle

Choroid Plexus Neoplasms
Folic Acid
Transgenic Mice
Choroid Plexus
Ependymoma

Isolation of anti-T cell receptor scFv mutants by yeast surface display

Kieke, M. C., Cho, B. K., Boder, E. T., Kranz, D. M. & Wittrup, K. D., 1997, In : Protein Engineering. 10, 11, p. 1303-1310 8 p.

Research output: Contribution to journalArticle

T-cells
T-Cell Antigen Receptor
Yeast
Epitopes
Yeasts

Single-chain Fv/folate conjugates mediate efficient lysis of folate-receptor-positive tumor cells

Cho, B. K., Roy, E. J., Patrick, T. A. & Kranz, D. M., May 1 1997, In : Bioconjugate Chemistry. 8, 3, p. 338-346 9 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Folic Acid
Tumors
T-cells
Cells
1996

A Residue in the Center of Peptide QL9 Affects Binding to Both Ld and the T Cell Receptor

Schlueter, C. J., Manning, T. C., Schodin, B. A. & Kranz, D. M., Nov 15 1996, In : Journal of Immunology. 157, 10, p. 4478-4485 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Peptides
QL9 peptide
Clone Cells
T-Lymphocytes

A strategy for the synthesis and screening of thiol-modified peptide variants recognized by T cells

Manning, T. C., Schodin, B. A. & Kranz, D. M., Jun 10 1996, In : Journal of Immunological Methods. 192, 1-2, p. 125-132 8 p.

Research output: Contribution to journalArticle

Sulfhydryl Compounds
T-Lymphocytes
Peptides
Cysteine
Contact Dermatitis

Binding properties and solubility of single-chain T cell receptors expressed in E. coli

Schodin, B. A., Schlueter, C. J. & Kranz, D. M., Jan 1 1996, In : Molecular Immunology. 33, 9, p. 819-829 11 p.

Research output: Contribution to journalArticle

Thioredoxins
T-Cell Antigen Receptor
Solubility
Escherichia coli
Proteins

Comparison of affinity purification techniques for single chain antibody NC 6.8

Jackson, M. G., Brodnicki, T. C., Kranz, D. M. & Linthicum, D. S., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

Single-Chain Antibodies
purification methods
Purification
Fusion reactions
Immunoglobulin G

Construction and characterization of a single chain antibody that binds a superpotent sweetener ligand

Pledger, D. W., Graham, B. L., Brodnicki, T. C., Kranz, D. M. & Linthicum, D. S., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

Sweetening Agents
Single-Chain Antibodies
His-His-His-His-His-His
Dialysis
Complementary DNA

Correlation between the number of T cell receptors required for T cell activation and TCR-ligand affinity

Schodin, B. A., Tsomides, T. J. & Kranz, D. M., Jan 1 1996, In : Immunity. 5, 2, p. 137-146 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Ligands
T-Lymphocytes
Superantigens
Peptides

Determination of the role of aromatic residues in the binding pocket of an antibody that binds a sweetener lioand

Harris, J. S., Brodnicki, T. C., Kranz, D. M. & Linthicum, D. S., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

Sweetening Agents
sweeteners
aromatic compounds
Quenching
His-His-His-His-His-His

Erratum: Reactivity and epitope mapping of single chain T cell receptors with monoclonal antibodies (Molecular Immunology (1996) 33 (253- 263))

Brodnicki, T. C., Holman, P. O. & Kranz, D. M., Jan 1 1996, In : Molecular Immunology. 33, 7-8, 1 p.

Research output: Contribution to journalComment/debate

Epitope Mapping
T-Cell Antigen Receptor
Allergy and Immunology
Monoclonal Antibodies

Identification of peptide and T cell receptor residues involved in the interaction of CTL 2C and QL9/Ld

Schlueter, C., Manning, T., Brodnicki, T. & Kranz, D. M., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

Peptide T
T-Cell Antigen Receptor
Alanine
alanine
T-lymphocytes

Reactivity and epitope mapping of single-chain T cell receptors with monoclonal antibodies

Brodnicki, T. C., Holman, P. O. & Kranz, D. M., Jan 1 1996, In : Molecular Immunology. 33, 3, p. 253-263 11 p.

Research output: Contribution to journalArticle

Epitope Mapping
T-Cell Antigen Receptor
Monoclonal Antibodies
Antibodies
Epitopes

Specificity and binding properties of a single-chain T cell receptor

Schlueter, C. J., Schodin, B. A., Tetin, S. Y. & Kranz, D. M., Mar 15 1996, In : Journal of Molecular Biology. 256, 5, p. 859-869 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Complementarity Determining Regions
Peptides
T-Cell Antigen Receptor Specificity