David M Kranz

2023

Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model

Ranoa, D. R. E., Sharma, P., Schane, C. P., Lewis, A. N., Valdez, E., Marada, V. V. V. R., Hager, M. V., Montgomery, W., Wolf, S. P., Schreiber, K., Schreiber, H., Bailey, K., Fan, T. M., Hergenrother, P. J., Roy, E. J. & Kranz, D. M., May 31 2023, In: Journal for ImmunoTherapy of Cancer. 11, 5, e006509.

Research output: Contribution to journal › Article › peer-review

Open Access

TCR-engineered adoptive cell therapy effectively treats intracranial murine glioblastoma

Schaettler, M. O., Desai, R., Wang, A. Z., Livingstone, A. J., Kobayashi, D. K., Coxon, A. T., Bowman-Kirigin, J. A., Liu, C. J., Li, M., Bender, D. E., White, M. J., Kranz, D. M., Johanns, T. M. & Dunn, G. P., Feb 20 2023, In: Journal for ImmunoTherapy of Cancer. 11, 2, e006121.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Engineering Proteins by Combining Deep Mutational Scanning and Yeast Display

Sharma, P., Procko, E. & Kranz, D. M., 2022, Methods in Molecular Biology. Humana Press Inc., p. 117-142 26 p. (Methods in Molecular Biology; vol. 2491).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Engineering t cell receptors

Smith, S. N. (Inventor) & Kranz, D. M. (Inventor), Jul 12 2022, U.S. Patent No. 11384133, Apr 13 2018

Research output: Patent

Mitigation of SARS-CoV-2 transmission at a large public university

Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., Wang, L., Fredrickson, R. L., Wang, T., Wong, G. N., Uelmen, J., Maslov, S., Weiner, Z. J., Tkachenko, A. V., Zhang, H., Liu, Z., Ibrahim, A., Patel, S. J., Paul, J. M., Vance, N. P., Gulick, J. G. & Satheesan, S. P. & 129 others, Galvan, I. J., Miller, A., Grohens, J., Nelson, T. J., Stevens, M. P., Hennessy, P. M., Parker, R. C., Santos, E., Brackett, C., Steinman, J. D., Fenner, M. R., Dohrer, K., DeLorenzo, M., Wilhelm-Barr, L., Brauer, B. R., Best-Popescu, C., Durack, G., Wetter, N., Kranz, D. M., Breitbarth, J., Simpson, C., Pryde, J. A., Kaler, R. N., Harris, C., Vance, A. C., Silotto, J. L., Johnson, M., Valera, E. A., Anton, P. K., Mwilambwe, L., Bryan, S. P., Stone, D. S., Young, D. B., Ward, W. E., Lantz, J., Vozenilek, J. A., Bashir, R., Moore, J. S., Garg, M., Cooper, J. C., Snyder, G., Lore, M. H., Yocum, D. L., Cohen, N. J., Novakofski, J. E., Loots, M. J., Ballard, R. L., Band, M., Banks, K. M., Barnes, J. D., Bentea, I., Black, J., Busch, J., Conte, A., Conte, M., Curry, M., Eardley, J., Edwards, A., Eggett, T., Fleurimont, J., Foster, D., Fouke, B. W., Gallagher, N., Gastala, N., Genung, S. A., Glueck, D., Gray, B., Greta, A., Healy, R. M., Hetrick, A., Holterman, A. A., Ismail, N., Jasenof, I., Kelly, P., Kielbasa, A., Kiesel, T., Kindle, L. M., Lipking, R. L., Manabe, Y. C., Mayes, J., McGuffin, R., McHenry, K. G., Mirza, A., Moseley, J., Mostafa, H. H., Mumford, M., Munoz, K., Murray, A. D., Nolan, M., Parikh, N. A., Pekosz, A., Pflugmacher, J., Phillips, J. M., Pitts, C., Potter, M. C., Quisenberry, J., Rear, J., Robinson, M. L., Rosillo, E., Rye, L. N., Sherwood, M. E., Simon, A., Singson, J. M., Skadden, C., Skelton, T. H., Smith, C., Stech, M., Thomas, R., Tomaszewski, M. A., Tyburski, E. A., Vanwingerden, S., Vlach, E., Watkins, R. S., Watson, K., White, K. C., Killeen, T. L., Jones, R. J., Cangellaris, A. C., Martinis, S. A., Vaid, A., Brooke, C. B., Walsh, J. T., Elbanna, A., Sullivan, W. C., Smith, R. L., Goldenfeld, N., Fan, T. M., Hergenrother, P. J. & Burke, M. D., Dec 2022, In: Nature communications. 13, 1, 3207.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

An engineered T cell receptor variant realizes the limits of functional binding modes

Singh, N. K., Alonso, J. A., Harris, D. T., Anderson, S. D., Ma, J., Hellman, L. M., Rosenberg, A. M., Kolawole, E. M., Evavold, B. D., Kranz, D. M. & Baker, B. M., Nov 3 2020, In: Biochemistry. 59, 43, p. 4163-4175 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

Chan, K. K., Dorosky, D., Sharma, P., Abbasi, S. A., Dye, J. M., Kranz, D. M., Herbert, A. S. & Procko, E., Sep 4 2020, In: Science. 369, 6508, p. 1261-1265 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides

Sharma, P., Marada, V. V. V. R., Cai, Q., Kizerwetter, M., He, Y., Wolf, S. P., Schreiber, K., Clausen, H., Schreiber, H. & Kranz, D. M., Jun 30 2020, In: Proceedings of the National Academy of Sciences. 117, 26, p. 15148-15159 12 p., 201920662.

Research output: Contribution to journal › Article › peer-review

Treatment of an aggressive orthotopic murine glioblastoma model with combination checkpoint blockade and a multivalent neoantigen vaccine

Liu, C. J., Schaettler, M., Blaha, D. T., Bowman-Kirigin, J. A., Kobayashi, D. K., Livingstone, A. J., Bender, D., Miller, C. A., Kranz, D. M., Johanns, T. M. & Dunn, G. P., Sep 1 2020, In: Neuro-Oncology. 22, 9, p. 1276-1288 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Breaking tolerance with engineered class I antigen-presenting molecules

Parks, C. A., Henning, K. R., Pavelko, K. D., Hansen, M. J., Van Keulen, V. P., Reed, B. K., Stone, J. D., Schrum, A. G., Gil, D., Kranz, D. M., Bordner, A. J., Barry, M. A. & Pease, L. R., Feb 19 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3136-3145 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Engineered High-affinity Human T Cell Receptors

Smith, S. N. (Inventor), Harris, D. T. (Inventor), Kranz, D. M. (Inventor), Greenberg, P. D. (Inventor) & Schmitt, T. M. (Inventor), Jul 9 2019, U.S. Patent No. 10344075, Nov 21 2014

Research output: Patent

High-throughput stability screening of neoantigen/HLA complexes improves immunogenicity predictions

Blaha, D. T., Anderson, S. D., Yoakum, D. M., Hager, M. V., Zha, Y., Gajewski, T. F. & Kranz, D. M., Jan 2019, In: Cancer Immunology Research. 7, 1, p. 50-61 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Human single-chain T cell receptors

Kranz, D. M. (Inventor) & Aggen, D. H. (Inventor), Nov 5 2019, U.S. Patent No. 10464987, Oct 6 2010

Research output: Patent

Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell

He, Y., Schreiber, K., Wolf, S. P., Wen, F., Steentoft, C., Zerweck, J., Steiner, M., Sharma, P., Michael Shepard, H., Posey, A., June, C. H., Mandel, U., Clausen, H., Leisegang, M., Meredith, S. C., Kranz, D. M. & Schreiber, H., Oct 17 2019, In: JCI Insight. 4, 21, e130416.

Research output: Contribution to journal › Article › peer-review

Open Access

T-cell receptors engineered de novo for peptide specificity can mediate optimal t-cell activity without self cross-reactivity

Sharma, P., Harris, D. T., Stone, J. D. & Kranz, D. M., 2019, In: Cancer Immunology Research. 7, 12, p. 2025-2035 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

T cell receptors for gene transfer in adoptive T cell therapy

Sharma, P. & Kranz, D. M., 2019, In: Critical Reviews in Immunology. 39, 2, p. 105-122 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Comparison of t cell activities mediated by human TCRs and CARs that use the same recognition domains

Harris, D. T., Hager, M. V., Smith, S. N., Cai, Q., Stone, J. D., Kruger, P., Lever, M., Dushek, O., Schmitt, T. M., Greenberg, P. D. & Kranz, D. M., Feb 1 2018, In: Journal of Immunology. 200, 3, p. 1088-1100 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Engineered high-affinity human T cell receptors

Smith, S. N. (Inventor), Harris, D. T. (Inventor) & Kranz, D. M. (Inventor), Jul 17 2018, U.S. Patent No. 10023625, Nov 21 2014

Research output: Patent

Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity

Sharma, P. & Kranz, D. M., Feb 2 2018, In: Journal of Biological Chemistry. 293, 5, p. 1820-1834 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor t cells in vitro

Schmitt, T. M., Aggen, D. H., Ishida-Tsubota, K., Ochsenreither, S., Kranz, D. M. & Greenberg, P. D., 2017, In: Nature Biotechnology. 35, 12, p. 1188-1195 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors

Harris, D. T. & Kranz, D. M., Mar 1 2016, In: Trends in Pharmacological Sciences. 37, 3, p. 220-230 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry

Harris, D., Singh, N. K., Cai, Q., Smith, S. N., Vander Kooi, C. W., Procko, E., Kranz, D. M. & Baker, B. M., Jul 6 2016, In: Structure. 24, 7, p. 1142-1154 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Deep mutational scans as a guide to engineering high affinity t cell receptor interactions with peptide-bound major histocompatibility complex

Harris, D. T., Wang, N., Riley, T. P., Anderson, S. D., Singh, N. K., Procko, E., Baker, B. M. & Kran, D. M., Nov 18 2016, In: Journal of Biological Chemistry. 291, 47, p. 24566-24578 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

Posey, A. D., Schwab, R. D., Boesteanu, A. C., Steentoft, C., Mandel, U., Engels, B., Stone, J. D., Madsen, T. D., Schreiber, K., Haines, K. M., Cogdill, A. P., Chen, T. J., Song, D., Scholler, J., Kranz, D. M., Feldman, M. D., Young, R., Keith, B., Schreiber, H. & Clausen, H. & 2 others, Johnson, L. A. & June, C. H., Jun 21 2016, In: Immunity. 44, 6, p. 1444-1454 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Recent advances in T-cell engineering for use in immunotherapy

Kranz, D. M. & Sharma, P., 2016, In: F1000Research. 5, 2344.

Research output: Contribution to journal › Review article › peer-review

Open Access

Restoring immune tolerance in neuromyelitis optica Part I

Steinman, L., Bar-Or, A., Behne, J. M., Benitez-Ribas, D., Chin, P. S., Clare-Salzler, M., Healey, D., Kim, J. I., Kranz, D. M., Lutterotti, A., Martin, R., Schippling, S., Villoslada, P., Wei, C. H., Weiner, H. L., Zamvil, S. S., Yeaman, M. R. & Smith, T. J., 2016, In: Neurology: Neuroimmunology and NeuroInflammation. 3, 5, e276.

Research output: Contribution to journal › Review article › peer-review

Open Access

Restoring immune tolerance in neuromyelitis optica Part II

Bar-Or, A., Steinman, L., Behne, J. M., Benitez-Ribas, D., Chin, P. S., Clare-Salzler, M., Healey, D., Kim, J. I., Kranz, D. M., Lutterotti, A., Martin, R., Schippling, S., Villoslada, P., Wei, C. H., Weiner, H. L., Zamvil, S. S., Smith, T. J. & Yeaman, M. R., 2016, In: Neurology: Neuroimmunology and NeuroInflammation. 3, 5, e277.

Research output: Contribution to journal › Article › peer-review

Open Access

Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity

Adams, J. J., Narayanan, S., Birnbaum, M. E., Sidhu, S. S., Blevins, S. J., Gee, M. H., Sibener, L. V., Baker, B. M., Kranz, D. M. & Garcia, K. C., Jan 1 2016, In: Nature Immunology. 17, 1, p. 87-94 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

A multiplex assay for detection of staphylococcal and streptococcal exotoxins

Sharma, P., Wang, N., Chervin, A. S., Quinn, C. L., Stone, J. D. & Kranz, D. M., Aug 25 2015, In: PloS one. 10, 8, e0135986.

Research output: Contribution to journal › Article › peer-review

Open Access

Herman N. Eisen: Mentor to many

Kranz, D. M. & Sykulev, Y., Feb 10 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 6, p. 1650-1651 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses

Mattis, D. M., Chervin, A. S., Ranoa, D. R., Kelley, S. L., Tapping, R. I. & Kranz, D. M., May 8 2015, In: Molecular Immunology. 68, 2, p. 203-212 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

T cell receptor engineering and analysis using the yeast display platform

Smith, S. N., Harris, D. T. & Kranz, D. M., 2015, In: Methods in Molecular Biology. 1319, p. 95-141 47 p.

Research output: Contribution to journal › Article › peer-review

TCR affinity for p/MHC formed by tumor antigens that are self-proteins: Impact on efficacy and toxicity

Stone, J. D., Harris, D. T. & Kranz, D. M., Apr 1 2015, In: Current Opinion in Immunology. 33, p. 16-22 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Yeast cell surface display of proteins and uses thereof

Kieke, M. (Inventor), Kranz, D. M. (Inventor), Boder, E. (Inventor) & Wittrup, K. D. (Inventor), Sep 22 2015, U.S. Patent No. 9139637, Feb 12 2013

Research output: Patent

2014

A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control

Stone, J. D., Harris, D. T., Soto, C. M., Chervin, A. S., Aggen, D. H., Roy, E. J. & Kranz, D. M., Nov 2014, In: Cancer Immunology, Immunotherapy. 63, 11, p. 1163-1176 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Changing the peptide specificity of a human T-cell receptor by directed evolution

Smith, S. N., Wang, Y., Baylon, J. L., Singh, N. K., Baker, B. M., Tajkhorshid, E. & Kranz, D. M., 2014, In: Nature communications. 5, 5223.

Research output: Contribution to journal › Article › peer-review

Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity

Tosic, V., Thomas, D. L., Kranz, D. M., Liu, J., McFadden, G., Shisler, J. L., MacNeill, A. L. & Roy, E. J., Oct 16 2014, In: PloS one. 9, 10, e109801.

Research output: Contribution to journal › Article › peer-review

Soluble T cell receptor Vβ domains engineered for high-affinity binding to staphylococcal or streptococcal superantigens

Sharma, P., Wang, N. & Kranz, D. M., 2014, In: Toxins. 6, 2, p. 556-574 19 p.

Research output: Contribution to journal › Review article › peer-review

TCR scanning of peptide/MHC through complementary matching of receptor and ligand molecular flexibility

Hawse, W. F., De, S., Greenwood, A. I., Nicholson, L. K., Zajicek, J., Kovrigin, E. L., Kranz, D. M., Garcia, K. C. & Baker, B. M., Mar 15 2014, In: Journal of Immunology. 192, 6, p. 2885-2891 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2013

Characterization of the Staphylococcal enterotoxin A: Vβ receptor interaction using human receptor fragments engineered for high affinity

Sharma, P., Postel, S., Sundberg, E. J. & Kranz, D. M., Dec 2013, In: Protein Engineering, Design and Selection. 26, 12, p. 781-789 9 p.

Research output: Contribution to journal › Article › peer-review

Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses

Chervin, A. S., Stone, J. D., Soto, C. M., Engels, B., Schreiber, H., Roy, E. J. & Kranz, D. M., Jun 2013, In: Gene therapy. 20, 6, p. 634-644 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Engineering a soluble high-affinity receptor domain that neutralizes staphylococcal enterotoxin C in rabbit models of disease

Mattis, D. M., Spaulding, A. R., Chuang-Smith, O. N., Sundberg, E. J., Schlievert, P. M. & Kranz, D. M., Feb 2013, In: Protein Engineering, Design and Selection. 26, 2, p. 133-142 10 p.

Research output: Contribution to journal › Article › peer-review

Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection

Schmitt, T. M., Aggen, D. H., Stromnes, I. M., Dossett, M. L., Richman, S. A., Kranz, D. M. & Greenberg, P. D., Jul 18 2013, In: Blood. 122, 3, p. 348-356 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

MHC-class I-restricted CD4 T cells: A nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR

Soto, C. M., Stone, J. D., Chervin, A. S., Engels, B., Schreiber, H., Roy, E. J. & Kranz, D. M., Feb 2013, In: Cancer Immunology, Immunotherapy. 62, 2, p. 359-369 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Novel platform for the detection of staphylococcus aureus enterotoxin B in foods

Tallent, S. M., DeGrasse, J. A., Wang, N., Mattis, D. M. & Kranz, D. M., Mar 2013, In: Applied and environmental microbiology. 79, 5, p. 1422-1427 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes

Smith, S. N., Sommermeyer, D., Piepenbrink, K. H., Blevins, S. J., Bernhard, H., Uckert, W., Baker, B. M. & Kranz, D. M., Nov 15 2013, In: Journal of Molecular Biology. 425, 22, p. 4496-4507 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The same major histocompatibility complex polymorphism involved in control of HIV influences peptide binding in the mouse H-2L^d system

Narayanan, S. & Kranz, D. M., Nov 1 2013, In: Journal of Biological Chemistry. 288, 44, p. 31784-31794 11 p.

Research output: Contribution to journal › Article › peer-review

David M Kranz

Research output

Search results