David M Kranz

1975 …2019
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Research Output 1975 2019

2019

Breaking tolerance with engineered class I antigen-presenting molecules

Parks, C. A., Henning, K. R., Pavelko, K. D., Hansen, M. J., Van Keulen, V. P., Reed, B. K., Stone, J. D., Schrum, A. G., Gil, D., Kranz, D. M., Bordner, A. J., Barry, M. A. & Pease, L. R., Feb 19 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3136-3145 10 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens Class I
Peptides
T-Lymphocytes
Autoantigens
Isoantigens

High-throughput stability screening of neoantigen/HLA complexes improves immunogenicity predictions

Blaha, D. T., Anderson, S. D., Yoakum, D. M., Hager, M. V., Zha, Y., Gajewski, T. F. & Kranz, D. M., Jan 2019, In : Cancer Immunology Research. 7, 1, p. 50-61 12 p.

Research output: Contribution to journalArticle

Peptides
T-Lymphocytes
Peptide T
HLA-A2 Antigen
Fluorometry

T cell receptors for gene transfer in adoptive T cell therapy

Sharma, P. & Kranz, D. M., Jan 1 2019, In : Critical Reviews in Immunology. 39, 2, p. 105-122 18 p.

Research output: Contribution to journalArticle

T-Cell Receptor Genes
Adoptive Transfer
Cell- and Tissue-Based Therapy
T-Lymphocytes
Antigen Receptors
2018

Comparison of t cell activities mediated by human TCRs and CARs that use the same recognition domains

Harris, D. T., Hager, M. V., Smith, S. N., Cai, Q., Stone, J. D., Kruger, P., Lever, M., Dushek, O., Schmitt, T. M., Greenberg, P. D. & Kranz, D. M., Feb 1 2018, In : Journal of Immunology. 200, 3, p. 1088-1100 13 p.

Research output: Contribution to journalArticle

Human Activities
HLA-A2 Antigen
Single-Chain Antibodies
Cell- and Tissue-Based Therapy
T-Lymphocytes

Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity

Sharma, P. & Kranz, D. M., Jan 1 2018, In : Journal of Biological Chemistry. 293, 5, p. 1820-1834 15 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Complementarity Determining Regions
varespladib methyl
Binding Sites
Substitution reactions
2017

Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor t cells in vitro

Schmitt, T. M., Aggen, D. H., Ishida-Tsubota, K., Ochsenreither, S., Kranz, D. M. & Greenberg, P. D., Jan 1 2017, In : Nature Biotechnology. 35, 12, p. 1188-1195 8 p.

Research output: Contribution to journalArticle

T-cells
Antigens
T-Cell Antigen Receptor
Stem Cells
Autoantigens
2016

Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors

Harris, D. T. & Kranz, D. M., Mar 1 2016, In : Trends in Pharmacological Sciences. 37, 3, p. 220-230 11 p.

Research output: Contribution to journalReview article

Antigen Receptors
T-cells
Cell- and Tissue-Based Therapy
T-Cell Antigen Receptor
T-Lymphocytes

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry

Harris, DT., Singh, NK. K., Cai, Q., Smith, SN. N., Vander Kooi, CW. W., Procko, E., Kranz, D. M. & Baker, BM. M., Jul 6 2016, In : Structure. 24, 7, p. 1142-1154 13 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor Specificity
Major Histocompatibility Complex
Peptide Receptors
Molecular Evolution
Proteins

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

Posey, A. D., Schwab, R. D., Boesteanu, A. C., Steentoft, C., Mandel, U., Engels, B., Stone, J. D., Madsen, T. D., Schreiber, K., Haines, K. M., Cogdill, A. P., Chen, T. J., Song, D., Scholler, J., Kranz, D. M., Feldman, M. D., Young, R., Keith, B., Schreiber, H., Clausen, H. & 2 others, Johnson, L. A. & June, C. H., Jun 21 2016, In : Immunity. 44, 6, p. 1444-1454 11 p.

Research output: Contribution to journalArticle

Mucins
T-Cell Antigen Receptor
Adenocarcinoma
Membranes
Antigen Receptors

Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity

Adams, J. J., Narayanan, S., Birnbaum, M. E., Sidhu, S. S., Blevins, S. J., Gee, M. H., Sibener, L. V., Baker, B. M., Kranz, D. M. & Garcia, K. C., Jan 1 2016, In : Nature Immunology. 17, 1, p. 87-94 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Peptides
T-Lymphocytes
Antigens
2015

A multiplex assay for detection of staphylococcal and streptococcal exotoxins

Sharma, P., Wang, N., Chervin, A. S., Quinn, C. L., Stone, J. D. & Kranz, D. M., Aug 25 2015, In : PloS one. 10, 8, e0135986.

Research output: Contribution to journalArticle

exotoxins
Exotoxins
Assays
toxins
Food

Herman N. Eisen: Mentor to many

Kranz, D. M. & Sykulev, Y., Feb 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 6, p. 1650-1651 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Career Choice
Mentors
Allergy and Immunology

Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses

Mattis, D. M., Chervin, A. S., Ranoa, D. R., Kelley, S. L., Tapping, R. I. & Kranz, D. M., May 8 2015, In : Molecular Immunology. 68, 2, p. 203-212 10 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Lipopolysaccharides
Yeasts
Proteins
Immune System

T cell receptor engineering and analysis using the yeast display platform

Smith, S. N., Harris, D. T. & Kranz, D. M., Jan 1 2015, In : Methods in Molecular Biology. 1319, p. 95-141 47 p.

Research output: Contribution to journalArticle

Cell Engineering
T-Cell Antigen Receptor
Yeasts
Antigens
Peptides

TCR affinity for p/MHC formed by tumor antigens that are self-proteins: Impact on efficacy and toxicity

Stone, J. D., Harris, D. T. & Kranz, D. M., Apr 1 2015, In : Current Opinion in Immunology. 33, p. 16-22 7 p.

Research output: Contribution to journalReview article

Neoplasm Antigens
T-Cell Antigen Receptor
Peptides
Proteins
T-Lymphocytes
2014

A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control

Stone, J. D., Harris, D. T., Soto, C. M., Chervin, A. S., Aggen, D. H., Roy, E. J. & Kranz, D. M., Jan 1 2014, In : Cancer Immunology, Immunotherapy. 63, 11, p. 1163-1176 14 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Antigens
Neoplasms
Immunoglobulin Fragments

Changing the peptide specificity of a human T-cell receptor by directed evolution

Smith, S. N., Wang, Y., Baylon, J. L., Singh, N. K., Baker, B. M., Tajkhorshid, E. & Kranz, D. M., 2014, In : Nature communications. 5, 5223.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-cells
peptides
clone cells
Peptides

Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity

Tosic, V., Thomas, D. L., Kranz, D. M., Liu, J., McFadden, G., Shisler, J. L., MacNeill, A. L. & Roy, E. J., Oct 16 2014, In : PloS one. 9, 10, e109801.

Research output: Contribution to journalArticle

Interleukin-15 Receptor alpha Subunit
Myxoma virus
viral fusion proteins
Interleukin-15
Viruses

Soluble T cell receptor Vβ domains engineered for high-affinity binding to staphylococcal or streptococcal superantigens

Sharma, P., Wang, N. & Kranz, D. M., Feb 13 2014, In : Toxins. 6, 2, p. 556-574 19 p.

Research output: Contribution to journalReview article

Superantigens
T-Cell Antigen Receptor
T-cells
T-Lymphocytes
Staphylococcus aureus

TCR scanning of peptide/MHC through complementary matching of receptor and ligand molecular flexibility

Hawse, W. F., De, S., Greenwood, A. I., Nicholson, L. K., Zajicek, J., Kovrigin, E. L., Kranz, D. M., Garcia, K. C. & Baker, B. M., Mar 15 2014, In : Journal of Immunology. 192, 6, p. 2885-2891 7 p.

Research output: Contribution to journalArticle

Ligands
Peptides
Allergy and Immunology
Thermodynamics
Proteins
2013

Characterization of the Staphylococcal enterotoxin A: Vβ receptor interaction using human receptor fragments engineered for high affinity

Sharma, P., Postel, S., Sundberg, E. J. & Kranz, D. M., Dec 1 2013, In : Protein Engineering, Design and Selection. 26, 12, p. 781-789 9 p.

Research output: Contribution to journalArticle

T-cells
Enterotoxins
Proteins
Superantigens
Staphylococcal Food Poisoning

Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses

Chervin, A. S., Stone, J. D., Soto, C. M., Engels, B., Schreiber, H., Roy, E. J. & Kranz, D. M., Jun 1 2013, In : Gene therapy. 20, 6, p. 634-644 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Tumor-Infiltrating Lymphocytes
Neoplasm Antigens
Neoplasms

Engineering a soluble high-affinity receptor domain that neutralizes staphylococcal enterotoxin C in rabbit models of disease

Mattis, D. M., Spaulding, A. R., Chuang-Smith, O. N., Sundberg, E. J., Schlievert, P. M. & Kranz, D. M., Feb 1 2013, In : Protein Engineering, Design and Selection. 26, 2, p. 133-142 10 p.

Research output: Contribution to journalArticle

T-cells
Rabbits
Proteins
Superantigens
Antibiotics

Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection

Schmitt, T. M., Aggen, D. H., Stromnes, I. M., Dossett, M. L., Richman, S. A., Kranz, D. M. & Greenberg, P. D., Jul 18 2013, In : Blood. 122, 3, p. 348-356 9 p.

Research output: Contribution to journalArticle

Gene therapy
T-cells
Autoantigens
Neoplasm Antigens
T-Cell Antigen Receptor

MHC-class I-restricted CD4 T cells: A nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR

Soto, C. M., Stone, J. D., Chervin, A. S., Engels, B., Schreiber, H., Roy, E. J. & Kranz, D. M., Feb 1 2013, In : Cancer Immunology, Immunotherapy. 62, 2, p. 359-369 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Neoplasms
Histocompatibility Antigens Class I
Helper-Inducer T-Lymphocytes

Novel platform for the detection of staphylococcus aureus enterotoxin B in foods

Tallent, S. M., DeGrasse, J. A., Wang, N., Mattis, D. M. & Kranz, D. M., Mar 1 2013, In : Applied and environmental microbiology. 79, 5, p. 1422-1427 6 p.

Research output: Contribution to journalArticle

Enterotoxins
enterotoxins
Staphylococcus aureus
antibody
T-Cell Antigen Receptor

Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes

Smith, S. N., Sommermeyer, D., Piepenbrink, K. H., Blevins, S. J., Bernhard, H., Uckert, W., Baker, B. M. & Kranz, D. M., Nov 15 2013, In : Journal of Molecular Biology. 425, 22, p. 4496-4507 12 p.

Research output: Contribution to journalArticle

HLA-A2 Antigen
T-Cell Antigen Receptor
Major Histocompatibility Complex
Peptides
Codon

Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity

Engels, B., Engelhard, V. H., Sidney, J., Sette, A., Binder, D. C., Liu, R. B., Kranz, D. M., Meredith, S. C., Rowley, D. A. & Schreiber, H., Apr 15 2013, In : Cancer Cell. 23, 4, p. 516-526 11 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
T-Lymphocytes
Recurrence
Peptides
Neoplasms

Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies

Stone, J. D. & Kranz, D. M., Sep 16 2013, In : Frontiers in immunology. 4, AUG, Article 244.

Research output: Contribution to journalReview article

Cell- and Tissue-Based Therapy
T-Cell Antigen Receptor
T-Lymphocytes
Antigens
Single-Chain Antibodies

Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells

Lynch, J. N., Donermeyer, D. L., Weber, K. S., Kranz, D. M. & Allen, P. M., Mar 1 2013, In : Molecular Immunology. 53, 3, p. 283-294 12 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Mutation
Peptides
T-Cell Antigen Receptor Specificity
Autoimmunity
Major Histocompatibility Complex
Polymorphism
HIV
Peptides
T-cells
2012

A sensitivity scale for targeting t cells with chimeric antigen receptors (CARs) and bispecific t-cell engagers (BiTEs)

Stone, J. D., Aggen, D. H., Schietinger, A., Schreiber, H. & Kranz, D. M., Dec 1 2012, In : OncoImmunology. 1, 6, p. 863-873 11 p.

Research output: Contribution to journalArticle

Antigen Receptors
T-Lymphocytes
T-Cell Antigen Receptor
Epitopes
Neoplasms

Binding of TCR Multimers and a TCR-Like Antibody with Distinct Fine-Specificities Is Dependent on the Surface Density of HLA Complexes

Low, J. L., Naidoo, A., Yeo, G., Gehring, A. J., Ho, Z. Z., Yau, Y. H., Shochat, S. G., Kranz, D. M., Bertoletti, A. & Grotenbreg, G. M., Dec 10 2012, In : PloS one. 7, 12, e51397.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-lymphocytes
Viruses
receptors
antibodies

Design and characterization of a protein superagonist of IL-15 fused with IL-15Rα and a high-affinity T cell receptor

Stone, J. D., Chervin, A. S., Schreiber, H. & Kranz, D. M., Nov 1 2012, In : Biotechnology Progress. 28, 6, p. 1588-1597 10 p.

Research output: Contribution to journalArticle

Interleukin-15
T-Cell Antigen Receptor
Cytokines
Proteins
Cross-Priming

Endogenous viral antigen processing generates pepvtide-specific MHC class I cell-surface clusters

Lu, X., Gibbs, J. S., Hickman, H. D., David, A., Dolan, B. P., Jin, Y., Kranz, D. M., Bennink, J. R., Yewdell, J. W. & Varma, R., Sep 18 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 38, p. 15407-15412 6 p.

Research output: Contribution to journalArticle

Viral Antigens
Antigen Presentation
Peptides
T-Lymphocytes
Antigen-Presenting Cells

Long-term persistence of CD4+ but rapid disappearance of CD8+ T cells expressing an MHC class I-restricted TCR of nanomolar affinity

Engels, B., Chervin, A. S., Sant, A. J., Kranz, D. M. & Schreiber, H., Mar 2012, In : Molecular Therapy. 20, 3, p. 652-660 9 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
T-Lymphocytes
Peptides
Histocompatibility Antigens Class I

Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains

Aggen, D. H., Chervin, A. S., Schmitt, T. M., Engels, B., Stone, J. D., Richman, S. A., Piepenbrink, K. H., Baker, B. M., Greenberg, P. D., Schreiber, H. & Kranz, D. M., Apr 1 2012, In : Gene therapy. 19, 4, p. 365-374 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
CD3 Antigens
T-Cell Receptor Genes
Virus Diseases

Staphylococcus aureus isolates encode variant staphylococcal enterotoxin B proteins that are diverse in superantigenicity and lethality

Kohler, P. L., Greenwood, S. D., Nookala, S., Kotb, M., Kranz, D. M. & Schlievert, P. M., Jul 16 2012, In : PloS one. 7, 7, e41157.

Research output: Contribution to journalArticle

superantigens
septic shock
Superantigens
enterotoxins
Staphylococcus aureus

T cell receptor engineering

Stone, J. D., Chervin, A. S., Aggen, D. H. & Kranz, D. M., 2012, Methods in Enzymology. Academic Press Inc., p. 189-222 34 p. (Methods in Enzymology; vol. 503).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell Engineering
T-cells
T-Cell Antigen Receptor
T-Lymphocytes
Major Histocompatibility Complex
2011

Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells

Fuertes, M. B., Kacha, A. K., Kline, J., Woo, S. R., Kranz, D. M., Murphy, K. M. & Gajewski, T. F., Sep 26 2011, In : Journal of Experimental Medicine. 208, 10, p. 2005-2016 12 p.

Research output: Contribution to journalArticle

Interferon Type I
Dendritic Cells
T-Lymphocytes
Interferons
Neoplasms

Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors

Aggen, D. H., Chervin, A. S., Insaidoo, F. K., Piepenbrink, K. H., Baker, B. M. & Kranz, D. M., Apr 1 2011, In : Protein Engineering, Design and Selection. 24, 4, p. 361-372 12 p.

Research output: Contribution to journalArticle

Forensic Anthropology
T-cells
Human Engineering
T-Cell Antigen Receptor
HLA-A2 Antigen

Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRs

Stone, J. D., Artyomov, M. N., Chervin, A. S., Chakraborty, A. K., Eisen, H. N. & Kranz, D. M., Dec 15 2011, In : Journal of Immunology. 187, 12, p. 6281-6290 10 p.

Research output: Contribution to journalArticle

Streptavidin
Peptides
T-Lymphocytes
Hybridomas
Cell Surface Receptors

Molecular basis of a million-fold affinity maturation process in a protein-protein interaction

Bonsor, D. A., Postel, S., Pierce, B. G., Wang, N., Zhu, P., Buonpane, R. A., Weng, Z., Kranz, D. M. & Sundberg, E. J., Aug 12 2011, In : Journal of Molecular Biology. 411, 2, p. 321-328 8 p.

Research output: Contribution to journalArticle

Protein Engineering
Proteins
Superantigens
X Ray Crystallography
Firearms

Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors

Thomas, D. L., Doty, R., Tosic, V., Liu, J., Kranz, D. M., McFadden, G., MacNeill, A. L. & Roy, E. J., Oct 1 2011, In : Cancer Immunology, Immunotherapy. 60, 10, p. 1461-1472 12 p.

Research output: Contribution to journalArticle

Myxoma virus
Sirolimus
Cell- and Tissue-Based Therapy
Brain Neoplasms
Melanoma

Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8

Stone, J. D., Aggen, D. H., Chervin, A. S., Narayanan, S., Schmitt, T. M., Greenberg, P. D. & Kranz, D. M., May 1 2011, In : Journal of Immunology. 186, 9, p. 5193-5200 8 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Peptides
Ligands
Alleles

T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex

Adams, J. J., Narayanan, S., Liu, B., Birnbaum, M. E., Kruse, A. C., Bowerman, N. A., Chen, W., Levin, A. M., Connolly, J. M., Zhu, C., Kranz, D. M. & Garcia, K. C., Nov 23 2011, In : Immunity. 35, 5, p. 681-693 13 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Peptides
Adaptive Immunity
Libraries
2010

A single, engineered protein therapeutic agent neutralizes exotoxins from both Staphylococcus aureus and Streptococcus pyogenes

Wang, N., Mattis, D. M., Sundberg, E. J., Schlievert, P. M. & Kranz, D. M., Nov 1 2010, In : Clinical and Vaccine Immunology. 17, 11, p. 1781-1789 9 p.

Research output: Contribution to journalArticle

Exotoxins
Streptococcus pyogenes
Staphylococcus aureus
Superantigens
Proteins

Assessing energetic contributions to binding from a disordered region in a protein-protein interaction

Cho, S., Swaminathan, C. P., Bonsor, D. A., Kerzic, M. C., Guan, R., Yang, J., Kieke, M. C., Andersen, P. S., Kranz, D. M., Mariuzza, R. A. & Sundberg, E. J., Nov 2 2010, In : Biochemistry. 49, 43, p. 9256-9268 13 p.

Research output: Contribution to journalArticle

Proteins
Protein Binding
Carrier Proteins
Hot Temperature
Specific heat

High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics

Persaud, S. P., Donermeyer, D. L., Weber, K. S., Kranz, D. M. & Allen, P. M., May 1 2010, In : Molecular Immunology. 47, 9, p. 1793-1801 9 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Thermodynamics
Ligands
Peptides
Antigens

Staphylococcal superantigens cause lethal pulmonary disease in rabbits

Strandberg, K. L., Rotschafer, J. H., Vetter, S. M., Buonpane, R. A., Kranz, D. M. & Schlievert, P. M., Dec 1 2010, In : Journal of Infectious Diseases. 202, 11, p. 1690-1697 8 p.

Research output: Contribution to journalArticle

Superantigens
Lung Diseases
Methicillin Resistance
Rabbits
Lung