1975 …2018
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Fingerprint Fingerprint is based on mining the text of the expert's scholarly documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 3 Similar Profiles
T-Cell Antigen Receptor Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Peptides Medicine & Life Sciences
Major Histocompatibility Complex Medicine & Life Sciences
Ligands Medicine & Life Sciences
Superantigens Medicine & Life Sciences
T-cells Chemical Compounds
Single-Chain Antibodies Medicine & Life Sciences

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Research Output 1975 2018

Comparison of t cell activities mediated by human TCRs and CARs that use the same recognition domains

Harris, D. T., Hager, M. V., Smith, S. N., Cai, Q., Stone, J. D., Kruger, P., Lever, M., Dushek, O., Schmitt, T. M., Greenberg, P. D. & Kranz, D. M., Feb 1 2018, In : Journal of Immunology. 200, 3, p. 1088-1100 13 p.

Research output: Contribution to journalArticle

Human Activities
HLA-A2 Antigen
Single-Chain Antibodies
Cell- and Tissue-Based Therapy

Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity

Sharma, P. & Kranz, D. M., Jan 1 2018, In : Journal of Biological Chemistry. 293, 5, p. 1820-1834 15 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Complementarity Determining Regions
varespladib methyl
Binding Sites
Substitution reactions

Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor t cells in vitro

Schmitt, T. M., Aggen, D. H., Ishida-Tsubota, K., Ochsenreither, S., Kranz, D. M. & Greenberg, P. D., Jan 1 2017, In : Nature Biotechnology. 35, 12, p. 1188-1195 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Stem Cells

Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors

Harris, D. T. & Kranz, D. M., Mar 1 2016, In : Trends in Pharmacological Sciences. 37, 3, p. 220-230 11 p.

Research output: Contribution to journalReview article

Antigen Receptors
Cell- and Tissue-Based Therapy
T-Cell Antigen Receptor

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry

Harris, DT., Singh, NK. K., Cai, Q., Smith, SN. N., Vander Kooi, CW. W., Procko, E., Kranz, D. M. & Baker, BM. M., Jul 6 2016, In : Structure. 24, 7, p. 1142-1154 13 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor Specificity
T-Cell Antigen Receptor
Major Histocompatibility Complex
Peptide Receptors
Molecular Evolution