David M Kranz

1975 …2019
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  • 2 Similar Profiles
T-Cell Antigen Receptor Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Peptides Medicine & Life Sciences
Major Histocompatibility Complex Medicine & Life Sciences
Ligands Medicine & Life Sciences
Superantigens Medicine & Life Sciences
T-cells Chemical Compounds
Single-Chain Antibodies Medicine & Life Sciences

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Research Output 1975 2019

Breaking tolerance with engineered class I antigen-presenting molecules

Parks, C. A., Henning, K. R., Pavelko, K. D., Hansen, M. J., Van Keulen, V. P., Reed, B. K., Stone, J. D., Schrum, A. G., Gil, D., Kranz, D. M., Bordner, A. J., Barry, M. A. & Pease, L. R., Feb 19 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3136-3145 10 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens Class I
Peptides
T-Lymphocytes
Autoantigens
Isoantigens

High-throughput stability screening of neoantigen/HLA complexes improves immunogenicity predictions

Blaha, D. T., Anderson, S. D., Yoakum, D. M., Hager, M. V., Zha, Y., Gajewski, T. F. & Kranz, D. M., Jan 1 2019, In : Cancer Immunology Research. 7, 1, p. 50-61 12 p.

Research output: Contribution to journalArticle

Peptides
T-Lymphocytes
Peptide T
HLA-A2 Antigen
Fluorometry

Comparison of t cell activities mediated by human TCRs and CARs that use the same recognition domains

Harris, D. T., Hager, M. V., Smith, S. N., Cai, Q., Stone, J. D., Kruger, P., Lever, M., Dushek, O., Schmitt, T. M., Greenberg, P. D. & Kranz, D. M., Feb 1 2018, In : Journal of Immunology. 200, 3, p. 1088-1100 13 p.

Research output: Contribution to journalArticle

Human Activities
HLA-A2 Antigen
Single-Chain Antibodies
Cell- and Tissue-Based Therapy
T-Lymphocytes

Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity

Sharma, P. & Kranz, D. M., Jan 1 2018, In : Journal of Biological Chemistry. 293, 5, p. 1820-1834 15 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Complementarity Determining Regions
varespladib methyl
Binding Sites
Substitution reactions

Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor t cells in vitro

Schmitt, T. M., Aggen, D. H., Ishida-Tsubota, K., Ochsenreither, S., Kranz, D. M. & Greenberg, P. D., Jan 1 2017, In : Nature Biotechnology. 35, 12, p. 1188-1195 8 p.

Research output: Contribution to journalArticle

T-cells
Antigens
T-Cell Antigen Receptor
Stem Cells
Autoantigens