David J Shapiro

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Research Output

2020

Src couples estrogen receptor to the anticipatory unfolded protein response and regulates cancer cell fate under stress

Yu, L., Wang, L., Kim, J. E., Mao, C. & Shapiro, D. J., Jan 1 2020, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular Cell Research. 118765.

Research output: Contribution to journalArticle

2019

Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells expressing ERαY537S and ERαD538G mutations

Yu, L., Wang, L., Mao, C., Duraki, D., Kim, J. E., Huang, R., Helferich, W. G., Nelson, E. R., Park, B. H. & Shapiro, D. J., Feb 1 2019, In : Cancer Letters. 442, p. 373-382 10 p.

Research output: Contribution to journalArticle

Protein kinase C- is upregulated by IMP1 in melanoma and is linked to poor survival

Mahapatra, L., Andruska, N., Mao, C., Gruber, S. B., Johnson, T. M., Fullen, D. R., Raskin, L. & Shapiro, D. J., Oct 1 2019, In : Melanoma research. 29, 5, p. 539-543 5 p.

Research output: Contribution to journalArticle

2018

A new role for estrogen receptor a in cell proliferation and cancer: Activating the anticipatory unfolded protein response

Livezey, M., Kim, J. E. & Shapiro, D. J., Jun 15 2018, In : Frontiers in Endocrinology. 9, JUN, 325.

Research output: Contribution to journalShort survey

Strong and sustained activation of the anticipatory unfolded protein response induces necrotic cell death

Livezey, M., Huang, R., Hergenrother, P. J. & Shapiro, D. J., Oct 2018, In : Cell Death and Differentiation. 25, 10, p. 1796-1807 12 p.

Research output: Contribution to journalArticle

Targeting multidrug-resistant ovarian cancer through estrogen receptor a dependent ATP depletion caused by hyperactivation of the unfolded protein response

Zheng, X., Andruska, N., Lambrecht, M. J., He, S., Parissenti, A., Hergenrother, P. J., Nelson, E. R. & Shapiro, D. J., Jan 1 2018, In : Oncotarget. 9, 19, p. 14741-14753 13 p.

Research output: Contribution to journalArticle

2017

A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation

Mahapatra, L., Andruska, N., Mao, C., Le, J. & Shapiro, D. J., Oct 2017, In : Translational Oncology. 10, 5, p. 818-827 10 p.

Research output: Contribution to journalArticle

Structurally novel antiestrogens elicit differential responses from constitutively active mutant estrogen receptors in breast cancer cells and tumors

Zhao, Y., Laws, M. J., Guillen, V. S., Ziegler, Y., Min, J., Sharma, A., Kim, S. H., Chu, D., Park, B. H., Oesterreich, S., Mao, C., Shapiro, D. J., Nettles, K. W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Oct 15 2017, In : Cancer Research. 77, 20, p. 5602-5613 12 p.

Research output: Contribution to journalArticle

2016

Anticipatory UPR Activation: A Protective Pathway and Target in Cancer

Shapiro, D. J., Livezey, M., Yu, L., Zheng, X. & Andruska, N., Oct 1 2016, In : Trends in Endocrinology and Metabolism. 27, 10, p. 731-741 11 p.

Research output: Contribution to journalReview article

Antiestrogen resistant cell lines expressing estrogen receptor α mutations upregulate the unfolded protein response and are killed by BHPI

Mao, C., Livezey, M., Kim, J. E. & Shapiro, D. J., Oct 7 2016, In : Scientific reports. 6, 34753.

Research output: Contribution to journalArticle

Interplay between steroid hormone activation of the unfolded protein response and nuclear receptor action

Zheng, X., Andruska, N., Yu, L., Mao, C., Kim, J. E., Livezey, M., Helferich, W. G. & Shapiro, D. J., 2016, In : Steroids. 114, p. 2-6 5 p.

Research output: Contribution to journalReview article

2015

Anticipatory estrogen activation of the unfolded protein response is linked to cell proliferation and poor survival in estrogen receptor α-positive breast cancer

Andruska, N., Zheng, X., Yang, X., Helferich, W. G. & Shapiro, D. J., Jul 21 2015, In : Oncogene. 34, 29, p. 3760-3769 10 p.

Research output: Contribution to journalArticle

Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression

Andruska, N. D., Zheng, X., Yang, X., Mao, C., Cherian, M. M., Mahapatra, L., Helferich, W. G. & Shapiro, D. J., Apr 14 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 15, p. 4737-4742 6 p.

Research output: Contribution to journalArticle

2014

High-throughput fluorescence anisotropy screen for inhibitors of the oncogenic mrna binding protein, IMP-1

Mahapatra, L., Mao, C., Andruska, N., Zhang, C. & Shapiro, D. J., Mar 2014, In : Journal of Biomolecular Screening. 19, 3, p. 427-436 10 p.

Research output: Contribution to journalArticle

The immune system and inflammation in breast cancer

Jiang, X. & Shapiro, D. J., Jan 25 2014, In : Molecular and Cellular Endocrinology. 382, 1, p. 673-682 10 p.

Research output: Contribution to journalArticle

2013

Fluorescence anisotropy microplate assay to investigate the interaction of full-length steroid receptor coactivator-1a with steroid receptors

Zhang, C., Nordeen, S. K. & Shapiro, D. J., 2013, Gene Regulation: Methods and Protocols. Humana Press Inc., p. 339-351 13 p. (Methods in Molecular Biology; vol. 977).

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

8-Alkylthio-6-thio-substituted theophylline analogues as selective noncompetitive progesterone receptor antagonists

Aninye, I. O., Berg, K. C., Mollo, A. R., Nordeen, S. K., Wilson, E. M. & Shapiro, D. J., May 1 2012, In : Steroids. 77, 6, p. 596-601 6 p.

Research output: Contribution to journalArticle

A competitive inhibitor that reduces recruitment of androgen receptor to androgen-responsive genes

Cherian, M. T., Wilson, E. M. & Shapiro, D. J., Jul 6 2012, In : Journal of Biological Chemistry. 287, 28, p. 23368-23380 13 p.

Research output: Contribution to journalArticle

Evaluation of a luciferase-based reporter assay as a screen for inhibitors of estrogen-ERα-induced proliferation of breast cancer cells

Andruska, N., Mao, C., Cherian, M., Zhang, C. & Shapiro, D. J., Aug 2012, In : Journal of Biomolecular Screening. 17, 7, p. 921-932 12 p.

Research output: Contribution to journalArticle

RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor α

Huang, B., Qu, Z., Ong, C. W., Tsang, Y. H. N., Xiao, G., Shapiro, D., Salto-Tellez, M., Ito, K., Ito, Y. & Chen, L. F., Jan 26 2012, In : Oncogene. 31, 4, p. 527-534 8 p.

Research output: Contribution to journalArticle

2011

Posttranscriptional suppression of proto-oncogene c-fms expression by vigilin in breast cancer

Woo, H. H., Yi, X., Lamb, T., Menzl, I., Baker, T., Shapiro, D. J. & Chambers, S. K., Jan 1 2011, In : Molecular and cellular biology. 31, 1, p. 215-225 11 p.

Research output: Contribution to journalArticle

Small molecule inhibitors as probes for estrogen and androgen receptor action

Shapiro, D. J., Mao, C. & Cherian, M. T., Feb 11 2011, In : Journal of Biological Chemistry. 286, 6, p. 4043-4048 6 p.

Research output: Contribution to journalShort survey

2010

A noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor α

Kretzer, N. M., Cherian, M. T., Mao, C., Aninye, I. O., Reynolds, P. D., Schiff, R., Hergenrother, P. J., Nordeen, S. K., Wilson, E. M. & Shapiro, D. J., Dec 31 2010, In : Journal of Biological Chemistry. 285, 53, p. 41863-41873 11 p.

Research output: Contribution to journalArticle

Differential requirements of Hsp90 and DNA for the formation of estrogen receptor homodimers and heterodimers

Powell, E., Wang, Y., Shapiro, D. J. & Xu, W., May 21 2010, In : Journal of Biological Chemistry. 285, 21, p. 16125-16134 10 p.

Research output: Contribution to journalArticle

2008

A new small molecule inhibitor of estrogen receptor α binding to estrogen response elements blocks estrogen-dependent growth of cancer cells

Mao, C., Patterson, N. M., Cherian, M. T., Aninye, I. O., Zhang, C., Montoya, J. B., Cheng, J., Putt, K. S., Hergenrother, P. J., Wilson, E. M., Nardulli, A. M., Nordeen, S. K. & Shapiro, D. J., May 9 2008, In : Journal of Biological Chemistry. 283, 19, p. 12819-12830 12 p.

Research output: Contribution to journalArticle

Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells

Jiang, X., Patterson, N. M., Ling, Y., Xie, J., Helferich, W. G. & Shapiro, D. J., Nov 2008, In : Endocrinology. 149, 11, p. 5366-5373 8 p.

Research output: Contribution to journalArticle

2007

Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death

Zhou, J. H., Yu, D. V., Cheng, J. & Shapiro, D. J., Oct 1 2007, In : Steroids. 72, 11-12, p. 765-777 13 p.

Research output: Contribution to journalArticle

Expression of high levels of human proteinase inhibitor 9 blocks both perforin/granzyme and Fas/Fas ligand-mediated cytotoxicity

Cunningham, T. D., Jiang, X. & Shapiro, D. J., Jan 1 2007, In : Cellular Immunology. 245, 1, p. 32-41 10 p.

Research output: Contribution to journalArticle

Tamoxifen induction of CCAAT enhancer-binding protein α is required for tamoxifen-induced apoptosis

Cheng, J., Yu, D. V., Zhou, J. H. & Shapiro, D. J., Oct 19 2007, In : Journal of Biological Chemistry. 282, 42, p. 30535-30543 9 p.

Research output: Contribution to journalArticle

2006

Analysis of RNA-protein interactions by a microplate-based fluorescence anisotropy assay

Mao, C., Flavin, K. G., Wang, S., Dodson, R., Ross, J. & Shapiro, D. J., Mar 15 2006, In : Analytical Biochemistry. 350, 2, p. 222-232 11 p.

Research output: Contribution to journalArticle

Regulation of Hepatic 3-Hydroxy-3-Methylglutaryl-Coenzyme a Reductase

Rodwell, V. W., McNamara, D. J. & Shapiro, D. J., Nov 27 2006, Advances in Enzymology and Related Areas of Molecular Biology. Wiley, Vol. 38. p. 373-412 40 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2004

Fluorescence anisotropy microplate assay for analysis of steroid receptor-DNA interactions

Wang, S. Y., Ahn, B. S., Harris, R., Nordeen, S. K. & Shapiro, D. J., Nov 2004, In : BioTechniques. 37, 5, p. 807-817 11 p.

Research output: Contribution to journalArticle

Open Access

Interplay between Estrogen Response Element Sequence and Ligands Controls in Vivo Binding of Estrogen Receptor to Regulated Genes

Krieg, A. J., Krieg, S. A., Ahn, B. S. & Shapiro, D. J., Feb 6 2004, In : Journal of Biological Chemistry. 279, 6, p. 5025-5034 10 p.

Research output: Contribution to journalArticle

2003

RNA Gel Shift Assays for Analysis of Hormone Control of mRNA Stability

Dodson, R. E., Goolsby, K. M., Acena-Nagel, M., Mao, C. & Shapiro, D. J., Jan 1 2003, In : Methods in enzymology. 364, p. 350-361 12 p.

Research output: Contribution to journalReview article

2002

Estrogen receptor-dependent and estrogen receptor-independent pathways for tamoxifen and 4-hydroxytamoxifen-induced programmed cell death

Obrero, M., Yu, D. V. & Shapiro, D. J., Nov 22 2002, In : Journal of Biological Chemistry. 277, 47, p. 45695-45703 9 p.

Research output: Contribution to journalArticle

Regulation of pathways of mRNA destabilization and stabilization

Dodson, R. E. & Shapiro, D. J., Dec 1 2002, Progress in Nucleic Acid Research and Molecular Biology. p. 129-164 36 p. (Progress in Nucleic Acid Research and Molecular Biology; vol. 72).

Research output: Chapter in Book/Report/Conference proceedingChapter

2001
2000

A histone deacetylase inhibitor potentiates estrogen receptor activation of a stably integrated vitellogenin promoter in HepG2 cells

Mao, C. & Shapiro, D. J., Jan 1 2000, In : Endocrinology. 141, 7, p. 2361-2369 9 p.

Research output: Contribution to journalArticle

Estrogen receptor-KRAB chimeras are potent ligand-dependent repressors of estrogen-regulated gene expression

De Haan, G., Chusacultanachai, S., Mao, C., Katzenellenbogen, B. S. & Shapiro, D. J., May 5 2000, In : Journal of Biological Chemistry. 275, 18, p. 13493-13501 9 p.

Research output: Contribution to journalArticle

Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells

Kanamori, H., Krieg, S., Mao, C., Di Pippo, V. A., Wang, S., Zajchowski, D. A. & Shapiro, D. J., Feb 25 2000, In : Journal of Biological Chemistry. 275, 8, p. 5867-5873 7 p.

Research output: Contribution to journalArticle