Research output per year
Research output per year
Personal profile
Research Interests
Research Topics
Computational Biology, Imaging, Neurobiology, Optogenetics, Sensory Processing
Disease Research Interests
Aging Related Diseases, Neurological and Behavioral Disorders
Professional Information
The role of top-down projections in the processing of complex sounds
Our laboratory studies the mechanisms by which complex sounds, such as speech, are processed by the auditory system. We hypothesize that the auditory system generates internal models of the sensory world, and uses these models to extract meaning from complex sensory stimuli. One potential neuronal substrate for this generative model is the massive system of descending projections from the auditory cortex to virtually every level of the subcortical auditory system. These projections are critical for shaping the response properties of neurons in the auditory periphery, but very little is known about their functional organization.
We employ electrophysiological, novel optical and advanced anatomical approaches to study the projections from the auditory cortex to subcortical structures. One specific set of issues that we address concerns the role of different cortical subnetworks in complex sound processing. For example, neurons in both cortical layer 5 and cortical layer 6 project to subcortical structures, and the neurons in these layers have very different intrinsic, integrative and synaptic properties. Our work explores the different roles that these groups of neurons play in the processing of complex sound.
Clinical/Translational
My patient care work is focused on aging and neurodegenerative disease. Consequently, our laboratory has an interest aging-related auditory network dysfunction, particularly as it relates to changes in network properties in the auditory thalamus and cortex.
Honors & Awards
Excellence in Teaching Recognition, 2012-2019, 2021
Presidential Early Career Award for Scientists and Engineers (PECASE), 2019
Helen Corley Petit Scholar, 2017
Benjamin R. and Elinor W. Bullock and Edwin E. and Jeanne Bullock
Goldberg Professorial Scholar, 2017
Advances in Medicine Award, Carle Hospital, 2016
Golden Apple Teaching Award, 2015
Office Phone
(217) 244-0740
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Contrast-free Super-resolution Power Doppler (CS-PD) based on Deep Neural Networks
You, Q., Lowerison, M. R., Shin, Y. R., Chen, X., Sekaran, N. V. C., Dong, Z., Llano, D. A., Anastasio, M. A. & Song, P., 2023, (Accepted/In press) In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. p. 1 1 p.Research output: Contribution to journal › Article › peer-review
Open Access -
CSF peptides from VGF and other markers enhance prediction of MCI to AD progression using the ATN framework
Alzheimer’s Disease Neuroimaging Initiative (ADNI), Jan 2023, In: Neurobiology of Aging. 121, p. 15-27 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Descending projections to the auditory midbrain: evolutionary considerations
Macias, S. & Llano, D. A., Jan 2023, In: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 209, 1, p. 131-143 13 p.Research output: Contribution to journal › Review article › peer-review
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Developmental Exposure to Polychlorinated Biphenyls Prevents Recovery from Noise-Induced Hearing Loss and Disrupts the Functional Organization of the Inferior Colliculus
Ibrahim, B. A., Louie, J. J., Shinagawa, Y., Xiao, G., Asilador, A. R., Sable, H. J. K., Schantz, S. L. & Llano, D. A., Jun 21 2023, In: Journal of Neuroscience. 43, 25, p. 4580-4597 18 p.Research output: Contribution to journal › Article › peer-review
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High-Level Synthesis Design of Scalable Ultrafast Ultrasound Beamformer with Single FPGA
Kou, Z., You, Q., Kim, J., Dong, Z., Lowerison, M. R., Sekaran, N. V. C., Llano, D. A., Song, P. & Oelze, M. L., Jun 1 2023, In: IEEE Transactions on Biomedical Circuits and Systems. 17, 3, p. 446-457 12 p.Research output: Contribution to journal › Article › peer-review
Open Access
Honors & Recognition
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Presidential Early Career Award for Scientists and Engineers (PECASE)
Llano, Daniel Adolfo (Recipient), 2019
Prize: Prize/Award