Christopher Byron Brooke

20102019
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Research Output 2010 2019

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Article
2010

T cells facilitate recovery from Venezuelan equine encephalitis virus-induced encephalomyelitis in the absence of antibody

Brooke, C. B., Deming, D. J., Whitmore, A. C., White, L. J. & Johnston, R. E., May 1 2010, In : Journal of virology. 84, 9, p. 4556-4568 13 p.

Research output: Contribution to journalArticle

Venezuelan Equine Encephalitis Viruses
Venezuelan equine encephalitis virus
Encephalomyelitis
encephalitis
T-lymphocytes
2011

The role of the blood-brain barrier during venezuelan equine encephalitis virus infection

Schäfer, A., Brooke, C. B., Whitmore, A. C. & Johnston, R. E., Oct 1 2011, In : Journal of virology. 85, 20, p. 10682-10690 9 p.

Research output: Contribution to journalArticle

Venezuelan Equine Encephalitis Viruses
Venezuelan equine encephalitis virus
blood-brain barrier
Virus Diseases
Blood-Brain Barrier
2012

Early activation of the host complement system is required to restrict central nervous system invasion and limit neuropathology during Venezuelan equine encephalitis virus infection

Brooke, C. B., Schäfer, A., Matsushima, G. K., White, L. J. & Johnston, R. E., Apr 1 2012, In : Journal of General Virology. 93, 4, p. 797-806 10 p.

Research output: Contribution to journalArticle

Venezuelan Equine Encephalitis Viruses
Complement Activation
Virus Diseases
Central Nervous System
Encephalitis

Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells

Hou, W., Gibbs, J. S., Lu, X., Brooke, C. B., Roy, D., Modlin, R. L., Bennink, J. R. & Yewdell, J. W., Mar 29 2012, In : Blood. 119, 13, p. 3128-3131 4 p.

Research output: Contribution to journalArticle

Virus Diseases
Viruses
Dendritic Cells
Monocytes
Blood
2013

Defining influenza a virus hemagglutinin antigenic drift by sequential monoclonal antibody selection

Das, S. R., Hensley, S. E., Ince, W. L., Brooke, C. B., Subba, A., Delboy, M. G., Russ, G., Gibbs, J. S., Bennink, J. R. & Yewdell, J. W., Mar 13 2013, In : Cell Host and Microbe. 13, 3, p. 314-323 10 p.

Research output: Contribution to journalArticle

Hemagglutinins
Orthomyxoviridae
Monoclonal Antibodies
Influenza A virus
Amino Acid Substitution

Host versus flu: Antibodies win a round?

Brooke, C. B. & Yewdell, J. W., Mar 1 2013, In : Nature Structural and Molecular Biology. 20, 3, p. 245-246 2 p.

Research output: Contribution to journalArticle

Influenza Virus Hemagglutinin Glycoproteins
Viral Antibodies
Immunoglobulin Fab Fragments
Antibodies

Most influenza A virions fail to express at least one essential viral protein

Brooke, C. B., Ince, W. L., Wrammert, J., Ahmed, R., Wilson, P. C., Bennink, J. R. & Yewdell, J. W., Mar 1 2013, In : Journal of virology. 87, 6, p. 3155-3162 8 p.

Research output: Contribution to journalArticle

viral proteins
Influenza A virus
Viral Proteins
virion
influenza
2014

Influenza A virus nucleoprotein selectively decreases neuraminidase gene-segment packaging while enhancing viral fitness and transmissibility

Brooke, C. B., Ince, W. L., Wei, J., Bennink, J. R., Yewdell, J. W. & Lamb, R. A., Nov 25 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 47, p. 16854-16859 6 p.

Research output: Contribution to journalArticle

Neuraminidase
Product Packaging
Influenza A virus
Virion
Nucleoproteins
2017

Population diversity and collective interactions during influenza virus infection

Brooke, C. B., Nov 1 2017, In : Journal of virology. 91, 22, e01164-17.

Research output: Contribution to journalArticle

Influenza A virus
Virus Diseases
Orthomyxoviridae
infection
Population
2018

Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs

Kosik, I., Ince, W. L., Gentles, L. E., Oler, A. J., Kosikova, M., Angel, M., Magadán, J. G., Xie, H., Brooke, C. B. & Yewdell, J. W., Jan 2018, In : PLoS pathogens. 14, 1, e1006796.

Research output: Contribution to journalArticle

Influenza A virus
Hemagglutinins
Glycosylation
Costs and Cost Analysis
Polysaccharides

Influenza A Virus Superinfection Potential Is Regulated by Viral Genomic Heterogeneity

Sun, J. & Brooke, C. B., Oct 30 2018, In : mBio. 9, 5

Research output: Contribution to journalArticle

Superinfection
Influenza A virus
Viral Genes
Virion
Infection
2019

MORC3 Is a Target of the Influenza A Viral Protein NS1

Zhang, Y., Ahn, J. W., Green, K. J., Vann, K. R., Black, J., Brooke, C. B. & Kutateladze, T. G., Jun 4 2019, In : Structure. 27, 6, p. 1029-1033.e3

Research output: Contribution to journalArticle

Viral Proteins
Histones
Human Influenza
Adenosine Triphosphatases
Influenza A virus

Neuraminidase inhibition contributes to influenza A virus neutralization by anti-hemagglutinin stem antibodies

Kosik, I., Angeletti, D., Gibbs, J. S., Angel, M., Takeda, K., Kosikova, M., Nair, V., Hickman, H. D., Xie, H., Brooke, C. B. & Yewdell, J. W., Feb 1 2019, In : Journal of Experimental Medicine. 216, 2, p. 304-316 13 p.

Research output: Contribution to journalArticle

Influenza A virus
Hemagglutinins
Neuraminidase
Antibodies
Human Influenza

Sequencing framework for the sensitive detection and precise mapping of defective interfering particle-associated deletions across influenza A and B viruses

Alnaji, F. G., Holmes, J. R., Rendon, G., Cristobal Vera, J., Fields, C. J., Martin, B. E. & Brooke, C. B., Jan 1 2019, In : Journal of virology. 93, 11, e0035419.

Research output: Contribution to journalArticle

Influenza B virus
Defective Viruses
Influenza A virus
Orthomyxoviridae
Computational Biology

What’s New with Flu? An Overview

Lakdawala, S. S. & Brooke, C. B., May 10 2019, In : Viruses. 11, 5, 433.

Research output: Contribution to journalArticle

Open Access