Christopher Byron Brooke

20102019
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Research Output 2010 2019

2019

Flu Shows the Power of Diversity

Martin, B. E. & Brooke, C. B., Jan 10 2019, In : Cell. 176, 1-2, p. 9-10 2 p.

Research output: Contribution to journalShort survey

Orthomyxoviridae
Viruses
Human Influenza
Population

MORC3 Is a Target of the Influenza A Viral Protein NS1

Zhang, Y., Ahn, J. W., Green, K. J., Vann, K. R., Black, J., Brooke, C. B. & Kutateladze, T. G., Jun 4 2019, In : Structure. 27, 6, p. 1029-1033.e3

Research output: Contribution to journalArticle

Viral Proteins
Histones
Human Influenza
Adenosine Triphosphatases
Influenza A virus

Neuraminidase inhibition contributes to influenza A virus neutralization by anti-hemagglutinin stem antibodies

Kosik, I., Angeletti, D., Gibbs, J. S., Angel, M., Takeda, K., Kosikova, M., Nair, V., Hickman, H. D., Xie, H., Brooke, C. B. & Yewdell, J. W., Feb 1 2019, In : Journal of Experimental Medicine. 216, 2, p. 304-316 13 p.

Research output: Contribution to journalArticle

Influenza A virus
Hemagglutinins
Neuraminidase
Antibodies
Human Influenza

Sequencing framework for the sensitive detection and precise mapping of defective interfering particle-associated deletions across influenza A and B viruses

Alnaji, F. G., Holmes, J. R., Rendon, G., Cristobal Vera, J., Fields, C. J., Martin, B. E. & Brooke, C. B., Jan 1 2019, In : Journal of virology. 93, 11, e0035419.

Research output: Contribution to journalArticle

Influenza B virus
Defective Viruses
Influenza A virus
Orthomyxoviridae
Computational Biology

Teaching an Old Virus New Tricks: A Review on New Approaches to Study Age-Old Questions in Influenza Biology

Lakdawala, S. S., Lee, N. & Brooke, C. B., Jan 1 2019, In : Journal of Molecular Biology.

Research output: Contribution to journalReview article

Orthomyxoviridae
Human Influenza
Teaching
Viruses
Virus Assembly

What’s New with Flu? An Overview

Lakdawala, S. S. & Brooke, C. B., May 10 2019, In : Viruses. 11, 5, 433.

Research output: Contribution to journalArticle

Open Access
2018

Causes and Consequences of Spatial Within-Host Viral Spread

Gallagher, M. E., Brooke, C. B., Ke, R. & Koelle, K., Nov 13 2018, In : Viruses. 10, 11

Research output: Contribution to journalReview article

Influenza A virus
Population Genetics
Population Dynamics
Virion
Respiratory System

Erratum: Correction: Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs (PLoS pathogens (2018) 14 1 (e1006796))

Kosik, I., Ince, W. L., Gentles, L. E., Oler, A. J., Kosikova, M., Angel, M., Magadán, J. G., Xie, H., Brooke, C. B. & Yewdell, J. W., Jun 1 2018, In : PLoS pathogens. 14, 6, p. e1007141

Research output: Contribution to journalComment/debate

Influenza A virus
Hemagglutinins
Glycosylation
Costs and Cost Analysis
Antibodies

Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs

Kosik, I., Ince, W. L., Gentles, L. E., Oler, A. J., Kosikova, M., Angel, M., Magadán, J. G., Xie, H., Brooke, C. B. & Yewdell, J. W., Jan 2018, In : PLoS pathogens. 14, 1, e1006796.

Research output: Contribution to journalArticle

Influenza A virus
Hemagglutinins
Glycosylation
Costs and Cost Analysis
Polysaccharides

Influenza A Virus Superinfection Potential Is Regulated by Viral Genomic Heterogeneity

Sun, J. & Brooke, C. B., Oct 30 2018, In : mBio. 9, 5

Research output: Contribution to journalArticle

Superinfection
Influenza A virus
Viral Genes
Virion
Infection

The parts are greater than the whole: the role of semi-infectious particles in influenza A virus biology

Diefenbacher, M., Sun, J. & Brooke, C. B., Dec 2018, In : Current Opinion in Virology. 33, p. 42-46 5 p.

Research output: Contribution to journalReview article

Influenza A virus
Genome
Virion
Virus Assembly
Essential Genes
2017

Population diversity and collective interactions during influenza virus infection

Brooke, C. B., Nov 1 2017, In : Journal of virology. 91, 22, e01164-17.

Research output: Contribution to journalArticle

Influenza A virus
Virus Diseases
Orthomyxoviridae
infection
Population
2014

Biological activities of 'noninfectious' influenza A virus particles

Brooke, C. B., Jan 1 2014, In : Future Virology. 9, 1, p. 41-51 11 p.

Research output: Contribution to journalReview article

Influenza A virus
Virion
Virus Diseases
Human Influenza
Population

Influenza A virus nucleoprotein selectively decreases neuraminidase gene-segment packaging while enhancing viral fitness and transmissibility

Brooke, C. B., Ince, W. L., Wei, J., Bennink, J. R., Yewdell, J. W. & Lamb, R. A., Nov 25 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 47, p. 16854-16859 6 p.

Research output: Contribution to journalArticle

Neuraminidase
Product Packaging
Influenza A virus
Virion
Nucleoproteins
2013

Defining influenza a virus hemagglutinin antigenic drift by sequential monoclonal antibody selection

Das, S. R., Hensley, S. E., Ince, W. L., Brooke, C. B., Subba, A., Delboy, M. G., Russ, G., Gibbs, J. S., Bennink, J. R. & Yewdell, J. W., Mar 13 2013, In : Cell Host and Microbe. 13, 3, p. 314-323 10 p.

Research output: Contribution to journalArticle

Hemagglutinins
Orthomyxoviridae
Monoclonal Antibodies
Influenza A virus
Amino Acid Substitution

Host versus flu: Antibodies win a round?

Brooke, C. B. & Yewdell, J. W., Mar 1 2013, In : Nature Structural and Molecular Biology. 20, 3, p. 245-246 2 p.

Research output: Contribution to journalArticle

Influenza Virus Hemagglutinin Glycoproteins
Viral Antibodies
Immunoglobulin Fab Fragments
Antibodies

Most influenza a virions fail to express at least one essential viral protein

Brooke, C. B., Ince, W. L., Wrammert, J., Ahmed, R., Wilson, P. C., Bennink, J. R. & Yewdell, J. W., Jul 1 2013, In : Journal of virology. 87, 14, 1 p.

Research output: Contribution to journalComment/debate

Viral Proteins
Virion
Human Influenza

Most influenza A virions fail to express at least one essential viral protein

Brooke, C. B., Ince, W. L., Wrammert, J., Ahmed, R., Wilson, P. C., Bennink, J. R. & Yewdell, J. W., Mar 1 2013, In : Journal of virology. 87, 6, p. 3155-3162 8 p.

Research output: Contribution to journalArticle

viral proteins
Influenza A virus
Viral Proteins
virion
influenza
2012

Early activation of the host complement system is required to restrict central nervous system invasion and limit neuropathology during Venezuelan equine encephalitis virus infection

Brooke, C. B., Schäfer, A., Matsushima, G. K., White, L. J. & Johnston, R. E., Apr 1 2012, In : Journal of General Virology. 93, 4, p. 797-806 10 p.

Research output: Contribution to journalArticle

Venezuelan Equine Encephalitis Viruses
Complement Activation
Virus Diseases
Central Nervous System
Encephalitis

Monocytes, viruses and metaphors: Hanging the Trojan horse

Yewdell, J. W. & Brooke, C. B., May 1 2012, In : Cell Cycle. 11, 9, p. 1748-1749 2 p.

Research output: Contribution to journalEditorial

Metaphor
Monocytes
Viruses

Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells

Hou, W., Gibbs, J. S., Lu, X., Brooke, C. B., Roy, D., Modlin, R. L., Bennink, J. R. & Yewdell, J. W., Mar 29 2012, In : Blood. 119, 13, p. 3128-3131 4 p.

Research output: Contribution to journalArticle

Virus Diseases
Viruses
Dendritic Cells
Monocytes
Blood
2011

The role of the blood-brain barrier during venezuelan equine encephalitis virus infection

Schäfer, A., Brooke, C. B., Whitmore, A. C. & Johnston, R. E., Oct 1 2011, In : Journal of virology. 85, 20, p. 10682-10690 9 p.

Research output: Contribution to journalArticle

Venezuelan Equine Encephalitis Viruses
Venezuelan equine encephalitis virus
blood-brain barrier
Virus Diseases
Blood-Brain Barrier
2010

T cells facilitate recovery from Venezuelan equine encephalitis virus-induced encephalomyelitis in the absence of antibody

Brooke, C. B., Deming, D. J., Whitmore, A. C., White, L. J. & Johnston, R. E., May 1 2010, In : Journal of virology. 84, 9, p. 4556-4568 13 p.

Research output: Contribution to journalArticle

Venezuelan Equine Encephalitis Viruses
Venezuelan equine encephalitis virus
Encephalomyelitis
encephalitis
T-lymphocytes