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Research Output 1996 2019

2019

Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity

Kim, D. H., Park, H. J., Park, H. S., Lee, J. U., Ko, C. M., Gye, M. C. & Choi, J. M., Apr 1 2019, In : Experimental and Molecular Medicine. 51, 4, 41.

Research output: Contribution to journalArticle

Open Access
T-cells
Estrogen Receptor alpha
Helper-Inducer T-Lymphocytes
Autoimmunity
Estrogen Receptors

Ovulation: Parallels with inflammatory processes

Duffy, D. M., Ko, C., Jo, M., Brannstrom, M. & Curry, T. E., Jan 1 2019, In : Endocrine reviews. 40, 2, p. 369-416 48 p.

Research output: Contribution to journalReview article

Ovulation
Oocytes
Granulosa Cells
Theca Cells
Inflammation

Prenatal exposure to an environmentally relevant phthalate mixture disrupts testicular steroidogenesis in adult male mice

Barakat, R., Seymore, T., Lin, P. C. P., Park, C. J. & Ko, C., May 2019, In : Environmental Research. 172, p. 194-201 8 p.

Research output: Contribution to journalArticle

phthalate
Endocrine Disruptors
Diethylhexyl Phthalate
androgen
Seminal Vesicles

Sanitary pads and diapers contain higher phthalate contents than those in common commercial plastic products

Park, C. J., Barakat, R., Ulanov, A., Li, Z. L., Lin, P. C., Chiu, K., Zhou, S., Perez, P., Lee, J., Flaws, J. A. & Ko, C., Mar 2019, In : Reproductive Toxicology. 84, p. 114-121 8 p.

Research output: Contribution to journalArticle

Plastic products
Volatile Organic Compounds
Plastics
Diethylhexyl Phthalate
Xylenes
2018

Core binding factor b expression in ovarian granulosa cells is essential for female fertility

Lee-Thacker, S., Choi, Y., Taniuchi, I., Takarada, T., Yoneda, Y., Ko, C. & Jo, M., May 1 2018, In : Endocrinology. 159, 5, p. 2094-2109 16 p.

Research output: Contribution to journalArticle

Core Binding Factors
Granulosa Cells
Fertility
Corpus Luteum
Ovary

Porcine intestinal lymphoid tissues synthesize estradiol

Park, C. J., Kim, H., Jin, J., Barakat, R., Lin, P. C., Choi, J. M. & Ko, C., Jan 1 2018, In : Journal of Veterinary Science. 19, 4, p. 477-482 6 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
estradiol
Estradiol
Swine
Peyer's Patches

Prenatal exposure to DEHP induces neuronal degeneration and neurobehavioral abnormalities in adult male mice

Barakat, R., Lin, P. C., Park, C. J., Best, C., Bakry, H. H., Abosalem, M. E., Abdelaleem, N. M., Flaws, J. A. & Ko, C., Jan 1 2018, In : Toxicological Sciences. 164, 2, p. 439-452 14 p.

Research output: Contribution to journalArticle

Neurons
Data storage equipment
Hippocampus
Androgen Receptors
phthalic acid
2017

Androgen receptor in the ovary theca cells plays a critical role in androgen-induced reproductive dysfunction

Ma, Y., Andrisse, S., Chen, Y., Childress, S., Xue, P., Wang, Z., Jones, D., Ko, C., Divall, S. & Wu, S., Jan 1 2017, In : Endocrinology. 158, 1, p. 98-108 11 p.

Research output: Contribution to journalArticle

Theca Cells
Dihydrotestosterone
Androgen Receptors
Androgens
Ovary

Birth of clones of the world's first cloned dog

Kim, M. J., Oh, H. J., Kim, G. A., Setyawan, E. M. N., Choi, Y. B., Lee, S. H., Petersen-Jones, S. M., Ko, C. & Lee, B. C., Dec 1 2017, In : Scientific reports. 7, 1, 15235.

Research output: Contribution to journalArticle

Clone Cells
Parturition
Dogs
Mesenchymal Stromal Cells
Organism Cloning

Estrogens in male physiology

Cooke, P. S., Nanjappa, M. K., Ko, C., Prins, G. S. & Hess, R. A., Jul 2017, In : Physiological Reviews. 97, 3, p. 995-1043 49 p.

Research output: Contribution to journalArticle

Estrogens
Reproduction
Aromatase
G-Protein-Coupled Receptors
Estrogen Receptors

Generation and characterization of an estrogen receptor alpha-iCre knock-in mouse

Park, C. J., Chen, G., Koo, Y., Lin, P. C. P., Cacioppo, J. A., Prohaska, H. & Ko, C., Dec 2017, In : Genesis. 55, 12, e23084.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Knockout Mice
Codon
Estrogen Receptors
Transgenic Mice

Granulosa cell endothelin-2 expression is fundamental for ovulatory follicle rupture

Cacioppo, J. A., Lin, P. C. P., Hannon, P. R., McDougle, D. R., Gal, A. & Ko, C., Dec 1 2017, In : Scientific reports. 7, 1, 817.

Research output: Contribution to journalArticle

Endothelin-2
Granulosa Cells
Oocytes
Rupture
Ovulation

IGF1R expression in ovarian granulosa cells is essential for steroidogenesis, follicle survival, and fertility in female mice

Baumgarten, S. C., Armouti, M., Ko, C. & Stocco, C., Jul 2017, In : Endocrinology. 158, 7, p. 2309-2318 10 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Granulosa Cells
Fertility
Follicle Stimulating Hormone
Ovary

Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

Han, K. A., Shin, W. H., Jung, S., Seol, W., Seo, H., Ko, C. & Chung, K. C., Jan 1 2017, In : Human molecular genetics. 26, 1, p. 1-18 18 p.

Research output: Contribution to journalArticle

Leucine
Histones
Phosphotransferases
Phosphorylation
Oxidopamine

Prenatal exposure to DEHP induces premature reproductive senescence in male mice

Barakat, R., Lin, P. C. P., Rattan, S., Brehm, E., Frederico Canisso, I., Abosalum, M. E., Flaws, J. A., Hess, R. A. & Ko, C., Mar 1 2017, In : Toxicological Sciences. 156, 1, p. 96-108 13 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Asthenozoospermia
Corn Oil
Tocopherols
phthalic acid

Selective deletion of Pten in theca-interstitial cells leads to androgen excess and ovarian dysfunction in mice

Lan, Z. J., Krause, M. S., Redding, S. D., Li, X., Wu, G. Z., Zhou, H. X., Bohler, H. C., Ko, C., Cooney, A. J., Zhou, J. & Lei, Z. M., Mar 15 2017, In : Molecular and Cellular Endocrinology. 444, p. 26-37 12 p.

Research output: Contribution to journalArticle

Theca Cells
Phosphatidylinositol 3-Kinases
Androgens
Phosphorylation
Response Elements
2016

Conditional deletion of Bmal1 in ovarian theca cells disrupts ovulation in female mice

Mereness, A. L., Murphy, Z. C., Forrestel, A. C., Butler, S., Ko, C., Richards, J. A. S. & Sellix, M. T., Feb 2016, In : Endocrinology. 157, 2, p. 913-927 15 p.

Research output: Contribution to journalArticle

Theca Cells
Ovulation
Granulosa Cells
Fertility
LH Receptors

Estradiol synthesis in gut-associated lymphoid tissue: Leukocyte regulation by a sexually monomorphic system

Oakley, O. R., Kim, K. J., Lin, P. C., Barakat, R., Cacioppo, J. A., Li, Z. L., Whitaker, A., Chung, K. C., Mei, W. & Ko, C., Dec 2016, In : Endocrinology. 157, 12, p. 4579-4587 9 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
Estradiol
Leukocytes
Aromatase
Peyer's Patches

Estrogen receptor alpha (ESR1)-dependent regulation of the mouse oviductal transcriptome

Cerny, K. L., Ribeiro, R. A. C., Jeoung, M., Ko, C. & Bridges, P. J., Jan 1 2016, In : PloS one. 11, 1, e0147685.

Research output: Contribution to journalArticle

Oviducts
Estrogen Receptor alpha
oviducts
Transcriptome
transcriptome

Extra-gonadal sites of estrogen biosynthesis and function

Barakat, R., Oakley, O., Kim, H., Jin, J. & Ko, C., Jan 1 2016, In : BMB Reports. 49, 9, p. 488-496 9 p.

Research output: Contribution to journalShort survey

Biosynthesis
Estrogens
Biological Phenomena
Immune system
Gonads

Generation of an estrogen receptor beta-iCre knock-in mouse

Cacioppo, J. A., Koo, Y., Lin, P. C. P., Osmulski, S. A., Ko, C. D. & Ko, C., Jan 1 2016, In : Genesis. 54, 1, p. 38-52 15 p.

Research output: Contribution to journalArticle

Estrogen Receptor beta
Estrogen Receptors
Polyadenylation
Neomycin
Initiator Codon

Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy

Min, E., Kandel, M. E., Ko, C., Popescu, G., Jung, W. & Best, C., Dec 23 2016, In : Scientific Reports. 6, 39667.

Research output: Contribution to journalArticle

Interference Microscopy
Light
Brain
Corpus Callosum
Olfactory Bulb

Loss of Fertility in the Absence of Progesterone Receptor Expression in Kisspeptin Neurons of Female Mice

Gal, A., Lin, P. C., Cacioppo, J. A., Hannon, P. R., Mahoney, M. M., Wolfe, A., Fernandez-Valdivia, R., Lydon, J. P., Elias, C. F. & Ko, C., Jul 2016, In : PloS one. 11, 7, e0159534.

Research output: Contribution to journalArticle

Kisspeptins
gonadotropin-releasing hormone
Progesterone Receptors
hypothalamus
Neurons
2015

Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis

Zhao, Y., Gong, P., Chen, Y., Nwachukwu, J. C., Srinivasan, S., Ko, C., Bagchi, M. K., Taylor, R. N., Korach, K. S., Nettles, K. W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jan 21 2015, In : Science Translational Medicine. 7, 271, 271ra9.

Research output: Contribution to journalArticle

Endometriosis
Estrogen Receptors
Estrogens
Fertility
Ligands

Erratum: Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis (Science Translational Medicine (2015) 7 (274er1))

Zhao, Y., Gong, P., Chen, Y., Nwachukwu, J. C., Srinivasan, S., Ko, C., Bagchi, M. K., Taylor, R. N., Korach, K. S., Nettles, K. W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Feb 11 2015, In : Science Translational Medicine. 7, 274

Research output: Contribution to journalComment/debate

Translational Medical Research
Endometriosis

Generation and characterization of an endothelin-2 iCre mouse

Cacioppo, J. A., Koo, Y., Lin, P. C. P., Gal, A. & Ko, C., Feb 1 2015, In : Genesis. 53, 2, p. 245-256 12 p.

Research output: Contribution to journalArticle

Endothelin-2
Genes
Gene Deletion
Genome
Cre recombinase
2014

Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor

Gawriluk, T. R., Ko, C., Hong, X., Christenson, L. K. & Rucker, E. B., Sep 22 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 40, p. E4194-E4203

Research output: Contribution to journalArticle

Premature Obstetric Labor
Autophagy
Progesterone
Ovary
Reproduction

Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism

Novaira, H. J., Sonko, M. L., Hoffman, G., Koo, Y., Ko, C., Wolfe, A. & Radovick, S., Feb 1 2014, In : Molecular Endocrinology. 28, 2, p. 225-238 14 p.

Research output: Contribution to journalArticle

Kisspeptins
Hypogonadism
Gonadotropin-Releasing Hormone
Neurons
Periodicity

Expression of genomic functional estrogen receptor 1 in mouse sertoli cells

Lin, J., Zhu, J., Li, X., Li, S., Lan, Z., Ko, C. & Lei, Z., Nov 12 2014, In : Reproductive Sciences. 21, 11, p. 1411-1422 12 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Sertoli Cells
Estrogens
Chromatin Immunoprecipitation
Small Interfering RNA

Loss of function of endothelin-2 leads to reduced ovulation and CL formation

Cacioppo, J. A., Oh, S. W., Kim, H. Y., Cho, J., Lin, P. C. P., Yanagisawa, M. & Ko, C., Apr 24 2014, In : PloS one. 9, 4, e96115.

Research output: Contribution to journalArticle

Endothelin-2
endothelins
Corpus Luteum
Ovulation
corpus luteum

Obesity-induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell

Wu, S., Divall, S., Nwaopara, A., Radovick, S., Wondisford, F., Ko, C. & Wolfe, A., Apr 1 2014, In : Diabetes. 63, 4, p. 1270-1282 13 p.

Research output: Contribution to journalArticle

Theca Cells
Hyperandrogenism
Insulin Receptor
Infertility
Obesity

Transforming growth factor-β1 signaling represses testicular steroidogenesis through cross-talk with orphan nuclear receptor Nur77

Park, E., Song, C. H., Park, J. I., Ahn, R. S., Choi, H. S., Ko, C. & Lee, K., Aug 20 2014, In : PloS one. 9, 8, e104812.

Research output: Contribution to journalArticle

Nuclear Receptor Subfamily 4, Group A, Member 1
transforming growth factors
steroidogenesis
Transforming Growth Factors
Leydig cells

Vaginal Fold Histology Reduces the Variability Introduced by Vaginal Exfoliative Cytology in the Classification of Mouse Estrous Cycle Stages

Gal, A., Lin, P. C., Barger, A. M., Macneill, A. L. & Ko, C., Dec 2014, In : Toxicologic Pathology. 42, 8, p. 1212-1220 9 p.

Research output: Contribution to journalArticle

Cytology
Histology
Estrous Cycle
Cell Biology
Gonadal Steroid Hormones
2013

A low-copy-number plasmid for retrieval of toxic genes from BACs and generation of conditional targeting constructs

Na, G., Wolfe, A., Ko, C., Youn, H., Lee, Y. M., Byun, S. J., Jeon, I. & Koo, Y., Jun 1 2013, In : Molecular Biotechnology. 54, 2, p. 504-514 11 p.

Research output: Contribution to journalArticle

Poisons
Bacterial Artificial Chromosomes
Plasmids
Genes
Chromosomes

RiboTag Analysis of Actively Translated mRNAs in Sertoli and Leydig Cells In Vivo

Sanz, E., Evanoff, R., Quintana, A., Evans, E., Miller, J. A., Ko, C., Amieux, P. S., Griswold, M. D. & McKnight, G. S., Jun 11 2013, In : PloS one. 8, 6, e66179.

Research output: Contribution to journalArticle

Leydig cells
Leydig Cells
Sertoli Cells
Sertoli cells
ribosomes
2012

Endothelin B receptor is not required but necessary for finite regulation of ovulation

Cho, J., Kim, H., Kang, D. W., Yanagisawa, M. & Ko, C., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 613-617 5 p.

Research output: Contribution to journalArticle

Endothelin B Receptors
Endothelins
Ovulation
Ovary
Corpus Luteum

ERα/E2 signaling suppresses the expression of steroidogenic enzyme genes via cross-talk with orphan nuclear receptor Nur77 in the testes

Lee, S. Y., Park, E., Kim, S. C., Ahn, R. S., Ko, C. & Lee, K., Oct 15 2012, In : Molecular and Cellular Endocrinology. 362, 1-2, p. 91-103 13 p.

Research output: Contribution to journalArticle

Nuclear Receptor Subfamily 4, Group A, Member 1
Estrogen Receptor alpha
Testis
Genes
Leydig Cells

Estrogen receptor (ESR) 2 partially offsets the absence of ESR1 in gonadotropes of pituitary-specific Esr1 knockout female mice

Sánchez-Criado, J. E., Trudgen, K., Millán, Y., Blanco, A., Monterde, J., Garrido-Gracia, J. C., Gordon, A., Aguilar, R., De Las Mulas, J. M. & Ko, C., Apr 1 2012, In : Reproduction. 143, 4, p. 549-558 10 p.

Research output: Contribution to journalArticle

Estrogen Receptor beta
Knockout Mice
Oils
Anterior Pituitary Gland
Estrogen Receptor alpha

Hematopoetic prostaglandin D synthase: An ESR1-dependent oviductal epithelial cell synthase

Bridges, P. J., Jeoung, M., Shim, S., Park, J. Y., Lee, J. E., Sapsford, L. A., Trudgen, K., Ko, C., Gye, M. C. & Jo, M., Apr 1 2012, In : Endocrinology. 153, 4, p. 1925-1935 11 p.

Research output: Contribution to journalArticle

prostaglandin R2 D-isomerase
Epithelial Cells
Oviducts
Inflammation
Epithelium

Why two endothelins and two receptors for ovulation and luteal regulation?

Ko, C., Meidan, R. & Bridges, P. J., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 501-506 6 p.

Research output: Contribution to journalArticle

Endothelin Receptors
Corpus Luteum
Endothelins
Ovulation
Ovary
2011

Endothelins in regulating ovarian and oviductal function

Bridges, P. J., Cho, J. & Ko, C., Jan 1 2011, In : Frontiers in Bioscience - Scholar. 3 S, 1, p. 145-155 11 p.

Research output: Contribution to journalArticle

Endothelins
Ligands
Luteolysis
Peptide Hormones
Ovulation

Expression pattern of endothelin system components and localization of smooth muscle cells in the human pre-ovulatory follicle

Choi, D. H., Kim, E. K., Kim, K. H., Lee, K. A., Kang, D. W., Kim, H. Y., Bridges, P. & Ko, C., May 2011, In : Human Reproduction. 26, 5, p. 1171-1180 10 p.

Research output: Contribution to journalArticle

Theca Cells
Endothelins
Smooth Muscle Myocytes
Endothelin-2
Endothelin A Receptors

Generation of transgenic dogs that conditionally express green fluorescent protein

Kim, M. J., Oh, H. J., Park, J. E., Kim, G. A., Hong, S. G., Jang, G., Kwon, M. S., Koo, B. C., Kim, T., Kang, S. K., Ra, J. C., Ko, C. & Lee, B. C., Jun 1 2011, In : Genesis. 49, 6, p. 472-478 7 p.

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Dogs
Doxycycline
Transgenes
Oocytes

Identification of estradiol/ERα-regulated genes in the mouse pituitary

Kim, H. J., Gieske, M. C., Trudgen, K. L., Hudgins-Spivey, S., Kim, B. G., Krust, A., Chambon, P., Jeong, J. W., Blalock, E. & Ko, C., Sep 1 2011, In : Journal of Endocrinology. 210, 3, p. 309-321 13 p.

Research output: Contribution to journalArticle

Estradiol Receptors
Estrogen Receptors
Estrogens
Genes
Gonadotropin-Releasing Hormone

Methodology matters: IVF versus ICSI and embryonic gene expression

Bridges, P. J., Jeoung, M., Kim, H., Kim, J. H., Lee, D. R., Ko, C. & Baker, D. J., Aug 1 2011, In : Reproductive BioMedicine Online. 23, 2, p. 234-244 11 p.

Research output: Contribution to journalArticle

Intracytoplasmic Sperm Injections
Gene Expression
Blastocyst
Oocytes
Microarray Analysis

Pituitary-ovary-spleen axis in ovulation

Oakley, O. R., Frazer, M. L. & Ko, C., Sep 1 2011, In : Trends in Endocrinology and Metabolism. 22, 9, p. 345-352 8 p.

Research output: Contribution to journalReview article

Ovulation
Ovary
Leukocytes
Spleen
Corpus Luteum

The leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult leydig cells and for fertility

Yamashita, S., Tai, P., Charron, J., Ko, C. & Ascoli, M., Jul 1 2011, In : Molecular Endocrinology. 25, 7, p. 1211-1222 12 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Leydig Cells
Fertility
Chorionic Gonadotropin
Population

The role of decay accelerating factor in the immunopathogenesis of cytomegalovirus infection

Bani-Ahmad, M., El-Amouri, I. S., Ko, C., Lin, F., Tang-Feldman, Y. & Oakley, O. R., Feb 1 2011, In : Clinical and Experimental Immunology. 163, 2, p. 199-206 8 p.

Research output: Contribution to journalArticle

CD55 Antigens
Cytomegalovirus Infections
Knockout Mice
Infection
Complement C3-C5 Convertases

The stromal overexpression of decay accelerating factor (DAF/CD55) correlates with poor clinical outcome in colorectal cancer patients

Baek, T. H., Kim, J. H., Park, M. J., Lee, H. K., Son, H. J., Soon, H. K., Kim, C. N., Ko, C. & Kang, D. W., Oct 2011, In : Korean Journal of Pathology. 45, 5, p. 445-454 10 p.

Research output: Contribution to journalArticle

CD55 Antigens
Colorectal Neoplasms
Neoplasms
Neoplasm Metastasis
Complement C3-C5 Convertases
2010

Absence of estrogen receptor alpha leads to physiological alterations in the mouse epididymis and consequent defects in sperm function

Joseph, A., Hess, R. A., Schaeffer, D. J., Ko, C., Hudgin-Spivey, S., Chambon, P. & Shur, B. D., May 1 2010, In : Biology of reproduction. 82, 5, p. 948-957 10 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Epididymis
Spermatozoa
Proteins
Spermatogenesis