Benita S Katzenellenbogen

1970 …2018
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Research Output 1970 2018

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Article
2001

The estrogen receptor: A structure-based approach to the design of new specific hormone-receptor combinations

Tedesco, R., Thomas, J. A., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Apr 25 2001, In : Chemistry and Biology. 8, 3, p. 277-287 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Hormones
Ligands
Transgenes
Reporter Genes

Triarylpyrazoles with basic side chains: Development of pyrazole-based estrogen receptor antagonists

Stauffer, S. R., Huang, Y. R., Aron, Z. D., Coletta, C. J., Sun, J., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Jan 8 2001, In : Bioorganic and Medicinal Chemistry. 9, 1, p. 151-161 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Pyrazoles
Estrogen Receptor Antagonists
pyrazole
Ligands
2000

Activation of estrogen receptor-α by the heavy metal cadmium

Stoica, A., Katzenellenbogen, B. S. & Martin, M. B., Dec 1 2000, In : Molecular Endocrinology. 14, 4, p. 545-553 9 p.

Research output: Contribution to journalArticle

Heavy Metals
Cadmium
Estrogen Receptors
Hormones
Estradiol

Acyclic amides as estrogen receptor ligands: Synthesis, binding, activity and receptor interaction

Stauffer, S. R., Sun, J., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Jun 1 2000, In : Bioorganic and Medicinal Chemistry. 8, 6, p. 1293-1316 24 p.

Research output: Contribution to journalArticle

Amides
Estrogen Receptors
Ligands
Benzamides
Acetamides

Analysis of estrogen receptor interaction with a repressor of estrogen receptor activity (REA) and the regulation of estrogen receptor transcriptional activity by REA

Delage-Mourroux, R., Martini, P. G. V., Choi, I., Kraichely, D. M., Hoeksema, J. & Katzenellenbogen, B. S., Nov 17 2000, In : Journal of Biological Chemistry. 275, 46, p. 35848-35856 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Competitive Binding
Response Elements
Cytoplasmic and Nuclear Receptors
Glutathione Transferase

A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I

Martin, M. B., Franke, T. F., Stoica, G. E., Chambon, P., Katzenellenbogen, B. S., Stoica, B. A., McLemore, M. S., Olivo, S. E. & Stoica, A., Jan 1 2000, In : Endocrinology. 141, 12, p. 4503-4511 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Epidermal Growth Factor
Transfection
Phosphatidylinositol 3-Kinase
Messenger RNA
Estrogen Receptors
Ligands
Estradiol
Estrogens
Aptitude
Brussels sprouts
estrogenic properties
Brassica
MCF-7 Cells
Gene expression

Estrogen receptor-KRAB chimeras are potent ligand-dependent repressors of estrogen-regulated gene expression

De Haan, G., Chusacultanachai, S., Mao, C., Katzenellenbogen, B. S. & Shapiro, D. J., May 5 2000, In : Journal of Biological Chemistry. 275, 18, p. 13493-13501 9 p.

Research output: Contribution to journalArticle

Gene expression
Estrogen Receptors
Response Elements
Estrogens
Ligands

Estrogen receptors: Selective ligands, partners, and distinctive pharmacology

Katzenellenbogen, B. S., Montano, M. M., Ediger, T. R., Sun, J., Ekena, K., Lazennec, G., Martini, P. G. V., McInerney, E. M., Delage-Mourroux, R., Weis, K., Katzenellenbogen, J. A., Nagel, S., Schrader, W., Bethea, C., Cutler, G. & Hock, J., Dec 1 2000, In : Recent Progress in Hormone Research. 55, p. 163-195 33 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Pharmacology
Ligands
Estrogens
Hormones

Molecular mechanisms of estrogen action: Selective ligands and receptor pharmacology

Katzenellenbogen, B. S., Choi, I., Delage-Mourroux, R., Ediger, T. R., Martini, P. G. V., Montano, M., Sun, J., Weis, K. & Katzenellenbogen, J. A., Nov 30 2000, In : Journal of Steroid Biochemistry and Molecular Biology. 74, 5, p. 279-285 7 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Pharmacology
Ligands
Estrogen Receptor Modulators

Multistep signaling and transcriptional requirements for pituitary organogenesis in vivo

Rosenfeld, M. G., Briata, P., Dasen, J., Gleiberman, A. S., Kioussi, C., Lin, C., O'Connell, S. M., Ryan, A., Szeto, D. P., Treier, M., Katzenellenbogen, B. S., Nilson, J., Lawrence, A., Arnhold, I., Frohman, L. & Kochupillai, N., Dec 1 2000, In : Recent Progress in Hormone Research. 55, p. 1-14 14 p.

Research output: Contribution to journalArticle

Organogenesis
Ectoderm
Transcription Factor Pit-1
Transcription Factors
Notochord

Prothymosin alpha selectively enhances estrogen receptor transcriptional activity by interacting with a repressor of estrogen receptor activity

Martini, P. G. V., Delage-Mourroux, R., Kraichely, D. M. & Katzenellenbogen, B. S., Sep 6 2000, In : Molecular and cellular biology. 20, 17, p. 6224-6232 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Cytoplasmic and Nuclear Receptors
prothymosin alpha
Proteins
Nuclear Receptor Coactivator 1

Pyrazole ligands: Structure - Affinity/activity relationships and estrogen receptor-α-selective agonists

Stauffer, S. R., Coletta, C. J., Tedesco, R., Nishiguchi, G., Carlson, K., Sun, J., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Dec 28 2000, In : Journal of Medicinal Chemistry. 43, 26, p. 4934-4947 14 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Estrogen Receptors
Estrogens
Ligands
pyrazole
Keratin-19
Gene expression
Estrogens
Genes
Cells
1999
Adenoviridae
Estrogen Receptors
Estrogens
Cell Proliferation
Breast Neoplasms

Analysis of estrogen response element binding by genetically selected steroid receptor DNA binding domain mutants exhibiting altered specificity and enhanced affinity

Chusacultanachai, S., Glenn, K. A., Rodriguez, A. O., Read, E. K., Gardner, J. F., Katzenellenbogen, B. S. & Shapiro, D. J., Aug 13 1999, In : Journal of Biological Chemistry. 274, 33, p. 23591-23598 8 p.

Research output: Contribution to journalArticle

Steroid Receptors
Response Elements
Estrogens
Amino Acids
Bacteriophage P22

An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens

Montano, M. M., Ekena, K., Delage-Mourroux, R., Chang, W., Martini, P. & Katzenellenbogen, B. S., Jun 8 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 12, p. 6947-6952 6 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Estrogen Receptors
Estrogens
Cytoplasmic and Nuclear Receptors
Breast Neoplasms

Caveolin-1 potentiates estrogen receptor α (ERα) signaling. Caveolin-1 drives ligand-independent nuclear translocation and activation of ERα

Schlegel, A., Wang, C., Katzenellenbogen, B. S., Pestell, R. G. & Lisanti, M. P., Nov 19 1999, In : Journal of Biological Chemistry. 274, 47, p. 33551-33556 6 p.

Research output: Contribution to journalArticle

Caveolin 1
Estrogen Receptors
Chemical activation
Ligands
Signal transduction

Coactivator peptides have a differential stabilizing effect on the binding of Estrogens and Antiestrogens with the estrogen receptor

Gee, A. C., Carlson, K. E., Martini, P. G. V., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Jan 1 1999, In : Molecular Endocrinology. 13, 11, p. 1912-1923 12 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Estrogen Receptors
Estrogens
Nuclear Receptor Coactivator 1
Ligands

Estrogen receptor regulation of the Na+/H+ exchanger regulatory factor

Ediger, T. R., Kraus, W. L., Weinman, E. J. & Katzenellenbogen, B. S., Jan 1 1999, In : Endocrinology. 140, 7, p. 2976-2982 7 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Breast Neoplasms
Estrogen Receptor Modulators
Microvilli

Estrogen receptor subtype-selective ligands: Asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl-5,6,11,12- tetrahydrochrysenes

Meyers, M. J., Jun, S., Carlson, K. E., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Jul 1 1999, In : Journal of Medicinal Chemistry. 42, 13, p. 2456-2468 13 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Estrogen Receptors
Dronabinol
Ligands
Enantiomers
Gene Transfer Techniques
Estrogen Receptors
Genes
Cells
Hormones

Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-α or estrogen receptor-β

Sun, J., Meyers, M. J., Fink, B. E., Rajendran, R., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jan 1 1999, In : Endocrinology. 140, 2, p. 800-804 5 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Estrogen Receptors
Estrogens
Ligands
Transcriptional Activation

The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions

Webb, P., Nguyen, P., Valentine, C., Lopez, G. N., Kwok, G. R., McInerney, E., Katzenellenbogen, B. S., Enmark, E., Gustafsson, J. Å., Nilsson, S. & Kushner, P. J., Jan 1 1999, In : Molecular Endocrinology. 13, 10, p. 1672-1685 14 p.

Research output: Contribution to journalArticle

Transcription Factor AP-1
Estrogen Receptors
Transcriptional Activation
Estrogens
Furylfuramide
1998

Determinants of ligand specificity of estrogen receptor-α: Estrogen versus androgen discrimination

Ekena, K., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jan 9 1998, In : Journal of Biological Chemistry. 273, 2, p. 693-699 7 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Androgens
Estrogens
Ligands
Estradiol

Estrogen receptor activation function 1 works by binding p160 coactivator proteins

Webb, P., Nguyen, P., Shinsako, J., Anderson, C., Feng, W., Nguyen, M. P., Chen, D., Huang, S. M., Subramanian, S., McKinerney, E., Katzenellenbogen, B. S., Stallcup, M. R. & Kushner, P. J., Jan 1 1998, In : Molecular Endocrinology. 12, 10, p. 1605-1618 14 p.

Research output: Contribution to journalArticle

Furylfuramide
Estrogen Receptors
Transcriptional Activation
Proteins
CREB-Binding Protein
Granulosa Cells
Progesterone Receptors
Genetic Promoter Regions
Cyclic AMP
Estradiol

Transcription activation by the human estrogen receptor subtype β (ERβ) studied with ERβ and ERα receptor chimeras

Mcinerney, E. M., Weis, K. E., Sun, J., Mosselman, S. & Katzenellenbogen, B. S., Jan 1 1998, In : Endocrinology. 139, 11, p. 4513-4522 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Transcriptional Activation
Estrogen Receptor Modulators
Ligands
Estrogens

Transcriptional regulation of the human quinone reductase gene by antiestrogen-liganded estrogen receptor-α and estrogen receptor-β

Montano, M. M., Jaiswal, A. K. & Katzenellenbogen, B. S., Sep 25 1998, In : Journal of Biological Chemistry. 273, 39, p. 25443-25449 7 p.

Research output: Contribution to journalArticle

NAD(P)H Dehydrogenase (Quinone)
Estrogen Receptor Modulators
Estrogen Receptors
Genes
Antioxidant Response Elements
1997

17α-(Haloacetamidoalkyl)estradiols alkylate the human estrogen receptor at cysteine residues 417 and 530

Aliau, S., El Garrouj, D., Yasri, A., Katzenellenbogen, B. S. & Borgna, J. L., May 13 1997, In : Biochemistry. 36, 19, p. 58615867 1 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Cysteine
Estradiol
Hormones
Labeling

Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: Evidence that an open pocket conformation is required for ligand interaction

Carlson, K. E., Choi, I., Gee, A., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Dec 2 1997, In : Biochemistry. 36, 48, p. 14897-14905 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Conformations
Ligands
Estradiol
Association reactions
Progesterone Receptors
Estrogen Receptors
Ligands
Estrogens
Response Elements

Different residues of the human estrogen receptor are involved in the recognition of structurally diverse estrogens and antiestrogens

Ekena, K., Weise, K. E., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Feb 21 1997, In : Journal of Biological Chemistry. 272, 8, p. 5069-5075 7 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Estrogen Receptors
Estrogens
Ligands
Estradiol
Estrogens
Hormones
Genes
Progesterone Receptors
Estrogen Receptors
Estrogen Receptors
DNA
Ligands
Estrogens
Hormones
NAD(P)H Dehydrogenase (Quinone)
Estrogen Receptor Modulators
Estrogen Receptors
Genes
Antioxidant Response Elements
1996

Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator

Mcinerney, E. M., Tsai, M. J., O'Malley, B. W. & Katzenellenbogen, B. S., Sep 17 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 19, p. 10069-10073 5 p.

Research output: Contribution to journalArticle

Nuclear Receptor Coactivators
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Ligands
Nuclear Receptor Coactivator 1

A transcriptionally active estrogen receptor mutant is a novel type of dominant negative inhibitor of estrogen action

McInerney, E. M., Ince, B. A., Shapiro, D. J. & Katzenellenbogen, B. S., Dec 17 1996, In : Molecular Endocrinology. 10, 12, p. 1519-1526 8 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Response Elements
DNA
Amino Acid Substitution

Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein

Weis, K. E., Ekena, K., Thomas, J. A., Lazennec, G. & Katzenellenbogen, B. S., Dec 1 1996, In : Molecular Endocrinology. 10, 11, p. 1388-1398 11 p.

Research output: Contribution to journalArticle

Amino Acid Substitution
Estrogen Receptors
Tyrosine
Nuclear Receptor Coactivator 1
Estrogens
Estrogen Receptor Modulators
Transcription
Transcriptional Activation
Estradiol
Chemical activation

Estrogen receptors: Bioactivities and interactions with cell signaling pathways

Katzenellenbogen, B. S., Feb 1 1996, In : Biology of reproduction. 54, 2, p. 287-293 7 p.

Research output: Contribution to journalArticle

Cell Communication
Estrogen Receptors
Estrogen Receptor Modulators
Estrogens
Ligands
Estrogen Receptor Modulators
Estrogen Receptors
Estrogens
Ligands
Estradiol

Identification of amino acids in the hormone binding domain of the human estrogen receptor important in estrogen binding

Ekena, K., Weis, K. E., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Sep 5 1996, In : Journal of Biological Chemistry. 271, 33, p. 20053-20059 7 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Hormones
Ligands
Amino Acids
Estrogen Receptor Modulators
Cells
Breast Neoplasms
Cell Line
Growth
1995

Analysis of mechanisms that determine dominant negative estrogen receptor effectiveness

Schodin, D. J., Zhuang, Y., Shapiro, D. J. & Katzenellenbogen, B. S., Dec 29 1995, In : Journal of Biological Chemistry. 270, 52, p. 31163-31171 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Dimerization
Response Elements
Mutation

Antiestrogens: Mechanisms and actions in target cells

Katzenellenbogen, B. S., Montano, M. M., Le Goff, P., Schodin, D. J., Kraus, W. L., Bhardwaj, B. & Fujimoto, N., Jun 1995, In : Journal of Steroid Biochemistry and Molecular Biology. 53, 1-6, p. 387-393 7 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Estrogen Receptors
Estrogens
Phosphorylation
Protein Kinases
Response Elements
Estrogen Receptors
Estradiol
Estrogens
Cricetulus
Steroid Receptors
Progesterone Receptors
Estrogen Receptors
Hormones
Ligands
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Steroids
Ligands
Estrogens