Benita S Katzenellenbogen

1970 …2018
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Research Output 1970 2018

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2005

Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo

Park, S. E., Xu, J., Frolova, A., Liao, L., O'Malley, B. W. & Katzenellenbogen, B. S., Mar 1 2005, In : Molecular and cellular biology. 25, 5, p. 1989-1999 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Uterus
Wild Animals
Genes

Indazole estrogens: Highly selective ligands for the estrogen receptor β

De Angelis, M., Stossi, F., Carlson, K. A., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Feb 24 2005, In : Journal of Medicinal Chemistry. 48, 4, p. 1132-1144 13 p.

Research output: Contribution to journalArticle

Indazoles
Estrogen Receptors
Estradiol
Estrogens
Ligands

Isocoumarins as estrogen receptor beta selective ligands: Isomers of isoflavone phytoestrogens and their metabolites

De Angelis, M., Stossi, F., Waibel, M., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Dec 1 2005, In : Bioorganic and Medicinal Chemistry. 13, 23, p. 6529-6542 14 p.

Research output: Contribution to journalArticle

Isocoumarins
Phytoestrogens
Estrogen Receptor beta
Isoflavones
Metabolites

Synthesis and evaluation of estrogen receptor ligands with bridged oxabicyclic cores containing a diarylethylene motif: Estrogen antagonists of unusual structure

Zhou, H. B., Comninos, J. S., Stossi, F., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Nov 17 2005, In : Journal of Medicinal Chemistry. 48, 23, p. 7261-7274 14 p.

Research output: Contribution to journalArticle

Estrogen Antagonists
Estrogen Receptors
Ligands
Transcription
Non-Steroidal Estrogens

The androgen derivative 5α-androstane-3β,17β-diol inhibits prostate cancer cell migration through activation of the estrogen receptor β subtype

Guerini, V., Sau, D., Scaccianoce, E., Rusmini, P., Ciana, P., Maggi, A., Martini, P. G. V., Katzenellenbogen, B. S., Martini, L., Motta, M. & Poletti, A., Jun 15 2005, In : Cancer Research. 65, 12, p. 5445-5453 9 p.

Research output: Contribution to journalArticle

Androstane-3,17-diol
Estrogen Receptors
Androgens
Cell Movement
Prostatic Neoplasms

Thyroid hormone can increase estrogen-mediated transcription from a consensus estrogen response element in neuroblastoma cells

Zhao, X., Lorenc, H., Stephenson, H., Wang, Y. J., Witherspoon, D., Katzenellenbogen, B. S., Pfaff, D. & Vasudevan, N., Mar 29 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 13, p. 4890-4895 6 p.

Research output: Contribution to journalArticle

Response Elements
Neuroblastoma
Thyroid Hormones
Consensus
Estrogens
2004

Allosteric Control of Ligand Selectivity between Estrogen Receptors α and β: Implications for Other Nuclear Receptors

Nettles, K. W., Sun, J., Radek, J. T., Sheng, S., Rodriguez, A. L., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Greene, G. L., Feb 13 2004, In : Molecular cell. 13, 3, p. 317-327 11 p.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Ligands
Amino Acid Substitution
Signal Transduction

Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc

Barletta, F., Wong, C. W., McNally, C., Komm, B. S., Katzenellenbogen, B. S. & Cheskis, B. J., May 1 2004, In : Molecular Endocrinology. 18, 5, p. 1096-1108 13 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Estrogen Receptors
src Homology Domains
Phosphotyrosine
Mutation

Directed evolution of human estrogen receptor variants with significantly enhanced androgen specificity and affinity

Chen, Z., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Zhao, H., Aug 6 2004, In : Journal of Biological Chemistry. 279, 32, p. 33855-33864 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Androgens
Ligands
Testosterone
Cytoplasmic and Nuclear Receptors

Equol, a natural estrogenic metabolite from soy isoflavones: Convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta

Muthyala, R. S., Ju, Y. H., Sheng, S., Williams, L. D., Doerge, D. R., Katzenellenbogen, B. S., Helferich, W. G. & Katzenellenbogen, J. A., Mar 15 2004, In : Bioorganic and Medicinal Chemistry. 12, 6, p. 1559-1567 9 p.

Research output: Contribution to journalArticle

Equol
Estrogen Receptor beta
Isoflavones
Estrogen Receptor alpha
Metabolites

Protein kinase A activation of estrogen receptor α transcription does not require proteasome activity and protects the receptor from ligand-mediated degradation

Tsai, H. W., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Shupnik, M. A., Jun 1 2004, In : Endocrinology. 145, 6, p. 2730-2738 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Cyclic AMP-Dependent Protein Kinases
Estrogen Receptors
Colforsin
Ligands

Pyrazolo[1,5-α]pyrimidines: Estrogen receptor ligands possessing estrogen receptor β antagonist activity

Compton, D. R., Sheng, S., Carlson, K. E., Rebacz, N. A., Lee, I. Y., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Nov 18 2004, In : Journal of Medicinal Chemistry. 47, 24, p. 5872-5893 22 p.

Research output: Contribution to journalArticle

Pyrimidines
Estrogen Receptors
Ligands
Estrogen Receptor Antagonists
Libraries

Selective Estrogen Receptor Modulators: Discrimination of Agonistic versus Antagonistic Activities by Gene Expression Profiling in Breast Cancer Cells

Frasor, J., Stossi, F., Danes, J. M., Komm, B., Lyttle, C. R. & Katzenellenbogen, B. S., Feb 15 2004, In : Cancer Research. 64, 4, p. 1522-1533 12 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Gene Expression Profiling
Breast Neoplasms
Tamoxifen
Estrogen Receptors

Selective recognition of distinct classes of coactivators by a ligand-inducible activation domain

Acevedo, M. L., Lee, K. C., Stender, J. D., Katzenellenbogen, B. S. & Kraus, W. L., Mar 5 2004, In : Molecular cell. 13, 5, p. 725-738 14 p.

Research output: Contribution to journalArticle

Mediator Complex
Cytoplasmic and Nuclear Receptors
Furylfuramide
Ligands
Estrogen Receptor beta

Therapeutic Targeting in the Estrogen Receptor Hormonal Pathway

Katzenellenbogen, B. S. & Frasor, J., Jan 1 2004, In : Seminars in Oncology. 31, 1 SUPPL. 3, p. 28-38 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Tamoxifen
Therapeutics
Estrogens

Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) α or ERβ in human osteosarcoma cells: Distinct and common target genes for these receptors

Stossi, F., Barnett, D. H., Frasor, J., Komm, B., Lyttle, C. R. & Katzenellenbogen, B. S., Jul 1 2004, In : Endocrinology. 145, 7, p. 3473-3486 14 p.

Research output: Contribution to journalArticle

Osteosarcoma
Estrogen Receptors
Estrogens
Gene Expression
Genes
2003

Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression

Harrington, W. R., Sheng, S., Barnett, D. H., Petz, L. N., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Aug 29 2003, In : Molecular and Cellular Endocrinology. 206, 1-2, p. 13-22 10 p.

Research output: Contribution to journalArticle

Estrogen Receptor beta
Estrogen Receptor alpha
Transcriptional Activation
Estrogens
Genes

Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor

Muthyala, R. S., Sheng, S., Carlson, K. E., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Apr 24 2003, In : Journal of Medicinal Chemistry. 46, 9, p. 1589-1602 14 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Ligands
Estrogens
Non-Steroidal Estrogens
Terpenes

DNA shuffling method for generating estrogen receptor α and β chimeras in yeast

Sun, J., Katzenellenbogen, J. A., Zhao, H. & Katzenellenbogen, B. S., Feb 1 2003, In : BioTechniques. 34, 2, p. 278-288 11 p.

Research output: Contribution to journalArticle

DNA Shuffling
Estrogen Receptors
Yeast
Yeasts
Ligands

Modulation of estrogen receptor activity by selective coregulators

Martini, P. G. V. & Katzenellenbogen, B. S., Jan 1 2003, In : Journal of Steroid Biochemistry and Molecular Biology. 85, 2-5, p. 117-122 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Modulation
Estrogens
Estrogen Receptor Modulators
Cytoplasmic and Nuclear Receptors

Molecular basis for the subtype discrimination of the estrogen receptor-β-selective ligand, diarylpropionitrile

Sun, J., Baudry, J., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Feb 1 2003, In : Molecular Endocrinology. 17, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Ligands
diarylpropionitrile
DNA Shuffling
Nitriles
Estrogen Receptors
Ligands
Estrogen Receptor beta
Estrogen Receptor alpha
Computational methods

Novel estrogen receptor ligands based on an anthranylaldoxime structure: Role of the phenol-type pseudocycle in the binding process

Minutolo, F., Antonello, M., Bertini, S., Ortore, G., Placanica, G., Rapposelli, S., Sheng, S., Carlson, K. E., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Macchia, M., Sep 11 2003, In : Journal of Medicinal Chemistry. 46, 19, p. 4032-4042 11 p.

Research output: Contribution to journalArticle

Phenol
Estrogen Receptors
Ligands
Hydrogen
Nitrogen

Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: Insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype

Frasor, J., Danes, J. M., Komm, B., Chang, K. C. N., Richard Lyttle, C. & Katzenellenbogen, B. S., Oct 1 2003, In : Endocrinology. 144, 10, p. 4562-4574 13 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Estrogens
Cell Proliferation
Breast Neoplasms
Phenotype

Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97)

Rajendran, R. R., Nye, A. C., Frasor, J., Balsara, R. D., Martini, P. G. V. & Katzenellenbogen, B. S., Feb 14 2003, In : Journal of Biological Chemistry. 278, 7, p. 4628-4638 11 p.

Research output: Contribution to journalArticle

DEAD-box RNA Helicases
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Estradiol Receptors
Genes

Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) α activity by ERβ in the uterus

Frasor, J., Barnett, D. H., Danes, J. M., Hess, R. A., Parlow, A. F. & Katzenellenbogen, B. S., Jul 1 2003, In : Endocrinology. 144, 7, p. 3159-3166 8 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Uterus
Ligands
Androgen Receptors
Progesterone Receptors

The effects of the phytoestrogen, coumestrol, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 GnRH neurones

Bowe, J., Li, X. F., Sugden, D., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & O'Byrne, K. T., Feb 1 2003, In : Journal of Neuroendocrinology. 15, 2, p. 105-108 4 p.

Research output: Contribution to journalArticle

Coumestrol
Phytoestrogens
Gonadotropin-Releasing Hormone
Neurons
Messenger RNA
2002

Alteration of large-scale chromatin structure by estrogen receptor

Nye, A. C., Rajendran, R. R., Stenoien, D. L., Mancini, M. A., Katzenellenbogen, B. S. & Belmont, A. S., May 9 2002, In : Molecular and cellular biology. 22, 10, p. 3437-3449 13 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Chromatin
Lac Repressors
Estradiol
Nuclear Receptor Coactivator 1

Antagonists selective for estrogen receptor α

Sun, J., Huang, Y. R., Harrington, W. R., Sheng, S., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jan 1 2002, In : Endocrinology. 143, 3, p. 941-947 7 p.

Research output: Contribution to journalArticle

Pyrazoles
Estrogen Receptor Modulators
Response Elements
Estrogens
Reporter Genes

Characterization of the biological roles of the estrogen receptors, ERα and ERβ, in estrogen target tissues in vivo through the use of an ERα-selective ligand

Harris, H. A., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Nov 1 2002, In : Endocrinology. 143, 11, p. 4172-4177 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Ligands
Arcuate Nucleus of Hypothalamus
Complement C3

Estrogenic diazenes: Heterocyclic non-steroidal estrogens of unusual structure with selectivity for estrogen receptor subtypes

Ghosh, U., Ganessunker, D., Sattigeri, V. J., Carlson, K. E., Mortensen, D. J., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Feb 1 2002, In : Bioorganic and Medicinal Chemistry. 11, 4, p. 629-657 29 p.

Research output: Contribution to journalArticle

Non-Steroidal Estrogens
Estrogen Receptors
Pyridazines
Pyrimidines
Ligands
Response Elements
Estrogen Receptors
Carrier Proteins
Estrogens
Genes

Estrogen receptor isoform-specific induction of progesterone receptors in human osteoblasts

Rickard, D. J., Waters, K. M., Ruesink, T. J., Khosla, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Riggs, B. L. & Spelsberg, T. C., Jan 1 2002, In : Journal of Bone and Mineral Research. 17, 4, p. 580-592 13 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Osteoblasts
Estrogen Receptors
Protein Isoforms
Estrogens

Localization of androgen and estrogen receptors in adult male mouse reproductive tract

Zhou, Q., Nie, R., Prins, G. S., Saunders, P. T. K., Katzenellenbogen, B. S. & Hess, R. A., Nov 1 2002, In : Journal of andrology. 23, 6, p. 870-881 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Stromal Cells
Estrogen Receptors
Epithelial Cells
Sertoli Cells

Molecular cloning of porcine estrogen receptor-β complementary DNAs and developmental expression in periimplantation embryos

Kowalski, A. A., Graddy, L. G., Vale-Cruz, D. S., Choi, I., Katzenellenbogen, B. S., Simmen, F. A. & Simmen, R. C. M., Jan 1 2002, In : Biology of reproduction. 66, 3, p. 760-769 10 p.

Research output: Contribution to journalArticle

Estrogen Receptor beta
Molecular Cloning
Estrogen Receptors
Swine
Embryonic Structures

Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism

Shiau, A. K., Barstad, D., Radek, J. T., Meyers, M. J., Nettles, K. W., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Agard, D. A. & Greene, G. L., May 13 2002, In : Nature Structural Biology. 9, 5, p. 359-364 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Ligands
Conformations
Association reactions
Enantiomers
2001

Activation of estrogen receptor β is a prerequisite for estrogen-dependent upregulation of nitric oxide synthases in neonatal rat cardiac myocytes

Nuedling, S., Karas, R. H., Mendelsohn, M. E., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Meyer, R., Vetter, H. & Grohé, C., Aug 3 2001, In : FEBS Letters. 502, 3, p. 103-108 6 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type II
Cardiac Myocytes
Nitric Oxide Synthase
Estrogen Receptors
Rats

Direct Acetylation of the Estrogen Receptor α Hinge Region by p300 Regulates Transactivation and Hormone Sensitivity

Wang, C., Fu, M., Angeletti, R. H., Siconolfi-Baez, L., Reutens, A. T., Albanese, C., Lisanti, M. P., Katzenellenbogen, B. S., Kato, S., Hopp, T., Fuqua, S. A. W., Lopez, G. N., Kushner, P. J. & Pestell, R. G., Jan 25 2001, In : Journal of Biological Chemistry. 276, 21, p. 18375-18383 9 p.

Research output: Contribution to journalArticle

Acetylation
Hinges
Estrogen Receptors
Transcriptional Activation
Hormones

Estrogen action and male fertility: Roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function

Zhou, Q., Clarke, L., Nie, R., Carnes, K., Lai, L. W., Lien, Y. H. H., Verkman, A., Lubahn, D., Fisher, J. S., Katzenellenbogen, B. S. & Hess, R. A., Nov 20 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 24, p. 14132-14137 6 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Fertility
Estrogens
Knockout Mice
Estrogen Receptors

Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor α: Studies with αERKO and βERKO mice

Prins, G. S., Birch, L., Couse, J. F., Korach, K. S., Couse, J. F., Choi, I. & Katzenellenbogen, B. S., Aug 15 2001, In : Cancer Research. 61, 16, p. 6089-6097 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Prostate
Estrogens
Diethylstilbestrol
Androgen Receptors

Estrogen receptor-β potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues

Meyers, M. J., Sun, J., Carlson, K. E., Marriner, G. A., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Nov 22 2001, In : Journal of Medicinal Chemistry. 44, 24, p. 4230-4251 22 p.

Research output: Contribution to journalArticle

Acetylene
Estrogen Receptor alpha
Structure-Activity Relationship
Estrogen Receptors
Ligands

Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform

Waters, K. M., Rickard, D. J., Lawrence Riggs, B., Khosla, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Moore, J. & Spelsberg, T. C., Nov 13 2001, In : Journal of Cellular Biochemistry. 83, 3, p. 448-462 15 p.

Research output: Contribution to journalArticle

Osteoblasts
Estrogen Receptors
Tamoxifen
Protein Isoforms
Estrogens

Furans with basic side chains: Synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha

Mortensen, D. S., Rodriguez, A. L., Sun, J., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Sep 17 2001, In : Bioorganic and Medicinal Chemistry Letters. 11, 18, p. 2521-2524 4 p.

Research output: Contribution to journalArticle

Furans
Estrogen Receptor alpha
Phenol
Estrogen Receptors
Ligands
Estrogen Receptor beta
Monoclonal Antibodies
Tissue
Antibodies
Granulosa Cells
Cyclic AMP Response Element-Binding Protein
Phosphorylation
Estrogen Receptors
Protein Kinases
Estradiol

Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity

Kousteni, S., Bellido, T., Plotkin, L. I., O'Brien, C. A., Bodenner, D. L., Han, L., Han, K., DiGregorio, G. B., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Roberson, P. K., Weinstein, R. S., Jilka, R. L. & Manolagas, S. C., Mar 9 2001, In : Cell. 104, 5, p. 719-730 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Estrogen Receptors
Ligands
Steroid hormones
Steroids
Gene Expression Regulation
Response Elements
Estrogen Receptors
Estrogens
Breast Neoplasms

Structure-function relationships in estrogen receptors and the characterization of novel selective estrogen receptor modulators with unique pharmacological profiles

Katzenellenbogen, B. S., Sun, J., Harrington, W. R., Kraichely, D. M., Ganessunker, D. & Katzenellenbogen, J. A., Jan 1 2001, In : Annals of the New York Academy of Sciences. 949, p. 6-15 10 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Estrogen Receptor alpha
Estrogen Receptors
Pharmacology
Ligands

Synergistic activation of the serotonin-1A receptor by nuclear factor-κB and estrogen

Wissink, S., Van Der Burg, B., Katzenellenbogen, B. S. & Van Der Saag, P. T., May 1 2001, In : Molecular Endocrinology. 15, 4, p. 543-552 10 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT1A
Estrogens
Estrogen Receptors
Aptitude
Estrogen Receptor Modulators

Synthesis and biological evaluation of a novel series of furans: Ligands selective for estrogen receptor α

Mortensen, D. S., Rodriguez, A. L., Carlson, K. E., Sun, J., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Nov 8 2001, In : Journal of Medicinal Chemistry. 44, 23, p. 3838-3848 11 p.

Research output: Contribution to journalArticle

Furans
Estrogen Receptors
Ligands
Thiophenes
Pyrroles