Benita S Katzenellenbogen

1970 …2020
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Research Output 1970 2020

Article
Estrogen Receptors
Yeasts
Ligands
Bacteria
Amino Acids
Mutagenesis
Estrogen Receptors
Yeast
Screening
Yeasts

Structure-function relationships in estrogen receptors and the characterization of novel selective estrogen receptor modulators with unique pharmacological profiles

Katzenellenbogen, B. S., Sun, J., Harrington, W. R., Kraichely, D. M., Ganessunker, D. & Katzenellenbogen, J. A., Jan 1 2001, In : Annals of the New York Academy of Sciences. 949, p. 6-15 10 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Estrogen Receptor alpha
Estrogen Receptors
Pharmacology
Ligands

Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains

Zhou, H. B., Sheng, S., Compton, D. R., Kim, Y., Joachimiak, A., Sharma, S., Carlson, K. E., Katzenellenbogen, B. S., Nettles, K. W., Greene, G. L. & Katzenellenbogen, J. A., Jan 25 2007, In : Journal of Medicinal Chemistry. 50, 2, p. 399-403 5 p.

Research output: Contribution to journalArticle

Pyrimidines
Estrogen Receptors
Ligands
Estrogen Receptor Antagonists

Suppression of FOXM1 activities and breast cancer growth in vitro and in vivo by a new class of compounds

Ziegler, Y., Laws, M. J., Sanabria Guillen, V., Kim, S. H., Dey, P., Smith, B. P., Gong, P., Bindman, N., Zhao, Y., Carlson, K., Yasuda, M. A., Singh, D., Li, Z., El-Ashry, D., Madak-Erdogan, Z., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Dec 1 2019, In : npj Breast Cancer. 5, 1, 45.

Research output: Contribution to journalArticle

Open Access
Breast Neoplasms
Growth
Triple Negative Breast Neoplasms
Gene Ontology
Proteasome Endopeptidase Complex
Estrogen Receptors
Protein Kinases
Estradiol
Chloramphenicol O-Acetyltransferase
1-Methyl-3-isobutylxanthine

Synergistic activation of the serotonin-1A receptor by nuclear factor-κB and estrogen

Wissink, S., Van Der Burg, B., Katzenellenbogen, B. S. & Van Der Saag, P. T., May 1 2001, In : Molecular Endocrinology. 15, 4, p. 543-552 10 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT1A
Estrogens
Estrogen Receptors
Aptitude
Estrogen Receptor Modulators

Synthesis and biological evaluation of a novel series of furans: Ligands selective for estrogen receptor α

Mortensen, D. S., Rodriguez, A. L., Carlson, K. E., Sun, J., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Nov 8 2001, In : Journal of Medicinal Chemistry. 44, 23, p. 3838-3848 11 p.

Research output: Contribution to journalArticle

Furans
Estrogen Receptors
Ligands
Thiophenes
Pyrroles

Synthesis and evaluation of estrogen receptor ligands with bridged oxabicyclic cores containing a diarylethylene motif: Estrogen antagonists of unusual structure

Zhou, H. B., Comninos, J. S., Stossi, F., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Nov 17 2005, In : Journal of Medicinal Chemistry. 48, 23, p. 7261-7274 14 p.

Research output: Contribution to journalArticle

Estrogen Antagonists
Estrogen Receptors
Ligands
Transcription
Non-Steroidal Estrogens
Estrous Cycle
Estrogens
Proteins
Uterus
Estrus

Tamoxifen antiestrogens. A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen

Robertson, D. W., Katzenellenbogen, J. A., Long, D. J., Rorke, E. A. & Katzenellenbogen, B. S., Jan 1982, In : Journal of Steroid Biochemistry. 16, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Estrogen Receptor Modulators
Tamoxifen
Isomers
Chemical activation

Tamoxifen aziridines: Effective inactivators of the estrogen receptor

Robertson, D. W., Wei, L. L., Hayes, J. R., Carlson, K. E., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Oct 1981, In : Endocrinology. 109, 4, p. 1298-1300 3 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Uterine Neoplasms
Estrogen Receptor Modulators
Tamoxifen

Tamoxifen downregulation of miR-451 increases 14-3-3ζ and promotes breast cancer cell survival and endocrine resistance

Bergamaschi, A. & Katzenellenbogen, B. S., Jan 5 2012, In : Oncogene. 31, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Tamoxifen
MicroRNAs
Cell Survival
Down-Regulation
Breast Neoplasms
Estriol
Uterus
Hormones
Weights and Measures
Ether

The activation function-1 of estrogen receptor alpha prevents arterial neointima development through a direct effect on smooth muscle cells

Smirnova, N. F., Fontaine, C., Buscato, M., Lupieri, A., Vinel, A., Valera, M. C., Guillaume, M., Malet, N., Foidart, J. M., Raymond-Letron, I., Lenfant, F., Gourdy, P., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Laffargue, M. & Arnal, J. F., Oct 9 2015, In : Circulation Research. 117, 9, p. 770-777 8 p.

Research output: Contribution to journalArticle

Neointima
Estrogen Receptor alpha
Estrogen Receptors
Smooth Muscle Myocytes
Vascular Smooth Muscle

The androgen derivative 5α-androstane-3β,17β-diol inhibits prostate cancer cell migration through activation of the estrogen receptor β subtype

Guerini, V., Sau, D., Scaccianoce, E., Rusmini, P., Ciana, P., Maggi, A., Martini, P. G. V., Katzenellenbogen, B. S., Martini, L., Motta, M. & Poletti, A., Jun 15 2005, In : Cancer Research. 65, 12, p. 5445-5453 9 p.

Research output: Contribution to journalArticle

Androstane-3,17-diol
Estrogen Receptors
Androgens
Cell Movement
Prostatic Neoplasms

The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro

Aumsuwan, P., Khan, S. I., Khan, I. A., Ali, Z., Avula, B., Walker, L. A., Shariat-Madar, Z., Helferich, W. G., Katzenellenbogen, B. S. & Dasmahapatra, A. K., Feb 1 2016, In : Archives of Biochemistry and Biophysics. 591, p. 98-110 13 p.

Research output: Contribution to journalArticle

Dioscorea
Saponins
Cells
Breast Neoplasms
Cell Line

The Capacity of the Antiestrogen CI-628 to Activate the Estrogen Receptor in Vitro

De Boer, W. D., Notides, A. C., Katzenellenbogen, B. S., Hayes, J. R. & Katzenellenbogen, J. A., Jan 1981, In : Endocrinology. 108, 1, p. 206-212 7 p.

Research output: Contribution to journalArticle

Nitromifene
Estrogen Receptor Modulators
Estrogen Receptors
Estradiol Receptors
Estradiol
Estrogen Antagonists
Estrogen Receptor Modulators
Estrogen Receptors
Estrogens
Hormones

The coregulator, repressor of estrogen receptor activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization

Zhao, Y., Park, S., Bagchi, M. K., Taylor, R. N. & Katzenellenbogen, B. S., Mar 1 2013, In : Endocrinology. 154, 3, p. 1349-1360 12 p.

Research output: Contribution to journalArticle

Stromal Cells
Estrogen Receptors
Pregnancy Maintenance
Interleukin-11
Janus Kinases
Estrogen Receptor Modulators
Progesterone Receptors
Estrogen Receptors
Estrogens
Breast Neoplasms

The effects of the phytoestrogen, coumestrol, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 GnRH neurones

Bowe, J., Li, X. F., Sugden, D., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & O'Byrne, K. T., Feb 1 2003, In : Journal of Neuroendocrinology. 15, 2, p. 105-108 4 p.

Research output: Contribution to journalArticle

Coumestrol
Phytoestrogens
Gonadotropin-Releasing Hormone
Neurons
Messenger RNA

The estrogen receptor: A structure-based approach to the design of new specific hormone-receptor combinations

Tedesco, R., Thomas, J. A., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Apr 25 2001, In : Chemistry and Biology. 8, 3, p. 277-287 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Hormones
Ligands
Transgenes
Reporter Genes

The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions

Webb, P., Nguyen, P., Valentine, C., Lopez, G. N., Kwok, G. R., McInerney, E., Katzenellenbogen, B. S., Enmark, E., Gustafsson, J. Å., Nilsson, S. & Kushner, P. J., Jan 1 1999, In : Molecular Endocrinology. 13, 10, p. 1672-1685 14 p.

Research output: Contribution to journalArticle

Transcription Factor AP-1
Estrogen Receptors
Transcriptional Activation
Estrogens
Furylfuramide

The estrogen-regulated transcription factor PITX1 coordinates gene-specific regulation by estrogen receptor-alpha in breast cancer cells

Stender, J. D., Stossi, F., Funk, C. C., Charn, T. H., Barnett, D. H. & Katzenellenbogen, B. S., Oct 1 2011, In : Molecular Endocrinology. 25, 10, p. 1699-1709 11 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Estrogen Receptors
Estrogens
Transcription Factors
Breast Neoplasms
Forkhead Transcription Factors
Neoplastic Stem Cells
Estrogen Receptors
Breast Neoplasms
Gene Regulatory Networks
Fractionation
Estrogen Receptors
Chromatin
Rats
Micrococcal Nuclease
NAD(P)H Dehydrogenase (Quinone)
Estrogen Receptor Modulators
Estrogen Receptors
Genes
Antioxidant Response Elements

Therapeutic Targeting in the Estrogen Receptor Hormonal Pathway

Katzenellenbogen, B. S. & Frasor, J., Feb 2004, In : Seminars in Oncology. 31, 1 SUPPL. 3, p. 28-38 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Tamoxifen
Therapeutics
Estrogens

The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells

Alyea, R. A., Laurence, S. E., Kim, S. H., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Watson, C. S., Aug 1 2008, In : Journal of Neurochemistry. 106, 4, p. 1525-1533 9 p.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
Estrogen Receptors
Dopamine
Membranes
G-Protein-Coupled Receptors

The stability of the uterine estrogen receptor when complexed with estrogens or antiestrogens

Pavlik, E. J. & Katzenellenbogen, B. S., 1980, In : Molecular Pharmacology. 18, 3, p. 406-412 7 p.

Research output: Contribution to journalArticle

Zeranol
Estrogen Receptor Modulators
Estrogen Receptors
Nitromifene
Estrogens

The tissue-specific effects of different 17β-estradiol doses reveal the key sensitizing role of AF1 domain in ERα activity

Fontaine, C., Buscato, M., Vinel, A., Giton, F., Raymond-Letron, I., Kim, S. H., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Gourdy, P., Milon, A., Flouriot, G., Ohlsson, C., Lenfant, F. & Arnal, J. F., Apr 5 2020, In : Molecular and Cellular Endocrinology. 505, 110741.

Research output: Contribution to journalArticle

Proestrus
Estradiol
Metestrus
Tissue
Estrogen Receptor alpha

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

Abot, A., Fontaine, C., Buscato, M., Solinhac, R., Flouriot, G., Fabre, A., Drougard, A., Rajan, S., Laine, M., Milon, A., Muller, I., Henrion, D., Adlanmerini, M., Valéra, M. C., Gompel, A., Gerard, C., Péqueux, C., Mestdagt, M., Raymond-Letron, I., Knauf, C. & 9 others, Ferriere, F., Valet, P., Gourdy, P., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Lenfant, F., Greene, G. L., Foidart, J. M. & Arnal, J. F., Oct 1 2014, In : EMBO Molecular Medicine. 6, 10, p. 1328-1346 19 p.

Research output: Contribution to journalArticle

Estetrol
Nuclear Envelope
Estrogen Receptors
Blood Vessels
Furylfuramide

Thyroid hormone can increase estrogen-mediated transcription from a consensus estrogen response element in neuroblastoma cells

Zhao, X., Lorenc, H., Stephenson, H., Wang, Y. J., Witherspoon, D., Katzenellenbogen, B., Pfaff, D. & Vasudevan, N., Mar 29 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 13, p. 4890-4895 6 p.

Research output: Contribution to journalArticle

Response Elements
Neuroblastoma
Thyroid Hormones
Consensus
Estrogens

Transcription activation by the human estrogen receptor subtype β (ERβ) studied with ERβ and ERα receptor chimeras

Mcinerney, E. M., Weis, K. E., Sun, J., Mosselman, S. & Katzenellenbogen, B. S., Jan 1 1998, In : Endocrinology. 139, 11, p. 4513-4522 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Transcriptional Activation
Estrogen Receptor Modulators
Ligands
Estrogens

Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) α or ERβ in human osteosarcoma cells: Distinct and common target genes for these receptors

Stossi, F., Barnett, D. H., Frasor, J., Komm, B., Lyttle, C. R. & Katzenellenbogen, B. S., Jul 1 2004, In : Endocrinology. 145, 7, p. 3473-3486 14 p.

Research output: Contribution to journalArticle

Osteosarcoma
Estrogen Receptors
Estrogens
Gene Expression
Genes

Transcriptional regulation of the human quinone reductase gene by antiestrogen-liganded estrogen receptor-α and estrogen receptor-β

Montano, M. M., Jaiswal, A. K. & Katzenellenbogen, B. S., Sep 25 1998, In : Journal of Biological Chemistry. 273, 39, p. 25443-25449 7 p.

Research output: Contribution to journalArticle

NAD(P)H Dehydrogenase (Quinone)
Estrogen Receptor Modulators
Estrogen Receptors
Genes
Antioxidant Response Elements

Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects

Marshall, G. M., Gherardi, S., Xu, N., Neiron, Z., Trahair, T., Scarlett, C. J., Chang, D. K., Liu, P. Y., Jankowski, K., Iraci, N., Haber, M., Norris, M. D., Keating, J., Sekyere, E., Jonquieres, G., Stossi, F., Katzenellenbogen, B. S., Biankin, A. V., Perini, G. & Liu, T., Nov 4 2010, In : Oncogene. 29, 44, p. 5957-5968 12 p.

Research output: Contribution to journalArticle

Cyclin G2
Histone Deacetylase 2
Histone Deacetylases
Up-Regulation
Neuroblastoma
Gene Regulatory Networks
Estrogen Receptors
Estrogens
Gene Expression
Glycyrrhiza

Triarylpyrazoles with basic side chains: Development of pyrazole-based estrogen receptor antagonists

Stauffer, S. R., Huang, Y. R., Aron, Z. D., Coletta, C. J., Sun, J., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Jan 8 2001, In : Bioorganic and Medicinal Chemistry. 9, 1, p. 151-161 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Pyrazoles
Estrogen Receptor Antagonists
pyrazole
Ligands

Uterine development and fertility are dependent on gene dosage of the nuclear receptor coregulator REA

Park, S., Yoon, S., Zhao, Y., Park, S. E., Liao, L., Xu, J., Lydon, J. P., DeMayo, F. J., O'Malley, B. W., Bagchi, M. K. & Katzenellenbogen, B. S., Aug 1 2012, In : Endocrinology. 153, 8, p. 3982-3994 13 p.

Research output: Contribution to journalArticle

Gene Dosage
Cytoplasmic and Nuclear Receptors
Infertility
Fertility
Estrogen Receptors
Ovalbumin
Estrogens
Proteins
Oviducts
gamma-Globulins

Uterine plasminogen activator activity: Modulation by steroid hormones

Kneifel, M. A., Leytus, S. P., Fletcher, E., Weber, T., Mangel, W. F. & Katzenellenbogen, B. S., Aug 1982, In : Endocrinology. 111, 2, p. 493-499 7 p.

Research output: Contribution to journalArticle

Plasminogen Activators
Steroids
Hormones
Estrogens
Zeranol

Whole-genome cartography of estrogen receptor α binding sites

Lin, C. Y., Vega, V. B., Thomsen, J. S., Zhang, T., Say, L. K., Xie, M., Kuo, P. C., Lipovich, L., Barnett, D. H., Stossi, F., Yeo, A., George, J., Kuznetsov, V. A., Yew, K. L., Tze, H. C., Palanisamy, N., Miller, L. D., Cheung, E., Katzenellenbogen, B. S., Ruan, Y. & 3 others, Bourque, G., Wei, C. L. & Liu, E. T., Jun 1 2007, In : PLoS genetics. 3, 6, p. 867-885 19 p.

Research output: Contribution to journalArticle

cartography
Estrogen Receptors
binding sites
genome
Binding Sites

Zearalenones: Characterization of the estrogenic potencies and receptor interactions of a series of fungal β-resorcylic acid lactones

Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Mordecai, D., Jul 1979, In : Endocrinology. 105, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

Zeranol
Zearalenone
Lactones
Cytoplasmic and Nuclear Receptors
Acids
Comment/debate

Corrigendum: NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses (Nature Chemical Biology (2008) 4, (241-247))

Nettles, K. W., Bruning, J. B., Gil, G., Nowak, J., Sharma, S. K., Hahm, J. B., Kulp, K., Hochberg, R. B., Zhou, H., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Kim, Y., Joachimiak, A. & Greene, G. L., Jun 2008, In : Nature chemical biology. 4, 6, 1 p.

Research output: Contribution to journalComment/debate

Estrogen Receptors
Ligands
corrigendum
Estrogen Receptor
Systems Biology
Molecular Biology
Genomics
Estrogen Receptors

Corrigendum to “Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity” [Mol. Cell Endocrinol. 440 (2016) 138–150] (S0303720716304853)(10.1016/j.mce.2016.11.016)

Nelson, A. W., Groen, A. J., Miller, J. L., Warren, A. Y., Holmes, K. A., Tarulli, G. A., Tilley, W. D., Katzenellenbogen, B. S., Hawse, J. R., Gnanapragasam, V. J. & Carroll, J. S., Mar 5 2017, In : Molecular and Cellular Endocrinology. 443, 1 p.

Research output: Contribution to journalComment/debate

Recombinant Fusion Proteins
Estrogen Receptor beta
Emotions
Cells
Tissue

Erratum: Pyrazolo[1.5-a]pyrimidines: Estrogen receptor ligands possessing estrogen receptor β antagonist activity (Journal of Medicinal Chemistry (2004) 47 (5877))

Compton, D. R., Sheng, S., Carlson, K. E., Rebacz, N. A., Lee, I. Y., Katzenellenbogen, B. S. & Kateenellenbogen, J. A., Apr 7 2005, In : Journal of Medicinal Chemistry. 48, 7, 1 p.

Research output: Contribution to journalComment/debate

Estrogen Receptor beta
Pyrimidines
Estrogen Receptors
Ligands
Pharmaceutical Chemistry

Erratum: Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis (Science Translational Medicine (2015) 7 (274er1))

Zhao, Y., Gong, P., Chen, Y., Nwachukwu, J. C., Srinivasan, S., Ko, C., Bagchi, M. K., Taylor, R. N., Korach, K. S., Nettles, K. W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Feb 11 2015, In : Science Translational Medicine. 7, 274

Research output: Contribution to journalComment/debate

Translational Medical Research
Endometriosis