Benita S Katzenellenbogen

1970 …2019
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Research Output 1970 2019

2011

Estrogen-regulated prohibitin is required for mouse uterine development and adult function

He, B., Kim, T. H., Kommagani, R., Feng, Q., Lanz, R. B., Jeong, J. W., DeMayo, F. J., Katzenellenbogen, B. S., Lydon, J. P. & O'Malley, B. W., Mar 1 2011, In : Endocrinology. 152, 3, p. 1047-1056 10 p.

Research output: Contribution to journalArticle

Estrogens
Estrogen Receptors
Uterus
Steroid Receptors
Genes
Mitogen-Activated Protein Kinase 1
Estrogen Receptors
Genes
Cytoplasmic and Nuclear Receptors
Mitogen-Activated Protein Kinases

Repressor of Estrogen Receptor Activity (REA) is essential for mammary gland morphogenesis and functional activities: Studies in conditional knockout mice

Park, S., Zhao, Y., Yoon, S., Xu, J., Liao, L., Lydon, J., DeMayo, F., O'Malley, B. W. & Katzenellenbogen, B. S., Nov 1 2011, In : Endocrinology. 152, 11, p. 4336-4349 14 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Morphogenesis
Knockout Mice
Estrogen Receptors
Breast

Reversal of endocrine resistance in breast cancer: Interrelationships among 14-3-3ζ, FOXM1, and a gene signature associated with mitosis

Bergamaschi, A., Christensen, B. L. & Katzenellenbogen, B. S., Jun 29 2011, In : Breast Cancer Research. 13, 3, R70.

Research output: Contribution to journalArticle

Mitosis
Breast Neoplasms
Estrogen Receptors
Genes
Aurora Kinase B

The estrogen-regulated transcription factor PITX1 coordinates gene-specific regulation by estrogen receptor-alpha in breast cancer cells

Stender, J. D., Stossi, F., Funk, C. C., Charn, T. H., Barnett, D. H. & Katzenellenbogen, B. S., Oct 1 2011, In : Molecular Endocrinology. 25, 10, p. 1699-1709 11 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Estrogen Receptors
Estrogens
Transcription Factors
Breast Neoplasms
2012
Nuclear Receptor Co-Repressor 1
Aryl Hydrocarbon Receptors
Gene expression
Estrogen Receptors
Chromatin
Mitogen-Activated Protein Kinases
Estrogen Receptors
Macrophages
Breast Neoplasms
Tumor Microenvironment
p38 Mitogen-Activated Protein Kinases
Estrogen Receptors
Phosphorylation
Breast Neoplasms
Estrogens

Tamoxifen downregulation of miR-451 increases 14-3-3ζ and promotes breast cancer cell survival and endocrine resistance

Bergamaschi, A. & Katzenellenbogen, B. S., Jan 5 2012, In : Oncogene. 31, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Tamoxifen
MicroRNAs
Cell Survival
Down-Regulation
Breast Neoplasms

Uterine development and fertility are dependent on gene dosage of the nuclear receptor coregulator REA

Park, S., Yoon, S., Zhao, Y., Park, S. E., Liao, L., Xu, J., Lydon, J. P., DeMayo, F. J., O'Malley, B. W., Bagchi, M. K. & Katzenellenbogen, B. S., Aug 1 2012, In : Endocrinology. 153, 8, p. 3982-3994 13 p.

Research output: Contribution to journalArticle

Gene Dosage
Cytoplasmic and Nuclear Receptors
Infertility
Fertility
Estrogen Receptors
2013

14-3-3ζ as a predictor of early time to recurrence and distant metastasis in hormone receptor-positive and -negative breast cancers

Bergamaschi, A., Frasor, J., Borgen, K., Stanculescu, A., Johnson, P., Rowland, K., Wiley, E. L. & Katzenellenbogen, B. S., Feb 1 2013, In : Breast Cancer Research and Treatment. 137, 3, p. 689-696 8 p.

Research output: Contribution to journalArticle

Hormones
Breast Neoplasms
Neoplasm Metastasis
Recurrence
Estrogen Receptors
Mitogen-Activated Protein Kinase 1
Estrogen Receptors
Breast Neoplasms
MicroRNAs
Neoplasms

Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators

Madak-Erdogan, Z., Charn, T. H., Jiang, Y., Liu, E. T., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jan 1 2013, In : Molecular Systems Biology. 9, 201328.

Research output: Contribution to journalArticle

Estrogen Receptor
Transcription factors
Transcription Factor
Genomics
Estrogen Receptors

Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens

Jiang, Y., Gong, P., Madak-Erdogan, Z., Martin, T. A., Jeyakumar, M., Carlson, K., Khan, I., Smillie, T. J., Chittiboyina, A. G., Rotte, S. C. K., Helferich, W. G., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Nov 1 2013, In : FASEB Journal. 27, 11, p. 4406-4418 13 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Gene expression
Chromatin
Equol

Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass

Bartell, S. M., Han, L., Kim, H. N., Kim, S. H., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Chambliss, K. L., Shaul, P. W., Roberson, P. K., Weinstein, R. S., Jilka, R. L., Almeida, M. & Manolagas, S. C., Apr 1 2013, In : Molecular Endocrinology. 27, 4, p. 649-656 8 p.

Research output: Contribution to journalArticle

Dendrimers
Estrogen Receptors
Estrogens
Bone and Bones
Skeleton

The coregulator, repressor of estrogen receptor activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization

Zhao, Y., Park, S., Bagchi, M. K., Taylor, R. N. & Katzenellenbogen, B. S., Mar 1 2013, In : Endocrinology. 154, 3, p. 1349-1360 12 p.

Research output: Contribution to journalArticle

Stromal Cells
Estrogen Receptors
Pregnancy Maintenance
Interleukin-11
Janus Kinases
2014

Endocrine Society 2014 Laureate Awards

Gustafsson, J. A., Katzenellenbogen, B., Jameson, J. L., Roth, J., Melmed, S., McDonnell, D., Wartofsky, L., Crowley, W. F., Griz, L. H. E., Becker, C., Moore, D. D., Drucker, D., Singh, N. & O'Malley, B., Oct 1 2014, In : Hormones & cancer. 5, 5, p. 339-355 17 p.

Research output: Contribution to journalArticle

21st Century History
Endocrinology
Medical Societies

Estrogen-induced CCN1 Is critical for establishment of endometriosis-like lesions in mice

Zhao, Y., Li, Q., Katzenellenbogen, B. S., Lau, L. F., Taylor, R. N., Bagchi, I. C. & Bagchi, M. K., Jan 1 2014, In : Molecular Endocrinology. 28, 12, p. 1934-1947 14 p.

Research output: Contribution to journalArticle

Endometriosis
Estrogens
Choristoma
Cell Proliferation
Vascular Endothelial Growth Factor C

Estrogen receptor-mediated transcription involves the activation of multiple kinase pathways in neuroblastoma cells

Clark, S., Rainville, J., Zhao, X., Katzenellenbogen, B. S., Pfaff, D. & Vasudevan, N., Jan 1 2014, In : Journal of Steroid Biochemistry and Molecular Biology. 139, p. 45-53 9 p.

Research output: Contribution to journalArticle

Transcription
Neuroblastoma
Estrogen Receptors
Transcriptional Activation
Estrogens

Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells

Aumsuwan, P., Khan, S. I., Khan, I. A., Avula, B., Walker, L. A., Helferich, W. G., Katzenellenbogen, B. S. & Dasmahapatra, A. K., Jan 1 2014, In : In Vitro Cellular and Developmental Biology - Animal. 51, 1, p. 59-71 13 p.

Research output: Contribution to journalArticle

5-methyldeoxycytidine
Dioscorea
Epigenomics
MCF-7 Cells
Breast Neoplasms

Highly sensitive quantitative imaging for monitoring single cancer cell growth kinetics and drug response

Mir, M., Bergamaschi, A., Katzenellenbogen, B. S. & Popescu, G., Feb 18 2014, In : PloS one. 9, 2, e89000.

Research output: Contribution to journalArticle

Light interference
Growth kinetics
Cell growth
cell growth
Microscopic examination
Endocrine Cells
Fibroblasts
breast neoplasms
fibroblasts
Cells
Actin Depolymerizing Factors
Estrogen Receptors
Actins
Breast Neoplasms
Hormones
Forkhead Transcription Factors
Neoplastic Stem Cells
Estrogen Receptors
Breast Neoplasms
Gene Regulatory Networks

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

Abot, A., Fontaine, C., Buscato, M., Solinhac, R., Flouriot, G., Fabre, A., Drougard, A., Rajan, S., Laine, M., Milon, A., Muller, I., Henrion, D., Adlanmerini, M., Valéra, M. C., Gompel, A., Gerard, C., Péqueux, C., Mestdagt, M., Raymond-Letron, I., Knauf, C. & 9 others, Ferriere, F., Valet, P., Gourdy, P., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Lenfant, F., Greene, G. L., Foidart, J. M. & Arnal, J. F., Oct 1 2014, In : EMBO Molecular Medicine. 6, 10, p. 1328-1346 19 p.

Research output: Contribution to journalArticle

Estetrol
Nuclear Envelope
Estrogen Receptors
Blood Vessels
Furylfuramide
Gene Regulatory Networks
Estrogen Receptors
Estrogens
Gene Expression
Glycyrrhiza
2015

Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis

Zhao, Y., Gong, P., Chen, Y., Nwachukwu, J. C., Srinivasan, S., Ko, C., Bagchi, M. K., Taylor, R. N., Korach, K. S., Nettles, K. W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jan 21 2015, In : Science Translational Medicine. 7, 271, 271ra9.

Research output: Contribution to journalArticle

Endometriosis
Estrogen Receptors
Estrogens
Fertility
Ligands

Erratum: Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis (Science Translational Medicine (2015) 7 (274er1))

Zhao, Y., Gong, P., Chen, Y., Nwachukwu, J. C., Srinivasan, S., Ko, C., Bagchi, M. K., Taylor, R. N., Korach, K. S., Nettles, K. W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Feb 11 2015, In : Science Translational Medicine. 7, 274

Research output: Contribution to journalComment/debate

Translational Medical Research
Endometriosis

Highly selective salicylketoxime-based estrogen receptor β agonists display antiproliferative activities in a glioma model

Paterni, I., Bertini, S., Granchi, C., Tuccinardi, T., Macchia, M., Martinelli, A., Caligiuri, I., Toffoli, G., Rizzolio, F., Carlson, K. E., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Minutolo, F., Feb 12 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1184-1194 11 p.

Research output: Contribution to journalArticle

Glioma
Estrogen Receptors
Estrogens
Heterografts
Pharmacology

Ligand accessibility and bioactivity of a hormone-dendrimer conjugate depend on pH and pH history

Kim, S. H., Madak-Erdogan, Z., Bae, S. C., Carlson, K. E., Mayne, C. G., Granick, S., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Aug 19 2015, In : Journal of the American Chemical Society. 137, 32, p. 10326-10335 10 p.

Research output: Contribution to journalArticle

Dendrimers
bioactivity
Hormones
Bioactivity
accessibility

Protective hematopoietic effect of estrogens in a mouse model of thrombosis: Respective roles of nuclear versus membrane estrogen receptor α

Valera, M. C., Fontaine, C., Lenfant, F., Cabou, C., Guillaume, M., Smirnova, N., Kim, S. H., Chambon, P., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Payrastre, B. & Arnal, J. F., Nov 2015, In : Endocrinology. 156, 11, p. 4293-4301 9 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Nuclear Envelope
Estrogen Receptors
Estrogens
Thrombosis

Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination

Poitelon, Y., Bogni, S., Matafora, V., Della-Flora Nunes, G., Hurley, E., Ghidinelli, M., Katzenellenbogen, B. S., Taveggia, C., Silvestri, N., Bachi, A., Sannino, A., Wrabetz, L. & Feltri, M. L., Sep 18 2015, In : Nature communications. 6, 8303.

Research output: Contribution to journalArticle

Neuroglia
axons
Molecules
molecules
interactions

The activation function-1 of estrogen receptor alpha prevents arterial neointima development through a direct effect on smooth muscle cells

Smirnova, N. F., Fontaine, C., Buscato, M., Lupieri, A., Vinel, A., Valera, M. C., Guillaume, M., Malet, N., Foidart, J. M., Raymond-Letron, I., Lenfant, F., Gourdy, P., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Laffargue, M. & Arnal, J. F., Oct 9 2015, In : Circulation Research. 117, 9, p. 770-777 8 p.

Research output: Contribution to journalArticle

Neointima
Estrogen Receptor alpha
Estrogen Receptors
Smooth Muscle Myocytes
Vascular Smooth Muscle
2016

Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues

Madak-Erdogan, Z., Kim, S. H., Gong, P., Zhao, Y. C., Zhang, H., Chambliss, K. L., Carlson, K. E., Mayne, C. G., Shaul, P. W., Korach, K. S., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., May 24 2016, In : Science Signaling. 9, 429, ra53.

Research output: Contribution to journalArticle

Blood Vessels
Estrogens
Tissue
Ligands
Estrogen Receptors

Dietary licorice root supplementation reduces diet-induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland

Madak-Erdogan, Z., Gong, P., Zhao, Y. C., Xu, L., Wrobel, K. U., Hartman, J. A., Wang, M., Cam, A., Iwaniec, U. T., Turner, R. T., Twaddle, N. C., Doerge, D. R., Khan, I. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Helferich, W. G., Feb 1 2016, In : Molecular Nutrition and Food Research. 60, 2, p. 369-380 12 p.

Research output: Contribution to journalArticle

Glycyrrhiza
licorice
fatty liver
Human Mammary Glands
mammary glands
Selective Estrogen Receptor Modulators
Conjugated (USP) Estrogens
Cytoplasmic and Nuclear Receptors
Estrogens
Tissue

Endocrine treatment in breast cancer: Cure, resistance and beyond

Tryfonidis, K., Zardavas, D., Katzenellenbogen, B. S. & Piccart, M., Nov 1 2016, In : Cancer Treatment Reviews. 50, p. 68-81 14 p.

Research output: Contribution to journalReview article

Tumor Microenvironment
Biomarkers
Hormones
Breast Neoplasms
Recurrence

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

Fanning, S. W., Mayne, C. G., Dharmarajan, V., Carlson, K. E., Martin, T. A., Novick, S. J., Toy, W., Green, B., Panchamukhi, S., Katzenellenbogen, B. S., Tajkhorshid, E., Griffin, P. R., Shen, Y., Chandarlapaty, S., Katzenellenbogen, J. A. & Greene, G. L., Feb 2 2016, In : eLife. 5, FEBRUARY2016, e12792.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Estrogen Receptor Modulators
Conformations
Breast Neoplasms
Mutation
Aryl Hydrocarbon Receptors
Estrogen Receptors
Estrogens
Gene expression
Crosstalk

Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities

Boonmuen, N., Gong, P., Ali, Z., Chittiboyina, A. G., Khan, I., Doerge, D. R., Helferich, W. G., Carlson, K. E., Martin, T., Piyachaturawat, P., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jan 1 2016, In : Steroids. 105, p. 42-49 8 p.

Research output: Contribution to journalArticle

Dietary supplements
Glycyrrhiza
Selective Estrogen Receptor Modulators
Dietary Supplements
Estrogen Receptors

Multiple beneficial roles of repressor of estrogen receptor activity (REA) in suppressing the progression of endometriosis

Zhao, Y., Chen, Y., Kuang, Y., Bagchi, M. K., Taylor, R. N., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Feb 2016, In : Endocrinology. 157, 2, p. 900-912 13 p.

Research output: Contribution to journalArticle

Endometriosis
Estrogen Receptors
Tissue Donors
Estradiol Receptors
Choristoma

Nonnuclear estrogen receptor activation improves hepatic steatosis in female mice

Chambliss, K. L., Barrera, J., Umetani, M., Umetani, J., Kim, S. H., Madak-Erdogan, Z., Huang, L., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Mineo, C. & Shaul, P. W., Jan 1 2016, In : Endocrinology. 157, 10, p. 3731-3741 11 p.

Research output: Contribution to journalArticle

Dendrimers
Estrogen Receptors
Estrogens
Liver
Adiposity

OCT-4: A novel estrogen receptor-α collaborator that promotes tamoxifen resistance in breast cancer cells

Bhatt, S., Stender, J. D., Joshi, S., Wu, G. & Katzenellenbogen, B. S., Nov 3 2016, In : Oncogene. 35, 44, p. 5722-5734 13 p.

Research output: Contribution to journalArticle

Tamoxifen
Estrogen Receptors
Breast Neoplasms
Binding Sites
MCF-7 Cells

Science Signaling podcast for 24 May 2016: Designer estrogens

Katzenellenbogen, B. S., Katzenellenbogen, J. A., Madak-Erdogan, Z. & Van hook, A. M., May 24 2016, In : Science Signaling. 9, 429, pc13.

Research output: Contribution to journalReview article

Webcasts
Estrogens
Metabolism
Estradiol Congeners
Bone

The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro

Aumsuwan, P., Khan, S. I., Khan, I. A., Ali, Z., Avula, B., Walker, L. A., Shariat-Madar, Z., Helferich, W. G., Katzenellenbogen, B. S. & Dasmahapatra, A. K., Feb 1 2016, In : Archives of Biochemistry and Biophysics. 591, p. 98-110 13 p.

Research output: Contribution to journalArticle

Dioscorea
Saponins
Cells
Breast Neoplasms
Cell Line
2017

Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells

Min, J., Guillen, V. S., Sharma, A., Zhao, Y., Ziegler, Y., Gong, P., Mayne, C. G., Srinivasan, S., Kim, S. H., Carlson, K. E., Nettles, K. W., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Jul 27 2017, In : Journal of Medicinal Chemistry. 60, 14, p. 6321-6336 16 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Estrogen Receptors
Breast Neoplasms
Down-Regulation
Ligands

Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity

Nelson, A. W., Groen, A. J., Miller, J. L., Warren, A. Y., Holmes, K. A., Tarulli, G. A., Tilley, W. D., Katzenellenbogen, B. S., Hawse, J. R., Gnanapragasam, V. J. & Carroll, J. S., Jan 15 2017, In : Molecular and Cellular Endocrinology. 440, p. 138-150 13 p.

Research output: Contribution to journalArticle

Estrogen Receptor beta
Estrogen Receptors
Cells
Tissue
Cell Line
Estrogen Receptor
Systems Biology
Molecular Biology
Genomics
Estrogen Receptors

Corrigendum to “Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity” [Mol. Cell Endocrinol. 440 (2016) 138–150] (S0303720716304853)(10.1016/j.mce.2016.11.016)

Nelson, A. W., Groen, A. J., Miller, J. L., Warren, A. Y., Holmes, K. A., Tarulli, G. A., Tilley, W. D., Katzenellenbogen, B. S., Hawse, J. R., Gnanapragasam, V. J. & Carroll, J. S., Mar 5 2017, In : Molecular and Cellular Endocrinology. 443, 1 p.

Research output: Contribution to journalComment/debate

Recombinant Fusion Proteins
Estrogen Receptor beta
Emotions
Cells
Tissue
Estrogen Receptors
Apoptosis
Breast Neoplasms
Gene Expression
Histones