Benita S Katzenellenbogen

1970 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1970 2019

New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons

Wang, L., Guillen, V. S., Sharma, N., Flessa, K., Min, J., Carlson, K. E., Toy, W., Braqi, S., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Chandarlapaty, S. & Sharma, A., Aug 9 2018, In : ACS Medicinal Chemistry Letters. 9, 8, p. 803-808 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Scaffolds
Proteins
Breast Neoplasms
Pharmacokinetics

NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

Nettles, K. W., Bruning, J. B., Gil, G., Nowak, J., Sharma, S. K., Hahm, J. B., Kulp, K., Hochberg, R. B., Zhou, H., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Kim, Y., Joachmiak, A. & Greene, G. L., Apr 2008, In : Nature chemical biology. 4, 4, p. 241-247 7 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Steroid Receptors
Crystallization
Ligands
Hormones

Nitrosourea and nitrosocarbamate derivatives of the antiestrogen tamoxifen as potential estrogen receptor-mediated cytotoxic agents in human breast cancer cells

Wei, L. L., Katzenellenbogen, B. S., Robertson, D. W., Simpson, D. M. & Katzenellenbogen, J. A., Jun 1 1986, In : Breast Cancer Research and Treatment. 7, 2, p. 77-90 14 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Cytotoxins
Tamoxifen
Estrogen Receptors
MCF-7 Cells

Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice

Miranda, C. L., Johnson, L. A., De Montgolfier, O., Elias, V. D., Ullrich, L. S., Hay, J. J., Paraiso, I. L., Choi, J., Reed, R. L., Revel, J. S., Kioussi, C., Bobe, G., Iwaniec, U. T., Turner, R. T., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Blakemore, P. R., Gombart, A. F., Maier, C. S., Raber, J. & 1 others, Stevens, J. F., Dec 1 2018, In : Scientific reports. 8, 1, 613.

Research output: Contribution to journalArticle

Obese Mice
High Fat Diet
Insulin Resistance
Cognitive Dysfunction
xanthohumol

Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity

Kousteni, S., Bellido, T., Plotkin, L. I., O'Brien, C. A., Bodenner, D. L., Han, L., Han, K., DiGregorio, G. B., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Roberson, P. K., Weinstein, R. S., Jilka, R. L. & Manolagas, S. C., Mar 9 2001, In : Cell. 104, 5, p. 719-730 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Estrogen Receptors
Ligands
Steroid hormones
Steroids

Nonnuclear estrogen receptor activation improves hepatic steatosis in female mice

Chambliss, K. L., Barrera, J., Umetani, M., Umetani, J., Kim, S. H., Madak-Erdogan, Z., Huang, L., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Mineo, C. & Shaul, P. W., Jan 1 2016, In : Endocrinology. 157, 10, p. 3731-3741 11 p.

Research output: Contribution to journalArticle

Dendrimers
Estrogen Receptors
Estrogens
Liver
Adiposity

Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice

Menazza, S., Sun, J., Appachi, S., Chambliss, K. L., Kim, S. H., Aponte, A., Khan, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Shaul, P. W. & Murphy, E., Jun 1 2017, In : Journal of Molecular and Cellular Cardiology. 107, p. 41-51 11 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Reperfusion Injury
Estrogen Receptors
Endothelium
Dendrimers

Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice

Chambliss, K. L., Wu, Q., Oltmann, S., Konaniah, E. S., Umetani, M., Korach, K. S., Thomas, G. D., Mineo, C., Yuhanna, I. S., Kim, S. H., Madak-Erdogan, Z., Maggi, A., Dineen, S. P., Roland, C. L., Hui, D. Y., Brekken, R. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Shaul, P. W., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2319-2330 12 p.

Research output: Contribution to journalArticle

Uterine Neoplasms
Dendrimers
Estrogen Receptors
Estrogens
Breast Neoplasms

Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass

Bartell, S. M., Han, L., Kim, H. N., Kim, S. H., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Chambliss, K. L., Shaul, P. W., Roberson, P. K., Weinstein, R. S., Jilka, R. L., Almeida, M. & Manolagas, S. C., Apr 1 2013, In : Molecular Endocrinology. 27, 4, p. 649-656 8 p.

Research output: Contribution to journalArticle

Dendrimers
Estrogen Receptors
Estrogens
Bone and Bones
Skeleton

Novel estrogen receptor ligands based on an anthranylaldoxime structure: Role of the phenol-type pseudocycle in the binding process

Minutolo, F., Antonello, M., Bertini, S., Ortore, G., Placanica, G., Rapposelli, S., Sheng, S., Carlson, K. E., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Macchia, M., Sep 11 2003, In : Journal of Medicinal Chemistry. 46, 19, p. 4032-4042 11 p.

Research output: Contribution to journalArticle

Phenol
Estrogen Receptors
Ligands
Hydrogen
Nitrogen

Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-α or estrogen receptor-β

Sun, J., Meyers, M. J., Fink, B. E., Rajendran, R., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jan 1 1999, In : Endocrinology. 140, 2, p. 800-804 5 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Estrogen Receptors
Estrogens
Ligands
Transcriptional Activation
Actin Depolymerizing Factors
Estrogen Receptors
Actins
Breast Neoplasms
Hormones

Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors

Madak-Erdogan, Z., Kieser, K. J., Sung, H. K., Komm, B., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Sep 1 2008, In : Molecular Endocrinology. 22, 9, p. 2116-2127 12 p.

Research output: Contribution to journalArticle

Gene Expression Regulation
Estrogen Receptors
Dendrimers
Estrogens
Genes

Nuclear hormone receptors: Ligand-activated regulators of transcription and diverse cell responses

Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jul 1996, In : Chemistry and Biology. 3, 7, p. 529-536 8 p.

Research output: Contribution to journalReview article

Transcription
Cytoplasmic and Nuclear Receptors
Transcriptional Activation
Chemical activation
Ligands

Observations arising from the use of pure antioestrogens on oestrogen-responsive (MCF-7) and oestrogen growth-independent (K3) human breast cancer cells

Nicholson, R. I., Gee, J. M. W., Francis, A. B., Manning, D. L., Wakeling, A. E. & Katzenellenbogen, B. S., 1995, In : Endocrine-Related Cancer. 2, 1, p. 115-121 7 p.

Research output: Contribution to journalArticle

OCT-4: A novel estrogen receptor-α collaborator that promotes tamoxifen resistance in breast cancer cells

Bhatt, S., Stender, J. D., Joshi, S., Wu, G. & Katzenellenbogen, B. S., Nov 3 2016, In : Oncogene. 35, 44, p. 5722-5734 13 p.

Research output: Contribution to journalArticle

Tamoxifen
Estrogen Receptors
Breast Neoplasms
Binding Sites
MCF-7 Cells

Ontogeny of uterine responsiveness to estrogen during early development in the rat

Katzenellenbogen, B. S. & Greger, N. G., Dec 1974, In : Molecular and Cellular Endocrinology. 2, 1, p. 31-42 12 p.

Research output: Contribution to journalArticle

Rats
Estrogens
Proteins
Uterus
Metabolism

Phenethyl pyridines with non-polar internal substitutents as selective ligands for estrogen receptor beta

Waibel, M., Kieser, K. J., Carlson, K. E., Stossi, F., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Sep 1 2009, In : European Journal of Medicinal Chemistry. 44, 9, p. 3560-3570 11 p.

Research output: Contribution to journalArticle

Pyridines
Estrogen Receptor beta
Ligands
Picolines
Alkylation
Phenolsulfonphthalein
Culture Media
Estrogens
Cell Culture Techniques
Estrogen Receptors
p38 Mitogen-Activated Protein Kinases
Estrogen Receptors
Phosphorylation
Breast Neoplasms
Estrogens

Phosphorylation of the human estrogen receptor. Identification of hormone- regulated sites and examination of their influence on transcriptional activity

Le Goff, P., Montano, M. M., Schodin, D. J. & Katzenellenbogen, B. S., Jan 1 1994, In : Journal of Biological Chemistry. 269, 6, p. 4458-4466 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Estrogen Receptors
Hormones
Serine
1-Methyl-3-isobutylxanthine
Estrogen Receptors
Estrogens
Physical properties
Cells
Breast Neoplasms

Plasminogen activators in human breast cancer cell lines: Hormonal regulation and properties

Mangel, W. F., Toledo, D. L., Nardulli, A. M., Reiner, G. C. A., Norman, M. J. & Katzenellenbogen, B. S., 1988, In : Journal of Steroid Biochemistry. 30, 1-6, p. 79-88 10 p.

Research output: Contribution to journalArticle

Plasminogen Activators
Cells
Breast Neoplasms
Cell Line
Estrogen Receptors

Plasminogen activators in tissues of the immature and estrogen-stimulated rat uterus and in uterine luminal fluid: Characterization and properties

Peltz, S. W., Katzenellenbogen, B. S., Kneifel, M. A. & Mangel, W. F., Mar 1983, In : Endocrinology. 112, 3, p. 890-897 8 p.

Research output: Contribution to journalArticle

Plasminogen Activators
Tissue Plasminogen Activator
Uterus
Estrogens
Estradiol
Chemokine Receptors
Estrogen Receptors
Estrogens
Breast Neoplasms
MCF-7 Cells

Powerful dominant negative mutants of the human estrogen receptor

Ince, B. A., Zhuang, Y., Wrenn, C. K., Shapiro, D. J. & Katzenellenbogen, B. S., Jan 1 1993, In : Journal of Biological Chemistry. 268, 19, p. 14026-14032 7 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Transcription
Estrogens
Response Elements
Assays

Predominant role of nuclear versus membrane estrogen receptor α in arterial protection: Implications for estrogen receptor α modulation in cardiovascular prevention/safety

Guivarc’h, E., Buscato, M., Guihot, A. L., Favre, J., Vessières, E., Grimaud, L., Wakim, J., Melhem, N. J., Zahreddine, R., Adlanmerini, M., Loufrani, L., Knauf, C., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Foidart, J. M., Gourdy, P., Lenfant, F., Arnal, J. F., Henrion, D. & Fontaine, C., Jul 1 2018, In : Journal of the American Heart Association. 7, 13, e008950.

Research output: Contribution to journalArticle

Nuclear Envelope
Estrogen Receptors
Safety
Estrogens
Estetrol

Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: Insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype

Frasor, J., Danes, J. M., Komm, B., Chang, K. C. N., Richard Lyttle, C. & Katzenellenbogen, B. S., Oct 1 2003, In : Endocrinology. 144, 10, p. 4562-4574 13 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Estrogens
Cell Proliferation
Breast Neoplasms
Phenotype

Progesterone antagonism of estradiol-stimulated uterine 'induced protein' synthesis

Bhakoo, H. S. & Katzenellenbogen, B. S., Aug 1977, In : Molecular and Cellular Endocrinology. 8, 2, p. 105-120 16 p.

Research output: Contribution to journalArticle

Progesterone
Estradiol
Progestins
Proteins
Rats
Estrogen Receptors
Progesterone
Estrogens
Modulation
Estradiol
Progestins
Progesterone Receptors
Cell Count
Promegestone
Breast Neoplasms
Estrogen Receptor Modulators
Somatomedins
Progesterone Receptors
Protein Kinase Inhibitors
Adenosine
Progesterone Receptors
Promegestone
Cells
Breast Neoplasms
Amino Acids

Progression of human breast cancer cells from hormone-dependent to hormone-independent growth both in vitro and in vivo

Clarke, R., Brunner, N., Katzenellenbogen, B. S., Thompson, E. W., Norman, M. J., Koppi, C., Paik, S., Lippman, M. E. & Dickson, R. B., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 10, p. 3649-3653 5 p.

Research output: Contribution to journalArticle

Growth Hormone
Hormones
Breast Neoplasms
Phenotype
Estrogens

Proliferation, Hormonal Responsiveness, and Estrogen Receptor Content of MCF-7 Human Breast Cancer Cells Grown in the Short-Term and Long-Term Absence of Estrogens

Katzenellenbogen, B. S., Kendra, K. L., Norman, M. J. & Berthois, Y., Aug 1987, In : Cancer Research. 47, 16, p. 4355-4360 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Phenolsulfonphthalein
Breast Neoplasms
Estrogen Receptor Modulators

Protective hematopoietic effect of estrogens in a mouse model of thrombosis: Respective roles of nuclear versus membrane estrogen receptor α

Valera, M. C., Fontaine, C., Lenfant, F., Cabou, C., Guillaume, M., Smirnova, N., Kim, S. H., Chambon, P., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Payrastre, B. & Arnal, J. F., Nov 2015, In : Endocrinology. 156, 11, p. 4293-4301 9 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Nuclear Envelope
Estrogen Receptors
Estrogens
Thrombosis

Proteinases of silkmoth moulting fluid: Physical and catalytic properties

Katzenellenbogen, B. S. & Kafatos, F. C., Apr 1971, In : Journal of insect physiology. 17, 4, p. 775-800 26 p.

Research output: Contribution to journalArticle

Molting
Bombyx
molting
Peptide Hydrolases
proteinases

Protein kinase A activation of estrogen receptor α transcription does not require proteasome activity and protects the receptor from ligand-mediated degradation

Tsai, H. W., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Shupnik, M. A., Jun 1 2004, In : Endocrinology. 145, 6, p. 2730-2738 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Cyclic AMP-Dependent Protein Kinases
Estrogen Receptors
Colforsin
Ligands

Prothymosin alpha selectively enhances estrogen receptor transcriptional activity by interacting with a repressor of estrogen receptor activity

Martini, P. G. V., Delage-Mourroux, R., Kraichely, D. M. & Katzenellenbogen, B. S., Sep 6 2000, In : Molecular and cellular biology. 20, 17, p. 6224-6232 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Cytoplasmic and Nuclear Receptors
prothymosin alpha
Proteins
Nuclear Receptor Coactivator 1

Pyrazole ligands: Structure - Affinity/activity relationships and estrogen receptor-α-selective agonists

Stauffer, S. R., Coletta, C. J., Tedesco, R., Nishiguchi, G., Carlson, K., Sun, J., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Dec 28 2000, In : Journal of Medicinal Chemistry. 43, 26, p. 4934-4947 14 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Estrogen Receptors
Estrogens
Ligands
pyrazole

Pyrazolo[1,5-α]pyrimidines: Estrogen receptor ligands possessing estrogen receptor β antagonist activity

Compton, D. R., Sheng, S., Carlson, K. E., Rebacz, N. A., Lee, I. Y., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Nov 18 2004, In : Journal of Medicinal Chemistry. 47, 24, p. 5872-5893 22 p.

Research output: Contribution to journalArticle

Pyrimidines
Estrogen Receptors
Ligands
Estrogen Receptor Antagonists
Libraries
Hormone Antagonists
Gonadal Steroid Hormones
Estrogen Receptors
Intercellular Signaling Peptides and Proteins
RNA
Keratin-19
Gene expression
Estrogens
Genes
Cells

Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97)

Rajendran, R. R., Nye, A. C., Frasor, J., Balsara, R. D., Martini, P. G. V. & Katzenellenbogen, B. S., Feb 14 2003, In : Journal of Biological Chemistry. 278, 7, p. 4628-4638 11 p.

Research output: Contribution to journalArticle

DEAD-box RNA Helicases
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Estradiol Receptors
Genes
Hormone Antagonists
Gonadal Steroid Hormones
Progesterone Receptors
Uterus
Progesterone
Progesterone Receptors
Insulin-Like Growth Factor I
Adenosine
Estradiol
Breast Neoplasms
MCF-7 Cells
Progesterone Receptors
Estradiol
Estrogens
RNA
Gene Expression Regulation
Response Elements
Estrogen Receptors
Estrogens
Breast Neoplasms
Chloramphenicol O-Acetyltransferase
Estrogen Receptor Modulators
Gene Fusion
Gene Expression Regulation
Estrogens
Ornithine Decarboxylase
Estrogen Receptor Modulators
Polyamines
Estradiol
Growth