Benita S Katzenellenbogen

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Research Output

2006

Metabolite ligands of estrogen receptor-β reduce primate coronary hyperreactivity

Mishra, R. G., Stanczyk, F. Z., Burry, K. A., Oparil, S., Katzenellenbogen, B. S., Nealen, M. L., Katzenellenbogen, J. A. & Hermsmeyer, R. K., Jan 1 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 290, 1, p. H295-H303

Research output: Contribution to journalArticle

Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands

Minutolo, F., Bertini, S., Martinelli, A., Ortore, G., Placanica, G., Prota, G., Rapposelli, S., Tuccinardi, T., Sheng, S., Carlson, K. E., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Macchia, M., Jun 24 2006, In : Arkivoc. 2006, 8, p. 83-94 12 p.

Research output: Contribution to journalArticle

2005

Cyclin D1 antagonizes BRCA1 repression of estrogen receptor α activity

Wang, C., Fan, S., Li, Z., Fu, M., Rao, M., Ma, Y., Lisanti, M. P., Albanese, C., Katzenellenbogen, B. S., Kushner, P. J., Weber, B., Rosen, E. M. & Pestell, R. G., Aug 1 2005, In : Cancer Research. 65, 15, p. 6557-6567 11 p.

Research output: Contribution to journalArticle

Distinctive actions of membrane-targeted versus nuclear localized estrogen receptors in breast cancer cells

Rai, D., Frolova, A., Frasor, J., Carpenter, A. E. & Katzenellenbogen, B. S., Jun 2005, In : Molecular Endocrinology. 19, 6, p. 1606-1617 12 p.

Research output: Contribution to journalArticle

Estrogen receptor regulation of quinone reductase in breast cancer: implications for estrogen-induced breast tumor growth and therapeutic uses of tamoxifen.

Montano, M. M., Bianco, N. R., Deng, H., Wittmann, B. M., Chaplin, L. C. & Katzenellenbogen, B. S., 2005, In : Frontiers in bioscience : a journal and virtual library. 10, p. 1440-1461 22 p.

Research output: Contribution to journalReview article

Expression of steroid hormone receptors in BRCA1-associated ovarian carcinomas

Aghmesheh, M., Edwards, L., Clarke, C. L., Byth, K., Katzenellenbogen, B. S., Russell, P. J., Friedlander, M., Tucker, K. M. & De Fazio, A., Apr 2005, In : Gynecologic Oncology. 97, 1, p. 16-25 10 p.

Research output: Contribution to journalArticle

Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo

Park, S. E., Xu, J., Frolova, A., Liao, L., O'Malley, B. W. & Katzenellenbogen, B. S., Mar 1 2005, In : Molecular and cellular biology. 25, 5, p. 1989-1999 11 p.

Research output: Contribution to journalArticle

Indazole estrogens: Highly selective ligands for the estrogen receptor β

De Angelis, M., Stossi, F., Carlson, K. A., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Feb 24 2005, In : Journal of Medicinal Chemistry. 48, 4, p. 1132-1144 13 p.

Research output: Contribution to journalArticle

Isocoumarins as estrogen receptor beta selective ligands: Isomers of isoflavone phytoestrogens and their metabolites

De Angelis, M., Stossi, F., Waibel, M., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Dec 1 2005, In : Bioorganic and Medicinal Chemistry. 13, 23, p. 6529-6542 14 p.

Research output: Contribution to journalArticle

Synthesis and evaluation of estrogen receptor ligands with bridged oxabicyclic cores containing a diarylethylene motif: Estrogen antagonists of unusual structure

Zhou, H. B., Comninos, J. S., Stossi, F., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Nov 17 2005, In : Journal of Medicinal Chemistry. 48, 23, p. 7261-7274 14 p.

Research output: Contribution to journalArticle

The androgen derivative 5α-androstane-3β,17β-diol inhibits prostate cancer cell migration through activation of the estrogen receptor β subtype

Guerini, V., Sau, D., Scaccianoce, E., Rusmini, P., Ciana, P., Maggi, A., Martini, P. G. V., Katzenellenbogen, B. S., Martini, L., Motta, M. & Poletti, A., Jun 15 2005, In : Cancer Research. 65, 12, p. 5445-5453 9 p.

Research output: Contribution to journalArticle

Thyroid hormone can increase estrogen-mediated transcription from a consensus estrogen response element in neuroblastoma cells

Zhao, X., Lorenc, H., Stephenson, H., Wang, Y. J., Witherspoon, D., Katzenellenbogen, B., Pfaff, D. & Vasudevan, N., Mar 29 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 13, p. 4890-4895 6 p.

Research output: Contribution to journalArticle

2004

Allosteric Control of Ligand Selectivity between Estrogen Receptors α and β: Implications for Other Nuclear Receptors

Nettles, K. W., Sun, J., Radek, J. T., Sheng, S., Rodriguez, A. L., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Greene, G. L., Feb 13 2004, In : Molecular cell. 13, 3, p. 317-327 11 p.

Research output: Contribution to journalArticle

Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc

Barletta, F., Wong, C. W., McNally, C., Komm, B. S., Katzenellenbogen, B. & Cheskis, B. J., May 2004, In : Molecular Endocrinology. 18, 5, p. 1096-1108 13 p.

Research output: Contribution to journalArticle

Directed evolution of human estrogen receptor variants with significantly enhanced androgen specificity and affinity

Chen, Z., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Zhao, H., Aug 6 2004, In : Journal of Biological Chemistry. 279, 32, p. 33855-33864 10 p.

Research output: Contribution to journalArticle

Equol, a natural estrogenic metabolite from soy isoflavones: Convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta

Muthyala, R. S., Ju, Y. H., Sheng, S., Williams, L. D., Doerge, D. R., Katzenellenbogen, B. S., Helferich, W. G. & Katzenellenbogen, J. A., Mar 15 2004, In : Bioorganic and Medicinal Chemistry. 12, 6, p. 1559-1567 9 p.

Research output: Contribution to journalArticle

Protein kinase A activation of estrogen receptor α transcription does not require proteasome activity and protects the receptor from ligand-mediated degradation

Tsai, H. W., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Shupnik, M. A., Jun 1 2004, In : Endocrinology. 145, 6, p. 2730-2738 9 p.

Research output: Contribution to journalArticle

Pyrazolo[1,5-α]pyrimidines: Estrogen receptor ligands possessing estrogen receptor β antagonist activity

Compton, D. R., Sheng, S., Carlson, K. E., Rebacz, N. A., Lee, I. Y., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Nov 18 2004, In : Journal of Medicinal Chemistry. 47, 24, p. 5872-5893 22 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators: Discrimination of Agonistic versus Antagonistic Activities by Gene Expression Profiling in Breast Cancer Cells

Frasor, J., Stossi, F., Danes, J. M., Komm, B., Lyttle, C. R. & Katzenellenbogen, B. S., Feb 15 2004, In : Cancer Research. 64, 4, p. 1522-1533 12 p.

Research output: Contribution to journalArticle

Selective recognition of distinct classes of coactivators by a ligand-inducible activation domain

Acevedo, M. L., Lee, K. C., Stender, J. D., Katzenellenbogen, B. S. & Kraus, W. L., Mar 5 2004, In : Molecular cell. 13, 5, p. 725-738 14 p.

Research output: Contribution to journalArticle

Therapeutic Targeting in the Estrogen Receptor Hormonal Pathway

Katzenellenbogen, B. S. & Frasor, J., Feb 2004, In : Seminars in Oncology. 31, 1 SUPPL. 3, p. 28-38 11 p.

Research output: Contribution to journalArticle

Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) α or ERβ in human osteosarcoma cells: Distinct and common target genes for these receptors

Stossi, F., Barnett, D. H., Frasor, J., Komm, B., Lyttle, C. R. & Katzenellenbogen, B. S., Jul 1 2004, In : Endocrinology. 145, 7, p. 3473-3486 14 p.

Research output: Contribution to journalArticle

2003

Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression

Harrington, W. R., Sheng, S., Barnett, D. H., Petz, L. N., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Aug 29 2003, In : Molecular and Cellular Endocrinology. 206, 1-2, p. 13-22 10 p.

Research output: Contribution to journalArticle

Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor

Muthyala, R. S., Sheng, S., Carlson, K. E., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Apr 24 2003, In : Journal of Medicinal Chemistry. 46, 9, p. 1589-1602 14 p.

Research output: Contribution to journalArticle

DNA shuffling method for generating estrogen receptor α and β chimeras in yeast

Sun, J., Katzenellenbogen, J. A., Zhao, H. & Katzenellenbogen, B. S., Feb 1 2003, In : BioTechniques. 34, 2, p. 278-288 11 p.

Research output: Contribution to journalArticle

Modulation of estrogen receptor activity by selective coregulators

Martini, P. G. V. & Katzenellenbogen, B. S., Jun 2003, In : Journal of Steroid Biochemistry and Molecular Biology. 85, 2-5, p. 117-122 6 p.

Research output: Contribution to journalArticle

Molecular basis for the subtype discrimination of the estrogen receptor-β-selective ligand, diarylpropionitrile

Sun, J., Baudry, J., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Feb 1 2003, In : Molecular Endocrinology. 17, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

Novel estrogen receptor ligands based on an anthranylaldoxime structure: Role of the phenol-type pseudocycle in the binding process

Minutolo, F., Antonello, M., Bertini, S., Ortore, G., Placanica, G., Rapposelli, S., Sheng, S., Carlson, K. E., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Macchia, M., Sep 11 2003, In : Journal of Medicinal Chemistry. 46, 19, p. 4032-4042 11 p.

Research output: Contribution to journalArticle

Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: Insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype

Frasor, J., Danes, J. M., Komm, B., Chang, K. C. N., Richard Lyttle, C. & Katzenellenbogen, B. S., Oct 1 2003, In : Endocrinology. 144, 10, p. 4562-4574 13 p.

Research output: Contribution to journalArticle

Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97)

Rajendran, R. R., Nye, A. C., Frasor, J., Balsara, R. D., Martini, P. G. V. & Katzenellenbogen, B. S., Feb 14 2003, In : Journal of Biological Chemistry. 278, 7, p. 4628-4638 11 p.

Research output: Contribution to journalArticle

Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) α activity by ERβ in the uterus

Frasor, J., Barnett, D. H., Danes, J. M., Hess, R., Parlow, A. F. & Katzenellenbogen, B. S., Jul 1 2003, In : Endocrinology. 144, 7, p. 3159-3166 8 p.

Research output: Contribution to journalArticle

The effects of the phytoestrogen, coumestrol, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 GnRH neurones

Bowe, J., Li, X. F., Sugden, D., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & O'Byrne, K. T., Feb 1 2003, In : Journal of Neuroendocrinology. 15, 2, p. 105-108 4 p.

Research output: Contribution to journalArticle

2002

Alteration of large-scale chromatin structure by estrogen receptor

Nye, A. C., Rajendran, R. R., Stenoien, D. L., Mancini, M. A., Katzenellenbogen, B. S. & Belmont, A. S., May 9 2002, In : Molecular and cellular biology. 22, 10, p. 3437-3449 13 p.

Research output: Contribution to journalArticle

Antagonists selective for estrogen receptor α

Sun, J., Huang, Y. R., Harrington, W. R., Sheng, S., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jan 1 2002, In : Endocrinology. 143, 3, p. 941-947 7 p.

Research output: Contribution to journalArticle

Characterization of the biological roles of the estrogen receptors, ERα and ERβ, in estrogen target tissues in vivo through the use of an ERα-selective ligand

Harris, H. A., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Nov 1 2002, In : Endocrinology. 143, 11, p. 4172-4177 6 p.

Research output: Contribution to journalArticle

Defining the "S" in SERMs

Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Mar 29 2002, In : Science. 295, 5564, p. 2380-2381 2 p.

Research output: Contribution to journalShort survey

Estrogenic diazenes: Heterocyclic non-steroidal estrogens of unusual structure with selectivity for estrogen receptor subtypes

Ghosh, U., Ganessunker, D., Sattigeri, V. J., Carlson, K. E., Mortensen, D. J., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Feb 1 2002, In : Bioorganic and Medicinal Chemistry. 11, 4, p. 629-657 29 p.

Research output: Contribution to journalArticle

Estrogen receptor isoform-specific induction of progesterone receptors in human osteoblasts

Rickard, D. J., Waters, K. M., Ruesink, T. J., Khosla, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Riggs, B. L. & Spelsberg, T. C., Jan 1 2002, In : Journal of Bone and Mineral Research. 17, 4, p. 580-592 13 p.

Research output: Contribution to journalArticle

Localization of androgen and estrogen receptors in adult male mouse reproductive tract

Zhou, Q., Nie, R., Prins, G. S., Saunders, P. T. K., Katzenellenbogen, B. S. & Hess, R. A., Nov 1 2002, In : Journal of andrology. 23, 6, p. 870-881 12 p.

Research output: Contribution to journalArticle

Molecular cloning of porcine estrogen receptor-β complementary DNAs and developmental expression in periimplantation embryos

Kowalski, A. A., Graddy, L. G., Vale-Cruz, D. S., Choi, I., Katzenellenbogen, B. S., Simmen, F. A. & Simmen, R. C. M., Jan 1 2002, In : Biology of reproduction. 66, 3, p. 760-769 10 p.

Research output: Contribution to journalArticle

Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism

Shiau, A. K., Barstad, D., Radek, J. T., Meyers, M. J., Nettles, K. W., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Agard, D. A. & Greene, G. L., May 13 2002, In : Nature Structural Biology. 9, 5, p. 359-364 6 p.

Research output: Contribution to journalArticle

2001

Activation of estrogen receptor β is a prerequisite for estrogen-dependent upregulation of nitric oxide synthases in neonatal rat cardiac myocytes

Nuedling, S., Karas, R. H., Mendelsohn, M. E., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Meyer, R., Vetter, H. & Grohé, C., Aug 3 2001, In : FEBS Letters. 502, 3, p. 103-108 6 p.

Research output: Contribution to journalArticle

Direct Acetylation of the Estrogen Receptor α Hinge Region by p300 Regulates Transactivation and Hormone Sensitivity

Wang, C., Fu, M., Angeletti, R. H., Siconolfi-Baez, L., Reutens, A. T., Albanese, C., Lisanti, M. P., Katzenellenbogen, B. S., Kato, S., Hopp, T., Fuqua, S. A. W., Lopez, G. N., Kushner, P. J. & Pestell, R. G., Jan 25 2001, In : Journal of Biological Chemistry. 276, 21, p. 18375-18383 9 p.

Research output: Contribution to journalArticle

Estrogen action and male fertility: Roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function

Zhou, Q., Clarke, L., Nie, R., Carnes, K., Lai, L. W., Lien, Y. H. H., Verkman, A., Lubahn, D., Fisher, J. S., Katzenellenbogen, B. S. & Hess, R. A., Nov 20 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 24, p. 14132-14137 6 p.

Research output: Contribution to journalArticle

Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor α: Studies with αERKO and βERKO mice

Prins, G. S., Birch, L., Couse, J. F., Korach, K. S., Couse, J. F., Choi, I. & Katzenellenbogen, B., Aug 15 2001, In : Cancer Research. 61, 16, p. 6089-6097 9 p.

Research output: Contribution to journalArticle

Estrogen receptor-β potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues

Meyers, M. J., Sun, J., Carlson, K. E., Marriner, G. A., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Nov 22 2001, In : Journal of Medicinal Chemistry. 44, 24, p. 4230-4251 22 p.

Research output: Contribution to journalArticle

Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform

Waters, K. M., Rickard, D. J., Lawrence Riggs, B., Khosla, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Moore, J. & Spelsberg, T. C., Nov 13 2001, In : Journal of Cellular Biochemistry. 83, 3, p. 448-462 15 p.

Research output: Contribution to journalArticle