Benita S Katzenellenbogen

1970 …2020
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Research Output 1970 2020

2017

Estrogens and androgens inhibit association of RANKL with the pre-osteoblast membrane through post-translational mechanisms

Martin, A., Yu, J., Xiong, J., Khalid, A. B., Katzenellenbogen, B., Kim, S. H., Katzenellenbogen, J. A., Malaivijitnond, S., Gabet, Y., Krum, S. A. & Frenkel, B., Dec 2017, In : Journal of Cellular Physiology. 232, 12, p. 3798-3807 10 p.

Research output: Contribution to journalArticle

Osteoblasts
Dihydrotestosterone
Androgens
Estrogens
Association reactions

Full antagonism of the estrogen receptor without a prototypical ligand side chain

Srinivasan, S., Nwachukwu, J. C., Bruno, N. E., Dharmarajan, V., Goswami, D., Kastrati, I., Novick, S., Nowak, J., Cavett, V., Zhou, H. B., Boonmuen, N., Zhao, Y., Min, J., Frasor, J., Katzenellenbogen, B. S., Griffin, P. R., Katzenellenbogen, J. A. & Nettles, K. W., Jan 1 2017, In : Nature chemical biology. 13, 1, p. 111-118 8 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Ligands
Breast Neoplasms
Chemoprevention
Therapeutic Uses

Membrane and nuclear estrogen receptor alpha actions: From tissue specificity to medical implications

Arnal, J. F., Lenfant, F., Metivier, R., Flouriot, G., Henrion, D., Adlanmerini, M., Fontaine, C., Gourdy, P., Chambon, P., Katzenellenbogen, B. & Katzenellenbogen, J., Jul 2017, In : Physiological Reviews. 97, 3, p. 1045-1087 43 p.

Research output: Contribution to journalReview article

Organ Specificity
Estrogen Receptor alpha
Nuclear Envelope
Steroids
Membranes

MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression

Christenson, J. L., Butterfield, K. T., Spoelstra, N. S., Norris, J. D., Josan, J. S., Pollock, J. A., McDonnell, D. P., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Richer, J. K., Apr 1 2017, In : Hormones and Cancer. 8, 2, p. 69-77 9 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Mouse mammary tumor virus
Androgen Receptors
Neoplasm Antigens
Breast Neoplasms

Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice

Menazza, S., Sun, J., Appachi, S., Chambliss, K. L., Kim, S. H., Aponte, A., Khan, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Shaul, P. W. & Murphy, E., Jun 1 2017, In : Journal of Molecular and Cellular Cardiology. 107, p. 41-51 11 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Reperfusion Injury
Estrogen Receptors
Endothelium
Dendrimers

Structurally novel antiestrogens elicit differential responses from constitutively active mutant estrogen receptors in breast cancer cells and tumors

Zhao, Y., Laws, M. J., Guillen, V. S., Ziegler, Y., Min, J., Sharma, A., Kim, S. H., Chu, D., Park, B. H., Oesterreich, S., Mao, C., Shapiro, D. J., Nettles, K. W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Oct 15 2017, In : Cancer Research. 77, 20, p. 5602-5613 12 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Estrogen Receptors
Breast Neoplasms
Neoplasms
Inbred NOD Mouse
2018

Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain

Sharma, A., Toy, W., Guillen, V. S., Sharma, N., Min, J., Carlson, K. E., Mayne, C. G., Lin, S., Sabio, M., Greene, G., Katzenellenbogen, B. S., Chandarlapaty, S. & Katzenellenbogen, J. A., Dec 21 2018, In : ACS chemical biology. 13, 12, p. 3374-3384 11 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Estrogen Receptors
Ligands
Cell proliferation
Breast Neoplasms

Erratum to: Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance (Nature Reviews Cancer, (2018), 18, 6, (377-388), 10.1038/s41568-018-0001-z)

Katzenellenbogen, J. A., Mayne, C. G., Katzenellenbogen, B. S., Greene, G. L. & Chandarlapaty, S., Oct 1 2018, In : Nature Reviews Cancer. 18, 10, 1 p.

Research output: Contribution to journalComment/debate

Estrogen Receptors
Estrogens
Ligands
Mutation
Neoplasms

New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons

Wang, L., Guillen, V. S., Sharma, N., Flessa, K., Min, J., Carlson, K. E., Toy, W., Braqi, S., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Chandarlapaty, S. & Sharma, A., Aug 9 2018, In : ACS Medicinal Chemistry Letters. 9, 8, p. 803-808 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Scaffolds
Proteins
Breast Neoplasms
Pharmacokinetics

Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice

Miranda, C. L., Johnson, L. A., De Montgolfier, O., Elias, V. D., Ullrich, L. S., Hay, J. J., Paraiso, I. L., Choi, J., Reed, R. L., Revel, J. S., Kioussi, C., Bobe, G., Iwaniec, U. T., Turner, R. T., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Blakemore, P. R., Gombart, A. F., Maier, C. S., Raber, J. & 1 others, Stevens, J. F., Dec 1 2018, In : Scientific reports. 8, 1, 613.

Research output: Contribution to journalArticle

Obese Mice
High Fat Diet
Insulin Resistance
Cognitive Dysfunction
xanthohumol

Predominant role of nuclear versus membrane estrogen receptor α in arterial protection: Implications for estrogen receptor α modulation in cardiovascular prevention/safety

Guivarc’h, E., Buscato, M., Guihot, A. L., Favre, J., Vessières, E., Grimaud, L., Wakim, J., Melhem, N. J., Zahreddine, R., Adlanmerini, M., Loufrani, L., Knauf, C., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Foidart, J. M., Gourdy, P., Lenfant, F., Arnal, J. F., Henrion, D. & Fontaine, C., Jul 1 2018, In : Journal of the American Heart Association. 7, 13, e008950.

Research output: Contribution to journalArticle

Nuclear Envelope
Estrogen Receptors
Safety
Estrogens
Estetrol

Respective role of membrane and nuclear estrogen receptor (ER) α in the mandible of growing mice: Implications for ERα modulation

Vinel, A., Coudert, A. E., Buscato, M., Valera, M. C., Ostertag, A., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Berdal, A., Babajko, S., Arnal, J. F. & Fontaine, C., Aug 2018, In : Journal of Bone and Mineral Research. 33, 8, p. 1520-1531 12 p.

Research output: Contribution to journalArticle

Mandible
Estrogen Receptors
Bone and Bones
Membranes
Estrogens

Selective Nonnuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice

Selvaraj, U. M., Zuurbier, K. R., Whoolery, C. W., Plautz, E. J., Chambliss, K. L., Kong, X., Zhang, S., Kim, S. H., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Mineo, C., Shaul, P. W. & Stowe, A. M., Jan 1 2018, In : Endocrinology. 159, 11, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Middle Cerebral Artery Infarction
Stroke
Uterine Neoplasms

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance

Katzenellenbogen, J. A., Mayne, C. G., Katzenellenbogen, B. S., Greene, G. L. & Chandarlapaty, S., Jun 1 2018, In : Nature Reviews Cancer. 18, 6, p. 377-388 12 p.

Research output: Contribution to journalReview article

Estrogen Receptors
Ligands
Mutation
Androgen Receptors
Breast Neoplasms
2019

Suppression of FOXM1 activities and breast cancer growth in vitro and in vivo by a new class of compounds

Ziegler, Y., Laws, M. J., Sanabria Guillen, V., Kim, S. H., Dey, P., Smith, B. P., Gong, P., Bindman, N., Zhao, Y., Carlson, K., Yasuda, M. A., Singh, D., Li, Z., El-Ashry, D., Madak-Erdogan, Z., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Dec 1 2019, In : npj Breast Cancer. 5, 1, 45.

Research output: Contribution to journalArticle

Open Access
Breast Neoplasms
Growth
Triple Negative Breast Neoplasms
Gene Ontology
Proteasome Endopeptidase Complex
2020

The tissue-specific effects of different 17β-estradiol doses reveal the key sensitizing role of AF1 domain in ERα activity

Fontaine, C., Buscato, M., Vinel, A., Giton, F., Raymond-Letron, I., Kim, S. H., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Gourdy, P., Milon, A., Flouriot, G., Ohlsson, C., Lenfant, F. & Arnal, J. F., Apr 5 2020, In : Molecular and Cellular Endocrinology. 505, 110741.

Research output: Contribution to journalArticle

Proestrus
Estradiol
Metestrus
Tissue
Estrogen Receptor alpha