Benita S Katzenellenbogen

1970 …2019
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Research Output 1970 2019

2005
Co-Repressor Proteins
Estrogens
Down-Regulation
Genes
Estrogen Receptors

Estrogen receptor regulation of quinone reductase in breast cancer: implications for estrogen-induced breast tumor growth and therapeutic uses of tamoxifen.

Montano, M. M., Bianco, N. R., Deng, H., Wittmann, B. M., Chaplin, L. C. & Katzenellenbogen, B. S., 2005, In : Frontiers in bioscience : a journal and virtual library. 10, p. 1440-1461 22 p.

Research output: Contribution to journalReview article

NAD(P)H Dehydrogenase (Quinone)
Estrogen Receptor Modulators
Therapeutic Uses
Tamoxifen
Estrogen Receptors

Expression of steroid hormone receptors in BRCA1-associated ovarian carcinomas

Aghmesheh, M., Edwards, L., Clarke, C. L., Byth, K., Katzenellenbogen, B. S., Russell, P. J., Friedlander, M., Tucker, K. M. & De Fazio, A., Apr 2005, In : Gynecologic Oncology. 97, 1, p. 16-25 10 p.

Research output: Contribution to journalArticle

Steroid Receptors
Estrogen Receptors
Ovarian Neoplasms
Hormones
Carcinoma

Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo

Park, S. E., Xu, J., Frolova, A., Liao, L., O'Malley, B. W. & Katzenellenbogen, B. S., Mar 1 2005, In : Molecular and cellular biology. 25, 5, p. 1989-1999 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Uterus
Wild Animals
Genes

Indazole estrogens: Highly selective ligands for the estrogen receptor β

De Angelis, M., Stossi, F., Carlson, K. A., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Feb 24 2005, In : Journal of Medicinal Chemistry. 48, 4, p. 1132-1144 13 p.

Research output: Contribution to journalArticle

Indazoles
Estrogen Receptors
Estradiol
Estrogens
Ligands

Isocoumarins as estrogen receptor beta selective ligands: Isomers of isoflavone phytoestrogens and their metabolites

De Angelis, M., Stossi, F., Waibel, M., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Dec 1 2005, In : Bioorganic and Medicinal Chemistry. 13, 23, p. 6529-6542 14 p.

Research output: Contribution to journalArticle

Isocoumarins
Phytoestrogens
Estrogen Receptor beta
Isoflavones
Metabolites

Synthesis and evaluation of estrogen receptor ligands with bridged oxabicyclic cores containing a diarylethylene motif: Estrogen antagonists of unusual structure

Zhou, H. B., Comninos, J. S., Stossi, F., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Nov 17 2005, In : Journal of Medicinal Chemistry. 48, 23, p. 7261-7274 14 p.

Research output: Contribution to journalArticle

Estrogen Antagonists
Estrogen Receptors
Ligands
Transcription
Non-Steroidal Estrogens

The androgen derivative 5α-androstane-3β,17β-diol inhibits prostate cancer cell migration through activation of the estrogen receptor β subtype

Guerini, V., Sau, D., Scaccianoce, E., Rusmini, P., Ciana, P., Maggi, A., Martini, P. G. V., Katzenellenbogen, B. S., Martini, L., Motta, M. & Poletti, A., Jun 15 2005, In : Cancer Research. 65, 12, p. 5445-5453 9 p.

Research output: Contribution to journalArticle

Androstane-3,17-diol
Estrogen Receptors
Androgens
Cell Movement
Prostatic Neoplasms

Thyroid hormone can increase estrogen-mediated transcription from a consensus estrogen response element in neuroblastoma cells

Zhao, X., Lorenc, H., Stephenson, H., Wang, Y. J., Witherspoon, D., Katzenellenbogen, B., Pfaff, D. & Vasudevan, N., Mar 29 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 13, p. 4890-4895 6 p.

Research output: Contribution to journalArticle

Response Elements
Neuroblastoma
Thyroid Hormones
Consensus
Estrogens
2006

ERα and ERβ expression and transcriptional activity are differentially regulated by HDAC inhibitors

Duong, V., Licznar, A., Margueron, R., Boulle, N., Busson, M., Lacroix, M., Katzenellenbogen, B. S., Cavaillès, V. & Lazennec, G., Mar 16 2006, In : Oncogene. 25, 12, p. 1799-1806 8 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Neoplasms
Cell Cycle Checkpoints
HeLa Cells
Estrogens

Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action

Harrington, W. R., Kim, S. H., Funk, C. C., Madak-Erdogan, Z., Schiff, R., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Mar 1 2006, In : Molecular Endocrinology. 20, 3, p. 491-502 12 p.

Research output: Contribution to journalArticle

Dendrimers
Estrogens
Estradiol
Breast Neoplasms
Genes

Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter

Stossi, F., Likhite, V. S., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jun 16 2006, In : Journal of Biological Chemistry. 281, 24, p. 16272-16278 7 p.

Research output: Contribution to journalArticle

Cyclin G2
Gene expression
Estrogen Receptors
Estrogens
Gene Expression

Estrogen regulation of the glucuronidation enzyme UGT2B15 in estrogen receptor-positive breast cancer cells

Harrington, W. R., Sengupta, S. & Katzenellenbogen, B. S., Jul 24 2006, In : Endocrinology. 147, 8, p. 3843-3850 8 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Breast Neoplasms
Enzymes
Glucuronosyltransferase

Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome

Frasor, J., Chang, E. C., Komm, B., Lin, C. Y., Vega, V. B., Liu, E. T., Miller, L. D., Smeds, J., Bergh, J. & Katzenellenbogen, B. S., Jul 15 2006, In : Cancer Research. 66, 14, p. 7334-7340 7 p.

Research output: Contribution to journalArticle

Tamoxifen
Breast Neoplasms
Gene Expression
Estrogen Receptors
Genes

Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland

Mussi, P., Liao, L., Park, S. E., Ciana, P., Maggi, A., Katzenellenbogen, B. S., Xu, J. & O'Malley, B. W., Nov 7 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 45, p. 16716-16721 6 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Co-Repressor Proteins
Human Mammary Glands
Estrogen Receptors
Estrogens

Impact of estrogen receptor β on gene networks regulated by estrogen receptor α in breast cancer cells

Chang, E. C., Frasor, J., Komm, B. & Katzenellenbogen, B. S., Sep 22 2006, In : Endocrinology. 147, 10, p. 4831-4842 12 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Estrogen Receptors
Breast Neoplasms
Gene Expression
Genes

In memoriam: Jack Gorski (1931-2006).

Katzenellenbogen, B. S., Nov 2006, In : Molecular endocrinology (Baltimore, Md.). 20, 11, p. 2611-2612 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Endocrinology
Tamoxifen
Estrogen Receptors
Estrogens
Phosphotransferases
Phosphorylation

Metabolite ligands of estrogen receptor-β reduce primate coronary hyperreactivity

Mishra, R. G., Stanczyk, F. Z., Burry, K. A., Oparil, S., Katzenellenbogen, B. S., Nealen, M. L., Katzenellenbogen, J. A. & Hermsmeyer, R. K., Jan 1 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 290, 1, p. H295-H303

Research output: Contribution to journalArticle

Thromboxane Receptors
Estrogen Receptors
Primates
Blood Vessels
Muscle Cells

Salicylaldoximes and anthranylaldoximes as alternatives to phenol-based estrogen receptor ligands

Minutolo, F., Bertini, S., Martinelli, A., Ortore, G., Placanica, G., Prota, G., Rapposelli, S., Tuccinardi, T., Sheng, S., Carlson, K. E., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Macchia, M., Jun 24 2006, In : Arkivoc. 2006, 8, p. 83-94 12 p.

Research output: Contribution to journalArticle

Phenol
Estrogen Receptors
Ligands
Estrogens
Oximes
2007

Elemental Isomerism: A Boron-Nitrogen Surrogate for a Carbon-Carbon Double Bond Increases the Chemical Diversity of Estrogen Receptor Ligands

Zhou, H. B., Nettles, K. W., Bruning, J. B., Kim, Y., Joachimiak, A., Sharma, S., Carlson, K. E., Stossi, F., Katzenellenbogen, B. S., Greene, G. L. & Katzenellenbogen, J. A., Jun 25 2007, In : Chemistry and Biology. 14, 6, p. 659-669 11 p.

Research output: Contribution to journalArticle

Non-Steroidal Estrogens
Isomerism
Boron
Estrogen Receptors
Cyclofenil

Estrogen-regulated gene networks in human breast cancer cells: Involvement of E2F1 in the regulation of cell proliferation

Stender, J. D., Frasor, J., Komm, B., Chang, K. C. N., Kraus, W. L. & Katzenellenbogen, B. S., Sep 1 2007, In : Molecular Endocrinology. 21, 9, p. 2112-2123 12 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Estrogens
Cell Proliferation
Breast Neoplasms
Estrogen Receptors

Lipin1 regulation by estrogen in uterus and liver: Implications for diabetes and fertility

Gowri, P. M., Sengupta, S., Bertera, S. & Katzenellenbogen, B. S., Aug 1 2007, In : Endocrinology. 148, 8, p. 3685-3693 9 p.

Research output: Contribution to journalArticle

Uterus
Fertility
Estrogens
Liver
Lipids

Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains

Zhou, H. B., Sheng, S., Compton, D. R., Kim, Y., Joachimiak, A., Sharma, S., Carlson, K. E., Katzenellenbogen, B. S., Nettles, K. W., Greene, G. L. & Katzenellenbogen, J. A., Jan 25 2007, In : Journal of Medicinal Chemistry. 50, 2, p. 399-403 5 p.

Research output: Contribution to journalArticle

Pyrimidines
Estrogen Receptors
Ligands
Estrogen Receptor Antagonists

Whole-genome cartography of estrogen receptor α binding sites

Lin, C. Y., Vega, V. B., Thomsen, J. S., Zhang, T., Say, L. K., Xie, M., Kuo, P. C., Lipovich, L., Barnett, D. H., Stossi, F., Yeo, A., George, J., Kuznetsov, V. A., Yew, K. L., Tze, H. C., Palanisamy, N., Miller, L. D., Cheung, E., Katzenellenbogen, B. S., Ruan, Y. & 3 others, Bourque, G., Wei, C. L. & Liu, E. T., Jun 1 2007, In : PLoS genetics. 3, 6, p. 867-885 19 p.

Research output: Contribution to journalArticle

cartography
Estrogen Receptors
binding sites
genome
Binding Sites
2008

A human estrogen receptor (ER)α mutation with differential responsiveness to nonsteroidal ligands: Novel approaches for studying mechanism of ER action

Paulmurugan, R., Tamrazi, A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Gambhir, S. S., Jul 1 2008, In : Molecular Endocrinology. 22, 7, p. 1552-1564 13 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Ligands
Mutation
Estradiol
Transcriptional Activation

A repressive role for prohibitin in estrogen signaling

He, B., Feng, Q., Mukherjee, A., Lonard, D. M., DeMayo, F. J., Katzenellenbogen, B. S., Lydon, J. P. & O'Malley, B. W., Feb 1 2008, In : Molecular Endocrinology. 22, 2, p. 344-360 17 p.

Research output: Contribution to journalArticle

Estrogens
Co-Repressor Proteins
Estrogen Receptors
prohibitin
Protein Stability

Corrigendum: NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses (Nature Chemical Biology (2008) 4, (241-247))

Nettles, K. W., Bruning, J. B., Gil, G., Nowak, J., Sharma, S. K., Hahm, J. B., Kulp, K., Hochberg, R. B., Zhou, H., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Kim, Y., Joachimiak, A. & Greene, G. L., Jun 2008, In : Nature chemical biology. 4, 6, 1 p.

Research output: Contribution to journalComment/debate

Estrogen Receptors
Ligands
corrigendum
Keratin-13
Selective Estrogen Receptor Modulators
Gene expression
Estradiol
Estrogen Receptors

Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer

Barnett, D. H., Sheng, S., Charn, T. H., Waheed, A., Sly, W. S., Lin, C. Y., Liu, E. T. & Katzenellenbogen, B. S., May 1 2008, In : Cancer Research. 68, 9, p. 3505-3515 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Estrogens
Nuclear Receptor Coactivator 2
Genes

Estrogen receptors α and β as determinants of gene expression: Influence of ligand, dose, and chromatin binding

Chang, E. C., Charn, T. H., Park, S. H., Helferich, W. G., Komm, B., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., May 1 2008, In : Molecular Endocrinology. 22, 5, p. 1032-1043 12 p.

Research output: Contribution to journalArticle

Genistein
Estrogen Receptors
Chromatin
Ligands
Gene Expression

Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor β

Minutolo, F., Bellini, R., Bertini, S., Carboni, I., Lapucci, A., Pistolesi, L., Prota, G., Rapposelli, S., Solati, F., Tuccinardi, T., Martinelli, A., Stossi, F., Carlson, K. E., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Macchia, M., Mar 13 2008, In : Journal of Medicinal Chemistry. 51, 5, p. 1344-1351 8 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Ligands
Halogens
Phenols
Cross Reactions

NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

Nettles, K. W., Bruning, J. B., Gil, G., Nowak, J., Sharma, S. K., Hahm, J. B., Kulp, K., Hochberg, R. B., Zhou, H., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Kim, Y., Joachmiak, A. & Greene, G. L., Apr 2008, In : Nature chemical biology. 4, 4, p. 241-247 7 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Steroid Receptors
Crystallization
Ligands
Hormones

Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors

Madak-Erdogan, Z., Kieser, K. J., Sung, H. K., Komm, B., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Sep 1 2008, In : Molecular Endocrinology. 22, 9, p. 2116-2127 12 p.

Research output: Contribution to journalArticle

Gene Expression Regulation
Estrogen Receptors
Dendrimers
Estrogens
Genes

The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells

Alyea, R. A., Laurence, S. E., Kim, S. H., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Watson, C. S., Aug 1 2008, In : Journal of Neurochemistry. 106, 4, p. 1525-1533 9 p.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
Estrogen Receptors
Dopamine
Membranes
G-Protein-Coupled Receptors
2009

A case of premature thelarche with no central cause or genetic variants within the estrogen receptor signaling pathway

Hartmaier, R. J., Walenkamp, M. J. E., Richter, A. S., Wang, J., Katzenellenbogen, B. S., Oesterreich, S. & Wit, J. M., 2009, In : Journal of Pediatric Endocrinology and Metabolism. 22, 8, p. 751-758 8 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Hormones
Breast
Serum

Analogs of methyl-piperidinopyrazole (MPP): Antiestrogens with estrogen receptor α selective activity

Zhou, H. B., Carlson, K. E., Stossi, F., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Jan 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 1, p. 108-110 3 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Estrogen Receptors
Ether
Estrogens
Ligands

Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta

Waibel, M., De Angelis, M., Stossi, F., Kieser, K. J., Carlson, K. E., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Sep 1 2009, In : European Journal of Medicinal Chemistry. 44, 9, p. 3412-3424 13 p.

Research output: Contribution to journalArticle

Stilbenes
Estrogen Receptor beta
Estrogen Receptors
Ligands
Atoms

Distinct roles for AF-1 and -2 of ER-alpha in regulation of MMP-13 promoter activity

Achari, Y., Lu, T., Katzenellenbogen, B. S. & Hart, D. A., Mar 1 2009, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1792, 3, p. 211-220 10 p.

Research output: Contribution to journalArticle

Furylfuramide
Matrix Metalloproteinases
Transcription Factor AP-1
Mutagenesis
Transcriptional Activation

Estrogen receptor alpha represses transcription of early target genes via p300 and CtBP1

Stossi, F., Madak-Erdogan, Z. & Katzenellenbogen, B. S., Apr 1 2009, In : Molecular and cellular biology. 29, 7, p. 1749-1759 11 p.

Research output: Contribution to journalArticle

Genetic Transcription
Estrogen Receptor alpha
Estrogens
Genes
Binding Sites

Phenethyl pyridines with non-polar internal substitutents as selective ligands for estrogen receptor beta

Waibel, M., Kieser, K. J., Carlson, K. E., Stossi, F., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Sep 1 2009, In : European Journal of Medicinal Chemistry. 44, 9, p. 3560-3570 11 p.

Research output: Contribution to journalArticle

Pyridines
Estrogen Receptor beta
Ligands
Picolines
Alkylation
Chemokine Receptors
Estrogen Receptors
Estrogens
Breast Neoplasms
MCF-7 Cells
2010

Activation of ERα is necessary for estradiol's anorexigenic effect in female rats

Santollo, J., Katzenellenbogen, B. S., Katzenellenbogen, J. A. & Eckel, L. A., Nov 1 2010, In : Hormones and Behavior. 58, 5, p. 872-877 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estradiol
Eating
Hormones

Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs)

Kieser, K. J., Kim, D. W., Carlson, K. E., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Apr 22 2010, In : Journal of Medicinal Chemistry. 53, 8, p. 3320-3329 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Ligands
Cyclofenil
Ether
Hormones

Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis

Wong, W. P. S., Tiano, J. P., Liu, S., Hewitt, S. C., Le May, C., Dalle, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Korach, K. S. & Mauvais-Jarvis, F., Jul 20 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 29, p. 13057-13062 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Insulin
Response Elements
Islets of Langerhans
Estrogens

Genome-wide analysis of estrogen receptor α DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation

Stender, J. D., Kim, K., Charn, T. H., Komm, B., Chang, K. C. N., Kraus, W. L., Benner, C., Glass, C. K. & Katzenellenbogen, B. S., Aug 1 2010, In : Molecular and cellular biology. 30, 16, p. 3943-3955 13 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Estrogen Receptors
Transcriptional Activation
Genome
Response Elements

Genome-wide dynamics of chromatin binding of estrogen receptors α and β: Mutual restriction and competitive site selection

Charn, T. H., Liu, E. T. B., Chang, E. C., Lee, Y. K., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jan 1 2010, In : Molecular Endocrinology. 24, 1, p. 47-59 13 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Chromatin
Binding Sites
Genome
Cytoplasmic and Nuclear Receptors

Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice

Chambliss, K. L., Wu, Q., Oltmann, S., Konaniah, E. S., Umetani, M., Korach, K. S., Thomas, G. D., Mineo, C., Yuhanna, I. S., Kim, S. H., Madak-Erdogan, Z., Maggi, A., Dineen, S. P., Roland, C. L., Hui, D. Y., Brekken, R. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Shaul, P. W., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2319-2330 12 p.

Research output: Contribution to journalArticle

Uterine Neoplasms
Dendrimers
Estrogen Receptors
Estrogens
Breast Neoplasms

Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects

Marshall, G. M., Gherardi, S., Xu, N., Neiron, Z., Trahair, T., Scarlett, C. J., Chang, D. K., Liu, P. Y., Jankowski, K., Iraci, N., Haber, M., Norris, M. D., Keating, J., Sekyere, E., Jonquieres, G., Stossi, F., Katzenellenbogen, B. S., Biankin, A. V., Perini, G. & Liu, T., Nov 4 2010, In : Oncogene. 29, 44, p. 5957-5968 12 p.

Research output: Contribution to journalArticle

Cyclin G2
Histone Deacetylase 2
Histone Deacetylases
Up-Regulation
Neuroblastoma
2011

Estrogen receptor β ligands: Recent advances and biomedical applications

Minutolo, F., Macchia, M., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., May 1 2011, In : Medicinal Research Reviews. 31, 3, p. 364-442 79 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Ligands
Non-Steroidal Estrogens
Therapeutic Uses
Endometriosis