Auinash Kalsotra

20012019
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Research Output 2001 2019

2019

Cell-type specific polysome profiling from mammalian tissues

Seimetz, J., Arif, W., Bangru, S., Hernaez, M. & Kalsotra, A., Feb 15 2019, In : Methods. 155, p. 131-139 9 p.

Research output: Contribution to journalArticle

Polyribosomes
Tissue
Messenger RNA
Workflow
Gene Expression Regulation

Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1

Lee, J. Y., Bai, Y., Chembazhi, U. V., Peng, S., Yum, K., Luu, L. M., Hagler, L. D., Serrano, J. F., Edwin Chan, H. Y., Kalsotra, A. & Zimmerman, S. C., Apr 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 18, p. 8709-8714 6 p.

Research output: Contribution to journalArticle

Myotonic Dystrophy
Ligands
Permeability
Cell-Penetrating Peptides
RNA
2018

Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration

Bangru, S., Arif, W., Seimetz, J., Bhate, A., Chen, J., Rashan, E. H., Carstens, R. P., Anakk, S. & Kalsotra, A., Oct 2018, In : Nature Structural and Molecular Biology. 25, 10, p. 928-939 12 p.

Research output: Contribution to journalArticle

Liver Regeneration
Alternative Splicing
Hepatocytes
Wounds and Injuries
Protein Isoforms

Deregulation of RNA metabolism in microsatellite expansion diseases

Misra, C., Lin, F. & Kalsotra, A., Jan 1 2018, Advances in Neurobiology. Springer New York LLC, p. 213-238 26 p. (Advances in Neurobiology; vol. 20).

Research output: Chapter in Book/Report/Conference proceedingChapter

Deregulation
Metabolism
Microsatellite Repeats
Trinucleotide Repeat Expansion
RNA

Erratum: Correction: Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress (PLoS biology (2015) 13 7 (e1002197))

Jaiswal, M., Haelterman, N. A., Sandoval, H., Xiong, B., Donti, T., Kalsotra, A., Yamamoto, S., Cooper, T. A., Graham, B. H. & Bellen, H. J., Mar 1 2018, In : PLoS biology. 16, 3, p. e1002622

Research output: Contribution to journalComment/debate

Open Access
Oxidative stress
photoreceptors
Oxidative Stress
oxidative stress
Light
2017

Intersections of post-transcriptional gene regulatory mechanisms with intermediary metabolism

Arif, W., Datar, G. & Kalsotra, A., Mar 1 2017, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1860, 3, p. 349-362 14 p.

Research output: Contribution to journalReview article

Regulator Genes
Metabolism
Genes
Enzymes
Allosteric Regulation

Maternal dead-end 1 promotes translation of nanos1 by binding the eiF3 complex

Aguero, T., Jin, Z., Chorghade, S., Kalsotra, A., King, M. L. & Yang, J., Oct 15 2017, In : Development (Cambridge). 144, 20, p. 3755-3765 11 p.

Research output: Contribution to journalArticle

germ cell
embryo
Germ Cells
Mothers
Fertilization

Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity

Liu, D. C., Seimetz, J., Lee, K. Y., Kalsotra, A., Chung, H. J., Lu, H. & Tsai, N-P., Oct 15 2017, In : Human molecular genetics. 26, 20, p. 3895-3908 14 p.

Research output: Contribution to journalArticle

Fragile X Mental Retardation Protein
Protein Biosynthesis
Fragile X Syndrome
Neuronal Plasticity
Animal Behavior

Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain

Skariah, G., Seimetz, J., Norsworthy, M., Lannom, M. C., Kenny, P. J., Elrakhawy, M., Forsthoefel, C., Drnevich, J., Kalsotra, A. & Ceman, S. S., Jun 29 2017, In : BMC Biology. 15, 1, 54.

Research output: Contribution to journalArticle

Moloney murine leukemia virus
Retroelements
retrotransposons
leukemia
Viruses

Myotonic dystrophy: disease repeat range, penetrance, age of onset, and relationship between repeat size and phenotypes

Yum, K., Wang, E. T. & Kalsotra, A., Jun 1 2017, In : Current Opinion in Genetics and Development. 44, p. 30-37 8 p.

Research output: Contribution to journalReview article

Myotonic Dystrophy
Penetrance
Genetic Testing
Age of Onset
Myotonia

Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

Chorghade, S., Seimetz, J., Emmons, R., Yang, J., Bresson, S. M., de Lisio, M., Parise, G., Conrad, N. K. & Kalsotra, A., Jun 27 2017, In : eLife. 6, e24139.

Research output: Contribution to journalArticle

Poly(A)-Binding Protein I
Messenger RNA
Poly(A)-Binding Proteins
Cardiomegaly
Protein Biosynthesis

RNA modifications and structures cooperate to guide RNA-protein interactions

Lewis, C. J. T., Pan, T. & Kalsotra, A., Mar 1 2017, In : Nature Reviews Molecular Cell Biology. 18, 3, p. 202-210 9 p.

Research output: Contribution to journalReview article

Guide RNA
RNA
Proteins
Transcriptome
Gene Expression
2016
Transcriptome
Lenses
RNA
Polyadenylation
Data handling
2015

Developmental insights into the pathology of and therapeutic strategies for DM1: Back to the basics

Chau, A. & Kalsotra, A., Mar 1 2015, In : Developmental Dynamics. 244, 3, p. 377-390 14 p.

Research output: Contribution to journalReview article

Poisons
Trinucleotide Repeat Expansion
RNA
Fetal Proteins
Pathology

ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation

Bhate, A., Parker, D. J., Bebee, T. W., Ahn, J., Arif, W., Rashan, E. H., Chorghade, S., Chau, A., Lee, J. H., Anakk, S., Carstens, R. P., Xiao, X. & Kalsotra, A., Nov 4 2015, In : Nature communications. 6, 8768.

Research output: Contribution to journalArticle

Protein Splicing
splicing
liver
Liver
Hepatocytes

Impaired mitochondrial energy production causes light-induced photoreceptor degeneration independent of oxidative stress

Jaiswal, M., Haelterman, N. A., Sandoval, H., Xiong, B., Donti, T., Kalsotra, A., Yamamoto, S., Cooper, T. A., Graham, B. H. & Bellen, H. J., Jan 1 2015, In : PLoS biology. 13, 7

Research output: Contribution to journalArticle

Oxidative stress
photoreceptors
Oxidative Stress
oxidative stress
Light

Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation

Li, W., You, B., Hoque, M., Zheng, D., Luo, W., Ji, Z., Park, J. Y., Gunderson, S. I., Kalsotra, A., Manley, J. L. & Tian, B., Apr 1 2015, In : PLoS Genetics. 11, 4, e1005166.

Research output: Contribution to journalArticle

Polyadenylation
Poly A
3' untranslated regions
cleavage
introns

Uncovering RNA binding proteins associated with age and gender during liver maturation

Chaturvedi, P., Neelamraju, Y., Arif, W., Kalsotra, A. & Janga, S. C., Jan 1 2015, In : Scientific Reports. 5, 9512.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Liver
Protein Interaction Maps
Gene Expression
Cluster Analysis
2014

Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development

Giudice, J., Xia, Z., Wang, E. T., Scavuzzo, M. A., Ward, A. J., Kalsotra, A., Wang, W., Wehrens, X. H. T., Burge, C. B., Li, W. & Cooper, T. A., Apr 22 2014, In : Nature communications. 5, 3603.

Research output: Contribution to journalArticle

splicing
Alternative Splicing
Cardiac Myocytes
genes
Genes

Rbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis

Singh, R. K., Xia, Z., Bland, C. S., Kalsotra, A., Scavuzzo, M. A., Curk, T., Ule, J., Li, W. & Cooper, T. A., Aug 21 2014, In : Molecular cell. 55, 4, p. 592-603 12 p.

Research output: Contribution to journalArticle

Muscle Development
Myoblasts
Alternative Splicing
Protein Isoforms
RNA-Binding Proteins

The Mef2 transcription network is disrupted in myotonic dystrophy heart tissue, dramatically altering miRNA and mRNA expression

Kalsotra, A., Singh, R. K., Gurha, P., Ward, A. J., Creighton, C. J. & Cooper, T. A., Jan 10 2014, In : Cell Reports. 6, 2, p. 336-345 10 p.

Research output: Contribution to journalArticle

Myotonic Dystrophy
Transcription
MicroRNAs
Tissue
Messenger RNA
2011

Functional consequences of developmentally regulated alternative splicing

Kalsotra, A. & Cooper, T. A., Oct 1 2011, In : Nature Reviews Genetics. 12, 10, p. 715-729 15 p.

Research output: Contribution to journalReview article

Alternative Splicing
Biological Phenomena
Messenger RNA
Gene Expression Profiling
Transcriptome
2010

MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development

Kalsotra, A., Wang, K., Li, P. F. & Cooper, T. A., Apr 1 2010, In : Genes and Development. 24, 7, p. 653-658 6 p.

Research output: Contribution to journalArticle

Alternative Splicing
MicroRNAs
Vertebrates
Myocardium
Up-Regulation
2008

A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart

Kalsotra, A., Xiao, X., Ward, A. J., Castle, J. C., Johnson, J. M., Burge, C. B. & Cooper, T. A., Dec 23 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 51, p. 20333-20338 6 p.

Research output: Contribution to journalArticle

Alternative Splicing
Proteins
Knockout Mice
Introns
Transgenic Mice

CYP4Fs expression in rat brain correlates with changes in LTB4 levels after traumatic brain injury

Wang, Y., Zhao, J., Kalsotra, A., Turman, C. M., Grill, R. J., Dash, P. K. & Strobel, H. W., Oct 1 2008, In : Journal of Neurotrauma. 25, 10, p. 1187-1194 8 p.

Research output: Contribution to journalArticle

Leukotriene B4
Wounds and Injuries
Brain
Astrocytes
Cytochrome P-450 Enzyme System

Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines

Castle, J. C., Zhang, C., Shah, J. K., Kulkarni, A. V., Kalsotra, A., Cooper, T. A. & Johnson, J. M., Dec 1 2008, In : Nature Genetics. 40, 12, p. 1416-1425 10 p.

Research output: Contribution to journalArticle

Alternative Splicing
Exons
Cell Line
Heterogeneous-Nuclear Ribonucleoprotein Group F-H
RNA Splicing

Inflammation resolved by retinoid X receptor-mediated inactivation of leukotriene signaling pathways

Kalsotra, A., Du, L., Wang, Y., Ladd, P. A., Kikuta, Y., Duvic, M., Boyd, A. S., Keeney, D. S. & Strobel, H. W., Feb 1 2008, In : FASEB Journal. 22, 2, p. 538-547 10 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
leukotrienes
retinoids
Leukotrienes
inactivation
2007

Brain trauma leads to enhanced lung inflammation and injury: Evidence for role of P4504Fs in resolution

Kalsotra, A., Zhao, J., Anakk, S., Dash, P. K. & Strobel, H. W., May 16 2007, In : Journal of Cerebral Blood Flow and Metabolism. 27, 5, p. 963-974 12 p.

Research output: Contribution to journalArticle

Lung Injury
Leukotriene B4
Pneumonia
Cytochrome P-450 Enzyme System
Wounds and Injuries

Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytes

Kalsotra, A., Anakk, S., Brommer, C. L., Kikuta, Y., Morgan, E. T. & Strobel, H. W., May 1 2007, In : Archives of Biochemistry and Biophysics. 461, 1, p. 104-112 9 p.

Research output: Contribution to journalArticle

Leukotriene B4
Cytochrome P-450 Enzyme System
Rats
Hepatocytes
Cytokines
2006

Cytochrome P450 4F subfamily: At the crossroads of eicosanoid and drug metabolism

Kalsotra, A. & Strobel, H. W., Dec 1 2006, In : Pharmacology and Therapeutics. 112, 3, p. 589-611 23 p.

Research output: Contribution to journalReview article

Eicosanoids
Cytochrome P-450 Enzyme System
Pharmaceutical Preparations
Protein Isoforms
Inflammation
2005

Renal localization, expression, and developmental regulation of P450 4F cytochromes in three substrains of spontaneously hypertensive rats

Kalsotra, A., Cui, X., Anakk, S., Hinojos, C. A., Doris, P. A. & Strobel, H. W., Dec 9 2005, In : Biochemical and Biophysical Research Communications. 338, 1, p. 423-431 9 p.

Research output: Contribution to journalReview article

Inbred SHR Rats
Cytochrome P-450 Enzyme System
Rats
Kidney
Protein Isoforms
2004

CAR/PXR provides directives for Cyp3a41 gene regulation differently from Cyp3a11

Anakk, S., Kalsotra, A., Kikuta, Y., Huang, W., Zhang, J., Staudinger, J. L., Moore, D. D. & Strobel, H. W., Jan 1 2004, In : Pharmacogenomics Journal. 4, 2, p. 91-101 11 p.

Research output: Contribution to journalArticle

Pregnenolone Carbonitrile
Cytochrome P-450 CYP3A
Protein Isoforms
Genes
Chromosomes, Human, Pair 5

Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids

Kalsotra, A., Turman, C. M., Kikuta, Y. & Strobel, H. W., Sep 15 2004, In : Toxicology and Applied Pharmacology. 199, 3, p. 295-304 10 p.

Research output: Contribution to journalArticle

Eicosanoids
Erythromycin
Metabolism
Hydroxyeicosatetraenoic Acids
Leukotriene B4
2003

Differential Effects of Traumatic Brain Injury on the Cytochrome P450 System: A Perspective into Hepatic and Renal Drug Metabolism

Kalsotra, A., Turman, C. M., Dash, P. K. & Strobel, H. W., Jan 1 2003, In : Journal of Neurotrauma. 20, 12, p. 1339-1350 12 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Kidney
Liver
Pharmaceutical Preparations
Cytochrome P-450 CYP3A

Expression of cytochromes P450 4F4 and 4F5 in infection and injury models of inflammation

Cui, X., Kalsotra, A., Robida, A. M., Matzilevich, D., Moore, A. N., Boehme, C. L., Morgan, E. T., Dash, P. K. & Strobel, H. W., Feb 17 2003, In : Biochimica et Biophysica Acta - General Subjects. 1619, 3, p. 325-331 7 p.

Research output: Contribution to journalArticle

Leukotrienes
Cytochrome P-450 Enzyme System
Prostaglandins
Lipopolysaccharides
Rats

Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors.

Anakk, S., Kalsotra, A., Shen, Q., Vu, M. T., Staudinger, J. L., Davies, P. J. A. & Strobel, H. W., Jan 1 2003, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17, 12, p. 1736-1738 3 p.

Research output: Contribution to journalArticle

Xenobiotics
Cytoplasmic and Nuclear Receptors
Retinoid X Receptor gamma
Ethylmorphine
Benzphetamine

Inflammatory prompts produce isoform-specific changes in the expression of leukotriene B4 ω-hydroxylases in rat liver and kidney

Kalsotra, A., Cui, X., Antonovic, L., Robida, A. M., Morgan, E. T. & Strobel, H. W., Dec 4 2003, In : FEBS Letters. 555, 2, p. 236-242 7 p.

Research output: Contribution to journalArticle

Leukotriene B4
Mixed Function Oxygenases
Liver
Lipopolysaccharides
Rats
2002

Sexual dimorphism and tissue specificity in the expression of CYP4F forms in Sprague Dawley rats

Kalsotra, A., Anakk, S., Boehme, C. L. & Strobel, H. W., Sep 1 2002, In : Drug Metabolism and Disposition. 30, 9, p. 1022-1028 7 p.

Research output: Contribution to journalArticle

Organ Specificity
Sex Characteristics
Sprague Dawley Rats
Rats
Tissue
2001

Behavioural and anti-psychotic effects of Ca2+ channel blockers in rhesus monkey

Palit, G., Kalsotra, A., Kumar, R., Nath, C. & Dubey, M. P., Jan 26 2001, In : European Journal of Pharmacology. 412, 2, p. 139-144 6 p.

Research output: Contribution to journalArticle

Amphetamine
Macaca mulatta
Verapamil
Hyperkinesis
Nimodipine