Angad Pankaj Mehta

2024

Introducing carbon assimilation in yeasts using photosynthetic directed endosymbiosis

Gao, Y. L., Cournoyer, J. E., De, B. C., Wallace, C. L., Ulanov, A. V., La Frano, M. R. & Mehta, A. P., Dec 2024, In: Nature communications. 15, 1, 5947.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Characterization, Directed Evolution, and Targeting of DNA Virus-Encoded RNA Capping Enzymes Using Phenotypic Yeast Platforms

Ornelas, M. Y., Thomas, A. Y., Johnson Rosas, L. I., Medina, G. N. & Mehta, A. P., Aug 18 2023, In: ACS chemical biology. 18, 8, p. 1808-1820 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Engineering artificial photosynthetic life-forms through endosymbiosis

Cournoyer, J. E., Altman, S. D., Gao, Y.-L., Wallace, C. L., Zhang, D., Lo, G.-H., Haskin, N. T. & Mehta, A. P., Dec 2022, In: Nature communications. 13, 1, p. 2254 1 p., 2254.

Research output: Contribution to journal › Article › peer-review

Open Access

Synthetic Platforms for Characterizing and Targeting of SARS-CoV-2 Genome Capping Enzymes

Ornelas, M. Y., Thomas, A. Y., Johnson Rosas, L. I., Scoville, R. O. & Mehta, A. P., Nov 18 2022, In: ACS synthetic biology. 11, 11, p. 3759-3771 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Toward a Synthetic Yeast Endosymbiont with a Minimal Genome

Mehta, A. P., Ko, Y., Supekova, L., Pestonjamasp, K., Li, J. & Schultz, P. G., Sep 4 2019, In: Journal of the American Chemical Society. 141, 35, p. 13799-13802 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

An Aminoimidazole Radical Intermediate in the Anaerobic Biosynthesis of the 5,6-Dimethylbenzimidazole Ligand to Vitamin B12

Gagnon, D. M., Stich, T. A., Mehta, A. P., Abdelwahed, S. H., Begley, T. P. & Britt, R. D., Oct 10 2018, In: Journal of the American Chemical Society. 140, 40, p. 12798-12807 10 p.

Research output: Contribution to journal › Article › peer-review

Bacterial Genome Containing Chimeric DNA-RNA Sequences

Mehta, A. P., Wang, Y., Reed, S. A., Supekova, L., Javahishvili, T., Chaput, J. C. & Schultz, P. G., Sep 12 2018, In: Journal of the American Chemical Society. 140, 36, p. 11464-11473 10 p.

Research output: Contribution to journal › Article › peer-review

Engineering yeast endosymbionts as a step toward the evolution of mitochondria

Mehta, A. P., Supekova, L., Chen, J. H., Pestonjamasp, K., Webster, P., Ko, Y., Henderson, S. C., McDermott, G., Supek, F. & Schultz, P. G., Nov 13 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 46, p. 11796-11801 6 p.

Research output: Contribution to journal › Article › peer-review

Enhancing Protein Stability with Genetically Encoded Noncanonical Amino Acids

Li, J. C., Liu, T., Wang, Y., Mehta, A. P. & Schultz, P. G., Nov 28 2018, In: Journal of the American Chemical Society. 140, 47, p. 15997-16000 4 p.

Research output: Contribution to journal › Article › peer-review

Progress toward a reduced phage genetic code

Yao, A., Reed, S. A., Koh, M., Yu, C., Luo, X., Mehta, A. P. & Schultz, P. G., Oct 15 2018, In: Bioorganic and Medicinal Chemistry. p. 5247-5252 6 p.

Research output: Contribution to journal › Article › peer-review

2017

Recombinant Macrocyclic Lanthipeptides Incorporating Non-Canonical Amino Acids

Zambaldo, C., Luo, X., Mehta, A. P. & Schultz, P. G., Aug 30 2017, In: Journal of the American Chemical Society. 139, 34, p. 11646-11649 4 p.

Research output: Contribution to journal › Article › peer-review

2016

Identification of the first riboflavin catabolic gene cluster isolated from microbacterium maritypicum G10

Xu, H., Chakrabarty, Y., Philmus, B., Mehta, A. P., Bhandari, D., Hohmann, H. P. & Begley, T. P., Nov 4 2016, In: Journal of Biological Chemistry. 291, 45, p. 23506-23515 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Replacement of 2′-Deoxycytidine by 2′-Deoxycytidine Analogues in the E. coli Genome

Mehta, A. P., Li, H., Reed, S. A., Supekova, L., Javahishvili, T. & Schultz, P. G., Nov 2 2016, In: Journal of the American Chemical Society. 138, 43, p. 14230-14233 4 p.

Research output: Contribution to journal › Article › peer-review

Replacement of Thymidine by a Modified Base in the Escherichia coli Genome

Mehta, A. P., Li, H., Reed, S. A., Supekova, L., Javahishvili, T. & Schultz, P. G., Jun 15 2016, In: Journal of the American Chemical Society. 138, 23, p. 7272-7275 4 p.

Research output: Contribution to journal › Article › peer-review

2015

Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B₁₂ Biosynthesis

Mehta, A. P., Abdelwahed, S. H., Fenwick, M. K., Hazra, A. B., Taga, M. E., Zhang, Y., Ealick, S. E. & Begley, T. P., Aug 3 2015, In: Journal of the American Chemical Society. 137, 33, p. 10444-10447 4 p.

Research output: Contribution to journal › Article › peer-review

Anaerobic biosynthesis of the lower ligand of vitamin B₁₂

Hazra, A. B., Han, A. W., Mehta, A. P., Mok, K. C., Osadchiy, V., Begley, T. P. & Taga, M. E., Aug 25 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 34, p. 10792-10797 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase

Fenwick, M. K., Mehta, A. P., Zhang, Y., Abdelwahed, S. H., Begley, T. P. & Ealick, S. E., Mar 2015, In: Nature communications. 6, 6480.

Research output: Contribution to journal › Article › peer-review

Open Access

Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: A treasure trove of complex organic radical rearrangement reactions

Mehta, A. P., Abdelwahed, S. H., Mahanta, N., Fedoseyenko, D., Philmus, B., Cooper, L. E., Liu, Y., Jhulki, I., Ealick, S. E. & Begley, T. P., Feb 13 2015, In: Journal of Biological Chemistry. 290, 7, p. 3980-3986 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2014

Molybdopterin biosynthesis: Trapping of intermediates for the MoaA-catalyzed reaction using 2′-deoxyGTP and 2′-chloroGTP as substrate analogues.

Mehta, A. P., Abdelwahed, S. H., Xu, H. & Begley, T. P., Jul 30 2014, In: Journal of the American Chemical Society. 136, 30, p. 10609-10614 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2013

Catalysis of a new ribose carbon-insertion reaction by the molybdenum cofactor biosynthetic enzyme MoaA

Mehta, A. P., Hanes, J. W., Abdelwahed, S. H., Hilmey, D. G., Hänzelmann, P. & Begley, T. P., Feb 19 2013, In: Biochemistry. 52, 7, p. 1134-1136 3 p.

Research output: Contribution to journal › Article › peer-review

High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana

Coquille, S., Roux, C., Mehta, A., Begley, T. P., Fitzpatrick, T. B. & Thore, S., Dec 2013, In: Journal of Structural Biology. 184, 3, p. 438-444 7 p.

Research output: Contribution to journal › Article › peer-review

Molybdopterin biosynthesis: Trapping an unusual purine ribose adduct in the MoaA-catalyzed reaction

Mehta, A. P., Abdelwahed, S. H. & Begley, T. P., Jul 31 2013, In: Journal of the American Chemical Society. 135, 30, p. 10883-10885 3 p.

Research output: Contribution to journal › Article › peer-review

Angad Pankaj Mehta

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