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Research Output

2020

Gene expression amplification by nuclear speckle association

Kim, J., Venkata, N. C., Gonzalez, G. A. H., Khanna, N. & Belmont, A. S., Jan 6 2020, In : Journal of Cell Biology. 219, 1

Research output: Contribution to journalArticle

Open Access
2019

Genome organization around nuclear speckles

Chen, Y. & Belmont, A. S., Apr 2019, In : Current Opinion in Genetics and Development. 55, p. 91-99 9 p.

Research output: Contribution to journalReview article

Nuclear speckle fusion via long-range directional motion regulates speckle morphology after transcriptional inhibition

Kim, J., Han, K. Y., Khanna, N., Ha, T. & Belmont, A. S., Apr 1 2019, In : Journal of cell science. 132, 8, 226563.

Research output: Contribution to journalArticle

Open Access
2018

CRISPR/Cas9-mediated knock-in of an optimized TetO repeat for live cell imaging of endogenous loci

Tasan, I., Sustackova, G., Zhang, L., Kim, J., Sivaguru, M., HamediRad, M., Wang, Y., Genova, J., Ma, J., Belmont, A. S. & Zhao, H., Jan 1 2018, In : Nucleic acids research. 46, 17, e100.

Research output: Contribution to journalArticle

Mapping 3D genome organization relative to nuclear compartments using TSA-Seq as a cytological ruler

Chen, Y., Zhang, Y., Wang, Y., Zhang, L., Brinkman, E. K., Adam, S. A., Goldman, R., Van Steensel, B., Ma, J. & Belmont, A. S., Nov 1 2018, In : Journal of Cell Biology. 217, 11, p. 4025-4048 24 p.

Research output: Contribution to journalArticle

Stable and reproducible transgene expression independent of proliferative or differentiated state using BAC TG-EMBED

Chaturvedi, P., Zhao, B., Zimmerman, D. L. & Belmont, A. S., Aug 1 2018, In : Gene therapy. 25, 5, p. 376-391 16 p.

Research output: Contribution to journalArticle

2017

Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression

van Steensel, B. & Belmont, A. S., May 18 2017, In : Cell. 169, 5, p. 780-791 12 p.

Research output: Contribution to journalReview article

The 4D nucleome project

4D Nucleome Network, Sep 13 2017, In : Nature. 549, 7671, p. 219-226 8 p.

Research output: Contribution to journalReview article

2016

Cytology of DNA Replication Reveals Dynamic Plasticity of Large-Scale Chromatin Fibers

Deng, X., Zhironkina, O. A., Cherepanynets, V. D., Strelkova, O. S., Kireev, I. I. & Belmont, A. S., Sep 26 2016, In : Current Biology. 26, 18, p. 2527-2534 8 p.

Research output: Contribution to journalArticle

Labeling proteins inside living cells using external fluorophores for microscopy

Teng, K. W., Ishitsuka, Y., Ren, P., Youn, Y., Deng, X., Ge, P., Belmont, A. S. & Selvin, P. R., Dec 9 2016, In : eLife. 5, DECEMBER2016, e20378.

Research output: Contribution to journalArticle

Transcription upregulation via force-induced direct stretching of chromatin

Tajik, A., Zhang, Y., Wei, F., Sun, J., Jia, Q., Zhou, W., Singh, R., Khanna, N., Belmont, A. S. & Wang, N., Dec 1 2016, In : Nature Materials. 15, 12, p. 1287-1296 10 p.

Research output: Contribution to journalArticle

2015

CRISPR EATING on a Low Budget

Kaya-Okur, H. S. & Belmont, A. S., Aug 10 2015, In : Developmental cell. 34, 3, p. 253-254 2 p.

Research output: Contribution to journalShort survey

Overcoming steric hindrances during replication of peripheral heterochromatin

Zhironkina, O. A., Kurchashova, S. Y., Brattseva, A. L., Cherepaninets, V. D., Strelkova, O. S., Belmont, A. S. & Kireev, I. I., Mar 1 2015, In : Cell and Tissue Biology. 9, 2, p. 110-118 9 p.

Research output: Contribution to journalArticle

2014

HSP70 transgene directed motion to nuclear speckles facilitates heat shock activation

Khanna, N., Hu, Y. & Belmont, A. S., May 19 2014, In : Current Biology. 24, 10, p. 1138-1144 7 p.

Research output: Contribution to journalArticle

Large-scale chromatin organization: The good, the surprising, and the still perplexing

Belmont, A. S., Feb 1 2014, In : Current Opinion in Cell Biology. 26, 1, p. 69-78 10 p.

Research output: Contribution to journalReview article

Large-scale chromatin structure and dynamics: A combined structural and molecular approach

Deng, X., Sustackova, G., Chen, Y., Khanna, N. & Belmont, A. S., Aug 1 2014, In : Microscopy and Microanalysis. 20, 3, p. 1200-1201 2 p.

Research output: Contribution to journalConference article

Resolution of spatial constraints during replication of peripheral chromatin

Zhironkina, O. A., Kurchashova, S. Y., Bratseva, A. L., Cherepanynets, V. D., Strelkova, O. S., Belmont, A. S. & Kireev, I. I., Jan 1 2014, In : Tsitologiia. 56, 12, p. 899-906 8 p.

Research output: Contribution to journalArticle

2013

BAC manipulations for making BAC transgene arrays

Khanna, N., Bian, Q., Plutz, M. & Belmont, A. S., Jan 1 2013, Imaging Gene Expression: Methods and Protocols. Humana Press Inc., p. 197-210 14 p. (Methods in Molecular Biology; vol. 1042).

Research output: Chapter in Book/Report/Conference proceedingChapter

β-Globin cis-elements determine differential nuclear targeting through epigenetic modifications

Bian, Q., Khanna, N., Alvikas, J. & Belmont, A. S., Dec 9 2013, In : Journal of Cell Biology. 203, 5, p. 767-783 17 p.

Research output: Contribution to journalArticle

2012

Revisiting higher-order and large-scale chromatin organization

Bian, Q. & Belmont, A. S., Jun 1 2012, In : Current Opinion in Cell Biology. 24, 3, p. 359-366 8 p.

Research output: Contribution to journalReview article

2011

Live-cell chromosome dynamics and outcome of X chromosome pairing events during ES cell differentiation

Masui, O., Bonnet, I., Le Baccon, P., Brito, I., Pollex, T., Murphy, N., Hupé, P., Barillot, E., Belmont, A. S. & Heard, E., Apr 29 2011, In : Cell. 145, 3, p. 447-458 12 p.

Research output: Contribution to journalArticle

2010

BAC TG-EMBED: One-step method for high-level, copy-number-dependent, position-independent transgene expression

Bian, Q. & Belmont, A. S., Apr 10 2010, In : Nucleic acids research. 38, 11, p. e127-e127 gkq178.

Research output: Contribution to journalArticle

Dynamic plasticity of large-scale chromatin structure revealed by self-assembly of engineered chromosome regions

Sinclair, P., Bian, Q., Plutz, M., Heard, E. & Belmont, A. S., Sep 6 2010, In : Journal of Cell Biology. 190, 5, p. 761-776 16 p.

Research output: Contribution to journalArticle

Estrogen fueled, nuclear kiss: Did it move for you?

Belmont, A. S., Jan 1 2010, In : Nucleus. 1, 5, 13051.

Research output: Contribution to journalArticle

Hsp70 gene association with nuclear speckles is Hsp70 promoter specific

Hu, Y., Plutz, M. & Belmont, A. S., Nov 15 2010, In : Journal of Cell Biology. 191, 4, p. 711-719 9 p.

Research output: Contribution to journalArticle

Insights into interphase large-scale chromatin structure from analysis of engineered chromosome regions

Belmont, A. S., Hu, Y., Sinclair, P. B., Wu, W., Bian, Q. & Kireev, I., Dec 1 2010, In : Cold Spring Harbor symposia on quantitative biology. 75, p. 453-460 8 p.

Research output: Contribution to journalArticle

2009

Complexity in transcription control at the activation domain-Mediator interface

Balamotis, M. A., Pennella, M. A., Stevens, J. L., Wasylyk, B., Belmont, A. S. & Berk, A. J., May 5 2009, In : Science Signaling. 2, 69, p. ra20

Research output: Contribution to journalArticle

Large-scale chromatin structure of inducible genes: Transcription on a condensed, linear template

Hu, Y., Kireev, I., Plutz, M., Ashourian, N. & Belmont, A. S., Apr 6 2009, In : Journal of Cell Biology. 185, 1, p. 87-100 14 p.

Research output: Contribution to journalArticle

Mitotic chromosome structure: Reproducibility of folding and symmetry between sister chromatids

Strukov, Y. G. & Belmont, A. S., Feb 18 2009, In : Biophysical journal. 96, 4, p. 1617-1628 12 p.

Research output: Contribution to journalArticle

2008

Development of mammalian cells lines with lac operator-tagged chromosomes

Strukov, Y. G. & Belmont, A. S., Jan 1 2008, In : Cold Spring Harbor Protocols. 3, 1

Research output: Contribution to journalArticle

Ectopic histone H3S10 phosphorylation causes chromatin structure remodeling in Drosophila

Deng, H., Bao, X., Cai, W., Blacketer, M. J., Belmont, A. S., Girton, J., Johansen, J. & Johansen, K. M., Feb 2008, In : Development. 135, 4, p. 699-705 7 p.

Research output: Contribution to journalArticle

In vivo immunogold labeling confirms large-scale chromatin folding motifs

Kireev, I., Lakonishok, M., Liu, W., Joshi, V. N., Powell, R. & Belmont, A. S., Apr 1 2008, In : Nature Methods. 5, 4, p. 311-313 3 p.

Research output: Contribution to journalArticle

The facultative heterochromatin of the inactive X chromosome has a distinctive condensed ultrastructure

Rego, A., Sinclair, P. B., Tao, W., Kireev, I. & Belmont, A. S., Apr 1 2008, In : Journal of cell science. 121, 7, p. 1119-1127 9 p.

Research output: Contribution to journalArticle

2007

High-pressure treatment of polytene chromosomes improves structural resolution

Novikov, D. V., Kireev, I. & Belmont, A. S., Jun 1 2007, In : Nature Methods. 4, 6, p. 483-485 3 p.

Research output: Contribution to journalArticle

Moving chromatin within the interphase nucleus-controlled transitions?

Chuang, C. H. & Belmont, A. S., Oct 2007, In : Seminars in Cell and Developmental Biology. 18, 5, p. 698-706 9 p.

Research output: Contribution to journalReview article

2006

Long-Range Directional Movement of an Interphase Chromosome Site

Chuang, C. H., Carpenter, A. E., Fuchsova, B., Johnson, T., de Lanerolle, P. & Belmont, A. S., Apr 18 2006, In : Current Biology. 16, 8, p. 825-831 7 p.

Research output: Contribution to journalArticle

Mitotic chromosome structure and condensation

Belmont, A. S., Dec 1 2006, In : Current Opinion in Cell Biology. 18, 6, p. 632-638 7 p.

Research output: Contribution to journalReview article

Truncated HP1 lacking a functional chromodomain induces heterochromatinization upon in vivo targeting

Brink, M. C., Van Der Velden, Y., De Leeuw, W., Mateos-Langerak, J., Belmont, A. S., Van Driel, R. & Verschure, P. J., Jan 1 2006, In : Histochemistry and Cell Biology. 125, 1-2, p. 53-61 9 p.

Research output: Contribution to journalArticle

2005

Chromatin dynamics in interphase cells revealed by tracking in a two-photon excitation microscope

Levi, V., Ruan, Q. Q., Plutz, M., Belmont, A. S. & Gratton, E., Dec 2005, In : Biophysical journal. 89, 6, p. 4275-4285 11 p.

Research output: Contribution to journalArticle

Close encounters between active genes in the nucleus

Chuang, C. H. & Belmont, A. S., Dec 12 2005, In : Genome biology. 6, 11, 237.

Research output: Contribution to journalShort survey

Common effects of acidic activators on large-scale chromatin structure and transcription

Carpenter, A. E., Memedula, S., Plutz, M. J. & Belmont, A. S., Feb 1 2005, In : Molecular and cellular biology. 25, 3, p. 958-968 11 p.

Research output: Contribution to journalArticle

In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation

Verschure, P. J., Van Der Kraan, I., De Leeuw, W., Van Der Vlag, J., Carpenter, A. E., Belmont, A. S. & Van Driel, R., Jun 2005, In : Molecular and cellular biology. 25, 11, p. 4552-4564 13 p.

Research output: Contribution to journalArticle

2004

Automated Microscopy Identifies Estrogen Receptor Subdomains with Large-Scale Chromatin Structure Unfolding Activity

Carpenter, A. E., Ashouri, A. & Belmont, A. S., Apr 2004, In : Cytometry Part A. 58, 2, p. 157-166 10 p.

Research output: Contribution to journalArticle

Differential large-scale chromatin compaction and intranuclear positioning of transcribed versus nontranscribed transgene arrays containing β-globin regulatory sequences

Dietzel, S., Zolghadr, K., Hepperger, C. & Belmont, A. S., Sep 1 2004, In : Journal of cell science. 117, 19, p. 4603-4614 12 p.

Research output: Contribution to journalArticle

Upstream binding factor association induces large-scale chromatin decondensation

Chen, D., Belmont, A. S. & Huang, S., Oct 19 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 42, p. 15106-15111 6 p.

Research output: Contribution to journalArticle

Visualization of early chromosome condensation: A hierarchical folding, axial glue model of chromosome structure

Kireeva, N., Lakonishok, M., Kireev, I., Hirano, T. & Belmont, A. S., Sep 13 2004, In : Journal of Cell Biology. 166, 6, p. 775-785 11 p.

Research output: Contribution to journalArticle

2003

Direct Visualization of Transcription Factor-Induced Chromatin Remodeling and Cofactor Recruitment In Vivo

Carpenter, A. E. & Belmont, A. S., Jan 1 2003, In : Methods in enzymology. 375, p. 366-381 16 p.

Research output: Contribution to journalArticle

Dynamics of chromatin, proteins, and bodies within the cell nucleus

Belmont, A. S., Jun 2003, In : Current Opinion in Cell Biology. 15, 3, p. 304-310 7 p.

Research output: Contribution to journalReview article

Effects of tethering HP1 to euchromatic regions of the Drosophila genome

Li, Y., Danzer, J. R., Alvarez, P., Belmont, A. S. & Wallrath, L. L., May 1 2003, In : Development. 130, 9, p. 1817-1824 8 p.

Research output: Contribution to journalReview article

Engineered chromosome regions with altered sequence composition demonstrate hierarchical large-scale folding within metaphase chromosomes

Strukov, Y. G., Wang, Y. & Belmont, A. S., Jul 7 2003, In : Journal of Cell Biology. 162, 1, p. 23-35 13 p.

Research output: Contribution to journalArticle