Research output per year
Research output per year
Personal profile
Research Interests
Research Topics
Chromatin Structure, Imaging, Regulation of Gene Expression
Education
A.B., Princeton University (Physics)
M.D./Ph.D., Temple University (Biophysics)
Postdoc., University of California-San Francisco
Professional Information
Chromatin Structure, Gene expression, Nuclear Architecture
We are interested in how 10 and 30 nm chromatin fibers fold into interphase and mitotic chromosomes, how interphase chromosomes are moved and positioned within nuclei, and what this means for DNA functions such as transcription and replication. Currently, our understanding of these higher levels of chromatin organization, which we refer to as large-scale chromatin structure, is poor. We use a combination of molecular biology, cell biology, genetics, and microscopy to visualize nuclear positioning and folding dynamics of specific chromosome regions and individual gene loci and to relate this to regulation of transcription and replication.
Most recently we have begun to apply our knowledge of chromosome dynamics to design improved tools for gene therapy and biotechnology. We have also developed TSA-Seq, a new genomic method providing a direct readout of how interphase chromosomes are positioned within nuclei.
Office Address
Dept of Cell and Developmental Biology
University of Illinois
B107
601 S. Goodwin Avenue
Urbana, IL 61801
Office Phone
(217) 244-2311
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Imaging Method Using CRISPR/dCas9 and Engineered gRNA Scaffolds Can Perturb Replication Timing at the HSPA1 Locus
Xiong, X., Tasan, I., Yang, C., Zhang, M., Hernandez Gonzalez, G. A., Liu, S., Chaturvedi, P., Belmont, A. S. & Zhao, H., May 19 2023, In: ACS synthetic biology. 12, 5, p. 1424-1436 13 p.Research output: Contribution to journal › Article › peer-review
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Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project
Dekker, J., Alber, F., Aufmkolk, S., Beliveau, B. J., Bruneau, B. G., Belmont, A. S., Bintu, L., Boettiger, A., Calandrelli, R., Disteche, C. M., Gilbert, D. M., Gregor, T., Hansen, A. S., Huang, B., Huangfu, D., Kalhor, R., Leslie, C. S., Li, W., Li, Y. & Ma, J. & 15 others, , Aug 3 2023, In: Molecular cell. 83, 15, p. 2624-2640 17 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Measuring Cytological Proximity of Chromosomal Loci to Defined Nuclear Compartments with TSA-seq
Zhang, L., Chen, Y. & Belmont, A. S., 2022, Methods in Molecular Biology. Humana Press Inc., p. 145-186 42 p. (Methods in Molecular Biology; vol. 2532).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Nuclear Compartments: An Incomplete Primer to Nuclear Compartments, Bodies, and Genome Organization Relative to Nuclear Architecture
Belmont, A. S., Jul 2022, In: Cold Spring Harbor Perspectives in Biology. 14, 7, a041268.Research output: Contribution to journal › Article › peer-review
Open Access -
Nucleome Browser: an integrative and multimodal data navigation platform for 4D Nucleome
Zhu, X., Zhang, Y., Wang, Y., Tian, D., Belmont, A. S., Swedlow, J. R. & Ma, J., Aug 2022, In: Nature Methods. 19, 8, p. 911-913 3 p.Research output: Contribution to journal › Letter › peer-review
Open Access
Datasets
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Supporting material for Omid Gholamalamdari et al. 2024
Gholamalamdari, O. (Creator) & Belmont, A. S. (Creator), University of Illinois Urbana-Champaign, Jul 11 2024
DOI: 10.13012/B2IDB-4383352_V1
Dataset
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Nuclear locale immunofluorescence imaging and segmentation in four human cell lines
Belmont, A. S. (Creator), Gholamalamdari, O. (Creator) & Kumar, P. (Creator), University of Illinois Urbana-Champaign, Apr 15 2024
DOI: 10.13012/B2IDB-9792611_V1
Dataset