Aditi Das

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Research Output

2020

An Activity-Based Sensing Approach for the Detection of Cyclooxygenase-2 in Live Cells

Yadav, A. K., Reinhardt, C. J., Arango, A. S., Huff, H. C., Dong, L., Malkowski, M. G., Das, A., Tajkhorshid, E. & Chan, J., Feb 17 2020, In : Angewandte Chemie - International Edition. 59, 8, p. 3307-3314 8 p.

Research output: Contribution to journalArticle

2019

Bacterial expression of membrane-associated cytochrome P450s and their activity assay in nanodiscs

Maroutsos, D., Huff, H. & Das, A., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 47-72 26 p. (Methods in Molecular Biology; vol. 1927).

Research output: Chapter in Book/Report/Conference proceedingChapter

Combined ∆ 9 -tetrahydrocannabinol and moderate alcohol administration: effects on ingestive behaviors in adolescent male rats

Nelson, N. G., Law, W. X., Weingarten, M. J., Carnevale, L. N., Das, A. & Liang, N. C., Feb 14 2019, In : Psychopharmacology. 236, 2, p. 671-684 14 p.

Research output: Contribution to journalArticle

Emerging class of omega-3 fatty acid endocannabinoids & their derivatives

Watson, J. E., Kim, J. S. & Das, A., Aug 2019, In : Prostaglandins and Other Lipid Mediators. 143, 106337.

Research output: Contribution to journalReview article

Global analysis of osteosarcoma lipidomes reveal altered lipid profiles in metastatic versus nonmetastatic cells

Roy, J., Dibaeinia, P., Fan, T. M., Sinha, S. & Das, A., Jan 1 2019, In : Journal of Lipid Research. 60, 2, p. 375-387 13 p.

Research output: Contribution to journalArticle

Herring roe oil supplementation alters microglial cell gene expression and reduces peripheral inflammation after immune activation in a neonatal piglet model

Caputo, M. P., Radlowski, E. C., Lawson, M. A., Antonson, A. M., Watson, J. E., Matt, S. M., Leyshon, B. J., Das, A. & Johnson, R. W., Oct 2019, In : Brain, Behavior, and Immunity. 81, p. 455-469 15 p.

Research output: Contribution to journalArticle

Lipid composition and macromolecular crowding effects on CYP2J2-mediated drug metabolism in nanodiscs

Huff, H. C., Maroutsos, D. & Das, A., May 2019, In : Protein Science. 28, 5, p. 928-940 13 p.

Research output: Contribution to journalArticle

Novel Anti-inflammatory and Vasodilatory ω-3 Endocannabinoid Epoxide Regioisomers

Carnevale, L. N. & Das, A., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 219-232 14 p. (Advances in Experimental Medicine and Biology; vol. 1161).

Research output: Chapter in Book/Report/Conference proceedingChapter

Novel lactate dehydrogenase inhibitors with in vivo efficacy against Cryptosporidium parvum

Li, K., Nader, S. M., Zhang, X., Ray, B. C., Kim, C. Y., Das, A. & Witola, W. H., Jul 2019, In : PLoS pathogens. 15, 7, e1007953.

Research output: Contribution to journalArticle

Open Access

Polymorphisms of CYP2C8 alter first-electron transfer kinetics and increase catalytic uncoupling

Arnold, W. R., Zelasko, S., Meling, D. D., Sam, K. & Das, A., Sep 2 2019, In : International journal of molecular sciences. 20, 18, 4626.

Research output: Contribution to journalArticle

Open Access
2018

An Emerging Pathway of Doxorubicin Cardiotoxicity Mediated through CYP2J2

Arnold, W. R. & Das, A., Apr 24 2018, In : Biochemistry. 57, 16, p. 2294-2296 3 p.

Research output: Contribution to journalComment/debate

Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides

Roy, J., Watson, J. E., Hong, I. S., Fan, T. M. & Das, A., Jul 12 2018, In : Journal of Medicinal Chemistry. 61, 13, p. 5569-5579 11 p.

Research output: Contribution to journalArticle

Cross-talk of cannabinoid and endocannabinoid metabolism is mediated via human cardiac CYP2J2

Arnold, W. R., Weigle, A. T. & Das, A., Jul 2018, In : Journal of Inorganic Biochemistry. 184, p. 88-99 12 p.

Research output: Contribution to journalArticle

Endocannabinoid Virodhamine Is an Endogenous Inhibitor of Human Cardiovascular CYP2J2 Epoxygenase

Carnevale, L. N., Arango, A. S., Arnold, W. R., Tajkhorshid, E. & Das, A., Nov 20 2018, In : Biochemistry. 57, 46, p. 6489-6499 11 p.

Research output: Contribution to journalArticle

2017

Anti-inflammatory ω-3 endocannabinoid epoxides

McDougle, D. R., Watson, J. E., Abdeen, A. A., Adili, R., Caputo, M. P., Krapf, J. E., Johnson, R. W., Kilian, K. A., Holinstat, M. & Das, A., Jul 25 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. E6034-E6043

Research output: Contribution to journalArticle

Arachidonic Acid Metabolism by Human Cardiovascular CYP2J2 Is Modulated by Doxorubicin

Arnold, W. R., Baylon, J. L., Tajkhorshid, E. & Das, A., Dec 26 2017, In : Biochemistry. 56, 51, p. 6700-6712 13 p.

Research output: Contribution to journalArticle

Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine origin

Roy, J., Wycislo, K. L., Pondenis, H., Fan, T. M. & Das, A., Sep 2017, In : PloS one. 12, 9, e0183930.

Research output: Contribution to journalArticle

Heterologous expression and characterization of plant Taxadiene-5α-Hydroxylase (CYP725A4) in Escherichia coli

Rouck, J. E., Biggs, B. W., Kambalyal, A., Arnold, W. R., De Mey, M., Ajikumar, P. K. & Das, A., Apr 1 2017, In : Protein Expression and Purification. 132, p. 60-67 8 p.

Research output: Contribution to journalArticle

Recent advances in nanodisc technology for membrane protein studies (2012–2017)

Rouck, J. E., Krapf, J. E., Roy, J., Huff, H. C. & Das, A., Jul 1 2017, In : FEBS Letters. 591, 14, p. 2057-2088 32 p.

Research output: Contribution to journalReview article

2016

Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase

Arnold, W. R., Baylon, J. L., Tajkhorshid, E. & Das, A., Dec 20 2016, In : Biochemistry. 55, 50, p. 6969-6980 12 p.

Research output: Contribution to journalArticle

Development of poly unsaturated fatty acid derivatives of aspirin for inhibition of platelet functions

Roy, J., Adili, R., Kulmacz, R., Holinstat, M. & Das, A., Oct 2016, In : Journal of Pharmacology and Experimental Therapeutics. 359, 1, p. 134-141 8 p.

Research output: Contribution to journalArticle

Lipoprotein Nanoplatelets: Brightly Fluorescent, Zwitterionic Probes with Rapid Cellular Entry

Lim, S. J., McDougle, D. R., Zahid, M. U., Ma, L., Das, A. & Smith, A. M., Jan 13 2016, In : Journal of the American Chemical Society. 138, 1, p. 64-67 4 p.

Research output: Contribution to journalArticle

Orthogonal Assays Clarify the Oxidative Biochemistry of Taxol P450 CYP725A4

Biggs, B. W., Rouck, J. E., Kambalyal, A., Arnold, W., Lim, C. G., De Mey, M., Oneil-Johnson, M., Starks, C. M., Das, A. & Ajikumar, P. K., May 20 2016, In : ACS chemical biology. 11, 5, p. 1445-1451 7 p.

Research output: Contribution to journalArticle

Substrate binding to cytochrome P450-2J2 in Nanodiscs detected by nanoplasmonic Lycurgus cup arrays

Plucinski, L., Ranjan Gartia, M., Arnold, W. R., Ameen, A., Chang, T. W., Hsiao, A., Logan Liu, G. & Das, A., Jan 15 2016, In : Biosensors and Bioelectronics. 75, p. 337-346 10 p.

Research output: Contribution to journalArticle

2015

CYP2J2 epoxygenase membrane anchor plays an important role in facilitating electron transfer from CPR

Meling, D. D., McDougle, D. R. & Das, A., Jan 2015, In : Journal of Inorganic Biochemistry. 142, p. 47-53 7 p.

Research output: Contribution to journalArticle

Direct Capture of Functional Proteins from Mammalian Plasma Membranes into Nanodiscs

Roy, J., Pondenis, H., Fan, T. M. & Das, A., Oct 20 2015, In : Biochemistry. 54, 41, p. 6299-6302 4 p.

Research output: Contribution to journalArticle

Endocannabinoid metabolism by cytochrome P450 monooxygenases

Zelasko, S., Arnold, W. R. & Das, A., Jan 1 2015, In : Prostaglandins and Other Lipid Mediators. 116-117, p. 112-123 12 p.

Research output: Contribution to journalReview article

Functional role of the conserved I-helix residue I346 in CYP5A1-Nanodiscs

Meling, D. D., Zelasko, S., Kambalyal, A., Roy, J. & Das, A., Jul 1 2015, In : Biophysical Chemistry. 200-201, p. 34-40 7 p.

Research output: Contribution to journalArticle

Incorporation of charged residues in the CYP2J2 F-G loop disrupts CYP2J2-lipid bilayer interactions

McDougle, D. R., Baylon, J. L., Meling, D. D., Kambalyal, A., Grinkova, Y. V., Hammernik, J., Tajkhorshid, E. & Das, A., Aug 17 2015, In : Biochimica et Biophysica Acta - Biomembranes. 1848, 10, p. 2460-2470 11 p., 81959.

Research output: Contribution to journalArticle

Nanoscale synaptic membrane mimetic allows unbiased high throughput screen that targets binding sites for Alzheimer's-associated Aβ oligomers

Wilcox, K. C., Marunde, M. R., Das, A., Velasco, P. T., Kuhns, B. D., Marty, M. T., Jiang, H., Luan, C. H., Sligar, S. G. & Klein, W. L., Apr 1 2015, In : PloS one. 10, 4, e0125263.

Research output: Contribution to journalArticle

2014

Cyclooxygenase-2 catalysis and inhibition in lipid bilayer nanodiscs

Orlando, B. J., McDougle, D. R., Lucido, M. J., Eng, E. T., Graham, L. A., Schneider, C., Stokes, D. L., Das, A. & Malkowski, M. G., Apr 15 2014, In : Archives of Biochemistry and Biophysics. 546, p. 33-40 8 p.

Research output: Contribution to journalArticle

Endocannabinoids anandamide and 2-arachidonoylglycerol are substrates for human CYP2J2 epoxygenase

McDougle, D. R., Kambalyal, A., Meling, D. D. & Das, A., Dec 1 2014, In : Journal of Pharmacology and Experimental Therapeutics. 351, 3, p. 616-627 12 p.

Research output: Contribution to journalArticle

Functional investigations of Thromboxane synthase (CYP5A1) in lipid bilayers of nanodiscs

Das, A., Varma, S. S., Mularczyk, C. & Meling, D. D., Jan 1 2014, In : ChemBioChem. 15, 6, p. 892-899 8 p.

Research output: Contribution to journalArticle

2013

Functional studies of N-terminally modified CYP2J2 epoxygenase in model lipid bilayers

McDougle, D. R., Palaria, A., Magnetta, E., Meling, D. D. & Das, A., Jul 1 2013, In : Protein Science. 22, 7, p. 964-979 16 p.

Research output: Contribution to journalArticle

Optimizations to achieve high-level expression of cytochrome P450 proteins using Escherichia coli expression systems

Zelasko, S., Palaria, A. & Das, A., Nov 1 2013, In : Protein Expression and Purification. 92, 1, p. 77-87 11 p.

Research output: Contribution to journalReview article

2012

Ultra-thin layer MALDI mass spectrometry of membrane proteins in nanodiscs

Marty, M. T., Das, A. & Sligar, S. G., Jan 1 2012, In : Analytical and bioanalytical chemistry. 402, 2, p. 721-729 9 p.

Research output: Contribution to journalArticle

2011

Binding of small molecules to cavity forming mutants of a de novo designed protein

Das, A., Wei, Y., Pelczer, I. & Hecht, M. H., Apr 1 2011, In : Protein Science. 20, 4, p. 702-711 10 p.

Research output: Contribution to journalArticle

2010

Nanomechanical detection of cholera toxin using microcantilevers functionalized with ganglioside nanodiscs

Tark, S. H., Das, A., Sligar, S. & Dravid, V. P., Oct 29 2010, In : Nanotechnology. 21, 43, 435502.

Research output: Contribution to journalArticle

2009

Modulation of the cytochrome P450 reductase redox potential by the phospholipid bilayer

Das, A. & Sligar, S. G., Dec 29 2009, In : Biochemistry. 48, 51, p. 12104-12112 9 p.

Research output: Contribution to journalArticle

Screening of type I and II drug binding to human cytochrome P450-3A4 in nanodiscs by localized surface plasmon resonance spectroscopy

Das, A., Zhao, J., Schatz, G. C., Sligar, S. G. & Van Duyne, R. P., May 15 2009, In : Analytical chemistry. 81, 10, p. 3754-3759 6 p.

Research output: Contribution to journalArticle

2008

Exploring the electron transfer properties of neuronal nitric-oxide synthase by reversal of the FMN redox potential

Li, H., Das, A., Sibhatu, H., Jamal, J., Sligar, S. & Poulos, T. L., Dec 12 2008, In : Journal of Biological Chemistry. 283, 50, p. 34762-34772 11 p.

Research output: Contribution to journalArticle

Low-frequency dynamics of Caldariomyces fumago chloroperoxidase probed by femtosecond coherence spectroscopy

Gruia, F., Ionascu, D., Kubo, M., Ye, X., Dawson, J., Osborne, R. L., Sligar, S., Denisov, I., Das, A., Poulos, T. L., Terner, J. & Champion, P. M., May 6 2008, In : Biochemistry. 47, 18, p. 5156-5167 12 p.

Research output: Contribution to journalArticle

Low-frequency dynamics of Caldariomyces fumago chloroperoxidase probed by femtosecond coherence spectroscopy (Biochemistry (2008) 47, 18, (5156-5167))

Gruia, F., Ionascu, D., Kubo, M., Ye, X., Dawson, J., Osborne, R. L., Sligar, S., Denisov, I., Das, A., Poulos, T. L., Terner, J. & Champion, P. M., Sep 2 2008, In : Biochemistry. 47, 35, 1 p.

Research output: Contribution to journalComment/debate

Resonance localized surface plasmon spectroscopy: Sensing substrate and inhibitor binding to cytochrome P450

Zhao, J., Das, A., Schatz, G. C., Sligar, S. G. & Van Duyne, R. P., Aug 28 2008, In : Journal of Physical Chemistry C. 112, 34, p. 13084-13088 5 p.

Research output: Contribution to journalArticle

2007

Electron transfer between cytochrome P450cin and its FMN-containing redox partner, cindoxin

Kimmich, N., Das, A., Sevrioukova, I., Meharenna, Y., Sligar, S. G. & Poulos, T. L., Sep 14 2007, In : Journal of Biological Chemistry. 282, 37, p. 27006-27011 6 p.

Research output: Contribution to journalArticle

Peroxidase activity of de novo heme proteins immobilized on electrodes

Das, A. & Hecht, M. H., Nov 1 2007, In : Journal of Inorganic Biochemistry. 101, 11-12, p. 1820-1826 7 p.

Research output: Contribution to journalArticle

Redox potential control by drug binding to cytochrome P450 3A4

Das, A., Grinkova, Y. V. & Sligar, S. G., Nov 14 2007, In : Journal of the American Chemical Society. 129, 45, p. 13778-13779 2 p.

Research output: Contribution to journalArticle

2006

Electrochemical and ligand binding studies of a de novo heme protein

Das, A., Trammell, S. A. & Hecht, M. H., Sep 20 2006, In : Biophysical Chemistry. 123, 2-3, p. 102-112 11 p.

Research output: Contribution to journalArticle

Resonance surface plasmon spectroscopy: Low molecular weight substrate binding to cytochrome P450

Zhao, J., Das, A., Zhang, X., Schatz, G. C., Sligar, S. G. & Van Duyne, R. P., Aug 30 2006, In : Journal of the American Chemical Society. 128, 34, p. 11004-11005 2 p.

Research output: Contribution to journalArticle

2005

Nanografting de novo proteins onto gold surfaces

Hu, Y., Das, A., Hecht, M. H. & Scoles, G., Sep 27 2005, In : Langmuir. 21, 20, p. 9103-9109 7 p.

Research output: Contribution to journalArticle