Medical Biochemistry

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Review article
2020

Computational Dissection of Membrane Transport at a Microscopic Level

Jiang, T., Wen, P. C., Trebesch, N., Zhao, Z., Pant, S., Kapoor, K., Shekhar, M. & Tajkhorshid, E., Mar 2020, In : Trends in Biochemical Sciences. 45, 3, p. 202-216 15 p.

Research output: Contribution to journalReview article

2019

A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion

Sparks, R. P., Arango, A. S., Starr, M. L., Aboff, Z. L., Hurst, L. R., Rivera-Kohr, D. A., Zhang, C., Harnden, K. A., Jenkins, J. L., Guida, W. C., Tajkhorshid, E. & Fratti, R. A., Nov 15 2019, In : Journal of Biological Chemistry. 294, 46, p. 17168-17185 18 p.

Research output: Contribution to journalReview article

Open Access

Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation

Muller, M. P., Jiang, T., Sun, C., Lihan, M., Pant, S., Mahinthichaichan, P., Trifan, A. & Tajkhorshid, E., May 8 2019, In : Chemical reviews. 119, 9, p. 6086-6161 76 p.

Research output: Contribution to journalReview article

2018

Microscopic view of lipids and their diverse biological functions

Wen, P. C., Mahinthichaichan, P., Trebesch, N., Jiang, T., Zhao, Z., Shinn, E., Wang, Y., Shekhar, M., Kapoor, K., Chan, C. K. & Tajkhorshid, E., Aug 2018, In : Current Opinion in Structural Biology. 51, p. 177-186 10 p.

Research output: Contribution to journalReview article

Reconstitution and substrate specificity for isopentenyl pyrophosphate of the antiviral radical SAM enzyme viperin

Chakravarti, A., Selvadurai, K., Shahoei, R., Lee, H., Fatma, S., Tajkhorshid, E. & Huang, R. H., Sep 7 2018, In : Journal of Biological Chemistry. 293, 36, p. 14122-14133 12 p.

Research output: Contribution to journalReview article

Sensitivity of peripheral membrane proteins to the membrane context: A case study of phosphatidylserine and the TIM proteins

Kerr, D., Tietjen, G. T., Gong, Z., Tajkhorshid, E., Adams, E. J. & Lee, K. Y. C., Oct 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 10, p. 2126-2133 8 p.

Research output: Contribution to journalReview article

2017

Mitochondrial VDAC1: A key gatekeeper as potential therapeutic target

Camara, A. K. S., Zhou, Y. F., Wen, P. C., Tajkhorshid, E. & Kwok, W. M., Jun 30 2017, In : Frontiers in Physiology. 8, JUN, 460.

Research output: Contribution to journalReview article

2015

2013 Scientific Sessions Sol Sherry Distinguished Lecture in Thrombosis Polyphosphate: A Novel Modulator of Hemostasis and Thrombosis

Smith, S. A. & Morrissey, J. H., Jun 27 2015, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 6, p. 1298-1305 8 p.

Research output: Contribution to journalReview article

Computational characterization of structural dynamics underlying function in active membrane transporters

Li, J., Wen, P. C., Moradi, M. & Tajkhorshid, E., Apr 1 2015, In : Current Opinion in Structural Biology. 31, p. 96-105 10 p.

Research output: Contribution to journalReview article

How it all starts: Initiation of the clotting cascade

Smith, S. A., Travers, R. J. & Morrissey, J. H., Jul 4 2015, In : Critical Reviews in Biochemistry and Molecular Biology. 50, 4, p. 326-336 11 p.

Research output: Contribution to journalReview article

Polyphosphate, platelets, and coagulation

Travers, R. J., Smith, S. A. & Morrissey, J. H., May 1 2015, In : International Journal of Laboratory Hematology. 37, S1, p. 31-35 5 p.

Research output: Contribution to journalReview article

Polyphosphate as modulator of hemostasis, thrombosis, and inflammation

Morrissey, J. H. & Smith, S. A., Jun 1 2015, In : Journal of Thrombosis and Haemostasis. 13, S1, p. S92-S97

Research output: Contribution to journalReview article

2012

Polyphosphate: An ancient molecule that links platelets, coagulation, and inflammation

Morrissey, J. H., Choi, S. H. & Smith, S. A., Jun 21 2012, In : Blood. 119, 25, p. 5972-5979 8 p.

Research output: Contribution to journalReview article

2011

Nanoscale studies of protein-membrane interactions in blood clotting

Morrissey, J. H., Tajkhorshid, E. & Rienstra, C. M., Jul 1 2011, In : Journal of Thrombosis and Haemostasis. 9, 1 S, p. 162-167 6 p.

Research output: Contribution to journalReview article

2010

Capturing functional motions of membrane channels and transporters with molecular dynamics simulation

Shaikh, S. A., Wen, P. C., Enkavi, G., Huang, Z. & Tajkhorshid, E., Dec 1 2010, In : Journal of Computational and Theoretical Nanoscience. 7, 12, p. 2481-2500 20 p.

Research output: Contribution to journalReview article

Exploring transmembrane diffusion pathways with molecular dynamics

Wang, Y., Shaikh, S. A. & Tajkhorshid, E., Jun 2010, In : Physiology. 25, 3, p. 142-154 13 p.

Research output: Contribution to journalReview article

2009

Molecular dynamics simulations of membrane channels and transporters

Khalili-Araghi, F., Gumbart, J., Wen, P. C., Sotomayor, M., Tajkhorshid, E. & Schulten, K., Apr 1 2009, In : Current Opinion in Structural Biology. 19, 2, p. 128-137 10 p.

Research output: Contribution to journalReview article

Polyphosphate and omptins: Novel bacterial procoagulant agents

Yun, T. H. & Morrissey, J. H., Oct 1 2009, In : Journal of Cellular and Molecular Medicine. 13, 10, p. 4146-4153 8 p.

Research output: Contribution to journalReview article

Protein-membrane interactions: Blood clotting on nanoscale bilayers

Morrissey, J. H., Pureza, V., Davis-Harrison, R. L., Sligar, S. G., Rienstra, C. M., Kijac, A. Z., Ohkubo, Y. Z. & Tajkhorshid, E., Aug 4 2009, In : Journal of Thrombosis and Haemostasis. 7, SUPPL. 1, p. 169-172 4 p.

Research output: Contribution to journalReview article

2008

Blood clotting reactions on nanoscale phospholipid bilayers

Morrissey, J. H., Pureza, V., Davis-Harrison, R. L., Sligar, S. G., Ohkubo, Y. Z. & Tajkhorshid, E., Aug 6 2008, In : Thrombosis Research. 122, SUPPL.1, p. S23-S26

Research output: Contribution to journalReview article

Tissue factor and factor VIIa: Understanding the molecular mechanism

Morrissey, J. & Mackman, N., 2008, In : Thrombosis Research. 122, SUPPL.1, p. S1-S2

Research output: Contribution to journalReview article

2007

Encryption remains cryptic

Morrissey, J. H., Dec 1 2007, In : Blood. 110, 12, p. 3822-3823 2 p.

Research output: Contribution to journalReview article

2005

Molecular dynamics simulations of proteins in lipid bilayers

Gumbart, J., Wang, Y., Aksimentiev, A., Tajkhorshid, E. & Schulten, K., Aug 1 2005, In : Current Opinion in Structural Biology. 15, 4, p. 423-431 9 p.

Research output: Contribution to journalReview article

Scalable molecular dynamics with NAMD

Phillips, J. C., Braun, R., Wang, W., Gumbart, J., Tajkhorshid, E., Villa, E., Chipot, C., Skeel, R. D., Kalé, L. & Schulten, K., Dec 2005, In : Journal of Computational Chemistry. 26, 16, p. 1781-1802 22 p.

Research output: Contribution to journalReview article

2004

Tissue Factor: A Key Molecule in Hemostatic and Nonhemostatic Systems

Morrissey, J. H., Feb 2004, In : International Journal of Hematology. 79, 2, p. 103-108 6 p.

Research output: Contribution to journalReview article

2002

Tissue factor as a proinflammatory agent

Bokarewa, M. I., Morrissey, J. H. & Tarkowski, A., May 13 2002, In : Arthritis Research. 4, 3, p. 190-195 6 p.

Research output: Contribution to journalReview article

2001

CD antigens 2001

Mason, D., André, P., Bensussan, A., Buckley, C., Civin, C., Clark, E., De Haas, M., Goyert, S., Hadam, M., Hart, D., Hǒrejší, V., Meuer, S., Morrissey, J., Schwartz-Albiez, R., Shaw, S., Simmons, D., Uguccioni, M., Van Der Schoot, E., Vivier, E. & Zola, H., Dec 21 2001, In : Journal of Leukocyte Biology. 70, 5, p. 685-690 6 p.

Research output: Contribution to journalReview article