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2017

Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

Chorghade, S., Seimetz, J., Emmons, R., Yang, J., Bresson, S. M., de Lisio, M., Parise, G., Conrad, N. K. & Kalsotra, A., Jun 27 2017, In : eLife. 6, e24139.

Research output: Contribution to journalArticle

Polyphosphate and RNA differentially modulate the contact pathway of blood clotting

Gajsiewicz, J. M., Smith, S. A. & Morrissey, J. H., Feb 3 2017, In : Journal of Biological Chemistry. 292, 5, p. 1808-1814 7 p.

Research output: Contribution to journalArticle

Preoperative Metabolic Syndrome Is Predictive of Significant Gastric Cancer Mortality after Gastrectomy: The Fujian Prospective Investigation of Cancer (FIESTA) Study

Hu, D., Peng, F., Lin, X., Chen, G., Zhang, H., Liang, B., Ji, K., Lin, J., Chen, L. F., Zheng, X. & Niu, W., Feb 1 2017, In : EBioMedicine. 15, p. 73-80 8 p.

Research output: Contribution to journalArticle

Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4

Hu, X., Dong, S. H., Chen, J., Zhou, X. Z., Chen, R., Nair, S., Lu, K. P. & Chen, L. F., Sep 7 2017, In : Oncogene. 36, 36, p. 5177-5188 12 p.

Research output: Contribution to journalArticle

Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine Thiazole C-Methyltransferase in Thiomuracin Biosynthesis

Mahanta, N., Zhang, Z., Hudson, G. A., Van Der Donk, W. A. & Mitchell, D. A., Mar 29 2017, In : Journal of the American Chemical Society. 139, 12, p. 4310-4313 4 p.

Research output: Contribution to journalArticle

Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals

Grillo, A. S., SantaMaria, A. M., Kafina, M. D., Cioffi, A. G., Huston, N. C., Han, M., Seo, Y. A., Yien, Y. Y., Nardone, C., Menon, A. V., Fan, J., Svoboda, D. C., Anderson, J. B., Hong, J. D., Nicolau, B. G., Subedi, K., Gewirth, A. A., Wessling-Resnick, M., Kim, J., Paw, B. H. & 1 others, Burke, M., May 12 2017, In : Science. 356, 6338, p. 608-616 9 p.

Research output: Contribution to journalArticle

Ribosomal Natural Products, Tailored to Fit

Funk, M. A. & Van Der Donk, W. A., Jul 18 2017, In : Accounts of chemical research. 50, 7, p. 1577-1586 10 p.

Research output: Contribution to journalArticle

Searching for the low affinity ubiquinone binding site in cytochrome bo3 from Escherichia coli

Choi, S. K., Lin, M. T., Ouyang, H. & Gennis, R. B., May 1 2017, In : Biochimica et Biophysica Acta - Bioenergetics. 1858, 5, p. 366-370 5 p.

Research output: Contribution to journalArticle

Selective killing of Helicobacter pylori with pH-responsive helix–coil conformation transitionable antimicrobial polypeptides

Xiong, M., Bao, Y., Xu, X., Wang, H., Han, Z., Wang, Z., Liu, Y., Huang, S., Song, Z., Chen, J., Peek, R. M., Yin, L., Chen, L. F. & Cheng, J., Nov 28 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 48, p. 12675-12680 6 p.

Research output: Contribution to journalArticle

Small molecule T63 suppresses osteoporosis by modulating osteoblast differentiation via BMP and WNT signaling pathways

Zhao, X. L., Chen, J. J., Zhang, G. N., Wang, Y. C., Si, S. Y., Chen, L-F. & Wang, Z., Dec 1 2017, In : Scientific Reports. 7, 1, 10397.

Research output: Contribution to journalArticle

Structural basis for methylphosphonate biosynthesis

Born, D. A., Ulrich, E. C., Ju, K. S., Peck, S. C., Van Der Donk, W. A. & Drennan, C. L., Dec 8 2017, In : Science. 358, 6368, p. 1336-1339 4 p.

Research output: Contribution to journalArticle

Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome

Zeng, F., Chen, Y., Remis, J., Shekhar, M., Phillips, J. C., Tajkhorshid, E. & Jin, H., Jan 26 2017, In : Nature. 541, 7638, p. 554-557 4 p.

Research output: Contribution to journalArticle

Structurally novel antiestrogens elicit differential responses from constitutively active mutant estrogen receptors in breast cancer cells and tumors

Zhao, Y., Laws, M. J., Guillen, V. S., Ziegler, Y., Min, J., Sharma, A., Kim, S. H., Chu, D., Park, B. H., Oesterreich, S., Mao, C., Shapiro, D. J., Nettles, K. W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Oct 15 2017, In : Cancer Research. 77, 20, p. 5602-5613 12 p.

Research output: Contribution to journalArticle

Structure-Activity Relationships of the S-Linked Glycocin Sublancin

Biswas, S., Garcia De Gonzalo, C. V., Repka, L. M. & van der Donk, W. A., Dec 15 2017, In : ACS chemical biology. 12, 12, p. 2965-2969 5 p.

Research output: Contribution to journalArticle

The intestinal copper exporter CUA-1 is required for systemic copper homeostasis in Caenorhabditis elegans

Chun, H., Sharma, A. K., Lee, J., Chan, J., Jia, S. & Kim, B. E., Jan 6 2017, In : Journal of Biological Chemistry. 292, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes

Estrada, P., Manandhar, M., Dong, S. H., Deveryshetty, J., Agarwal, V., Cronan, J. E. & Nair, S. K., Jun 1 2017, In : Nature chemical biology. 13, 6, p. 668-674 7 p.

Research output: Contribution to journalArticle

Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis

Ortega, M. A., Cogan, D. P., Mukherjee, S., Garg, N., Li, B., Thibodeaux, G. N., Maffioli, S. I., Donadio, S., Sosio, M., Escano, J., Smith, L., Nair, S. K. & Van Der Donk, W. A., Feb 17 2017, In : ACS chemical biology. 12, 2, p. 548-557 10 p.

Research output: Contribution to journalArticle

X-ray transparent microfluidic chips for high-throughput screening and optimization of in meso membrane protein crystallization

Schieferstein, J. M., Pawate, A. S., Sun, C., Wan, F., Sheraden, P. N., Broecker, J., Ernst, O. P., Gennis, R. B. & Kenis, P. J. A., Mar 1 2017, In : Biomicrofluidics. 11, 2, 024118.

Research output: Contribution to journalArticle

2016

A Biotin Biosynthesis Gene Restricted to Helicobacter

Bi, H., Zhu, L., Jia, J. & Cronan, J. E., Feb 12 2016, In : Scientific reports. 6, 21162.

Research output: Contribution to journalArticle

An Atypical α/β-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus influenzae

Shi, J., Cao, X., Chen, Y., Cronan, J. E. & Guo, Z., Dec 6 2016, In : Biochemistry. 55, 48, p. 6705-6717 13 p.

Research output: Contribution to journalArticle

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry

Harris, DT., Singh, NK. K., Cai, Q., Smith, SN. N., Vander Kooi, CW. W., Procko, E., Kranz, DM. M. & Baker, BM. M., Jul 6 2016, In : Structure. 24, 7, p. 1142-1154 13 p.

Research output: Contribution to journalArticle

Antiestrogen resistant cell lines expressing estrogen receptor α mutations upregulate the unfolded protein response and are killed by BHPI

Mao, C., Livezey, M., Kim, J. E. & Shapiro, D. J., Oct 7 2016, In : Scientific reports. 6, 34753.

Research output: Contribution to journalArticle

A Purple Cupredoxin from Nitrosopumilus maritimus Containing a Mononuclear Type 1 Copper Center with an Open Binding Site

Hosseinzadeh, P., Tian, S., Marshall, N. M., Hemp, J., Mullen, T., Nilges, M. J., Gao, Y. G., Robinson, H., Stahl, D. A., Gennis, R. B. & Lu, Y., May 25 2016, In : Journal of the American Chemical Society. 138, 20, p. 6324-6327 4 p.

Research output: Contribution to journalArticle

Artificial Dense Granules: A Procoagulant Liposomal Formulation Modeled after Platelet Polyphosphate Storage Pools

Donovan, A. J., Kalkowski, J., Szymusiak, M., Wang, C., Smith, S. A., Klie, R. F., Morrissey, J. H. & Liu, Y., Aug 8 2016, In : Biomacromolecules. 17, 8, p. 2572-2581 10 p.

Research output: Contribution to journalArticle

Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars

Zhang, X., Carter, M. S., Vetting, M. W., Francisco, B. S., Zhao, S., Al-Obaidi, N. F., Solbiati, J. O., Thiaville, J. J., Crécy-Lagard, V. D., Jacobson, M. P., Almo, S. C. & Gerlt, J. A., Jul 19 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 29, p. E4161-E4169

Research output: Contribution to journalArticle

Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase

Arnold, W. R., Baylon, J. L., Tajkhorshid, E. & Das, A., Dec 20 2016, In : Biochemistry. 55, 50, p. 6969-6980 12 p.

Research output: Contribution to journalArticle

Atomic-level description of protein-lipid interactions using an accelerated membrane model

Baylon, J. L., Vermaas, J. V., Muller, M. P., Arcario, M. J., Pogorelov, T. V. & Tajkhorshid, E., Jul 1 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 7, p. 1573-1583 11 p.

Research output: Contribution to journalArticle

BET inhibition attenuates helicobacter pylori-induced inflammatory response by suppressing inflammatory gene transcription and enhancer activation

Chen, J., Wang, Z., Hu, X., Chen, R., Romero-Gallo, J., Peek, R. M. & Chen, L. F., May 15 2016, In : Journal of Immunology. 196, 10, p. 4132-4142 11 p.

Research output: Contribution to journalArticle

Binding Site Recognition and Docking Dynamics of a Single Electron Transport Protein: Cytochrome c2

Singharoy, A., Barragan, A. M., Thangapandian, S., Tajkhorshid, E. & Schulten, K., Sep 21 2016, In : Journal of the American Chemical Society. 138, 37, p. 12077-12089 13 p.

Research output: Contribution to journalArticle

Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes

Ding, W., Liu, W. Q., Jia, Y., Li, Y., Van Der Donk, W. A. & Zhang, Q., Mar 29 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 13, p. 3521-3526 6 p.

Research output: Contribution to journalArticle

Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin

Zhang, Z., Hudson, G. A., Mahanta, N., Tietz, J. I., Van der Donk, W. A. & Mitchell, D. A., Dec 7 2016, In : Journal of the American Chemical Society. 138, 48, p. 15511-15514 4 p.

Research output: Contribution to journalArticle

Characterization of the stereochemical configuration of lanthionines formed by the lanthipeptide synthetase GeoM

Garg, N., Goto, Y., Chen, T. & van der Donk, W. A., Nov 1 2016, In : Biopolymers. 106, 6, p. 834-842 9 p.

Research output: Contribution to journalArticle

Colloidal Confinement of Polyphosphate on Gold Nanoparticles Robustly Activates the Contact Pathway of Blood Coagulation

Szymusiak, M., Donovan, A. J., Smith, S. A., Ransom, R., Shen, H., Kalkowski, J., Morrissey, J. H. & Liu, Y., Jan 20 2016, In : Bioconjugate Chemistry. 27, 1, p. 102-109 8 p.

Research output: Contribution to journalArticle

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Berger, S., Procko, E., Margineantu, D., Lee, E. F., Shen, B. W., Zelter, A., Silva, D. A., Chawla, K., Herold, M. J., Garnier, J. M., Johnson, R., Maccoss, M. J., Lessene, G., Davis, T. N., Stayton, P. S., Stoddard, B. L., Fairlie, W. D., Hockenbery, D. M. & Baker, D., Nov 2 2016, In : eLife. 5, NOVEMBER2016, e20352.

Research output: Contribution to journalArticle

Conformational Dynamics of the Human Islet Amyloid Polypeptide in a Membrane Environment: Toward the Aggregation Prone Form

Skeby, K. K., Andersen, O. J., Pogorelov, T. V., Tajkhorshid, E. & Schiøtt, B., Apr 19 2016, In : Biochemistry. 55, 13, p. 2031-2042 12 p.

Research output: Contribution to journalArticle

Conformational equilibrium of talin is regulated by anionic lipids

Ye, X., McLean, M. A. & Sligar, S. G., Aug 1 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 8, p. 1833-1840 8 p.

Research output: Contribution to journalArticle

Copper regulates cyclic-AMP-dependent lipolysis

Krishnamoorthy, L., Cotruvo, J. A., Chan, J., Kaluarachchi, H., Muchenditsi, A., Pendyala, V. S., Jia, S., Aron, A. T., Ackerman, C. M., Wal, M. N. V., Guan, T., Smaga, L. P., Farhi, S. L., New, E. J., Lutsenko, S. & Chang, C. J., Aug 1 2016, In : Nature chemical biology. 12, 8, p. 586-592 7 p.

Research output: Contribution to journalArticle

CtaM is required for menaquinol oxidase aa 3 function in Staphylococcus aureus

Hammer, N. D., Schurig-Briccio, L. A., Gerdes, S. Y., Gennis, R. B. & Skaar, E. P., Jul 1 2016, In : mBio. 7, 4, e00823-16.

Research output: Contribution to journalArticle

Deep mutational scans as a guide to engineering high affinity t cell receptor interactions with peptide-bound major histocompatibility complex

Harris, D. T., Wang, N., Riley, T. P., Anderson, S. D., Singh, N. K., Procko, E., Baker, B. M. & Kran, D. M., Nov 18 2016, In : Journal of Biological Chemistry. 291, 47, p. 24566-24578 13 p.

Research output: Contribution to journalArticle

Development of poly unsaturated fatty acid derivatives of aspirin for inhibition of platelet functions

Roy, J., Adili, R., Kulmacz, R., Holinstat, M. & Das, A., Oct 2016, In : Journal of Pharmacology and Experimental Therapeutics. 359, 1, p. 134-141 8 p.

Research output: Contribution to journalArticle

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

Posey, A. D., Schwab, R. D., Boesteanu, A. C., Steentoft, C., Mandel, U., Engels, B., Stone, J. D., Madsen, T. D., Schreiber, K., Haines, K. M., Cogdill, A. P., Chen, T. J., Song, D., Scholler, J., Kranz, D. M., Feldman, M. D., Young, R., Keith, B., Schreiber, H., Clausen, H. & 2 others, Johnson, L. A. & June, C. H., Jun 21 2016, In : Immunity. 44, 6, p. 1444-1454 11 p.

Research output: Contribution to journalArticle

Enhancing Mn(II)-Binding and Manganese Peroxidase Activity in a Designed Cytochrome c Peroxidase through Fine-Tuning Secondary-Sphere Interactions

Hosseinzadeh, P., Mirts, E. N., Pfister, T. D., Gao, Y. G., Mayne, C., Robinson, H., Tajkhorshid, E. & Lu, Y., Mar 15 2016, In : Biochemistry. 55, 10, p. 1494-1502 9 p.

Research output: Contribution to journalArticle

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

Fanning, S. W., Mayne, C. G., Dharmarajan, V., Carlson, K. E., Martin, T. A., Novick, S. J., Toy, W., Green, B., Panchamukhi, S., Katzenellenbogen, B. S., Tajkhorshid, E., Griffin, P. R., Shen, Y., Chandarlapaty, S., Katzenellenbogen, J. A. & Greene, G. L., Feb 2 2016, In : eLife. 5, FEBRUARY2016, e12792.

Research output: Contribution to journalArticle