Research Output

2015

2013 Scientific Sessions Sol Sherry Distinguished Lecture in Thrombosis Polyphosphate: A Novel Modulator of Hemostasis and Thrombosis

Smith, S. A. & Morrissey, J. H., Jun 27 2015, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 6, p. 1298-1305 8 p.

Research output: Contribution to journalReview article

A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase

Peck, S. C., Chekan, J. R., Ulrich, E. C., Nair, S. K. & Van Der Donk, W. A., Feb 2015, In : Journal of the American Chemical Society. 137, 9, p. 3217-3220 4 p.

Research output: Contribution to journalArticle

Activation of molecular oxygen in cytochromes P450

Denisov, I. G. & Sligar, S. G., Jan 1 2015, Cytochrome P450: Structure, Mechanism, and Biochemistry, Fourth Edition. Springer International Publishing, p. 69-109 41 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

A dietary phytochemical alters caste-associated gene expression in honey bees

Mao, W., Schuler, M. A. & Berenbaum, M. R., Aug 2015, In : Science Advances. 1, 7, e1500795.

Research output: Contribution to journalArticle

A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

Kim, D. H., Xiao, Z., Kwon, S., Sun, X., Ryerson, D., Tkac, D., Ma, P., Wu, S. Y., Chiang, C. M., Zhou, E., Xu, H. E., Palvimo, J. J., Chen, L. F., Kemper, B. & Kemper, J. K., Jan 14 2015, In : EMBO Journal. 34, 2, p. 184-199 16 p.

Research output: Contribution to journalArticle

A General Strategy for the Discovery of Metabolic Pathways: D -Threitol, l -Threitol, and Erythritol Utilization in Mycobacterium smegmatis

Huang, H., Carter, M. S., Vetting, M. W., Al-Obaidi, N., Patskovsky, Y., Almo, S. C. & Gerlt, J. A., Nov 25 2015, In : Journal of the American Chemical Society. 137, 46, p. 14570-14573 4 p.

Research output: Contribution to journalArticle

A multiplex assay for detection of staphylococcal and streptococcal exotoxins

Sharma, P., Wang, N., Chervin, A. S., Quinn, C. L., Stone, J. D. & Kranz, D. M., Aug 25 2015, In : PloS one. 10, 8, e0135986.

Research output: Contribution to journalArticle

Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism

Zhao, H., Palencia, A., Seiradake, E., Ghaemi, Z., Cusack, S., Luthey-Schulten, Z. & Martinis, S., Oct 16 2015, In : ACS chemical biology. 10, 10, p. 2277-2285 9 p.

Research output: Contribution to journalArticle

Anticipatory estrogen activation of the unfolded protein response is linked to cell proliferation and poor survival in estrogen receptor α-positive breast cancer

Andruska, N., Zheng, X., Yang, X., Helferich, W. G. & Shapiro, D. J., Jul 21 2015, In : Oncogene. 34, 29, p. 3760-3769 10 p.

Research output: Contribution to journalArticle

Antiinfectives targeting enzymes and the proton motive force

Feng, X., Zhu, W., Schurig-Briccio, L. A., Lindert, S., Shoen, C., Hitchings, R., Li, J., Wang, Y., Baig, N., Zhou, T., Kim, B. K., Crick, D. C., Cynamon, M., McCammon, J. A., Gennis, R. B. & Oldfield, E., Dec 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 51, p. E7073-E7082

Research output: Contribution to journalArticle

An unexpected role for ergothioneine

Huang, Z. & Van der Donk, W. A., Dec 1 2015, In : National Science Review. 2, 4, p. 382-383 2 p.

Research output: Contribution to journalArticle

Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage

Tang, W., Dong, S. H., Repka, L. M., He, C., Nair, S. K. & Van Der Donk, W. A., Sep 2 2015, In : Chemical Science. 6, 11, p. 6270-6279 10 p.

Research output: Contribution to journalArticle

A Reaction-Based Fluorescent Probe for Imaging of Formaldehyde in Living Cells

Roth, A., Li, H., Anorma, C. & Chan, J., Sep 2 2015, In : Journal of the American Chemical Society. 137, 34, p. 10890-10893 4 p.

Research output: Contribution to journalArticle

A series of medium and high copy number arabinose-inducible Escherichia coli expression vectors compatible with pBR322 and pACYC184

Chakravartty, V. & Cronan, J. E., Sep 1 2015, In : Plasmid. 81, p. 21-26 6 p.

Research output: Contribution to journalArticle

Atomic-level characterization of transport cycle thermodynamics in the glycerol-3-phosphate:Phosphate antiporter

Moradi, M., Enkavi, G. & Tajkhorshid, E., Sep 29 2015, In : Nature communications. 6, 8393.

Research output: Contribution to journalArticle

ATP-binding cassette (ABC) transport system solute-binding protein-guided identification of novel D-altritol and galactitol catabolic pathways in Agrobacterium tumefaciens C58

Wichelecki, D. J., Vetting, M. W., Chou, L., Al-Obaidi, N., Bouvier, J. T., Almo, S. C. & Gerlt, J. A., Nov 27 2015, In : Journal of Biological Chemistry. 290, 48, p. 28963-28976 14 p.

Research output: Contribution to journalArticle

A unique cis -3-hydroxy- l -proline dehydratase in the enolase superfamily

Zhang, X., Kumar, R., Vetting, M. W., Zhao, S., Jacobson, M. P., Almo, S. C. & Gerlt, J. A., Feb 4 2015, In : Journal of the American Chemical Society. 137, 4, p. 1388-1391 4 p.

Research output: Contribution to journalArticle

Bacteria do it differently: An alternative path to squalene

Van Der Donk, W. A., May 27 2015, In : ACS Central Science. 1, 2, p. 64-65 2 p.

Research output: Contribution to journalShort survey

Biochemical Studies of Mycobacterial Fatty Acid Methyltransferase: A Catalyst for the Enzymatic Production of Biodiesel

Petronikolou, N. & Nair, S. K., Nov 19 2015, In : Chemistry and Biology. 22, 11, p. 1480-1490 11 p.

Research output: Contribution to journalArticle

Biosynthesis of fosfazinomycin is a convergent process

Huang, Z., Wang, K. K. A., Lee, J. & Van Der Donk, W. A., Feb 1 2015, In : Chemical Science. 6, 2, p. 1282-1287 6 p.

Research output: Contribution to journalArticle

Biosynthesis of squalene from farnesyl diphosphate in Bacteria: Three steps catalyzed by three enzymes

Pan, J. J., Solbiati, J. O., Ramamoorthy, G., Hillerich, B. S., Seidel, R. D., Cronan, J. E., Almo, S. C. & Poulter, C. D., May 27 2015, In : ACS Central Science. 1, 2, p. 77-82 6 p.

Research output: Contribution to journalArticle

C3-OH of Amphotericin B Plays an Important Role in Ion Conductance

Davis, S. A., Della Ripa, L. A., Hu, L., Cioffi, A. G., Pogorelov, T. V., Rienstra, C. M. & Burke, M. D., Dec 9 2015, In : Journal of the American Chemical Society. 137, 48, p. 15102-15104 3 p.

Research output: Contribution to journalArticle

Capturing Spontaneous Membrane Insertion of the Influenza Virus Hemagglutinin Fusion Peptide

Baylon, J. L. & Tajkhorshid, E., Jun 25 2015, In : Journal of Physical Chemistry B. 119, 25, p. 7882-7893 12 p.

Research output: Contribution to journalArticle

CHARMM-GUI HMMM Builder for Membrane Simulations with the Highly Mobile Membrane-Mimetic Model

Qi, Y., Cheng, X., Lee, J., Vermaas, J. V., Pogorelov, T. V., Tajkhorshid, E., Park, S., Klauda, J. B. & Im, W., Nov 17 2015, In : Biophysical journal. 109, 10, p. 2012-2022 11 p.

Research output: Contribution to journalArticle

Clotting activity of polyphosphate-functionalized silica Nanoparticles

Kudela, D., Smith, S. A., May-Masnou, A., Braun, G. B., Pallaoro, A., Nguyen, C. K., Chuong, T. T., Nownes, S., Allen, R., Parker, N. R., Rashidi, H. H., Morrissey, J. H. & Stucky, G. D., Mar 23 2015, In : Angewandte Chemie - International Edition. 54, 13, p. 4018-4022 5 p.

Research output: Contribution to journalArticle

Computational characterization of structural dynamics underlying function in active membrane transporters

Li, J., Wen, P. C., Moradi, M. & Tajkhorshid, E., Apr 1 2015, In : Current Opinion in Structural Biology. 31, p. 96-105 10 p.

Research output: Contribution to journalReview article

Contribution of clinically derived mutations in ERG11 to azole resistance in Candida albicans

Flowers, S. A., Colón, B., Whaley, S. G., Schuler, M. A. & David Rogers, P., Jan 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 1, p. 450-460 11 p.

Research output: Contribution to journalArticle

CYP2J2 epoxygenase membrane anchor plays an important role in facilitating electron transfer from CPR

Meling, D. D., McDougle, D. R. & Das, A., Jan 2015, In : Journal of Inorganic Biochemistry. 142, p. 47-53 7 p.

Research output: Contribution to journalArticle

Developmental insights into the pathology of and therapeutic strategies for DM1: Back to the basics

Chau, A. & Kalsotra, A., Mar 1 2015, In : Developmental Dynamics. 244, 3, p. 377-390 14 p.

Research output: Contribution to journalReview article

Direct Capture of Functional Proteins from Mammalian Plasma Membranes into Nanodiscs

Roy, J., Pondenis, H., Fan, T. M. & Das, A., Oct 20 2015, In : Biochemistry. 54, 41, p. 6299-6302 4 p.

Research output: Contribution to journalArticle

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

Ju, K. S., Gao, J., Doroghazi, J. R., Wang, K. K. A., Thibodeaux, C. J., Li, S., Metzger, E., Fudala, J., Su, J., Zhang, J. K., Lee, J., Cioni, J. P., Evans, B. S., Hirota, R., Labeda, D. P., Van Der Donk, W. A. & Metcalf, W. W., Sep 29 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 39, p. 12175-12180 6 p.

Research output: Contribution to journalArticle

Disease modeling and gene therapy of copper storage disease in canine hepatic organoids

Nantasanti, S., Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., Van Wolferen, M. E., Pelaez, N., Fieten, H., Wubbolts, R. W., Grinwis, G. C., Chan, J., Huch, M., Vries, R. R. G., Clevers, H., De Bruin, A., Rothuizen, J., Penning, L. C. & Schotanus, B. A., Nov 10 2015, In : Stem Cell Reports. 5, 5, p. 895-907 13 p.

Research output: Contribution to journalArticle

Division of labor in transhydrogenase by alternating proton translocation and hydride transfer

Leung, J. H., Schurig-Briccio, L. A., Yamaguchi, M., Moeller, A., Speir, J. A., Gennis, R. B. & Stout, C. D., Jan 9 2015, In : Science. 347, 6218, p. 178-181 4 p.

Research output: Contribution to journalArticle

Efficient Exploration of Membrane-Associated Phenomena at Atomic Resolution

Vermaas, J. V., Baylon, J. L., Arcario, M. J., Muller, M. P., Wu, Z., Pogorelov, T. V. & Tajkhorshid, E., Jun 1 2015, In : Journal of Membrane Biology. 248, 3, p. 563-582 20 p.

Research output: Contribution to journalArticle

Endocannabinoid metabolism by cytochrome P450 monooxygenases

Zelasko, S., Arnold, W. R. & Das, A., Jan 1 2015, In : Prostaglandins and Other Lipid Mediators. 116-117, p. 112-123 12 p.

Research output: Contribution to journalReview article

Enzyme function initiative-enzyme similarity tool (EFI-EST): A web tool for generating protein sequence similarity networks

Gerlt, J. A., Bouvier, J. T., Davidson, D. B., Imker, H. J., Sadkhin, B., Slater, D. R. & Whalen, K. L., Aug 1 2015, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1854, 8, p. 1019-1037 19 p.

Research output: Contribution to journalReview article

Escherichia coli Auxotroph Host Strains for Amino Acid-Selective Isotope Labeling of Recombinant Proteins

Lin, M. T., Fukazawa, R., Miyajima-Nakano, Y., Matsushita, S., Choi, S. K., Iwasaki, T. & Gennis, R. B., Jan 1 2015, Methods in Enzymology. Academic Press Inc., p. 45-66 22 p. (Methods in Enzymology; vol. 565).

Research output: Chapter in Book/Report/Conference proceedingChapter

ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation

Bhate, A., Parker, D. J., Bebee, T. W., Ahn, J., Arif, W., Rashan, E. H., Chorghade, S., Chau, A., Lee, J. H., Anakk, S., Carstens, R. P., Xiao, X. & Kalsotra, A., Nov 4 2015, In : Nature communications. 6, 8768.

Research output: Contribution to journalArticle

Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression

Andruska, N. D., Zheng, X., Yang, X., Mao, C., Cherian, M. M., Mahapatra, L., Helferich, W. G. & Shapiro, D. J., Apr 14 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 15, p. 4737-4742 6 p.

Research output: Contribution to journalArticle

Experimental protein structure verification by scoring with a single, unassigned NMR spectrum

Courtney, J. M., Ye, Q., Nesbitt, A. E., Tang, M., Tuttle, M. D., Watt, E. D., Nuzzio, K. M., Sperling, L. J., Comellas, G., Peterson, J. R., Morrissey, J. H. & Rienstra, C. M., Oct 6 2015, In : Structure. 23, 10, p. 1958-1966 9 p.

Research output: Contribution to journalArticle

Experimental strategies for functional annotation and metabolism discovery: Targeted screening of solute binding proteins and unbiased panning of metabolomes

Vetting, M. W., Al-Obaidi, N., Zhao, S., San Francisco, B., Kim, J., Wichelecki, D. J., Bouvier, J. T., Solbiati, J. O., Vu, H., Zhang, X., Rodionov, D. A., Love, J. D., Hillerich, B. S., Seidel, R. D., Quinn, R. J., Osterman, A. L., Cronan, J. E., Jacobson, M. P., Gerlt, J. A. & Almo, S. C., Jan 27 2015, In : Biochemistry. 54, 3, p. 909-931 23 p.

Research output: Contribution to journalArticle

Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid

Bindman, N. A., Bobeica, S. C., Liu, W. R. & Van Der Donk, W. A., Jun 10 2015, In : Journal of the American Chemical Society. 137, 22, p. 6975-6978 4 p.

Research output: Contribution to journalArticle

From Synthesis to Function via Iterative Assembly of N-Methyliminodiacetic Acid Boronate Building Blocks

Li, J., Grillo, A. S. & Burke, M. D., Jul 22 2015, In : Accounts of chemical research. 48, 8, p. 2297-2307 11 p.

Research output: Contribution to journalArticle

Functional role of the conserved I-helix residue I346 in CYP5A1-Nanodiscs

Meling, D. D., Zelasko, S., Kambalyal, A., Roy, J. & Das, A., Jul 1 2015, In : Biophysical Chemistry. 200-201, p. 34-40 7 p.

Research output: Contribution to journalArticle

FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow

Zhu, S., Travers, R. J., Morrissey, J. H. & Diamond, S. L., Sep 17 2015, In : Blood. 126, 12, p. 1494-1502 9 p.

Research output: Contribution to journalArticle

Helical antimicrobial polypeptides with radial amphiphilicity

Xiong, M., Lee, M. W., Mansbach, R. A., Song, Z., Bao, Y., Peek, R. M., Yao, C., Chen, L. F., Ferguson, A. L., Wong, G. C. L. & Cheng, J., Oct 27 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 43, p. 13155-13160 6 p.

Research output: Contribution to journalArticle

How it all starts: Initiation of the clotting cascade

Smith, S. A., Travers, R. J. & Morrissey, J. H., Jul 4 2015, In : Critical Reviews in Biochemistry and Molecular Biology. 50, 4, p. 326-336 11 p.

Research output: Contribution to journalReview article

Impaired mitochondrial energy production causes light-induced photoreceptor degeneration independent of oxidative stress

Jaiswal, M., Haelterman, N. A., Sandoval, H., Xiong, B., Donti, T., Kalsotra, A., Yamamoto, S., Cooper, T. A., Graham, B. H. & Bellen, H. J., Jan 1 2015, In : PLoS biology. 13, 7

Research output: Contribution to journalArticle

Incorporation of charged residues in the CYP2J2 F-G loop disrupts CYP2J2-lipid bilayer interactions

McDougle, D. R., Baylon, J. L., Meling, D. D., Kambalyal, A., Grinkova, Y. V., Hammernik, J., Tajkhorshid, E. & Das, A., Aug 17 2015, In : Biochimica et Biophysica Acta - Biomembranes. 1848, 10, p. 2460-2470 11 p., 81959.

Research output: Contribution to journalArticle

Insights into Methyltransferase Specificity and Bioactivity of Derivatives of the Antibiotic Plantazolicin

Hao, Y., Blair, P. M., Sharma, A., Mitchell, D. A. & Nair, S. K., May 15 2015, In : ACS chemical biology. 10, 5, p. 1209-1216 8 p.

Research output: Contribution to journalArticle