Research Output

2016

Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors

Harris, D. T. & Kranz, D. M., Mar 1 2016, In : Trends in Pharmacological Sciences. 37, 3, p. 220-230 11 p.

Research output: Contribution to journalReview article

An Atypical α/β-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus influenzae

Shi, J., Cao, X., Chen, Y., Cronan, J. E. & Guo, Z., Dec 6 2016, In : Biochemistry. 55, 48, p. 6705-6717 13 p.

Research output: Contribution to journalArticle

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry

Harris, DT., Singh, NK. K., Cai, Q., Smith, SN. N., Vander Kooi, CW. W., Procko, E., Kranz, DM. M. & Baker, BM. M., Jul 6 2016, In : Structure. 24, 7, p. 1142-1154 13 p.

Research output: Contribution to journalArticle

Anticipatory UPR Activation: A Protective Pathway and Target in Cancer

Shapiro, D. J., Livezey, M., Yu, L., Zheng, X. & Andruska, N., Oct 1 2016, In : Trends in Endocrinology and Metabolism. 27, 10, p. 731-741 11 p.

Research output: Contribution to journalReview article

Antiestrogen resistant cell lines expressing estrogen receptor α mutations upregulate the unfolded protein response and are killed by BHPI

Mao, C., Livezey, M., Kim, J. E. & Shapiro, D. J., Oct 7 2016, In : Scientific reports. 6, 34753.

Research output: Contribution to journalArticle

A Purple Cupredoxin from Nitrosopumilus maritimus Containing a Mononuclear Type 1 Copper Center with an Open Binding Site

Hosseinzadeh, P., Tian, S., Marshall, N. M., Hemp, J., Mullen, T., Nilges, M. J., Gao, Y. G., Robinson, H., Stahl, D. A., Gennis, R. B. & Lu, Y., May 25 2016, In : Journal of the American Chemical Society. 138, 20, p. 6324-6327 4 p.

Research output: Contribution to journalArticle

Artificial Dense Granules: A Procoagulant Liposomal Formulation Modeled after Platelet Polyphosphate Storage Pools

Donovan, A. J., Kalkowski, J., Szymusiak, M., Wang, C., Smith, S. A., Klie, R. F., Morrissey, J. H. & Liu, Y., Aug 8 2016, In : Biomacromolecules. 17, 8, p. 2572-2581 10 p.

Research output: Contribution to journalArticle

Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars

Zhang, X., Carter, M. S., Vetting, M. W., Francisco, B. S., Zhao, S., Al-Obaidi, N. F., Solbiati, J. O., Thiaville, J. J., Crécy-Lagard, V. D., Jacobson, M. P., Almo, S. C. & Gerlt, J. A., Jul 19 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 29, p. E4161-E4169

Research output: Contribution to journalArticle

Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase

Arnold, W. R., Baylon, J. L., Tajkhorshid, E. & Das, A., Dec 20 2016, In : Biochemistry. 55, 50, p. 6969-6980 12 p.

Research output: Contribution to journalArticle

Atomic-level description of protein-lipid interactions using an accelerated membrane model

Baylon, J. L., Vermaas, J. V., Muller, M. P., Arcario, M. J., Pogorelov, T. V. & Tajkhorshid, E., Jul 1 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 7, p. 1573-1583 11 p.

Research output: Contribution to journalArticle

BET inhibition attenuates helicobacter pylori-induced inflammatory response by suppressing inflammatory gene transcription and enhancer activation

Chen, J., Wang, Z., Hu, X., Chen, R., Romero-Gallo, J., Peek, R. M. & Chen, L. F., May 15 2016, In : Journal of Immunology. 196, 10, p. 4132-4142 11 p.

Research output: Contribution to journalArticle

Binding Site Recognition and Docking Dynamics of a Single Electron Transport Protein: Cytochrome c2

Singharoy, A., Barragan, A. M., Thangapandian, S., Tajkhorshid, E. & Schulten, K., Sep 21 2016, In : Journal of the American Chemical Society. 138, 37, p. 12077-12089 13 p.

Research output: Contribution to journalArticle

Biophysical and biochemical characterization of avian secretory component provides structural insights into the evolution of the polymeric Ig receptor

Stadtmueller, B. M., Yang, Z., Huey-Tubman, K. E., Roberts-Mataric, H., Hubbell, W. L. & Bjorkman, P. J., Aug 15 2016, In : Journal of Immunology. 197, 4, p. 1408-1414 7 p.

Research output: Contribution to journalArticle

Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes

Ding, W., Liu, W. Q., Jia, Y., Li, Y., Van Der Donk, W. A. & Zhang, Q., Mar 29 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 13, p. 3521-3526 6 p.

Research output: Contribution to journalArticle

Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin

Zhang, Z., Hudson, G. A., Mahanta, N., Tietz, J. I., Van der Donk, W. A. & Mitchell, D. A., Dec 7 2016, In : Journal of the American Chemical Society. 138, 48, p. 15511-15514 4 p.

Research output: Contribution to journalArticle

Cameo appearances of aminoacyl-tRNA in natural product biosynthesis

Ulrich, E. C. & van der Donk, W. A., Dec 1 2016, In : Current Opinion in Chemical Biology. 35, p. 29-36 8 p.

Research output: Contribution to journalReview article

Characterization of the stereochemical configuration of lanthionines formed by the lanthipeptide synthetase GeoM

Garg, N., Goto, Y., Chen, T. & van der Donk, W. A., Nov 1 2016, In : Biopolymers. 106, 6, p. 834-842 9 p.

Research output: Contribution to journalArticle

Colloidal Confinement of Polyphosphate on Gold Nanoparticles Robustly Activates the Contact Pathway of Blood Coagulation

Szymusiak, M., Donovan, A. J., Smith, S. A., Ransom, R., Shen, H., Kalkowski, J., Morrissey, J. H. & Liu, Y., Jan 20 2016, In : Bioconjugate Chemistry. 27, 1, p. 102-109 8 p.

Research output: Contribution to journalArticle

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Berger, S., Procko, E., Margineantu, D., Lee, E. F., Shen, B. W., Zelter, A., Silva, D. A., Chawla, K., Herold, M. J., Garnier, J. M., Johnson, R., Maccoss, M. J., Lessene, G., Davis, T. N., Stayton, P. S., Stoddard, B. L., Fairlie, W. D., Hockenbery, D. M. & Baker, D., Nov 2 2016, In : eLife. 5, NOVEMBER2016, e20352.

Research output: Contribution to journalArticle

Conformational Dynamics of the Human Islet Amyloid Polypeptide in a Membrane Environment: Toward the Aggregation Prone Form

Skeby, K. K., Andersen, O. J., Pogorelov, T. V., Tajkhorshid, E. & Schiøtt, B., Apr 19 2016, In : Biochemistry. 55, 13, p. 2031-2042 12 p.

Research output: Contribution to journalArticle

Conformational equilibrium of talin is regulated by anionic lipids

Ye, X., McLean, M. A. & Sligar, S. G., Aug 1 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 8, p. 1833-1840 8 p.

Research output: Contribution to journalArticle

Copper regulates cyclic-AMP-dependent lipolysis

Krishnamoorthy, L., Cotruvo, J. A., Chan, J., Kaluarachchi, H., Muchenditsi, A., Pendyala, V. S., Jia, S., Aron, A. T., Ackerman, C. M., Wal, M. N. V., Guan, T., Smaga, L. P., Farhi, S. L., New, E. J., Lutsenko, S. & Chang, C. J., Aug 1 2016, In : Nature chemical biology. 12, 8, p. 586-592 7 p.

Research output: Contribution to journalArticle

CtaM is required for menaquinol oxidase aa3 function in Staphylococcus aureus

Hammer, N. D., Schurig-Briccio, L. A., Gerdes, S. Y., Gennis, R. B. & Skaar, E. P., Jul 1 2016, In : mBio. 7, 4, e00823-16.

Research output: Contribution to journalArticle

Deeper understanding of carboxylase

Morrissey, J. H., Apr 14 2016, In : Blood. 127, 15, p. 1841-1842 2 p.

Research output: Contribution to journalComment/debate

Deep mutational scans as a guide to engineering high affinity t cell receptor interactions with peptide-bound major histocompatibility complex

Harris, D. T., Wang, N., Riley, T. P., Anderson, S. D., Singh, N. K., Procko, E., Baker, B. M. & Kran, D. M., Nov 18 2016, In : Journal of Biological Chemistry. 291, 47, p. 24566-24578 13 p.

Research output: Contribution to journalArticle

Development of poly unsaturated fatty acid derivatives of aspirin for inhibition of platelet functions

Roy, J., Adili, R., Kulmacz, R., Holinstat, M. & Das, A., Oct 2016, In : Journal of Pharmacology and Experimental Therapeutics. 359, 1, p. 134-141 8 p.

Research output: Contribution to journalArticle

Editorial overview: Biocatalysis and Biotransformation: Esoteric, Niche Enzymology

Tawfik, D. S. & van der Donk, W. A., Apr 1 2016, In : Current Opinion in Chemical Biology. 31, p. v-vii

Research output: Contribution to journalEditorial

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

Posey, A. D., Schwab, R. D., Boesteanu, A. C., Steentoft, C., Mandel, U., Engels, B., Stone, J. D., Madsen, T. D., Schreiber, K., Haines, K. M., Cogdill, A. P., Chen, T. J., Song, D., Scholler, J., Kranz, D. M., Feldman, M. D., Young, R., Keith, B., Schreiber, H., Clausen, H. & 2 others, Johnson, L. A. & June, C. H., Jun 21 2016, In : Immunity. 44, 6, p. 1444-1454 11 p.

Research output: Contribution to journalArticle

Enhancing Mn(II)-Binding and Manganese Peroxidase Activity in a Designed Cytochrome c Peroxidase through Fine-Tuning Secondary-Sphere Interactions

Hosseinzadeh, P., Mirts, E. N., Pfister, T. D., Gao, Y. G., Mayne, C., Robinson, H., Tajkhorshid, E. & Lu, Y., Mar 15 2016, In : Biochemistry. 55, 10, p. 1494-1502 9 p.

Research output: Contribution to journalArticle

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

Fanning, S. W., Mayne, C. G., Dharmarajan, V., Carlson, K. E., Martin, T. A., Novick, S. J., Toy, W., Green, B., Panchamukhi, S., Katzenellenbogen, B. S., Tajkhorshid, E., Griffin, P. R., Shen, Y., Chandarlapaty, S., Katzenellenbogen, J. A. & Greene, G. L., Feb 2 2016, In : eLife. 5, FEBRUARY2016, e12792.

Research output: Contribution to journalArticle

Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis

Duggal, R., Liu, Y., Gregory, M. C., Denisov, I. G., Kincaid, J. R. & Sligar, S. G., Aug 19 2016, In : Biochemical and Biophysical Research Communications. 477, 2, p. 202-208 7 p.

Research output: Contribution to journalArticle

High-resolution NMR studies of human tissue factor

Nuzzio, K. M., Watt, E. D., Boettcher, J. M., Gajsiewicz, J. M., Morrissey, J. H. & Rienstra, C. M., Sep 2016, In : PloS one. 11, 9, e0163206.

Research output: Contribution to journalArticle

Inorganic polyphosphate in blood coagulation

Smith, S. A. & Morrissey, J. H., Jan 1 2016, Inorganic Polyphosphates in Eukaryotic Cells. Springer International Publishing, p. 159-176 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Interplay between steroid hormone activation of the unfolded protein response and nuclear receptor action

Zheng, X., Andruska, N., Yu, L., Mao, C., Kim, J. E., Livezey, M., Helferich, W. G. & Shapiro, D. J., Jan 1 2016, In : Steroids. 114, p. 2-6 5 p.

Research output: Contribution to journalReview article

Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity during Lacticin 481 Biosynthesis

Thibodeaux, C. J., Wagoner, J., Yu, Y. & Van Der Donk, W. A., May 25 2016, In : Journal of the American Chemical Society. 138, 20, p. 6436-6444 9 p.

Research output: Contribution to journalArticle

Lipoprotein Nanoplatelets: Brightly Fluorescent, Zwitterionic Probes with Rapid Cellular Entry

Lim, S. J., McDougle, D. R., Zahid, M. U., Ma, L., Das, A. & Smith, A. M., Jan 13 2016, In : Journal of the American Chemical Society. 138, 1, p. 64-67 4 p.

Research output: Contribution to journalArticle

Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite

Thiaville, J. J., Flood, J., Yurgel, S., Prunetti, L., Elbadawi-Sidhu, M., Hutinet, G., Forouhar, F., Zhang, X., Ganesan, V., Reddy, P., Fiehn, O., Gerlt, J. A., Hunt, J. F., Copley, S. D. & De Crécy-Lagard, V., Aug 19 2016, In : ACS chemical biology. 11, 8, p. 2304-2311 8 p.

Research output: Contribution to journalArticle

Microscopic Characterization of Membrane Transporter Function by In Silico Modeling and Simulation

Vermaas, J. V., Trebesch, N., Mayne, C. G., Thangapandian, S., Shekhar, M., Mahinthichaichan, P., Baylon, J. L., Jiang, T., Wang, Y., Muller, M. P., Shinn, E., Zhao, Z., Wen, P. C. & Tajkhorshid, E., 2016, Methods in Enzymology. Academic Press Inc., p. 373-428 56 p. (Methods in Enzymology; vol. 578).

Research output: Chapter in Book/Report/Conference proceedingChapter

MIDA boronates are hydrolysed fast and slow by two different mechanisms

Gonzalez, J. A., Ogba, O. M., Morehouse, G. F., Rosson, N., Houk, K. N., Leach, A. G., Cheong, P. H. Y., Burke, M. D. & Lloyd-Jones, G. C., Nov 1 2016, In : Nature Chemistry. 8, 11, p. 1067-1075 9 p.

Research output: Contribution to journalArticle

Molecular basis for differential anion binding and proton coupling in the Cl-/H+ exchanger ClC-ec1

Jiang, T., Han, W., Maduke, M. & Tajkhorshid, E., Mar 9 2016, In : Journal of the American Chemical Society. 138, 9, p. 3066-3075 10 p.

Research output: Contribution to journalArticle

Molecular basis for resistance against phosphonate antibiotics and herbicides

Chekan, J. R., Cogan, D. P. & Nair, S. K., Jan 1 2016, In : MedChemComm. 7, 1, p. 28-36 9 p.

Research output: Contribution to journalReview article

Molecular basis for the broad substrate selectivity of a peptide prenyltransferase

Hao, Y., Pierce, E., Roe, D., Morita, M., McIntosh, J. A., Agarwal, V., Cheatham, T. E., Schmidt, E. W. & Nair, S. K., Dec 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 49, p. 14037-14042 6 p.

Research output: Contribution to journalArticle

Motif-driven design of protein–protein interfaces

Silva, D. A., Correia, B. E. & Procko, E., May 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 285-304 20 p. (Methods in Molecular Biology; vol. 1414).

Research output: Chapter in Book/Report/Conference proceedingChapter