Research Output 1968 2019

2017

Introduction: Unusual Enzymology in Natural Product Synthesis

Van Der Donk, W. A., Apr 26 2017, In : Chemical reviews. 117, 8, p. 5223-5225 3 p.

Research output: Contribution to journalEditorial

Cyclization
Biological Products
Catalysis
Peptides
Enzymes

Isolation of bacterial compartments to track movement of protein synthesis factors

Zhao, H. & Martinis, S. A., Jan 15 2017, In : Methods. 113, p. 120-126 7 p.

Research output: Contribution to journalArticle

Amino Acyl-tRNA Synthetases
Transfer RNA
Fractionation
Proteins
Membranes

Light-Mediated reversible modulation of the Mitogen-Activated protein Kinase pathway during cell differentiation and xenopus embryonic development

Krishnamurthy, V. V., Turgeon, A. J., Khamo, J. S., Mondal, P., Sharum, S. R., Mei, W., Yang, J. & Zhang, K., Jun 15 2017, In : Journal of Visualized Experiments. 2017, 124, e55823.

Research output: Contribution to journalArticle

Xenopus
Mitogen-Activated Protein Kinases
Embryonic Development
Cell Differentiation
Phosphotransferases

Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase

Jiang, T., Yu, K., Hartzell, H. C. & Tajkhorshid, E., Sep 16 2017, In : eLife. 6, e28671.

Research output: Contribution to journalArticle

Phospholipids
Ions
Membranes
Lipids
Adenosine Triphosphate

Lipid specificity of the membrane binding domain of coagulation factor X

Muller, M. P., Wang, Y., Morrissey, J. H. & Tajkhorshid, E., Oct 2017, In : Journal of Thrombosis and Haemostasis. 15, 10, p. 2005-2016 12 p.

Research output: Contribution to journalArticle

Factor X
Membrane Lipids
Phosphatidylserines
Membranes
Lipids

Localization of Short-Chain Polyphosphate Enhances its Ability to Clot Flowing Blood Plasma

Yeon, J. H., Mazinani, N., Schlappi, T. S., Chan, K. Y. T., Baylis, J. R., Smith, S. A., Donovan, A. J., Kudela, D., Stucky, G. D., Liu, Y., Morrissey, J. H. & Kastrup, C. J., Feb 10 2017, In : Scientific reports. 7, 42119.

Research output: Contribution to journalArticle

blood
plasma
polyp
polymer
fold

Location of the Substrate Binding Site of the Cytochrome bo3 Ubiquinol Oxidase from Escherichia coli

Choi, S. K., Schurig-Briccio, L., Ding, Z., Hong, S., Sun, C. & Gennis, R. B., Jun 21 2017, In : Journal of the American Chemical Society. 139, 24, p. 8346-8354 9 p.

Research output: Contribution to journalArticle

Binding sites
Cytochromes
Escherichia coli
cytochrome
coenzyme Q10

Mass spectrometry-based cross-linking study shows that the Psb28 protein binds to cytochrome b559 in Photosystem II

Weisz, D. A., Liu, H., Zhang, H., Thangapandian, S., Tajkhorshid, E., Gross, M. L. & Pakrasi, H. B., Feb 28 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. 2224-2229 6 p.

Research output: Contribution to journalArticle

Photosystem II Protein Complex
Mass Spectrometry
Proteins
cytochrome b559
Isotopes

Maternal dead-end 1 promotes translation of nanos1 by binding the eiF3 complex

Aguero, T., Jin, Z., Chorghade, S., Kalsotra, A., King, M. L. & Yang, J., Oct 15 2017, In : Development (Cambridge). 144, 20, p. 3755-3765 11 p.

Research output: Contribution to journalArticle

germ cell
embryo
Germ Cells
Mothers
Fertilization

Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity

Liu, D. C., Seimetz, J., Lee, K. Y., Kalsotra, A., Chung, H. J., Lu, H. & Tsai, N-P., Oct 15 2017, In : Human molecular genetics. 26, 20, p. 3895-3908 14 p.

Research output: Contribution to journalArticle

Fragile X Mental Retardation Protein
Protein Biosynthesis
Fragile X Syndrome
Neuronal Plasticity
Animal Behavior

Mechanism of a Class C Radical S-Adenosyl- l -methionine Thiazole Methyl Transferase

Zhang, Z., Mahanta, N., Hudson, G. A., Mitchell, D. A. & van der Donk, W. A., Dec 27 2017, In : Journal of the American Chemical Society. 139, 51, p. 18623-18631 9 p.

Research output: Contribution to journalArticle

Thiazoles
Methyltransferases
Transferases
Methionine
Hydrogen

Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes

Repka, L. M., Chekan, J. R., Nair, S. K. & Van Der Donk, W. A., Apr 26 2017, In : Chemical reviews. 117, 8, p. 5457-5520 64 p.

Research output: Contribution to journalArticle

Sulfides
Bioactivity
Bacteriocins
Peptides
Cyclization

Microfluidic platform for efficient Nanodisc assembly, membrane protein incorporation, and purification

Wade, J. H., Jones, J. D., Lenov, I. L., Riordan, C. M., Sligar, S. & Bailey, R. C., Jan 1 2017, In : Lab on a Chip. 17, 17, p. 2951-2959 9 p.

Research output: Contribution to journalArticle

Microfluidics
Purification
Membrane Proteins
Proteins
Membranes

Mitochondrial VDAC1: A key gatekeeper as potential therapeutic target

Camara, A. K. S., Zhou, Y. F., Wen, P. C., Tajkhorshid, E. & Kwok, W. M., Jun 30 2017, In : Frontiers in Physiology. 8, JUN, 460.

Research output: Contribution to journalReview article

Voltage-Dependent Anion Channel 1
Mitochondria
Therapeutics
Apoptosis
Apoptosis Regulatory Proteins

Molecular basis for the substrate specificity of quorum signal synthases

Dong, S. H., Frane, N. D., Christensen, Q. H., Greenberg, E. P., Nagarajan, R. & Nair, S. K., Aug 22 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 34, p. 9092-9097 6 p.

Research output: Contribution to journalArticle

Substrate Specificity
Methionine
Acyl Carrier Protein
Proteobacteria
Lactones

Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain

Skariah, G., Seimetz, J., Norsworthy, M., Lannom, M. C., Kenny, P. J., Elrakhawy, M., Forsthoefel, C., Drnevich, J., Kalsotra, A. & Ceman, S., Jun 29 2017, In : BMC biology. 15, 1, 54.

Research output: Contribution to journalArticle

Moloney murine leukemia virus
Retroelements
retrotransposons
leukemia
Viruses

Myeloid STAT3 promotes lung tumorigenesis by transforming tumor immunosurveillance into tumor-promoting inflammation

Zhou, J., Qu, Z., Sun, F., Han, L., Li, L., Yan, S., Stabile, L. P., Chen, L. F., Siegfried, J. M. & Xiao, G., Mar 2017, In : Cancer Immunology Research. 5, 3, p. 257-268 12 p.

Research output: Contribution to journalArticle

Immunologic Monitoring
Carcinogenesis
Inflammation
Lung
Neoplasms

Myotonic dystrophy: disease repeat range, penetrance, age of onset, and relationship between repeat size and phenotypes

Yum, K., Wang, E. T. & Kalsotra, A., Jun 1 2017, In : Current Opinion in Genetics and Development. 44, p. 30-37 8 p.

Research output: Contribution to journalReview article

Myotonic Dystrophy
Penetrance
Genetic Testing
Age of Onset
Myotonia

Nanodiscs in Membrane Biochemistry and Biophysics

Denisov, I. G. & Sligar, S. G., Mar 22 2017, In : Chemical reviews. 117, 6, p. 4669-4713 45 p.

Research output: Contribution to journalReview article

Biophysics
Biochemistry
Membrane Proteins
Membranes
Cell signaling

NitroxylFluor: A Thiol-Based Fluorescent Probe for Live-Cell Imaging of Nitroxyl

Pino, N. W., Davis, J., Yu, Z. & Chan, J. K. F., Dec 27 2017, In : Journal of the American Chemical Society. 139, 51, p. 18476-18479 4 p.

Research output: Contribution to journalArticle

thiol
Fluorescent Dyes
Sulfhydryl Compounds
probe
Imaging techniques

O-H activation by an unexpected ferryl intermediate during catalysis by 2-hydroxyethylphosphonate dioxygenase

Peck, S. C., Wang, C., Dassama, L. M. K., Zhang, B., Guo, Y., Rajakovich, L. J., Martin Bollinger, J., Krebs, C. & van der Donk, W. A., Feb 8 2017, In : Journal of the American Chemical Society. 139, 5, p. 2045-2052 8 p.

Research output: Contribution to journalArticle

Dioxygenases
catalysis
Catalysis
glufosinate
Chemical activation
Pimelic Acids
Biotin
Bacillus subtilis
Fatty Acids
Acids

Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

Chorghade, S., Seimetz, J., Emmons, R., Yang, J., Bresson, S. M., de Lisio, M., Parise, G., Conrad, N. K. & Kalsotra, A., Jun 27 2017, In : eLife. 6, e24139.

Research output: Contribution to journalArticle

Poly(A)-Binding Protein I
Messenger RNA
Poly(A)-Binding Proteins
Cardiomegaly
Protein Biosynthesis

Polyphosphate and RNA differentially modulate the contact pathway of blood clotting

Gajsiewicz, J. M., Smith, S. A. & Morrissey, J. H., Feb 3 2017, In : Journal of Biological Chemistry. 292, 5, p. 1808-1814 7 p.

Research output: Contribution to journalArticle

Polyphosphates
Blood Coagulation
Blood
RNA
Chemical activation

Preoperative Metabolic Syndrome Is Predictive of Significant Gastric Cancer Mortality after Gastrectomy: The Fujian Prospective Investigation of Cancer (FIESTA) Study

Hu, D., Peng, F., Lin, X., Chen, G., Zhang, H., Liang, B., Ji, K., Lin, J., Chen, L-F., Zheng, X. & Niu, W., Feb 1 2017, In : EBioMedicine. 15, p. 73-80 8 p.

Research output: Contribution to journalArticle

Gastrectomy
Stomach Neoplasms
Hazards
Mortality
Neoplasms
Azurin
Electron transitions
Amides
Peptides
Electronic structure

Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4

Hu, X., Dong, S. H., Chen, J., Zhou, X. Z., Chen, R., Nair, S., Lu, K. P. & Chen, L. F., Sep 7 2017, In : Oncogene. 36, 36, p. 5177-5188 12 p.

Research output: Contribution to journalArticle

Peptidylprolyl Isomerase
Stomach Neoplasms
Neoplasms
Ubiquitination
Threonine

Recent advances in nanodisc technology for membrane protein studies (2012–2017)

Rouck, J. E., Krapf, J. E., Roy, J., Huff, H. C. & Das, A., Jul 1 2017, In : FEBS Letters. 591, 14, p. 2057-2088 32 p.

Research output: Contribution to journalReview article

Membrane Proteins
Technology
Nanotechnology
Fluorescence microscopy
Scintillation

Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine Thiazole C-Methyltransferase in Thiomuracin Biosynthesis

Mahanta, N., Zhang, Z., Hudson, G. A., van der Donk, W. A. & Mitchell, D. A., Mar 29 2017, In : Journal of the American Chemical Society. 139, 12, p. 4310-4313 4 p.

Research output: Contribution to journalArticle

Thiazoles
methionine S-methyltransferase
Biosynthesis
Methyltransferases
Substrate Specificity

Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals

Grillo, A. S., SantaMaria, A. M., Kafina, M. D., Cioffi, A. G., Huston, N. C., Han, M., Seo, Y. A., Yien, Y. Y., Nardone, C., Menon, A. V., Fan, J., Svoboda, D. C., Anderson, J. B., Hong, J. D., Nicolau, B. G., Subedi, K., Gewirth, A. A., Wessling-Resnick, M., Kim, J., Paw, B. H. & 1 others, Burke, M., May 12 2017, In : Science. 356, 6338, p. 608-616 9 p.

Research output: Contribution to journalArticle

Iron
Zebrafish
Biological Products
Carrier Proteins
Membrane Proteins

Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era

Hetrick, K. J. & van der Donk, W. A., Jun 1 2017, In : Current Opinion in Chemical Biology. 38, p. 36-44 9 p.

Research output: Contribution to journalReview article

Biological Products
Genes
Genome
Bacterial Genomes
Peptides

Ribosomal Natural Products, Tailored to Fit

Funk, M. A. & van der Donk, W. A., Jul 18 2017, In : Accounts of chemical research. 50, 7, p. 1577-1586 10 p.

Research output: Contribution to journalArticle

Biological Products
Bioactivity
Amino Acids
Peptides
Enzymes

RNA modifications and structures cooperate to guide RNA-protein interactions

Lewis, C. J. T., Pan, T. & Kalsotra, A., Mar 1 2017, In : Nature Reviews Molecular Cell Biology. 18, 3, p. 202-210 9 p.

Research output: Contribution to journalReview article

Guide RNA
RNA
Proteins
Transcriptome
Gene Expression

Searching for the low affinity ubiquinone binding site in cytochrome bo 3 from Escherichia coli

Choi, S. K., Lin, M. T., Ouyang, H. & Gennis, R. B., May 1 2017, In : Biochimica et Biophysica Acta - Bioenergetics. 1858, 5, p. 366-370 5 p.

Research output: Contribution to journalArticle

Ubiquinone
Cytochromes
Escherichia coli
Binding Sites
Heme

Selective killing of Helicobacter pylori with pH-responsive helix–coil conformation transitionable antimicrobial polypeptides

Xiong, M., Bao, Y., Xu, X., Wang, H., Han, Z., Wang, Z., Liu, Y., Huang, S., Song, Z., Chen, J., Peek, R. M., Yin, L., Chen, L-F. & Cheng, J., Nov 28 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 48, p. 12675-12680 6 p.

Research output: Contribution to journalArticle

Helicobacter pylori
Bacteria
Stomach
Peptides
Glutamic Acid

Silica particles contribute to the procoagulant activity of DNA and polyphosphate isolated using commercial kits

Smith, S. A., Baker, C. J., Gajsiewicz, J. M. & Morrissey, J. H., Jul 6 2017, In : Blood. 130, 1, p. 88-91 4 p.

Research output: Contribution to journalLetter

Simultaneous removal of multiple DNA segments by polymerase chain reactions

Krishnamurthy, V. & Zhang, K., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 193-203 11 p. (Methods in Molecular Biology; vol. 1472).

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA-Directed DNA Polymerase
Synthetic Biology
Polymerase Chain Reaction
DNA
Organism Cloning
Neurons
Actins
Depolymerization
Nerve Growth Factor
Microfluidics

Small molecule T63 suppresses osteoporosis by modulating osteoblast differentiation via BMP and WNT signaling pathways

Zhao, X. L., Chen, J. J., Zhang, G. N., Wang, Y. C., Si, S. Y., Chen, L-F. & Wang, Z., Dec 1 2017, In : Scientific Reports. 7, 1, 10397.

Research output: Contribution to journalArticle

Osteoblasts
Osteoporosis
Osteogenesis
Bone and Bones
Catenins

Structural basis for methylphosphonate biosynthesis

Born, D. A., Ulrich, E. C., Ju, K. S., Peck, S. C., Van Der Donk, W. A. & Drennan, C. L., Dec 8 2017, In : Science. 358, 6368, p. 1336-1339 4 p.

Research output: Contribution to journalArticle

Methane
Glutamine
Oceans and Seas
Phosphorus
methylphosphonic acid

Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome

Zeng, F., Chen, Y., Remis, J., Shekhar, M., Phillips, J. C., Tajkhorshid, E. & Jin, H., Jan 26 2017, In : Nature. 541, 7638, p. 554-557 4 p.

Research output: Contribution to journalArticle

Ribosomes
Quality Control
Messenger RNA
Proteins
Cryoelectron Microscopy
Peptide Biosynthesis
Cycloaddition Reaction
Anti-Bacterial Agents
Catalytic Domain
Organic Chemistry

Structurally novel antiestrogens elicit differential responses from constitutively active mutant estrogen receptors in breast cancer cells and tumors

Zhao, Y., Laws, M. J., Guillen, V. S., Ziegler, Y., Min, J., Sharma, A., Kim, S. H., Chu, D., Park, B. H., Oesterreich, S., Mao, C., Shapiro, D. J., Nettles, K. W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Oct 15 2017, In : Cancer Research. 77, 20, p. 5602-5613 12 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Estrogen Receptors
Breast Neoplasms
Neoplasms
Inbred NOD Mouse

Structure-Activity Relationships of the S-Linked Glycocin Sublancin

Biswas, S., Garcia De Gonzalo, C. V., Repka, L. M. & van der Donk, W. A., Dec 15 2017, In : ACS chemical biology. 12, 12, p. 2965-2969 5 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Bioactivity
Biological Products
Biosynthetic Pathways
Disulfides

The intestinal copper exporter CUA-1 is required for systemic copper homeostasis in Caenorhabditis elegans

Chun, H., Sharma, A. K., Lee, J., Chan, J. K. F., Jia, S. & Kim, B. E., Jan 6 2017, In : Journal of Biological Chemistry. 292, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Copper
Homeostasis
Biochemical Phenomena
Menkes Kinky Hair Syndrome

The natural productome

Palazzolo, A. M. E., Simons, C. L. W. & Burke, M. D., May 30 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 22, p. 5564-5566 3 p.

Research output: Contribution to journalComment/debate

The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes

Estrada, P., Manandhar, M., Dong, S. H., Deveryshetty, J., Agarwal, V., Cronan, J. E. & Nair, S. K., Jun 1 2017, In : Nature chemical biology. 13, 6, p. 668-674 7 p.

Research output: Contribution to journalArticle

Amino Acyl-tRNA Synthetases
Catalytic Domain
Coenzyme A Ligases
Enzymes
Coenzyme A

Tribute to Klaus Schulten

Tajkhorshid, E. & Chipot, C., Apr 20 2017, In : Journal of Physical Chemistry B. 121, 15, p. 3203-3205 3 p.

Research output: Contribution to journalEditorial

Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis

Ortega, M. A., Cogan, D. P., Mukherjee, S., Garg, N., Li, B., Thibodeaux, G. N., Maffioli, S. I., Donadio, S., Sosio, M., Escano, J., Smith, L., Nair, S. K. & Van Der Donk, W. A., Feb 17 2017, In : ACS chemical biology. 12, 2, p. 548-557 10 p.

Research output: Contribution to journalArticle

Biosynthesis
Cysteine
Bacteriocins
Substrates
Bioinformatics

X-ray transparent microfluidic chips for high-throughput screening and optimization of in meso membrane protein crystallization

Schieferstein, J. M., Pawate, A. S., Sun, C., Wan, F., Sheraden, P. N., Broecker, J., Ernst, O. P., Gennis, R. B. & Kenis, P. J. A., Mar 1 2017, In : Biomicrofluidics. 11, 2, 024118.

Research output: Contribution to journalArticle

Microfluidics
Crystallization
Screening
Membrane Proteins
screening