Research Output

2018

Menthol stereoisomers exhibit different effects on α4β2 nAChR upregulation and dopamine neuron spontaneous firing

Henderson, B. J., Grant, S., Wong, B. K., Shahoei, R., Huard, S. M., Saladi, S. S. M., Tajkhorshid, E., Dougherty, D. A. & Lester, H. A., Nov 1 2018, In : eNeuro. 5, 6, e0465-18.2018.

Research output: Contribution to journalArticle

Microscopic view of lipids and their diverse biological functions

Wen, P. C., Mahinthichaichan, P., Trebesch, N., Jiang, T., Zhao, Z., Shinn, E., Wang, Y., Shekhar, M., Kapoor, K., Chan, C. K. & Tajkhorshid, E., Aug 2018, In : Current Opinion in Structural Biology. 51, p. 177-186 10 p.

Research output: Contribution to journalReview article

Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis

Ongpipattanakul, C. & Nair, S. K., Oct 19 2018, In : ACS chemical biology. 13, 10, p. 2989-2999 11 p.

Research output: Contribution to journalArticle

Molecular insight into drug exporters within the cellular membrane

Tajkhorshid, E., Jul 2018, In : Pharmacological Research. 133, 1 p.

Research output: Contribution to journalEditorial

Nanodiscs: A Controlled Bilayer Surface for the Study of Membrane Proteins

McLean, M. A., Gregory, M. C. & Sligar, S. G., May 20 2018, In : Annual Review of Biophysics. 47, p. 107-124 18 p.

Research output: Contribution to journalReview article

Near-Infrared Photoactivatable Nitric Oxide Donors with Integrated Photoacoustic Monitoring

Zhou, E. Y., Knox, H. J., Reinhardt, C. J., Partipilo, G., Nilges, M. J. & Chan, J. K. F., Sep 19 2018, In : Journal of the American Chemical Society. 140, 37, p. 11686-11697 12 p.

Research output: Contribution to journalArticle

Novel Xanthomonas campestris long-chain-specific 3-oxoacyl- acyl carrier protein reductase involved in diffusible signal factor synthesis

Hu, Z., Dong, H., Ma, J. C., Yu, Y., Li, K. H., Guo, Q. Q., Zhang, C., Zhang, W. B., Cao, X., Cronan, J. E. & Wang, H., May 1 2018, In : mBio. 9, 3, e00596-18.

Research output: Contribution to journalArticle

Peridinin Is an Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation

Haley, H. M. S., Hill, A. G., Greenwood, A. I., Woerly, E. M., Rienstra, C. M. & Burke, M. D., Nov 14 2018, In : Journal of the American Chemical Society. 140, 45, p. 15227-15240 14 p.

Research output: Contribution to journalArticle

Photophysical Tuning of N-Oxide-Based Probes Enables Ratiometric Photoacoustic Imaging of Tumor Hypoxia

Knox, H. J., Kim, T. W., Zhu, Z. & Chan, J., Jul 20 2018, In : ACS chemical biology. 13, 7, p. 1838-1843 6 p.

Research output: Contribution to journalArticle

Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis

Morita, M., Hao, Y., Jokela, J. K., Sardar, D., Lin, Z., Sivonen, K., Nair, S. K. & Schmidt, E. W., May 16 2018, In : Journal of the American Chemical Society. 140, 19, p. 6044-6048 5 p.

Research output: Contribution to journalArticle

Prediction of enzymatic pathways by integrative pathway mapping

Calhoun, S., Korczynska, M., Wichelecki, D. J., San Francisco, B., Zhao, S., Rodionov, D. A., Vetting, M. W., Al-Obaidi, N. F., Lin, H., O’Meara, M. J., Scott, D. A., Morris, J. H., Russel, D., Almo, S. C., Osterman, A. L., Gerlt, J. A., Jacobson, M. P., Shoichet, B. K. & Sali, A., Jan 29 2018, In : eLife. 7, e31097.

Research output: Contribution to journalArticle

Probing key elements of teixobactin-lipid II interactions in membranes

Wen, P. C., Vanegas, J. M., Rempe, S. B. & Tajkhorshid, E., Jan 1 2018, In : Chemical Science. 9, 34, p. 6997-7008 12 p.

Research output: Contribution to journalArticle

P-TEFb: Finding its ways to release promoter-proximally paused RNA polymerase II

Li, Y., Liu, M., Chen, L. F. & Chen, R., Mar 15 2018, In : Transcription. 9, 2, p. 88-94 7 p.

Research output: Contribution to journalReview article

PyContact: Rapid, Customizable, and Visual Analysis of Noncovalent Interactions in MD Simulations

Scheurer, M., Rodenkirch, P., Siggel, M., Bernardi, R. C., Schulten, K., Tajkhorshid, E. & Rudack, T., Feb 6 2018, In : Biophysical journal. 114, 3, p. 577-583 7 p.

Research output: Contribution to journalArticle

Rapid Discovery of Glycocins through Pathway Refactoring in Escherichia coli

Ren, H., Biswas, S., Ho, S., Van Der Donk, W. A. & Zhao, H., Oct 19 2018, In : ACS chemical biology. 13, 10, p. 2966-2972 7 p.

Research output: Contribution to journalArticle

Rapid Screening of Lanthipeptide Analogs via In-Colony Removal of Leader Peptides in Escherichia coli

Si, T., Tian, Q., Min, Y., Zhang, L., Sweedler, J. V., Van Der Donk, W. A. & Zhao, H., Sep 26 2018, In : Journal of the American Chemical Society. 140, 38, p. 11884-11888 5 p.

Research output: Contribution to journalArticle

Reconstitution and substrate specificity for isopentenyl pyrophosphate of the antiviral radical SAM enzyme viperin

Chakravarti, A., Selvadurai, K., Shahoei, R., Lee, H., Fatma, S., Tajkhorshid, E. & Huang, R. H., Sep 7 2018, In : Journal of Biological Chemistry. 293, 36, p. 14122-14133 12 p.

Research output: Contribution to journalReview article

Reduced axonal surface expression and phosphoinositide sensitivity in Kv7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathy

Kim, E. C., Zhang, J., Pang, W., Wang, S., Lee, K. Y., Cavaretta, J. P., Walters, J., Procko, E., Tsai, N. P. & Chung, H. J., Oct 2018, In : Neurobiology of Disease. 118, p. 76-93 18 p.

Research output: Contribution to journalArticle

Role of the tightly bound quinone for the oxygen reaction of cytochrome bo3 oxidase from Escherichia coli

Melin, F., Sabuncu, S., Choi, S. K., Leprince, A., Gennis, R. B. & Hellwig, P., Oct 2018, In : FEBS Letters. 592, 20, p. 3380-3387 8 p.

Research output: Contribution to journalArticle

Salt bridges gate ?-catenin activation at intercellular junctions

Barrick, S., Li, J., Kong, X., Ray, A., Tajkhorshid, E. & Leckband, D., Jan 15 2018, In : Molecular biology of the cell. 29, 2, p. 111-122 12 p.

Research output: Contribution to journalArticle

Sbp1 modulates the translation of Pab1 mRNA in a poly(A)- and RGG-dependent manner

Brandariz-Núñez, A., Zeng, F., Ngoc Lam, Q. & Hong, J. I. N., Jan 2018, In : RNA. 24, 1, p. 43-55 13 p.

Research output: Contribution to journalArticle

Selective Permeability of Carboxysome Shell Pores to Anionic Molecules

Mahinthichaichan, P., Morris, D. M., Wang, Y., Jensen, G. J. & Tajkhorshid, E., Oct 4 2018, In : Journal of Physical Chemistry B. 122, 39, p. 9110-9118 9 p.

Research output: Contribution to journalArticle

Sensitivity of peripheral membrane proteins to the membrane context: A case study of phosphatidylserine and the TIM proteins

Kerr, D., Tietjen, G. T., Gong, Z., Tajkhorshid, E., Adams, E. J. & Lee, K. Y. C., Oct 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 10, p. 2126-2133 8 p.

Research output: Contribution to journalReview article

SMPL synaptic membranes: Nanodisc-mediated synaptic membrane mimetics expand the toolkit for drug discovery and the molecular cell biology of synapses

Lo Bu, R., Clark, J., DiChiara, T., Sligar, S. G. & Klein, W. L., Jan 1 2018, Neuromethods. Humana Press Inc., p. 227-250 24 p. (Neuromethods; vol. 141).

Research output: Chapter in Book/Report/Conference proceedingChapter

Solid-State NMR of highly 13C-enriched cholesterol in lipid bilayers

Della Ripa, L. A., Petros, Z. A., Cioffi, A. G., Piehl, D. W., Courtney, J. M., Burke, M. D. & Rienstra, C. M., Apr 1 2018, In : Methods. 138-139, p. 47-53 7 p.

Research output: Contribution to journalArticle

Special Issue: Current Topics in Mechanistic Enzymology

Gerlt, J. A., Jun 5 2018, In : Biochemistry. 57, 22, p. 3085-3086 2 p.

Research output: Contribution to journalEditorial

Stereospecific Radical-Mediated B12-Dependent Methyl Transfer by the Fosfomycin Biosynthesis Enzyme Fom3

McLaughlin, M. I. & Van Der Donk, W. A., Aug 21 2018, In : Biochemistry. 57, 33, p. 4967-4971 5 p.

Research output: Contribution to journalArticle

Strong and sustained activation of the anticipatory unfolded protein response induces necrotic cell death

Livezey, M., Huang, R., Hergenrother, P. J. & Shapiro, D. J., Oct 2018, In : Cell Death and Differentiation. 25, 10, p. 1796-1807 12 p.

Research output: Contribution to journalArticle

Structural and Biochemical Studies of a Biocatalyst for the Enzymatic Production of Wax Esters

Petronikolou, N. & Nair, S. K., Jul 6 2018, In : ACS Catalysis. 8, 7, p. 6334-6344 11 p.

Research output: Contribution to journalArticle

Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop “Out” Conformation for LasR

O'Reilly, M. C., Dong, S. H., Rossi, F. M., Karlen, K. M., Kumar, R. S., Nair, S. K. & Blackwell, H. E., Sep 20 2018, In : Cell chemical biology. 25, 9, p. 1128-1139.e3

Research output: Contribution to journalArticle

Structural basis of transcriptional regulation by cour, a repressor of coumarate catabolism, in rhodopseudomonas palustris

Cogan, D. P., Baraquet, C., Harwood, C. S. & Nair, S. K., Jul 27 2018, In : Journal of Biological Chemistry. 293, 30, p. 11727-11735 9 p.

Research output: Contribution to journalArticle

Structure-Guided Analyses of a Key Enzyme Involved in the Biosynthesis of an Antivitamin

Kapoor, I. & Nair, S. K., Sep 11 2018, In : Biochemistry. 57, 36, p. 5282-5288 7 p.

Research output: Contribution to journalArticle

Structure of the alternative complex III in a supercomplex with cytochrome oxidase

Sun, C., Benlekbir, S., Venkatakrishnan, P., Wang, Y., Hong, S., Hosler, J., Tajkhorshid, E., Rubinstein, J. L. & Gennis, R. B., May 3 2018, In : Nature. 557, 7703, p. 123-126 4 p.

Research output: Contribution to journalArticle

Substrate-assisted enzymatic formation of lysinoalanine in duramycin

An, L., Cogan, D. P., Navo, C. D., Jiménez-Osés, G., Nair, S. K. & van der Donk, W. A., Oct 1 2018, In : Nature chemical biology. 14, 10, p. 928-933 6 p.

Research output: Contribution to journalArticle

Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity

Sharma, P. & Kranz, D. M., Feb 2 2018, In : Journal of Biological Chemistry. 293, 5, p. 1820-1834 15 p.

Research output: Contribution to journalArticle

Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1

Anorma, C., Hedhli, J., Bearrood, T. E., Pino, N. W., Gardner, S. H., Inaba, H., Zhang, P., Li, Y., Feng, D., Dibrell, S. E., Kilian, K. A., Dobrucki, L. W., Fan, T. M. & Chan, J., Aug 22 2018, In : ACS Central Science. 4, 8, p. 1045-1055 11 p.

Research output: Contribution to journalArticle

Synthesis of Antibiotics and Related Molecules

Movassaghi, M. & van der Donk, W. A., Jul 6 2018, In : Journal of Organic Chemistry. 83, 13, p. 6826-6828 3 p.

Research output: Contribution to journalEditorial

T63 inhibits osteoclast differentiation through regulating MAPKs and Akt signaling pathways

Zhao, X. L., Chen, J. J., SI, S. Y., Chen, L. F. & Wang, Z., Sep 5 2018, In : European Journal of Pharmacology. 834, p. 30-35 6 p.

Research output: Contribution to journalArticle

Targeting multidrug-resistant ovarian cancer through estrogen receptor a dependent ATP depletion caused by hyperactivation of the unfolded protein response

Zheng, X., Andruska, N., Lambrecht, M. J., He, S., Parissenti, A., Hergenrother, P. J., Nelson, E. R. & Shapiro, D. J., Jan 1 2018, In : Oncotarget. 9, 19, p. 14741-14753 13 p.

Research output: Contribution to journalArticle

The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis

Gu, W., Dong, S. H., Sarkar, S., Nair, S. K. & Schmidt, E. W., Jan 1 2018, Methods in Enzymology. Moore, B. S. (ed.). Academic Press Inc., p. 113-163 51 p. (Methods in Enzymology; vol. 604).

Research output: Chapter in Book/Report/Conference proceedingChapter

The electron distribution in the "activated" state of cytochrome c oxidase

Vilhjálmsdóttir, J., Gennis, R. B. & Brzezinski, P., Dec 1 2018, In : Scientific reports. 8, 1, 7502.

Research output: Contribution to journalArticle

Open Access

The Enzymology of Prochlorosin Biosynthesis

Bobeica, S. C. & van der Donk, W. A., Jan 1 2018, Methods in Enzymology. Moore, B. S. (ed.). Academic Press Inc., p. 165-203 39 p. (Methods in Enzymology; vol. 604).

Research output: Chapter in Book/Report/Conference proceedingChapter

The Molecular Industrial Revolution: Automated Synthesis of Small Molecules

Trobe, M. & Burke, M. D., Apr 9 2018, In : Angewandte Chemie - International Edition. 57, 16, p. 4192-4214 23 p.

Research output: Contribution to journalReview article

The Need for Manuscripts to Include Database Identifiers for Proteins

Gerlt, J. A., Jul 24 2018, In : Biochemistry. 57, 29, p. 4239-4240 2 p.

Research output: Contribution to journalEditorial

The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells

Fanning, S. W., Jeselsohn, R., Dharmarajan, V., Mayne, C. G., Karimi, M., Buchwalter, G., Houtman, R., Toy, W., Fowler, C. E., Han, R., Lainé, M., Carlson, K. E., Martin, T. A., Nowak, J., Nwachukwu, J. C., Hosfield, D. J., Chandarlapaty, S., Tajkhorshid, E., Nettles, K. W., Griffin, P. R. & 4 others, Shen, Y., Katzenellenbogen, J. A., Brown, M. & Greene, G. L., Nov 1 2018, In : eLife. 7, e37161.

Research output: Contribution to journalArticle

Towards the generalized iterative synthesis of small molecules

Lehmann, J. W., Blair, D. J. & Burke, M. D., Jan 1 2018, In : Nature Reviews Chemistry. 2, 2, 0115.

Research output: Contribution to journalReview article

Type 2 NADH dehydrogenase is the only point of entry for electrons into the Streptococcus agalactiae respiratory chain and is a potential drug target

Lencina, A. M., Franza, T., Sullivan, M. J., Ulett, G. C., Ipe, D. S., Gaudu, P., Gennis, R. B. & Schurig-Briccio, L. A., Jul 1 2018, In : mBio. 9, 4, e01034-18.

Research output: Contribution to journalArticle

Open Access

Unpaired Electron Spin Density Distribution across Reduced [2Fe-2S] Cluster Ligands by 13Cβ-Cysteine Labeling

Taguchi, A. T., Miyajima-Nakano, Y., Fukazawa, R., Lin, M. T., Baldansuren, A., Gennis, R. B., Hasegawa, K., Kumasaka, T., Dikanov, S. & Iwasaki, T., Jan 16 2018, In : Inorganic Chemistry. 57, 2, p. 741-746 6 p.

Research output: Contribution to journalArticle

X-ray transparent microfluidic platforms for membrane protein crystallization with microseeds

Schieferstein, J. M., Pawate, A. S., Varel, M. J., Guha, S., Astrauskaite, I., Gennis, R. B. & Kenis, P. J. A., Mar 21 2018, In : Lab on a chip. 18, 6, p. 944-954 11 p.

Research output: Contribution to journalArticle