Research Output

2018

Advances in synthesis of biotin and assembly of lipoic acid

Cronan, J. E., Dec 2018, In : Current Opinion in Chemical Biology. 47, p. 60-66 7 p.

Research output: Contribution to journalReview article

A lanthipeptide library used to identify a protein-protein interaction inhibitor article

Yang, X., Lennard, K. R., He, C., Walker, M. C., Ball, A. T., Doigneaux, C., Tavassoli, A. & Van Der Donk, W. A., Apr 1 2018, In : Nature chemical biology. 14, 4, p. 375-380 6 p.

Research output: Contribution to journalArticle

Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L.

Zhang, J., Zhang, X., Tang, H., Zhang, Q., Hua, X., Ma, X., Zhu, F., Jones, T., Zhu, X., Bowers, J., Wai, C. M., Zheng, C., Shi, Y., Chen, S., Xu, X., Yue, J., Nelson, D. R., Huang, L., Li, Z., Xu, H. & 88 others, Zhou, D., Wang, Y., Hu, W., Lin, J., Deng, Y., Pandey, N., Mancini, M., Zerpa, D., Nguyen, J. K., Wang, L., Yu, L., Xin, Y., Ge, L., Arro, J., Han, J. O., Chakrabarty, S., Pushko, M., Zhang, W., Ma, Y., Ma, P., Lv, M., Chen, F., Zheng, G., Xu, J., Yang, Z., Deng, F., Chen, X., Liao, Z., Zhang, X., Lin, Z., Lin, H., Yan, H., Kuang, Z., Zhong, W., Liang, P., Wang, G., Yuan, Y., Shi, J., Hou, J., Lin, J., Jin, J., Cao, P., Shen, Q., Jiang, Q., Zhou, P., Ma, Y., Zhang, X., Xu, R., Liu, J., Zhou, Y., Jia, H., Ma, Q., Qi, R., Zhang, Z., Fang, J., Fang, H., Song, J., Wang, M., Dong, G., Wang, G., Chen, Z., Ma, T., Liu, H., Dhungana, S. R., Huss, S. E., Yang, X., Sharma, A., Trujillo, J. H., Martinez, M. C., Hudson, M., Riascos, J. J., Schuler, M., Chen, L. Q., Braun, D. M., Li, L., Yu, Q., Wang, J., Wang, K., Schatz, M. C., Heckerman, D., Van Sluys, M. A., Souza, G. M., Moore, P. H., Sankoff, D., VanBuren, R., Paterson, A. H., Nagai, C. & Ming, R., Nov 1 2018, In : Nature Genetics. 50, 11, p. 1565-1573 9 p.

Research output: Contribution to journalArticle

Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration

Bangru, S., Arif, W., Seimetz, J., Bhate, A., Chen, J., Rashan, E. H., Carstens, R. P., Anakk, S. & Kalsotra, A., Oct 2018, In : Nature Structural and Molecular Biology. 25, 10, p. 928-939 12 p.

Research output: Contribution to journalArticle

An Emerging Pathway of Doxorubicin Cardiotoxicity Mediated through CYP2J2

Arnold, W. R. & Das, A., Apr 24 2018, In : Biochemistry. 57, 16, p. 2294-2296 3 p.

Research output: Contribution to journalComment/debate

A new role for estrogen receptor a in cell proliferation and cancer: Activating the anticipatory unfolded protein response

Livezey, M., Kim, J. E. & Shapiro, D. J., Jun 15 2018, In : Frontiers in Endocrinology. 9, JUN, 325.

Research output: Contribution to journalShort survey

Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides

Roy, J., Watson, J. E., Hong, I. S., Fan, T. M. & Das, A., Jul 12 2018, In : Journal of Medicinal Chemistry. 61, 13, p. 5569-5579 11 p.

Research output: Contribution to journalArticle

A Ratiometric Acoustogenic Probe for in Vivo Imaging of Endogenous Nitric Oxide

Reinhardt, C. J., Zhou, E. Y., Jorgensen, M. D., Partipilo, G. & Chan, J., Jan 24 2018, In : Journal of the American Chemical Society. 140, 3, p. 1011-1018 8 p.

Research output: Contribution to journalArticle

A Single Amino Acid Switch Alters the Isoprene Donor Specificity in Ribosomally Synthesized and Post-Translationally Modified Peptide Prenyltransferases

Estrada, P., Morita, M., Hao, Y., Schmidt, E. W. & Nair, S. K., Jul 5 2018, In : Journal of the American Chemical Society. 140, 26, p. 8124-8127 4 p.

Research output: Contribution to journalArticle

Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations

Castelle, C. J., Brown, C. T., Anantharaman, K., Probst, A. J., Huang, R. H. & Banfield, J. F., Oct 1 2018, In : Nature Reviews Microbiology. 16, 10, p. 629-645 17 p.

Research output: Contribution to journalArticle

Biosynthetic Proteases That Catalyze the Macrocyclization of Ribosomally Synthesized Linear Peptides

Ongpipattanakul, C. & Nair, S. K., Jun 12 2018, In : Biochemistry. 57, 23, p. 3201-3209 9 p.

Research output: Contribution to journalArticle

BRD4 regulates cellular senescence in gastric cancer cells via E2F/miR-106b/p21 axis

Dong, X., Hu, X., Chen, J., Hu, D. & Chen, L. F., Feb 1 2018, In : Cell Death and Disease. 9, 2, 203.

Research output: Contribution to journalArticle

Calcium-Induced Lipid Nanocluster Structures: Sculpturing of the Plasma Membrane

Hallock, M. J., Greenwood, A. I., Wang, Y., Morrissey, J. H., Tajkhorshid, E., Rienstra, C. M. & Pogorelov, T. V., Dec 18 2018, In : Biochemistry. 57, 50, p. 6897-6905 9 p.

Research output: Contribution to journalArticle

Carbon dots with induced surface oxidation permits imaging at single-particle level for intracellular studies

Misra, S. K., Srivastava, I., Khamo, J. S., Krishnamurthy, V. V., Sar, D., Schwartz-Duval, A. S., Soares, J. A. N. T., Zhang, K. & Pan, D., Aug 16 2018, In : Nanoscale. 10, 39, p. 18510-18519 10 p.

Research output: Contribution to journalArticle

Characterization of Leader Peptide Binding during Catalysis by the Nisin Dehydratase NisB

Repka, L. M., Hetrick, K. J., Chee, S. H. & Van Der Donk, W. A., Mar 28 2018, In : Journal of the American Chemical Society. 140, 12, p. 4200-4203 4 p.

Research output: Contribution to journalArticle

Chemical Physics in Living Cells-using Light to Visualize and Control Intracellular Signal Transduction

Krishnamurthy, V. V. & Zhang, K., 2018, In : Chinese Journal of Chemical Physics. 31, 4, p. 375-392 18 p.

Research output: Contribution to journalReview article

Comparison of t cell activities mediated by human TCRs and CARs that use the same recognition domains

Harris, D. T., Hager, M. V., Smith, S. N., Cai, Q., Stone, J. D., Kruger, P., Lever, M., Dushek, O., Schmitt, T. M., Greenberg, P. D. & Kranz, D. M., Feb 1 2018, In : Journal of Immunology. 200, 3, p. 1088-1100 13 p.

Research output: Contribution to journalArticle

Conformation of methylated GGQ in the Peptidyl Transferase Center during Translation Termination

Zeng, F. & Jin, H., Dec 1 2018, In : Scientific reports. 8, 1, 2349.

Research output: Contribution to journalArticle

Constructing atomic structural models into cryo-EM densities using molecular dynamics – Pros and cons

Wang, Y., Shekhar, M., Thifault, D., Williams, C. J., McGreevy, R., Richardson, J., Singharoy, A. & Tajkhorshid, E., Nov 2018, In : Journal of Structural Biology. 204, 2, p. 319-328 10 p.

Research output: Contribution to journalArticle

Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system

Xiao, T., Ackerman, C. M., Carroll, E. C., Jia, S., Hoagland, A., Chan, J., Thai, B., Liu, C. S., Isacoff, E. Y. & Chang, C. J., Jul 1 2018, In : Nature chemical biology. 14, 7, p. 655-663 9 p.

Research output: Contribution to journalArticle

Cross-talk of cannabinoid and endocannabinoid metabolism is mediated via human cardiac CYP2J2

Arnold, W. R., Weigle, A. T. & Das, A., Jul 2018, In : Journal of Inorganic Biochemistry. 184, p. 88-99 12 p.

Research output: Contribution to journalArticle

Cytochrome aa 3 Oxygen Reductase Utilizes the Tunnel Observed in the Crystal Structures to Deliver O2 for Catalysis

Mahinthichaichan, P., Gennis, R. B. & Tajkhorshid, E., Apr 10 2018, In : Biochemistry. 57, 14, p. 2150-2161 12 p.

Research output: Contribution to journalArticle

Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy-complex in the lyase step

Duggal, R., Denisov, I. G. & Sligar, S. G., Jul 2018, In : FEBS Letters. 592, 13, p. 2282-2288 7 p.

Research output: Contribution to journalLetter

Cytochromes bd-I and bo3 are essential for the bactericidal effect of microcin J25 on Escherichia coli cells

Galván, A. E., Chalón, M. C., Schurig-Briccio, L. A., Salomón, R. A., Minahk, C. J., Gennis, R. B. & Bellomio, A., Feb 2018, In : Biochimica et Biophysica Acta - Bioenergetics. 1859, 2, p. 110-118 9 p.

Research output: Contribution to journalArticle

Open Access

Damage-Responsive Microcapsules for Amplified Photoacoustic Detection of Microcracks in Polymers

Geng, J. L., Li, W., Smaga, L. P., Sottos, N. R. & Chan, J., Apr 10 2018, In : Chemistry of Materials. 30, 7, p. 2198-2202 5 p.

Research output: Contribution to journalArticle

DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions

Stadtmueller, B. M., Bridges, M. D., Dam, K. M., Lerch, M. T., Huey-Tubman, K. E., Hubbell, W. L. & Bjorkman, P. J., Aug 21 2018, In : Immunity. 49, 2, p. 235-246.e4

Research output: Contribution to journalArticle

Deregulation of RNA metabolism in microsatellite expansion diseases

Misra, C., Lin, F. & Kalsotra, A., Jan 1 2018, Advances in Neurobiology. Springer New York LLC, p. 213-238 26 p. (Advances in Neurobiology; vol. 20).

Research output: Chapter in Book/Report/Conference proceedingChapter

Development and Application of Yeast and Phage Display of Diverse Lanthipeptides

Hetrick, K. J., Walker, M. C. & Van Der Donk, W. A., Apr 25 2018, In : ACS Central Science. 4, 4, p. 458-467 10 p.

Research output: Contribution to journalArticle

Development of Photoacoustic Probes for in Vivo Molecular Imaging

Reinhardt, C. J. & Chan, J., Jan 16 2018, In : Biochemistry. 57, 2, p. 194-199 6 p.

Research output: Contribution to journalReview article

Direct protein-lipid interactions shape the conformational landscape of secondary transporters

Martens, C., Shekhar, M., Borysik, A. J., Lau, A. M., Reading, E., Tajkhorshid, E., Booth, P. J. & Politis, A., Dec 1 2018, In : Nature communications. 9, 1, 4151.

Research output: Contribution to journalArticle

Double methylation of tRNA-U54 to 2-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7

Keller, P., Freund, I., Marchand, V., Bec, G., Huang, R., Motorin, Y., Eigenbrod, T., Dalpke, A. & Helm, M., Jan 1 2018, In : Nucleic acids research. 46, 18, p. 9764-9775 12 p.

Research output: Contribution to journalArticle

Open Access

Drug-Drug Interactions between Atorvastatin and Dronedarone Mediated by Monomeric CYP3A4

Denisov, I. G., Baylon, J. L., Grinkova, Y. V., Tajkhorshid, E. & Sligar, S. G., Feb 6 2018, In : Biochemistry. 57, 5, p. 805-816 12 p.

Research output: Contribution to journalArticle

Editorial overview: Novel enzymes, coenzymes, and metabolic pathways

Gerlt, J. A. & Erb, T. J., Dec 2018, In : Current Opinion in Chemical Biology. 47, p. A4-A6

Research output: Contribution to journalEditorial

Electrostatic lock in the transport cycle of the multidrug resistance transporter EmrE

Vermaas, J. V., Rempe, S. B. & Tajkhorshid, E., Aug 7 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 32, p. E7502-E7511

Research output: Contribution to journalArticle

Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin

Hegemann, J. D., Schwalen, C. J., Mitchell, D. A. & Van der Donk, W. A., Jan 1 2018, In : Chemical Communications. 54, 65, p. 9007-9010 4 p.

Research output: Contribution to journalArticle

Endocannabinoid Virodhamine Is an Endogenous Inhibitor of Human Cardiovascular CYP2J2 Epoxygenase

Carnevale, L. N., Arango, A. S., Arnold, W. R., Tajkhorshid, E. & Das, A., Nov 20 2018, In : Biochemistry. 57, 46, p. 6489-6499 11 p.

Research output: Contribution to journalArticle

Enzymatic reconstitution of ribosomal peptide backbone thioamidation

Mahanta, N., Liu, A., Dong, S., Nair, S. K. & Mitchell, D. A., Mar 20 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 12, p. 3030-3035 6 p.

Research output: Contribution to journalArticle

Enzyme Architecture: Breaking Down the Catalytic Cage that Activates Orotidine 5′-Monophosphate Decarboxylase for Catalysis

Reyes, A. C., Plache, D. C., Koudelka, A. P., Amyes, T. L., Gerlt, J. A. & Richard, J. P., Dec 19 2018, In : Journal of the American Chemical Society. 140, 50, p. 17580-17590 11 p.

Research output: Contribution to journalArticle

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity

Yien, Y. Y., Shi, J., Chen, C., Cheung, J. T. M., Grillo, A. S., Shrestha, R., Li, L., Zhang, X., Kafina, M. D., Kingsley, P. D., King, M. J., Ablain, J., Li, H., Zon, L. I., Palis, J., Burke, M. D., Bauer, D. E., Orkin, S. H., Koehler, C. M., Phillips, J. D. & 4 others, Kaplan, J., Ward, D. M., Lodish, H. F. & Paw, B. H., Dec 21 2018, In : Journal of Biological Chemistry. 293, 51, p. 19797-19811 15 p.

Research output: Contribution to journalArticle

Functional assignment of multiple catabolic pathways for d-apiose article

Carter, M. S., Zhang, X., Huang, H., Bouvier, J. T., Francisco, B. S., Vetting, M. W., Al-Obaidi, N., Bonanno, J. B., Ghosh, A., Zallot, R. G., Andersen, H. M., Almo, S. C. & Gerlt, J. A., Jul 1 2018, In : Nature chemical biology. 14, 7, p. 696-705 10 p.

Research output: Contribution to journalArticle

Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin

Wang, K. K. A., Ng, T. L., Wang, P., Huang, Z., Balskus, E. P. & van der Donk, W. A., Dec 1 2018, In : Nature communications. 9, 1, 3687.

Research output: Contribution to journalArticle

Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone

Mak, P. J., Duggal, R., Denisov, I. G., Gregory, M. C., Sligar, S. G. & Kincaid, J. R., Jun 13 2018, In : Journal of the American Chemical Society. 140, 23, p. 7324-7331 8 p.

Research output: Contribution to journalArticle

Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202

Gregory, M. C., Mak, P. J., Khatri, Y., Kincaid, J. R. & Sligar, S. G., Feb 6 2018, In : Biochemistry. 57, 5, p. 764-771 8 p.

Research output: Contribution to journalArticle

Incorporation of Nonproteinogenic Amino Acids in Class i and II Lantibiotics

Kakkar, N., Perez, J. G., Liu, W. R., Jewett, M. C. & Van Der Donk, W. A., Apr 20 2018, In : ACS chemical biology. 13, 4, p. 951-957 7 p.

Research output: Contribution to journalArticle

Investigation of Amide Bond Formation during Dehydrophos Biosynthesis

Ulrich, E. C., Bougioukou, D. J. & Van Der Donk, W. A., Mar 16 2018, In : ACS chemical biology. 13, 3, p. 537-541 5 p.

Research output: Contribution to journalArticle

Investigation of Substrate Recognition and Biosynthesis in Class IV Lanthipeptide Systems

Hegemann, J. D. & Van Der Donk, W. A., May 2 2018, In : Journal of the American Chemical Society. 140, 17, p. 5743-5754 12 p.

Research output: Contribution to journalArticle

Ionophoric effects of the antitubercular drug bedaquiline

Hards, K., McMillan, D. G. G., Schurig-Briccio, L. A., Gennis, R. B., Lill, H., Bald, D. & Cook, G. M., Jul 10 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 28, p. 7326-7331 6 p.

Research output: Contribution to journalArticle