Research Output

2020

Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy

Misra, C., Bangru, S., Lin, F., Lam, K., Koenig, S. N., Lubbers, E. R., Hedhli, J., Murphy, N. P., Parker, D. J., Dobrucki, L. W., Cooper, T. A., Tajkhorshid, E., Mohler, P. J. & Kalsotra, A., Mar 23 2020, In : Developmental cell. 52, 6, p. 748-763.e6

Research output: Contribution to journalArticle

A bifunctional salvage pathway for two distinct S-adenosylmethionine by-products that is widespread in bacteria, including pathogenic Escherichia coli

North, J. A., Wildenthal, J. A., Erb, T. J., Evans, B. S., Byerly, K. M., Gerlt, J. A. & Tabita, F. R., May 1 2020, In : Molecular Microbiology. 113, 5, p. 923-937 15 p.

Research output: Contribution to journalArticle

A Computer Conquers Tactical Combinations

Blair, D. J. & Burke, M. D., Jan 9 2020, In : Chem. 6, 1, p. 12-13 2 p.

Research output: Contribution to journalArticle

Activity-Based Sensing of Ascorbate by Using Copper-Mediated Oxidative Bond Cleavage

Yu, Z. H., Reinhardt, C. J., Wong, T. H. F., Tong, K. Y., Chan, J. & Au-Yeung, H. Y., Jul 17 2020, In : Chemistry - A European Journal. 26, 40, p. 8794-8800 7 p.

Research output: Contribution to journalArticle

A Generalizable Optogenetic Strategy to Regulate Receptor Tyrosine Kinases during Vertebrate Embryonic Development

Krishnamurthy, V. V., Fu, J., Oh, T. J., Khamo, J., Yang, J. & Zhang, K., May 1 2020, In : Journal of Molecular Biology. 432, 10, p. 3149-3158 10 p.

Research output: Contribution to journalArticle

An Activity-Based Sensing Approach for the Detection of Cyclooxygenase-2 in Live Cells

Yadav, A. K., Reinhardt, C. J., Arango, A. S., Huff, H. C., Dong, L., Malkowski, M. G., Das, A., Tajkhorshid, E. & Chan, J., Feb 17 2020, In : Angewandte Chemie - International Edition. 59, 8, p. 3307-3314 8 p.

Research output: Contribution to journalArticle

Antibody Targeted PET Imaging of 64Cu-DOTA-Anti-CEA PEGylated Lipid Nanodiscs in CEA Positive Tumors

Wong, P., Li, L., Chea, J., Hu, W., Poku, E., Ebner, T., Bowles, N., Wong, J. Y. C., Yazaki, P. J., Sligar, S. & Shively, J. E., Mar 18 2020, In : Bioconjugate Chemistry. 31, 3, p. 743-753 11 p.

Research output: Contribution to journalArticle

A Photoactivatable Formaldehyde Donor with Fluorescence Monitoring Reveals Threshold to Arrest Cell Migration

Smaga, L. P., Pino, N. W., Ibarra, G. E., Krishnamurthy, V. & Chan, J., Jan 15 2020, In : Journal of the American Chemical Society. 142, 2, p. 680-684 5 p.

Research output: Contribution to journalArticle

Bacteroidetes can be a rich source of novel lanthipeptides: The case study of Pedobacter lusitanus

Caetano, T., van der Donk, W. & Mendo, S., May 2020, In : Microbiological Research. 235, 126441.

Research output: Contribution to journalArticle

Biochemical basis for the regulation of biosynthesis of antiparasitics by bacterial hormones

Kapoor, I., Olivares, P. & Nair, S. K., Jun 2020, In : eLife. 9, p. 1-33 33 p., e57824.

Research output: Contribution to journalArticle

Open Access

Biochemical basis for the regulation of biosynthesis of antiparasitics by bacterial hormones

Kapoor, I., Olivares, P. & Nair, S. K., Jun 8 2020, (Accepted/In press) In : eLife. 9, e57824.

Research output: Contribution to journalArticle

Open Access

Cellular and molecular basis of liver regeneration

Bangru, S. & Kalsotra, A., Apr 2020, In : Seminars in Cell and Developmental Biology. 100, p. 74-87 14 p.

Research output: Contribution to journalReview article

Characterization of a Dehydratase and Methyltransferase in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides in Lachnospiraceae

Huo, L., Zhao, X., Acedo, J. Z., Estrada, P., Nair, S. K. & van der Donk, W. A., Jan 15 2020, In : ChemBioChem. 21, 1-2, p. 190-199 10 p.

Research output: Contribution to journalArticle

Characterization of an l -Ascorbate Catabolic Pathway with Unprecedented Enzymatic Transformations

Stack, T. M. M., Morrison, K. N., Dettmer, T. M., Wille, B., Kim, C., Joyce, R., Jermain, M., Naing, Y. T., Bhatti, K., Francisco, B. S., Carter, M. S. & Gerlt, J. A., Jan 29 2020, In : Journal of the American Chemical Society. 142, 4, p. 1657-1661 5 p.

Research output: Contribution to journalArticle

Chromatin accessibility and histone acetylation in the regulation of competence in early development

Esmaeili, M., Blythe, S. A., Tobias, J. W., Zhang, K., Yang, J. & Klein, P. S., Jun 1 2020, In : Developmental Biology. 462, 1, p. 20-35 16 p.

Research output: Contribution to journalArticle

Comparative Pharmacokinetics of Δ9-Tetrahydrocannabinol in Adolescent and Adult Male Mice

Torrens, A., Vozella, V., Huff, H., McNeil, B., Ahmed, F., Ghidini, A., Mahler, S. V., Huestis, M. A., Das, A. & Piomelli, D., Jul 1 2020, In : Journal of Pharmacology and Experimental Therapeutics. 374, 1, p. 151-160 10 p.

Research output: Contribution to journalArticle

Open Access

Computational Dissection of Membrane Transport at a Microscopic Level

Jiang, T., Wen, P. C., Trebesch, N., Zhao, Z., Pant, S., Kapoor, K., Shekhar, M. & Tajkhorshid, E., Mar 2020, In : Trends in Biochemical Sciences. 45, 3, p. 202-216 15 p.

Research output: Contribution to journalReview article

CYP2J2 Molecular Recognition: A New Axis for Therapeutic Design

Das, A., Weigle, A. T., Arnold, W. R., Kim, J. S., Carnevale, L. N. & Huff, H. C., Nov 2020, In : Pharmacology and Therapeutics. 215, 107601.

Research output: Contribution to journalReview article

Discovery and Characterization of a Class IV Lanthipeptide with a Nonoverlapping Ring Pattern

Ren, H., Shi, C., Bothwell, I. R., Van Der Donk, W. A., Van Der Donk, W. A., Van Der Donk, W. A., Zhao, H., Zhao, H., Zhao, H., Zhao, H. & Zhao, H., Jun 19 2020, In : ACS chemical biology. 15, 6, p. 1642-1649 8 p.

Research output: Contribution to journalArticle

Duplication of leucyl-tRNA synthetase in an archaeal extremophile may play a role in adaptation to variable environmental conditions

Weitzel, C. S., Li, L., Zhang, C., Eilts, K. K., Bretz, N. M., Gatten, A. L., Whitaker, R. J. & Martinis, S. A., Apr 3 2020, In : Journal of Biological Chemistry. 295, 14, p. 4563-4576 14 p.

Research output: Contribution to journalArticle

Early But Not Delayed Optogenetic RAF Activation Promotes Astrocytogenesis in Mouse Neural Progenitors

Su, Y., Huang, X., Huang, Z., Huang, T., Li, T., Fan, H., Zhang, K. & Yi, C., Jul 24 2020, In : Journal of Molecular Biology. 432, 16, p. 4358-4368 11 p.

Research output: Contribution to journalArticle

Open Access

Effect of PFOA on DNA Methylation and Alternative Splicing in Mouse Liver

Wen, Y., Chen, J., Li, J., Arif, W., Kalsotra, A. & Irudayaraj, J., Sep 1 2020, In : Toxicology Letters. 329, p. 38-46 9 p.

Research output: Contribution to journalArticle

Open Access

Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans

Nayak, D. D., Liu, A., Agrawal, N., Rodriguez-Carerro, R., Dong, S. H., Mitchell, D. A., Nair, S. K. & Metcalf, W. W., Feb 2020, In : PLoS biology. 18, 2, e3000507.

Research output: Contribution to journalArticle

Open Access

Identifying mutation hotspots reveals pathogenetic mechanisms of KCNQ2 epileptic encephalopathy

Zhang, J., Kim, E. C., Chen, C., Procko, E., Pant, S., Lam, K., Patel, J., Choi, R., Hong, M., Joshi, D., Bolton, E., Tajkhorshid, E. & Chung, H. J., Dec 1 2020, In : Scientific reports. 10, 1, 4756.

Research output: Contribution to journalArticle

Open Access

Membrane-Bound Ras as a Conformational Clock

Gorfe, A. A. & Sligar, S. G., Jan 1 2020, (Accepted/In press) In : Biophysical journal.

Research output: Contribution to journalArticle

Menthol Binding to the Human α4β2 Nicotinic Acetylcholine Receptor Facilitated by Its Strong Partitioning in the Membrane

Shahoei, R. & Tajkhorshid, E., Mar 12 2020, In : Journal of Physical Chemistry B. 124, 10, p. 1866-1880 15 p.

Research output: Contribution to journalArticle

Microscopic Characterization of GRP1 PH Domain Interaction with Anionic Membranes

Pant, S. & Tajkhorshid, E., Mar 5 2020, In : Journal of Computational Chemistry. 41, 6, p. 489-499 11 p.

Research output: Contribution to journalArticle

Molecular Insights into the Loading and Dynamics of Doxorubicin on PEGylated Graphene Oxide Nanocarriers

Mahdavi, M., Fattahi, A., Tajkhorshid, E. & Nouranian, S., Jan 1 2020, (Accepted/In press) In : ACS Applied Bio Materials.

Research output: Contribution to journalArticle

Molecular Orientation Determination in Nanodiscs at the Single-Molecule Level

Camp, T., Mehta, K., Sligar, S. G. & Zhang, K., Jan 21 2020, In : Analytical chemistry. 92, 2, p. 2229-2236 8 p.

Research output: Contribution to journalArticle

Nanodisc self-assembly is thermodynamically reversible and controllable

Camp, T., Sligar, S. G., Sligar, S. G. & Sligar, S. G., Jun 28 2020, In : Soft Matter. 16, 24, p. 5615-5623 9 p.

Research output: Contribution to journalArticle

Natural product biosynthesis: What’s next? An introduction to the JBC Reviews Thematic Series

Nair, S. K. & Jez, J. M., Jan 10 2020, In : Journal of Biological Chemistry. 295, 2, p. 335-336 2 p.

Research output: Contribution to journalReview article

Open Access

Near-infrared photoactivatable nitric oxide donors with photoacoustic readout

Zhou, E. Y., Knox, H. J., Reinhardt, C. J., Partipilo, G. & Chan, J., 2020, Methods in Enzymology. Chenoweth, D. M. (ed.). Academic Press Inc., p. 113-147 35 p. (Methods in Enzymology; vol. 641).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nitric oxide imaging in cancer enabled by steric relaxation of a photoacoustic probe platform

Reinhardt, C. J., Xu, R. & Chan, J., Feb 14 2020, In : Chemical Science. 11, 6, p. 1587-1592 6 p.

Research output: Contribution to journalArticle

Open Access

Nonribosomal peptide extension by a peptide amino-acyl tRNA ligase

Zhang, Z. & Van Der Donk, W. A., Jan 1 2020, In : Journal of the American Chemical Society. 141, 50, p. 19625-19633 9 p.

Research output: Contribution to journalArticle

PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome

Yang, X. D., Li, W., Zhang, S., Wu, D., Jiang, X., Tan, R., Niu, X., Wang, Q., Wu, X., Liu, Z., Chen, L. F., Qin, J. & Su, B., Jan 15 2020, In : EMBO Journal. 39, 2, e102201.

Research output: Contribution to journalArticle

Polymer-Peptide Conjugates Convert Amyloid into Protein Nanobundles through Fragmentation and Lateral Association

Smith, J. W., Jiang, X., An, H., Barclay, A. M., Licari, G., Tajkhorshid, E., Moore, E. G., Rienstra, C. M., Moore, J. S. & Chen, Q., Feb 28 2020, In : ACS Applied Nano Materials. 3, 2, p. 937-945 9 p.

Research output: Contribution to journalArticle

Probing cholesterol binding and translocation in P-glycoprotein

Thangapandian, S., Kapoor, K. & Tajkhorshid, E., Jan 1 2020, In : Biochimica et Biophysica Acta - Biomembranes. 1862, 1, 183090.

Research output: Contribution to journalArticle

Progress in the Enzymology of the Mitochondrial Diseases of Lipoic Acid Requiring Enzymes

Cronan, J. E., May 21 2020, In : Frontiers in Genetics. 11, 510.

Research output: Contribution to journalReview article

Open Access

Rational Design of a Red Fluorescent Sensor for ALDH1A1 Displaying Enhanced Cellular Uptake and Reactivity

Bearrood, T. E., Aguirre-Figueroa, G. & Chan, J., Feb 19 2020, In : Bioconjugate Chemistry. 31, 2, p. 224-228 5 p.

Research output: Contribution to journalArticle

Role of respiratory NADH oxidation in the regulation of Staphylococcus aureus virulence

Schurig-Briccio, L. A., Parraga Solorzano, P. K., Lencina, A. M., Radin, J. N., Chen, G. Y., Sauer, J. D., Kehl-Fie, T. E. & Gennis, R. B., May 6 2020, In : EMBO Reports. 21, 5, e45832.

Research output: Contribution to journalArticle

Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction

Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., Wang, L., Brooke, C. B., Burke, M., Fan, T. M. & Hergenrother, P., Jun 18 2020, (In preparation) Cold Spring Harbor Laboratory Press, 35 p. (bioRxiv).

Research output: Working paper

Small Molecule Channels Harness Membrane Potential to Concentrate Potassium in trk1Δtrk2Δ Yeast

Hou, J., Daniels, P. N. & Burke, M. D., Jun 19 2020, In : ACS chemical biology. 15, 6, p. 1575-1580 6 p.

Research output: Contribution to journalArticle

Src couples estrogen receptor to the anticipatory unfolded protein response and regulates cancer cell fate under stress

Yu, L., Wang, L., Kim, J. E., Mao, C. & Shapiro, D. J., Jan 1 2020, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular Cell Research. 118765.

Research output: Contribution to journalArticle

Structure-Guided Biochemical Analysis of Quorum Signal Synthase Specificities

Dong, S. H., Nhu-Lam, M., Nagarajan, R. & Nair, S. K., Jun 19 2020, In : ACS chemical biology. 15, 6, p. 1497-1504 8 p.

Research output: Contribution to journalArticle

Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides

Sharma, P., Marada, V. V. V. R., Cai, Q., Kizerwetter, M., He, Y., Wolf, S. P., Schreiber, K., Clausen, H., Schreiber, H. & Kranz, D. M., Jun 30 2020, In : Proceedings of the National Academy of Sciences. 117, 26, p. 15148-15159 12 p., 201920662.

Research output: Contribution to journalArticle

Structure of the cytochrome aa3-600 heme-copper menaquinol oxidase bound to inhibitor HQNO shows TM0 is part of the quinol binding site

Xu, J., Ding, Z., Liu, B., Yi, S. M., Li, J., Zhang, Z., Liu, Y., Li, J., Liu, L., Zhou, A., Gennis, R. B. & Zhu, J., Jan 14 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 2, p. 872-876 5 p.

Research output: Contribution to journalArticle

Substrate Recognition by the Class II Lanthipeptide Synthetase HalM2

Rahman, I. R., Acedo, J. Z., Liu, X. R., Zhu, L., Arrington, J., Gross, M. L. & Van Der Donk, W. A., Jun 19 2020, In : ACS chemical biology. 15, 6, p. 1473-1486 14 p.

Research output: Contribution to journalArticle

The carboxy-terminal insert in the Q-loop is needed for functionality of Escherichia coli cytochrome bd-I

Goojani, H. G., Konings, J., Hakvoort, H., Hong, S., Gennis, R. B., Sakamoto, J., Lill, H. & Bald, D., Jun 1 2020, In : Biochimica et Biophysica Acta - Bioenergetics. 1861, 5-6, 148175.

Research output: Contribution to journalArticle